Putative serine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, putative

Species:

Leishmania mexicana

UniProt:

E9B3L8_LEIMU

TriTrypDb:

LmxM.32.0400

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3L8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008474	palmitoyl-(protein) hydrolase activity	3	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0098599	palmitoyl hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.357
CLV_NRD_NRD_1	240	242	PF00675	0.351
CLV_NRD_NRD_1	251	253	PF00675	0.452
CLV_NRD_NRD_1	27	29	PF00675	0.464
CLV_NRD_NRD_1	309	311	PF00675	0.508
CLV_PCSK_KEX2_1	204	206	PF00082	0.357
CLV_PCSK_KEX2_1	240	242	PF00082	0.365
CLV_PCSK_KEX2_1	246	248	PF00082	0.428
CLV_PCSK_KEX2_1	250	252	PF00082	0.480
CLV_PCSK_KEX2_1	29	31	PF00082	0.435
CLV_PCSK_KEX2_1	309	311	PF00082	0.508
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.436
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.502
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.414
CLV_PCSK_PC7_1	247	253	PF00082	0.504
CLV_PCSK_SKI1_1	246	250	PF00082	0.457
CLV_PCSK_SKI1_1	252	256	PF00082	0.453
CLV_PCSK_SKI1_1	377	381	PF00082	0.496
CLV_PCSK_SKI1_1	384	388	PF00082	0.672
CLV_PCSK_SKI1_1	8	12	PF00082	0.307
DEG_Kelch_Keap1_1	36	41	PF01344	0.302
DEG_Nend_Nbox_1	1	3	PF02207	0.426
DOC_CYCLIN_RxL_1	240	253	PF00134	0.320
DOC_MAPK_gen_1	28	34	PF00069	0.438
DOC_PP1_RVXF_1	6	12	PF00149	0.295
DOC_PP4_FxxP_1	11	14	PF00568	0.386
DOC_USP7_MATH_1	260	264	PF00917	0.635
DOC_USP7_MATH_1	332	336	PF00917	0.482
DOC_USP7_MATH_1	390	394	PF00917	0.631
DOC_USP7_UBL2_3	164	168	PF12436	0.340
DOC_USP7_UBL2_3	246	250	PF12436	0.353
DOC_WW_Pin1_4	113	118	PF00397	0.272
LIG_14-3-3_CanoR_1	15	21	PF00244	0.387
LIG_14-3-3_CanoR_1	183	193	PF00244	0.465
LIG_14-3-3_CanoR_1	262	267	PF00244	0.540
LIG_Actin_WH2_2	168	185	PF00022	0.312
LIG_BRCT_BRCA1_1	359	363	PF00533	0.427
LIG_FHA_1	177	183	PF00498	0.385
LIG_FHA_1	240	246	PF00498	0.326
LIG_FHA_2	114	120	PF00498	0.398
LIG_FHA_2	356	362	PF00498	0.345
LIG_HCF-1_HBM_1	130	133	PF13415	0.388
LIG_LIR_Gen_1	130	141	PF02991	0.454
LIG_LIR_Gen_1	358	367	PF02991	0.461
LIG_LIR_Nem_3	102	106	PF02991	0.312
LIG_LIR_Nem_3	130	136	PF02991	0.335
LIG_LIR_Nem_3	198	203	PF02991	0.419
LIG_LIR_Nem_3	303	308	PF02991	0.367
LIG_LIR_Nem_3	360	366	PF02991	0.434
LIG_MAD2	183	191	PF02301	0.457
LIG_NRBOX	244	250	PF00104	0.484
LIG_Pex14_2	339	343	PF04695	0.356
LIG_Pex14_2	359	363	PF04695	0.222
LIG_Pex14_2	369	373	PF04695	0.220
LIG_RPA_C_Fungi	236	248	PF08784	0.462
LIG_SH2_CRK	312	316	PF00017	0.424
LIG_SH2_NCK_1	126	130	PF00017	0.312
LIG_SH2_STAP1	133	137	PF00017	0.466
LIG_SH2_STAP1	86	90	PF00017	0.389
LIG_SH2_STAT5	103	106	PF00017	0.461
LIG_SH2_STAT5	141	144	PF00017	0.267
LIG_SH2_STAT5	160	163	PF00017	0.312
LIG_SH2_STAT5	192	195	PF00017	0.443
LIG_SH2_STAT5	365	368	PF00017	0.427
LIG_SH2_STAT5	45	48	PF00017	0.364
LIG_SH3_3	7	13	PF00018	0.399
LIG_SUMO_SIM_par_1	171	177	PF11976	0.312
LIG_SUMO_SIM_par_1	300	306	PF11976	0.300
LIG_WRC_WIRS_1	175	180	PF05994	0.312
LIG_WRC_WIRS_1	2	7	PF05994	0.297
LIG_WW_3	12	16	PF00397	0.443
MOD_CK1_1	124	130	PF00069	0.363
MOD_CK1_1	176	182	PF00069	0.334
MOD_CK1_1	36	42	PF00069	0.454
MOD_CK1_1	393	399	PF00069	0.556
MOD_CK2_1	113	119	PF00069	0.327
MOD_CK2_1	35	41	PF00069	0.296
MOD_CK2_1	355	361	PF00069	0.284
MOD_GlcNHglycan	108	111	PF01048	0.351
MOD_GlcNHglycan	279	282	PF01048	0.609
MOD_GlcNHglycan	38	41	PF01048	0.493
MOD_GlcNHglycan	381	384	PF01048	0.504
MOD_GlcNHglycan	392	395	PF01048	0.504
MOD_GSK3_1	173	180	PF00069	0.328
MOD_GSK3_1	267	274	PF00069	0.654
MOD_GSK3_1	277	284	PF00069	0.761
MOD_GSK3_1	32	39	PF00069	0.475
MOD_GSK3_1	82	89	PF00069	0.388
MOD_N-GLC_1	260	265	PF02516	0.442
MOD_N-GLC_1	274	279	PF02516	0.624
MOD_N-GLC_1	332	337	PF02516	0.326
MOD_N-GLC_1	64	69	PF02516	0.258
MOD_NEK2_1	1	6	PF00069	0.421
MOD_NEK2_1	174	179	PF00069	0.348
MOD_NEK2_1	289	294	PF00069	0.384
MOD_NEK2_1	32	37	PF00069	0.462
MOD_NEK2_1	327	332	PF00069	0.586
MOD_OFUCOSY	181	188	PF10250	0.500
MOD_PKA_2	239	245	PF00069	0.384
MOD_Plk_1	121	127	PF00069	0.312
MOD_Plk_1	332	338	PF00069	0.431
MOD_Plk_1	64	70	PF00069	0.256
MOD_Plk_2-3	300	306	PF00069	0.395
MOD_Plk_2-3	355	361	PF00069	0.356
MOD_Plk_4	1	7	PF00069	0.412
MOD_Plk_4	121	127	PF00069	0.312
MOD_Plk_4	300	306	PF00069	0.527
MOD_Plk_4	64	70	PF00069	0.363
MOD_ProDKin_1	113	119	PF00069	0.272
TRG_DiLeu_BaEn_1	211	216	PF01217	0.345
TRG_DiLeu_BaEn_1	376	381	PF01217	0.481
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.474
TRG_ENDOCYTIC_2	133	136	PF00928	0.326
TRG_ENDOCYTIC_2	203	206	PF00928	0.426
TRG_ENDOCYTIC_2	312	315	PF00928	0.421
TRG_ENDOCYTIC_2	45	48	PF00928	0.438
TRG_ER_diArg_1	203	205	PF00400	0.362
TRG_ER_diArg_1	308	310	PF00400	0.569
TRG_NES_CRM1_1	88	102	PF08389	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M6	Leptomonas seymouri	58%	100%
A0A3S7X6G6	Leishmania donovani	88%	100%
A4HL75	Leishmania braziliensis	73%	100%
A4I8Q4	Leishmania infantum	88%	100%
Q4Q4J7	Leishmania major	86%	100%