Beta-galactofuranosyltransferase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-galactofuranosyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9B3L0_LEIMU

TriTrypDb:

LmxM.32.0300

Length:

445

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 38
NetGPI	no	yes: 0, no: 38

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9B3L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3L0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	39
GO:0016740	transferase activity	2	39
GO:0016757	glycosyltransferase activity	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.464
CLV_NRD_NRD_1	185	187	PF00675	0.598
CLV_NRD_NRD_1	225	227	PF00675	0.444
CLV_NRD_NRD_1	72	74	PF00675	0.495
CLV_PCSK_KEX2_1	16	18	PF00082	0.442
CLV_PCSK_KEX2_1	185	187	PF00082	0.598
CLV_PCSK_KEX2_1	225	227	PF00082	0.445
CLV_PCSK_KEX2_1	72	74	PF00082	0.514
CLV_PCSK_PC7_1	221	227	PF00082	0.448
CLV_PCSK_SKI1_1	161	165	PF00082	0.489
CLV_PCSK_SKI1_1	17	21	PF00082	0.345
CLV_PCSK_SKI1_1	281	285	PF00082	0.563
CLV_PCSK_SKI1_1	314	318	PF00082	0.439
CLV_PCSK_SKI1_1	376	380	PF00082	0.628
DEG_APCC_DBOX_1	15	23	PF00400	0.547
DEG_APCC_DBOX_1	375	383	PF00400	0.426
DEG_SCF_FBW7_1	232	239	PF00400	0.257
DOC_MAPK_DCC_7	166	176	PF00069	0.226
DOC_MAPK_gen_1	16	22	PF00069	0.401
DOC_MAPK_MEF2A_6	166	173	PF00069	0.192
DOC_MAPK_MEF2A_6	405	412	PF00069	0.370
DOC_PP1_RVXF_1	15	22	PF00149	0.547
DOC_PP2B_PxIxI_1	171	177	PF00149	0.345
DOC_PP4_FxxP_1	392	395	PF00568	0.369
DOC_USP7_MATH_1	135	139	PF00917	0.412
DOC_USP7_MATH_1	342	346	PF00917	0.467
DOC_WW_Pin1_4	10	15	PF00397	0.677
DOC_WW_Pin1_4	232	237	PF00397	0.415
DOC_WW_Pin1_4	382	387	PF00397	0.361
LIG_14-3-3_CanoR_1	225	229	PF00244	0.339
LIG_14-3-3_CanoR_1	249	254	PF00244	0.403
LIG_14-3-3_CanoR_1	3	12	PF00244	0.558
LIG_Actin_WH2_2	118	135	PF00022	0.382
LIG_APCC_Cbox_2	189	195	PF00515	0.202
LIG_BRCT_BRCA1_1	309	313	PF00533	0.196
LIG_BRCT_BRCA1_1	319	323	PF00533	0.253
LIG_deltaCOP1_diTrp_1	300	306	PF00928	0.399
LIG_deltaCOP1_diTrp_1	369	374	PF00928	0.378
LIG_deltaCOP1_diTrp_1	96	103	PF00928	0.374
LIG_FHA_1	124	130	PF00498	0.407
LIG_FHA_1	233	239	PF00498	0.330
LIG_FHA_1	30	36	PF00498	0.338
LIG_FHA_1	391	397	PF00498	0.407
LIG_FHA_1	423	429	PF00498	0.430
LIG_FHA_1	75	81	PF00498	0.355
LIG_FHA_2	61	67	PF00498	0.406
LIG_IRF3_LxIS_1	236	241	PF10401	0.236
LIG_LIR_Gen_1	94	104	PF02991	0.321
LIG_LIR_Nem_3	170	176	PF02991	0.242
LIG_LIR_Nem_3	292	298	PF02991	0.281
LIG_LIR_Nem_3	310	316	PF02991	0.292
LIG_LIR_Nem_3	320	326	PF02991	0.364
LIG_LIR_Nem_3	385	390	PF02991	0.383
LIG_LIR_Nem_3	94	100	PF02991	0.349
LIG_Pex14_2	173	177	PF04695	0.331
LIG_Pex14_2	323	327	PF04695	0.420
LIG_REV1ctd_RIR_1	324	333	PF16727	0.254
LIG_SH2_CRK	196	200	PF00017	0.357
LIG_SH2_CRK	250	254	PF00017	0.308
LIG_SH2_NCK_1	348	352	PF00017	0.236
LIG_SH2_NCK_1	37	41	PF00017	0.330
LIG_SH2_SRC	113	116	PF00017	0.362
LIG_SH2_SRC	191	194	PF00017	0.211
LIG_SH2_STAP1	152	156	PF00017	0.254
LIG_SH2_STAP1	250	254	PF00017	0.255
LIG_SH2_STAP1	302	306	PF00017	0.232
LIG_SH2_STAP1	348	352	PF00017	0.393
LIG_SH2_STAT3	115	118	PF00017	0.382
LIG_SH2_STAT3	145	148	PF00017	0.256
LIG_SH2_STAT3	302	305	PF00017	0.222
LIG_SH2_STAT5	113	116	PF00017	0.357
LIG_SH2_STAT5	182	185	PF00017	0.370
LIG_SH2_STAT5	187	190	PF00017	0.349
LIG_SH2_STAT5	191	194	PF00017	0.317
LIG_SH2_STAT5	298	301	PF00017	0.304
LIG_SH3_3	166	172	PF00018	0.195
LIG_SH3_3	86	92	PF00018	0.378
LIG_SH3_5	363	367	PF00018	0.373
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.379
LIG_SUMO_SIM_anti_2	30	35	PF11976	0.343
LIG_SUMO_SIM_par_1	32	38	PF11976	0.203
LIG_SUMO_SIM_par_1	408	414	PF11976	0.253
LIG_SUMO_SIM_par_1	91	96	PF11976	0.270
LIG_TRAF2_1	121	124	PF00917	0.235
LIG_TRAF2_1	208	211	PF00917	0.384
LIG_TRAF2_1	63	66	PF00917	0.260
LIG_TYR_ITIM	248	253	PF00017	0.209
MOD_CDC14_SPxK_1	13	16	PF00782	0.644
MOD_CDK_SPxK_1	10	16	PF00069	0.659
MOD_CDK_SPxxK_3	10	17	PF00069	0.506
MOD_CK1_1	429	435	PF00069	0.291
MOD_CK2_1	249	255	PF00069	0.274
MOD_CK2_1	60	66	PF00069	0.465
MOD_Cter_Amidation	223	226	PF01082	0.501
MOD_GlcNHglycan	319	322	PF01048	0.650
MOD_GlcNHglycan	382	385	PF01048	0.599
MOD_GSK3_1	123	130	PF00069	0.417
MOD_GSK3_1	232	239	PF00069	0.352
MOD_GSK3_1	340	347	PF00069	0.341
MOD_GSK3_1	416	423	PF00069	0.464
MOD_GSK3_1	426	433	PF00069	0.417
MOD_N-GLC_1	426	431	PF02516	0.579
MOD_NEK2_1	238	243	PF00069	0.266
MOD_NEK2_1	27	32	PF00069	0.295
MOD_NEK2_1	277	282	PF00069	0.272
MOD_NEK2_1	390	395	PF00069	0.404
MOD_NEK2_1	422	427	PF00069	0.408
MOD_NEK2_1	430	435	PF00069	0.407
MOD_NEK2_1	68	73	PF00069	0.406
MOD_NEK2_2	224	229	PF00069	0.420
MOD_PK_1	416	422	PF00069	0.456
MOD_PKA_2	224	230	PF00069	0.360
MOD_PKA_2	248	254	PF00069	0.429
MOD_PKB_1	247	255	PF00069	0.253
MOD_Plk_1	123	129	PF00069	0.393
MOD_Plk_1	426	432	PF00069	0.308
MOD_Plk_4	426	432	PF00069	0.406
MOD_Plk_4	81	87	PF00069	0.229
MOD_ProDKin_1	10	16	PF00069	0.675
MOD_ProDKin_1	232	238	PF00069	0.408
MOD_ProDKin_1	382	388	PF00069	0.362
MOD_SUMO_rev_2	366	373	PF00179	0.374
TRG_DiLeu_BaEn_1	124	129	PF01217	0.230
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.393
TRG_ENDOCYTIC_2	113	116	PF00928	0.385
TRG_ENDOCYTIC_2	196	199	PF00928	0.372
TRG_ENDOCYTIC_2	250	253	PF00928	0.272
TRG_ER_diArg_1	110	113	PF00400	0.264
TRG_ER_diArg_1	185	187	PF00400	0.396
TRG_ER_diArg_1	247	250	PF00400	0.318
TRG_ER_diArg_1	72	74	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P269	Leptomonas seymouri	29%	100%
A0A0N1PC27	Leptomonas seymouri	65%	99%
A0A0N1PES8	Leptomonas seymouri	30%	100%
A0A1X0NWK3	Trypanosomatidae	35%	100%
A0A1X0NWM3	Trypanosomatidae	35%	100%
A0A3Q8IHI5	Leishmania donovani	29%	67%
A0A3R7N1J7	Trypanosoma rangeli	35%	100%
A0A3S5H7D9	Leishmania donovani	30%	100%
A0A3S7WZK8	Leishmania donovani	30%	83%
A0A3S7X6F1	Leishmania donovani	93%	97%
A4HDU8	Leishmania braziliensis	29%	100%
A4HER0	Leishmania braziliensis	28%	66%
A4HL36	Leishmania braziliensis	33%	77%
A4I143	Leishmania infantum	30%	100%
A4I1Y7	Leishmania infantum	30%	83%
A4I8P7	Leishmania infantum	93%	97%
E9AHM5	Leishmania infantum	29%	75%
E9AXX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AY34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B3H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	76%
Q05889	Leishmania donovani	30%	100%
Q4Q9D9	Leishmania major	29%	100%
Q4QD44	Leishmania major	28%	74%
Q6XFB5	Leishmania major	92%	100%
Q9NC61	Leishmania major	29%	100%
V5AJV9	Trypanosoma cruzi	37%	100%
V5AJW5	Trypanosoma cruzi	36%	100%
V5AM55	Trypanosoma cruzi	38%	100%
V5AR28	Trypanosoma cruzi	38%	100%
V5ASN8	Trypanosoma cruzi	36%	100%
V5AUJ2	Trypanosoma cruzi	37%	100%
V5B2H2	Trypanosoma cruzi	37%	100%
V5B4V1	Trypanosoma cruzi	35%	100%
V5B8H6	Trypanosoma cruzi	36%	100%
V5BB47	Trypanosoma cruzi	37%	100%
V5BRK8	Trypanosoma cruzi	37%	100%
V5BXG8	Trypanosoma cruzi	36%	100%
V5DD11	Trypanosoma cruzi	35%	100%