Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3L6_LEIMU

TriTrypDb:

LmxM.32.0380

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3L6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.524
CLV_NRD_NRD_1	331	333	PF00675	0.414
CLV_NRD_NRD_1	58	60	PF00675	0.462
CLV_PCSK_FUR_1	56	60	PF00082	0.458
CLV_PCSK_KEX2_1	20	22	PF00082	0.520
CLV_PCSK_KEX2_1	330	332	PF00082	0.348
CLV_PCSK_KEX2_1	58	60	PF00082	0.462
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.361
CLV_PCSK_SKI1_1	251	255	PF00082	0.374
CLV_PCSK_SKI1_1	319	323	PF00082	0.460
CLV_PCSK_SKI1_1	351	355	PF00082	0.504
CLV_PCSK_SKI1_1	399	403	PF00082	0.489
DEG_COP1_1	4	12	PF00400	0.431
DEG_Nend_UBRbox_3	1	3	PF02207	0.536
DEG_SCF_FBW7_1	25	32	PF00400	0.563
DEG_SPOP_SBC_1	72	76	PF00917	0.483
DEG_SPOP_SBC_1	83	87	PF00917	0.468
DOC_CKS1_1	42	47	PF01111	0.478
DOC_CYCLIN_RxL_1	410	421	PF00134	0.285
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.373
DOC_MAPK_DCC_7	135	145	PF00069	0.432
DOC_MAPK_gen_1	114	123	PF00069	0.573
DOC_MAPK_MEF2A_6	259	267	PF00069	0.439
DOC_PP1_RVXF_1	379	385	PF00149	0.273
DOC_PP2B_LxvP_1	143	146	PF13499	0.407
DOC_PP2B_LxvP_1	153	156	PF13499	0.376
DOC_PP2B_LxvP_1	290	293	PF13499	0.293
DOC_PP4_FxxP_1	384	387	PF00568	0.275
DOC_USP7_MATH_1	23	27	PF00917	0.614
DOC_USP7_MATH_1	258	262	PF00917	0.328
DOC_USP7_MATH_1	30	34	PF00917	0.572
DOC_USP7_MATH_1	36	40	PF00917	0.516
DOC_USP7_MATH_1	68	72	PF00917	0.495
DOC_USP7_MATH_1	73	77	PF00917	0.468
DOC_USP7_MATH_1	83	87	PF00917	0.488
DOC_USP7_UBL2_3	326	330	PF12436	0.399
DOC_WW_Pin1_4	180	185	PF00397	0.552
DOC_WW_Pin1_4	25	30	PF00397	0.737
DOC_WW_Pin1_4	269	274	PF00397	0.467
DOC_WW_Pin1_4	32	37	PF00397	0.784
DOC_WW_Pin1_4	41	46	PF00397	0.511
DOC_WW_Pin1_4	76	81	PF00397	0.571
DOC_WW_Pin1_4	86	91	PF00397	0.600
DOC_WW_Pin1_4	99	104	PF00397	0.673
LIG_14-3-3_CanoR_1	179	184	PF00244	0.502
LIG_14-3-3_CanoR_1	201	206	PF00244	0.381
LIG_14-3-3_CanoR_1	319	328	PF00244	0.375
LIG_14-3-3_CanoR_1	331	339	PF00244	0.273
LIG_BIR_III_2	346	350	PF00653	0.431
LIG_BRCT_BRCA1_1	226	230	PF00533	0.255
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.329
LIG_eIF4E_1	115	121	PF01652	0.466
LIG_EVH1_1	290	294	PF00568	0.420
LIG_FHA_1	189	195	PF00498	0.665
LIG_FHA_1	202	208	PF00498	0.612
LIG_FHA_1	241	247	PF00498	0.286
LIG_FHA_1	26	32	PF00498	0.488
LIG_FHA_1	316	322	PF00498	0.513
LIG_FHA_1	368	374	PF00498	0.403
LIG_FHA_1	4	10	PF00498	0.435
LIG_FHA_2	294	300	PF00498	0.309
LIG_FHA_2	331	337	PF00498	0.271
LIG_FHA_2	50	56	PF00498	0.674
LIG_GBD_Chelix_1	407	415	PF00786	0.269
LIG_LIR_Apic_2	286	291	PF02991	0.341
LIG_LIR_Gen_1	160	168	PF02991	0.365
LIG_LIR_Gen_1	299	308	PF02991	0.291
LIG_LIR_Gen_1	333	343	PF02991	0.338
LIG_LIR_Gen_1	406	417	PF02991	0.302
LIG_LIR_LC3C_4	243	246	PF02991	0.226
LIG_LIR_Nem_3	147	152	PF02991	0.433
LIG_LIR_Nem_3	160	164	PF02991	0.411
LIG_LIR_Nem_3	299	304	PF02991	0.299
LIG_LIR_Nem_3	333	338	PF02991	0.401
LIG_LIR_Nem_3	389	395	PF02991	0.322
LIG_LIR_Nem_3	406	412	PF02991	0.395
LIG_LIR_Nem_3	426	431	PF02991	0.372
LIG_MLH1_MIPbox_1	226	230	PF16413	0.245
LIG_PDZ_Class_2	432	437	PF00595	0.438
LIG_Pex14_2	338	342	PF04695	0.380
LIG_REV1ctd_RIR_1	339	348	PF16727	0.306
LIG_SH2_CRK	203	207	PF00017	0.369
LIG_SH2_CRK	288	292	PF00017	0.317
LIG_SH2_CRK	409	413	PF00017	0.375
LIG_SH2_GRB2like	161	164	PF00017	0.496
LIG_SH2_NCK_1	428	432	PF00017	0.446
LIG_SH2_PTP2	161	164	PF00017	0.380
LIG_SH2_SRC	161	164	PF00017	0.380
LIG_SH2_SRC	409	412	PF00017	0.218
LIG_SH2_SRC	8	11	PF00017	0.492
LIG_SH2_STAT3	115	118	PF00017	0.475
LIG_SH2_STAT5	161	164	PF00017	0.404
LIG_SH2_STAT5	203	206	PF00017	0.495
LIG_SH2_STAT5	229	232	PF00017	0.287
LIG_SH2_STAT5	282	285	PF00017	0.322
LIG_SH2_STAT5	340	343	PF00017	0.326
LIG_SH2_STAT5	418	421	PF00017	0.343
LIG_SH2_STAT5	8	11	PF00017	0.492
LIG_SH3_1	288	294	PF00018	0.431
LIG_SH3_2	349	354	PF14604	0.428
LIG_SH3_3	100	106	PF00018	0.495
LIG_SH3_3	134	140	PF00018	0.399
LIG_SH3_3	24	30	PF00018	0.555
LIG_SH3_3	288	294	PF00018	0.372
LIG_SH3_3	346	352	PF00018	0.398
LIG_SH3_3	428	434	PF00018	0.411
LIG_SH3_3	62	68	PF00018	0.485
LIG_SUMO_SIM_par_1	242	248	PF11976	0.292
LIG_SUMO_SIM_par_1	97	102	PF11976	0.485
LIG_TYR_ITIM	407	412	PF00017	0.391
LIG_WW_1	387	390	PF00397	0.317
MOD_CDK_SPK_2	269	274	PF00069	0.467
MOD_CK1_1	175	181	PF00069	0.472
MOD_CK1_1	183	189	PF00069	0.731
MOD_CK1_1	32	38	PF00069	0.690
MOD_CK1_1	71	77	PF00069	0.483
MOD_CK1_1	86	92	PF00069	0.703
MOD_CK2_1	293	299	PF00069	0.315
MOD_CK2_1	330	336	PF00069	0.283
MOD_CK2_1	49	55	PF00069	0.542
MOD_GlcNHglycan	10	13	PF01048	0.486
MOD_GlcNHglycan	15	18	PF01048	0.480
MOD_GlcNHglycan	3	6	PF01048	0.514
MOD_GlcNHglycan	359	362	PF01048	0.359
MOD_GlcNHglycan	70	73	PF01048	0.777
MOD_GSK3_1	175	182	PF00069	0.496
MOD_GSK3_1	184	191	PF00069	0.553
MOD_GSK3_1	25	32	PF00069	0.571
MOD_GSK3_1	315	322	PF00069	0.380
MOD_GSK3_1	68	75	PF00069	0.733
MOD_GSK3_1	82	89	PF00069	0.763
MOD_N-GLC_1	315	320	PF02516	0.417
MOD_NEK2_1	113	118	PF00069	0.614
MOD_NEK2_1	223	228	PF00069	0.418
MOD_NEK2_1	230	235	PF00069	0.351
MOD_NEK2_1	417	422	PF00069	0.410
MOD_NEK2_1	84	89	PF00069	0.485
MOD_PIKK_1	30	36	PF00454	0.475
MOD_PIKK_1	330	336	PF00454	0.304
MOD_PIKK_1	355	361	PF00454	0.481
MOD_PIKK_1	419	425	PF00454	0.422
MOD_PKA_1	330	336	PF00069	0.304
MOD_PKA_2	113	119	PF00069	0.534
MOD_PKA_2	224	230	PF00069	0.339
MOD_PKA_2	330	336	PF00069	0.313
MOD_PKA_2	57	63	PF00069	0.469
MOD_Plk_1	315	321	PF00069	0.424
MOD_Plk_4	145	151	PF00069	0.266
MOD_Plk_4	240	246	PF00069	0.329
MOD_ProDKin_1	180	186	PF00069	0.556
MOD_ProDKin_1	25	31	PF00069	0.739
MOD_ProDKin_1	269	275	PF00069	0.461
MOD_ProDKin_1	32	38	PF00069	0.784
MOD_ProDKin_1	41	47	PF00069	0.508
MOD_ProDKin_1	76	82	PF00069	0.573
MOD_ProDKin_1	86	92	PF00069	0.602
MOD_ProDKin_1	99	105	PF00069	0.669
MOD_SUMO_rev_2	311	318	PF00179	0.420
TRG_AP2beta_CARGO_1	336	345	PF09066	0.265
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.313
TRG_ENDOCYTIC_2	161	164	PF00928	0.404
TRG_ENDOCYTIC_2	391	394	PF00928	0.327
TRG_ENDOCYTIC_2	409	412	PF00928	0.256
TRG_ENDOCYTIC_2	428	431	PF00928	0.402
TRG_ER_diArg_1	132	135	PF00400	0.606
TRG_ER_diArg_1	263	266	PF00400	0.386
TRG_ER_diArg_1	56	59	PF00400	0.456
TRG_NLS_MonoCore_2	328	333	PF00514	0.449
TRG_NLS_MonoExtN_4	326	333	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I000	Leptomonas seymouri	64%	94%
A0A0S4IZ12	Bodo saltans	41%	100%
A0A1X0P257	Trypanosomatidae	47%	100%
A0A3Q8IGF0	Leishmania donovani	95%	100%
A0A3R7L0A9	Trypanosoma rangeli	47%	100%
A4HL73	Leishmania braziliensis	87%	100%
A4I8Q2	Leishmania infantum	95%	100%
D0A4N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q4G9	Leishmania major	94%	100%
V5BFU1	Trypanosoma cruzi	50%	100%