Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B3L5_LEIMU

TriTrypDb:

LmxM.32.0370

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9B3L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3L5

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	8
GO:0010604	positive regulation of macromolecule metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0031396	regulation of protein ubiquitination	8	7
GO:0031398	positive regulation of protein ubiquitination	9	7
GO:0031399	regulation of protein modification process	6	7
GO:0031401	positive regulation of protein modification process	7	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0044093	positive regulation of molecular function	3	7
GO:0048518	positive regulation of biological process	3	8
GO:0050789	regulation of biological process	2	8
GO:0050790	regulation of catalytic activity	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051173	positive regulation of nitrogen compound metabolic process	5	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0051247	positive regulation of protein metabolic process	6	8
GO:0051338	regulation of transferase activity	4	7
GO:0051347	positive regulation of transferase activity	5	7
GO:0051438	regulation of ubiquitin-protein transferase activity	5	7
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	7
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0065009	regulation of molecular function	2	7
GO:0080090	regulation of primary metabolic process	4	8
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	7
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	7
GO:1904666	regulation of ubiquitin protein ligase activity	6	7
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	7
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030162	regulation of proteolysis	6	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045732	positive regulation of protein catabolic process	6	1
GO:0045862	positive regulation of proteolysis	7	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901800	positive regulation of proteasomal protein catabolic process	7	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	1
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	1
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	1
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008047	enzyme activator activity	3	8
GO:0010997	anaphase-promoting complex binding	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0044877	protein-containing complex binding	2	8
GO:0055106	ubiquitin-protein transferase regulator activity	3	8
GO:0097027	ubiquitin-protein transferase activator activity	4	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8
GO:1990757	ubiquitin ligase activator activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	435	439	PF00656	0.553
CLV_MEL_PAP_1	85	91	PF00089	0.720
CLV_NRD_NRD_1	273	275	PF00675	0.808
CLV_NRD_NRD_1	37	39	PF00675	0.768
CLV_NRD_NRD_1	45	47	PF00675	0.763
CLV_NRD_NRD_1	534	536	PF00675	0.467
CLV_NRD_NRD_1	643	645	PF00675	0.506
CLV_NRD_NRD_1	705	707	PF00675	0.684
CLV_NRD_NRD_1	74	76	PF00675	0.759
CLV_PCSK_KEX2_1	273	275	PF00082	0.808
CLV_PCSK_KEX2_1	37	39	PF00082	0.716
CLV_PCSK_KEX2_1	45	47	PF00082	0.713
CLV_PCSK_KEX2_1	534	536	PF00082	0.467
CLV_PCSK_KEX2_1	560	562	PF00082	0.499
CLV_PCSK_KEX2_1	582	584	PF00082	0.676
CLV_PCSK_KEX2_1	705	707	PF00082	0.626
CLV_PCSK_KEX2_1	74	76	PF00082	0.759
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.499
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.676
CLV_PCSK_PC7_1	41	47	PF00082	0.731
CLV_PCSK_PC7_1	701	707	PF00082	0.614
CLV_PCSK_SKI1_1	139	143	PF00082	0.812
CLV_PCSK_SKI1_1	247	251	PF00082	0.693
CLV_PCSK_SKI1_1	27	31	PF00082	0.740
CLV_PCSK_SKI1_1	307	311	PF00082	0.702
CLV_PCSK_SKI1_1	49	53	PF00082	0.819
CLV_PCSK_SKI1_1	492	496	PF00082	0.470
CLV_PCSK_SKI1_1	540	544	PF00082	0.479
CLV_PCSK_SKI1_1	563	567	PF00082	0.483
CLV_Separin_Metazoa	279	283	PF03568	0.701
DEG_Kelch_Keap1_1	402	407	PF01344	0.594
DEG_Nend_UBRbox_3	1	3	PF02207	0.739
DEG_SCF_FBW7_1	165	170	PF00400	0.717
DEG_SCF_FBW7_1	56	63	PF00400	0.527
DOC_CKS1_1	227	232	PF01111	0.700
DOC_CKS1_1	57	62	PF01111	0.740
DOC_MAPK_gen_1	453	463	PF00069	0.503
DOC_MAPK_gen_1	636	643	PF00069	0.474
DOC_MAPK_MEF2A_6	428	436	PF00069	0.402
DOC_PP1_RVXF_1	419	426	PF00149	0.387
DOC_PP2B_LxvP_1	369	372	PF13499	0.475
DOC_PP4_FxxP_1	655	658	PF00568	0.502
DOC_USP7_MATH_1	13	17	PF00917	0.733
DOC_USP7_MATH_1	147	151	PF00917	0.729
DOC_USP7_MATH_1	215	219	PF00917	0.688
DOC_USP7_MATH_1	241	245	PF00917	0.543
DOC_USP7_MATH_1	268	272	PF00917	0.702
DOC_USP7_MATH_1	474	478	PF00917	0.450
DOC_USP7_MATH_1	60	64	PF00917	0.532
DOC_WW_Pin1_4	111	116	PF00397	0.731
DOC_WW_Pin1_4	139	144	PF00397	0.813
DOC_WW_Pin1_4	163	168	PF00397	0.718
DOC_WW_Pin1_4	226	231	PF00397	0.705
DOC_WW_Pin1_4	297	302	PF00397	0.598
DOC_WW_Pin1_4	361	366	PF00397	0.469
DOC_WW_Pin1_4	535	540	PF00397	0.551
DOC_WW_Pin1_4	56	61	PF00397	0.735
DOC_WW_Pin1_4	709	714	PF00397	0.804
DOC_WW_Pin1_4	9	14	PF00397	0.739
LIG_14-3-3_CanoR_1	247	253	PF00244	0.630
LIG_14-3-3_CanoR_1	262	269	PF00244	0.601
LIG_14-3-3_CanoR_1	307	312	PF00244	0.700
LIG_14-3-3_CanoR_1	359	365	PF00244	0.478
LIG_14-3-3_CanoR_1	447	452	PF00244	0.528
LIG_14-3-3_CanoR_1	534	539	PF00244	0.625
LIG_14-3-3_CanoR_1	611	619	PF00244	0.447
LIG_14-3-3_CanoR_1	644	650	PF00244	0.470
LIG_14-3-3_CanoR_1	74	78	PF00244	0.834
LIG_BRCT_BRCA1_1	561	565	PF00533	0.514
LIG_EH1_1	616	624	PF00400	0.506
LIG_FHA_1	315	321	PF00498	0.720
LIG_FHA_1	377	383	PF00498	0.495
LIG_FHA_1	438	444	PF00498	0.417
LIG_FHA_1	608	614	PF00498	0.482
LIG_FHA_1	646	652	PF00498	0.479
LIG_FHA_2	285	291	PF00498	0.666
LIG_FHA_2	361	367	PF00498	0.472
LIG_FHA_2	38	44	PF00498	0.833
LIG_FHA_2	564	570	PF00498	0.488
LIG_FHA_2	587	593	PF00498	0.701
LIG_IBAR_NPY_1	129	131	PF08397	0.773
LIG_LIR_Apic_2	654	658	PF02991	0.500
LIG_LIR_Gen_1	188	199	PF02991	0.560
LIG_LIR_Gen_1	448	458	PF02991	0.580
LIG_LIR_Gen_1	647	657	PF02991	0.517
LIG_LIR_Gen_1	96	105	PF02991	0.722
LIG_LIR_Nem_3	188	194	PF02991	0.573
LIG_LIR_Nem_3	448	454	PF02991	0.582
LIG_LIR_Nem_3	647	652	PF02991	0.532
LIG_LIR_Nem_3	684	690	PF02991	0.486
LIG_MAD2	367	375	PF02301	0.535
LIG_PCNA_yPIPBox_3	611	623	PF02747	0.589
LIG_Pex14_2	687	691	PF04695	0.441
LIG_PTB_Apo_2	505	512	PF02174	0.547
LIG_PTB_Phospho_1	505	511	PF10480	0.547
LIG_RPA_C_Fungi	442	454	PF08784	0.510
LIG_SH2_STAP1	159	163	PF00017	0.812
LIG_SH2_STAP1	223	227	PF00017	0.811
LIG_SH2_STAT5	346	349	PF00017	0.655
LIG_SH2_STAT5	511	514	PF00017	0.376
LIG_SH2_STAT5	518	521	PF00017	0.376
LIG_SH2_STAT5	608	611	PF00017	0.546
LIG_SH3_2	372	377	PF14604	0.646
LIG_SH3_3	162	168	PF00018	0.601
LIG_SH3_3	295	301	PF00018	0.711
LIG_SH3_3	369	375	PF00018	0.485
LIG_SH3_3	452	458	PF00018	0.458
LIG_SH3_3	465	471	PF00018	0.473
LIG_SH3_3	50	56	PF00018	0.812
LIG_SUMO_SIM_par_1	409	415	PF11976	0.523
LIG_SUMO_SIM_par_1	471	477	PF11976	0.441
LIG_TRAF2_1	253	256	PF00917	0.600
LIG_TRAF2_1	591	594	PF00917	0.688
LIG_WRC_WIRS_1	172	177	PF05994	0.734
LIG_WRC_WIRS_1	652	657	PF05994	0.497
LIG_WRC_WIRS_1	95	100	PF05994	0.717
MOD_CDC14_SPxK_1	114	117	PF00782	0.714
MOD_CDK_SPK_2	535	540	PF00069	0.551
MOD_CDK_SPxK_1	111	117	PF00069	0.714
MOD_CDK_SPxK_1	361	367	PF00069	0.472
MOD_CDK_SPxK_1	56	62	PF00069	0.733
MOD_CK1_1	111	117	PF00069	0.800
MOD_CK1_1	12	18	PF00069	0.696
MOD_CK1_1	170	176	PF00069	0.700
MOD_CK1_1	178	184	PF00069	0.682
MOD_CK1_1	185	191	PF00069	0.613
MOD_CK1_1	20	26	PF00069	0.694
MOD_CK1_1	218	224	PF00069	0.803
MOD_CK1_1	232	238	PF00069	0.578
MOD_CK1_1	376	382	PF00069	0.509
MOD_CK1_1	39	45	PF00069	0.521
MOD_CK1_1	402	408	PF00069	0.521
MOD_CK1_1	446	452	PF00069	0.535
MOD_CK1_1	665	671	PF00069	0.496
MOD_CK2_1	171	177	PF00069	0.733
MOD_CK2_1	232	238	PF00069	0.811
MOD_CK2_1	250	256	PF00069	0.667
MOD_CK2_1	284	290	PF00069	0.775
MOD_CK2_1	297	303	PF00069	0.631
MOD_CK2_1	360	366	PF00069	0.479
MOD_CK2_1	37	43	PF00069	0.835
MOD_CK2_1	456	462	PF00069	0.508
MOD_CK2_1	563	569	PF00069	0.485
MOD_CK2_1	587	593	PF00069	0.596
MOD_Cter_Amidation	72	75	PF01082	0.756
MOD_DYRK1A_RPxSP_1	535	539	PF00069	0.551
MOD_GlcNHglycan	14	18	PF01048	0.805
MOD_GlcNHglycan	149	152	PF01048	0.698
MOD_GlcNHglycan	19	22	PF01048	0.823
MOD_GlcNHglycan	216	220	PF01048	0.713
MOD_GlcNHglycan	238	242	PF01048	0.711
MOD_GlcNHglycan	270	273	PF01048	0.681
MOD_GlcNHglycan	311	314	PF01048	0.688
MOD_GlcNHglycan	334	337	PF01048	0.706
MOD_GlcNHglycan	347	350	PF01048	0.670
MOD_GlcNHglycan	401	404	PF01048	0.501
MOD_GlcNHglycan	458	461	PF01048	0.485
MOD_GlcNHglycan	476	479	PF01048	0.443
MOD_GlcNHglycan	692	696	PF01048	0.581
MOD_GlcNHglycan	700	704	PF01048	0.698
MOD_GlcNHglycan	75	78	PF01048	0.765
MOD_GSK3_1	101	108	PF00069	0.670
MOD_GSK3_1	147	154	PF00069	0.675
MOD_GSK3_1	159	166	PF00069	0.695
MOD_GSK3_1	167	174	PF00069	0.671
MOD_GSK3_1	178	185	PF00069	0.560
MOD_GSK3_1	232	239	PF00069	0.767
MOD_GSK3_1	28	35	PF00069	0.772
MOD_GSK3_1	285	292	PF00069	0.688
MOD_GSK3_1	309	316	PF00069	0.645
MOD_GSK3_1	320	327	PF00069	0.680
MOD_GSK3_1	341	348	PF00069	0.653
MOD_GSK3_1	443	450	PF00069	0.538
MOD_GSK3_1	559	566	PF00069	0.501
MOD_GSK3_1	56	63	PF00069	0.782
MOD_GSK3_1	9	16	PF00069	0.694
MOD_N-GLC_1	232	237	PF02516	0.691
MOD_N-GLC_1	313	318	PF02516	0.555
MOD_N-GLC_1	361	366	PF02516	0.507
MOD_N-GLC_2	387	389	PF02516	0.557
MOD_NEK2_1	100	105	PF00069	0.623
MOD_NEK2_1	175	180	PF00069	0.670
MOD_NEK2_1	207	212	PF00069	0.783
MOD_NEK2_1	461	466	PF00069	0.482
MOD_NEK2_1	575	580	PF00069	0.512
MOD_NEK2_1	651	656	PF00069	0.534
MOD_NEK2_1	691	696	PF00069	0.598
MOD_NEK2_1	93	98	PF00069	0.641
MOD_NEK2_2	186	191	PF00069	0.615
MOD_NEK2_2	681	686	PF00069	0.505
MOD_OFUCOSY	660	666	PF10250	0.515
MOD_PIKK_1	105	111	PF00454	0.559
MOD_PIKK_1	376	382	PF00454	0.476
MOD_PIKK_1	612	618	PF00454	0.515
MOD_PK_1	524	530	PF00069	0.212
MOD_PKA_1	37	43	PF00069	0.835
MOD_PKA_1	45	51	PF00069	0.681
MOD_PKA_1	534	540	PF00069	0.625
MOD_PKA_1	644	650	PF00069	0.523
MOD_PKA_2	17	23	PF00069	0.772
MOD_PKA_2	33	39	PF00069	0.756
MOD_PKA_2	446	452	PF00069	0.516
MOD_PKA_2	45	51	PF00069	0.741
MOD_PKA_2	534	540	PF00069	0.625
MOD_PKA_2	7	13	PF00069	0.723
MOD_PKA_2	73	79	PF00069	0.739
MOD_PKB_1	339	347	PF00069	0.736
MOD_PKB_1	561	569	PF00069	0.502
MOD_Plk_1	181	187	PF00069	0.598
MOD_Plk_1	232	238	PF00069	0.694
MOD_Plk_1	289	295	PF00069	0.512
MOD_Plk_1	302	308	PF00069	0.755
MOD_Plk_1	660	666	PF00069	0.586
MOD_Plk_1	681	687	PF00069	0.449
MOD_Plk_1	91	97	PF00069	0.690
MOD_Plk_4	167	173	PF00069	0.697
MOD_Plk_4	175	181	PF00069	0.633
MOD_Plk_4	182	188	PF00069	0.571
MOD_Plk_4	320	326	PF00069	0.580
MOD_Plk_4	447	453	PF00069	0.481
MOD_ProDKin_1	111	117	PF00069	0.733
MOD_ProDKin_1	139	145	PF00069	0.815
MOD_ProDKin_1	163	169	PF00069	0.722
MOD_ProDKin_1	226	232	PF00069	0.703
MOD_ProDKin_1	297	303	PF00069	0.598
MOD_ProDKin_1	361	367	PF00069	0.472
MOD_ProDKin_1	535	541	PF00069	0.544
MOD_ProDKin_1	56	62	PF00069	0.740
MOD_ProDKin_1	709	715	PF00069	0.801
MOD_ProDKin_1	9	15	PF00069	0.740
MOD_SUMO_for_1	29	32	PF00179	0.730
TRG_ENDOCYTIC_2	191	194	PF00928	0.558
TRG_ER_diArg_1	338	341	PF00400	0.703
TRG_ER_diArg_1	418	421	PF00400	0.486
TRG_ER_diArg_1	533	535	PF00400	0.536
TRG_ER_diArg_1	561	564	PF00400	0.523
TRG_ER_diArg_1	704	706	PF00400	0.681
TRG_NLS_MonoExtN_4	558	564	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N4	Leptomonas seymouri	61%	97%
A0A3Q8ILY5	Leishmania donovani	93%	100%
A4HL72	Leishmania braziliensis	82%	100%
A4I8Q1	Leishmania infantum	93%	100%
D0A4N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q4H0	Leishmania major	92%	100%