Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B3L5_LEIMU

TriTrypDb:

LmxM.32.0370

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005840	ribosome	5	5
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5

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Expansion

Sequence features

E9B3L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3L5

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	8
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008047	enzyme activator activity	3	8
GO:0010997	anaphase-promoting complex binding	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0044877	protein-containing complex binding	2	8
GO:0055106	ubiquitin-protein transferase regulator activity	3	8
GO:0097027	ubiquitin-protein transferase activator activity	4	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8
GO:1990757	ubiquitin ligase activator activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	435	439	PF00656	0.553
CLV_MEL_PAP_1	85	91	PF00089	0.720
CLV_NRD_NRD_1	273	275	PF00675	0.808
CLV_NRD_NRD_1	37	39	PF00675	0.768
CLV_NRD_NRD_1	45	47	PF00675	0.763
CLV_NRD_NRD_1	534	536	PF00675	0.467
CLV_NRD_NRD_1	643	645	PF00675	0.506
CLV_NRD_NRD_1	705	707	PF00675	0.684
CLV_NRD_NRD_1	74	76	PF00675	0.759
CLV_PCSK_KEX2_1	273	275	PF00082	0.808

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N4	Leptomonas seymouri	61%	97%
A0A3Q8ILY5	Leishmania donovani	93%	100%
A4HL72	Leishmania braziliensis	82%	100%
A4I8Q1	Leishmania infantum	93%	100%
D0A4N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q4H0	Leishmania major	92%	100%

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