Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3M2_LEIMU

TriTrypDb:

LmxM.32.0440

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.433
CLV_NRD_NRD_1	196	198	PF00675	0.466
CLV_PCSK_FUR_1	194	198	PF00082	0.542
CLV_PCSK_KEX2_1	196	198	PF00082	0.492
CLV_PCSK_SKI1_1	156	160	PF00082	0.533
DEG_MDM2_SWIB_1	94	101	PF02201	0.412
DOC_CKS1_1	48	53	PF01111	0.456
DOC_CYCLIN_RxL_1	59	67	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.442
DOC_MAPK_gen_1	194	201	PF00069	0.469
DOC_MAPK_MEF2A_6	96	103	PF00069	0.372
DOC_MAPK_NFAT4_5	96	104	PF00069	0.445
DOC_PP1_RVXF_1	60	67	PF00149	0.374
DOC_PP2B_LxvP_1	99	102	PF13499	0.470
DOC_USP7_MATH_1	147	151	PF00917	0.596
DOC_WW_Pin1_4	139	144	PF00397	0.592
DOC_WW_Pin1_4	47	52	PF00397	0.494
LIG_14-3-3_CanoR_1	168	178	PF00244	0.292
LIG_Clathr_ClatBox_1	63	67	PF01394	0.447
LIG_deltaCOP1_diTrp_1	202	209	PF00928	0.499
LIG_FHA_1	165	171	PF00498	0.409
LIG_FHA_2	48	54	PF00498	0.484
LIG_LIR_Apic_2	18	24	PF02991	0.375
LIG_LIR_Gen_1	18	26	PF02991	0.364
LIG_LIR_Gen_1	36	47	PF02991	0.471
LIG_LIR_Nem_3	18	22	PF02991	0.374
LIG_LIR_Nem_3	36	42	PF02991	0.397
LIG_MYND_1	139	143	PF01753	0.522
LIG_Pex14_1	90	94	PF04695	0.399
LIG_Pex14_2	94	98	PF04695	0.406
LIG_Rb_LxCxE_1	167	186	PF01857	0.424
LIG_SH2_STAP1	39	43	PF00017	0.440
LIG_SH2_STAT3	86	89	PF00017	0.416
LIG_SH2_STAT5	21	24	PF00017	0.350
LIG_SH2_STAT5	86	89	PF00017	0.416
LIG_SH3_3	117	123	PF00018	0.648
LIG_SH3_3	140	146	PF00018	0.577
LIG_SH3_3	45	51	PF00018	0.476
MOD_CK1_1	142	148	PF00069	0.593
MOD_CK2_1	106	112	PF00069	0.552
MOD_CK2_1	169	175	PF00069	0.382
MOD_CK2_1	34	40	PF00069	0.408
MOD_CK2_1	47	53	PF00069	0.429
MOD_GlcNHglycan	6	9	PF01048	0.584
MOD_GSK3_1	11	18	PF00069	0.478
MOD_GSK3_1	2	9	PF00069	0.690
MOD_LATS_1	2	8	PF00433	0.600
MOD_NEK2_1	6	11	PF00069	0.708
MOD_NEK2_1	75	80	PF00069	0.405
MOD_PKA_2	182	188	PF00069	0.493
MOD_Plk_1	2	8	PF00069	0.722
MOD_Plk_1	75	81	PF00069	0.368
MOD_Plk_4	121	127	PF00069	0.626
MOD_Plk_4	34	40	PF00069	0.567
MOD_ProDKin_1	139	145	PF00069	0.598
MOD_ProDKin_1	47	53	PF00069	0.489
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.437
TRG_ENDOCYTIC_2	39	42	PF00928	0.455
TRG_ER_diArg_1	193	196	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL76	Leptomonas seymouri	48%	68%
A0A1X0P0M0	Trypanosomatidae	32%	72%
A0A3Q8IDL0	Leishmania donovani	89%	100%
A4HL79	Leishmania braziliensis	75%	100%
D0A4P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	70%
E9AHN1	Leishmania infantum	90%	100%
Q4Q4G5	Leishmania major	88%	100%