LeishMANIAdb
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Glucose transporter/membrane transporter D2,putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter/membrane transporter D2,putative
Gene product:
glucose transporter/membrane transporter D2, putative
Species:
Leishmania mexicana
UniProt:
E9B3K8_LEIMU
TriTrypDb:
LmxM.32.0290
Length:
627

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Expansion

Sequence features

E9B3K8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 17
GO:0008643 carbohydrate transport 5 17
GO:0051179 localization 1 17
GO:0051234 establishment of localization 2 17
GO:0071702 organic substance transport 4 17
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0022857 transmembrane transporter activity 2 40
GO:0015144 carbohydrate transmembrane transporter activity 3 14
GO:0015145 monosaccharide transmembrane transporter activity 5 2
GO:0015149 hexose transmembrane transporter activity 6 2
GO:0051119 sugar transmembrane transporter activity 4 2
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 614 618 PF00656 0.672
CLV_MEL_PAP_1 463 469 PF00089 0.301
CLV_NRD_NRD_1 380 382 PF00675 0.319
CLV_NRD_NRD_1 393 395 PF00675 0.323
CLV_NRD_NRD_1 465 467 PF00675 0.255
CLV_NRD_NRD_1 72 74 PF00675 0.512
CLV_PCSK_KEX2_1 147 149 PF00082 0.350
CLV_PCSK_KEX2_1 243 245 PF00082 0.307
CLV_PCSK_KEX2_1 380 382 PF00082 0.329
CLV_PCSK_KEX2_1 465 467 PF00082 0.240
CLV_PCSK_KEX2_1 74 76 PF00082 0.534
CLV_PCSK_PC1ET2_1 147 149 PF00082 0.350
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.337
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.384
CLV_PCSK_SKI1_1 249 253 PF00082 0.238
CLV_PCSK_SKI1_1 281 285 PF00082 0.266
CLV_PCSK_SKI1_1 470 474 PF00082 0.256
DEG_Nend_UBRbox_2 1 3 PF02207 0.583
DEG_SPOP_SBC_1 30 34 PF00917 0.573
DOC_CKS1_1 110 115 PF01111 0.179
DOC_CYCLIN_yClb3_PxF_3 98 106 PF00134 0.475
DOC_MAPK_gen_1 498 508 PF00069 0.285
DOC_MAPK_MEF2A_6 249 256 PF00069 0.336
DOC_PP2B_PxIxI_1 58 64 PF00149 0.551
DOC_PP4_FxxP_1 127 130 PF00568 0.359
DOC_PP4_FxxP_1 601 604 PF00568 0.341
DOC_USP7_MATH_1 146 150 PF00917 0.273
DOC_USP7_MATH_1 15 19 PF00917 0.753
DOC_USP7_MATH_1 26 30 PF00917 0.563
DOC_USP7_MATH_1 540 544 PF00917 0.393
DOC_USP7_MATH_2 41 47 PF00917 0.595
DOC_WW_Pin1_4 109 114 PF00397 0.327
DOC_WW_Pin1_4 37 42 PF00397 0.811
DOC_WW_Pin1_4 64 69 PF00397 0.596
LIG_14-3-3_CanoR_1 181 188 PF00244 0.345
LIG_14-3-3_CanoR_1 343 349 PF00244 0.253
LIG_14-3-3_CanoR_1 465 470 PF00244 0.412
LIG_14-3-3_CanoR_1 73 79 PF00244 0.778
LIG_APCC_ABBA_1 531 536 PF00400 0.526
LIG_BRCT_BRCA1_1 219 223 PF00533 0.273
LIG_BRCT_BRCA1_1 249 253 PF00533 0.468
LIG_BRCT_BRCA1_1 32 36 PF00533 0.575
LIG_BRCT_BRCA1_1 463 467 PF00533 0.410
LIG_DLG_GKlike_1 465 472 PF00625 0.376
LIG_EH1_1 102 110 PF00400 0.456
LIG_EH1_1 399 407 PF00400 0.376
LIG_eIF4E_1 247 253 PF01652 0.508
LIG_FHA_1 110 116 PF00498 0.280
LIG_FHA_1 181 187 PF00498 0.267
LIG_FHA_1 240 246 PF00498 0.268
LIG_FHA_1 401 407 PF00498 0.458
LIG_FHA_1 455 461 PF00498 0.219
LIG_FHA_1 469 475 PF00498 0.366
LIG_FHA_1 544 550 PF00498 0.361
LIG_FHA_1 563 569 PF00498 0.262
LIG_FHA_2 169 175 PF00498 0.354
LIG_FHA_2 495 501 PF00498 0.297
LIG_FHA_2 6 12 PF00498 0.807
LIG_FHA_2 81 87 PF00498 0.773
LIG_Integrin_RGD_1 381 383 PF01839 0.166
LIG_LIR_Apic_2 598 604 PF02991 0.281
LIG_LIR_Gen_1 250 259 PF02991 0.332
LIG_LIR_Gen_1 362 371 PF02991 0.376
LIG_LIR_Gen_1 457 463 PF02991 0.329
LIG_LIR_Nem_3 170 175 PF02991 0.248
LIG_LIR_Nem_3 182 188 PF02991 0.231
LIG_LIR_Nem_3 250 256 PF02991 0.334
LIG_LIR_Nem_3 326 332 PF02991 0.288
LIG_LIR_Nem_3 362 367 PF02991 0.359
LIG_LIR_Nem_3 457 461 PF02991 0.326
LIG_LIR_Nem_3 536 541 PF02991 0.470
LIG_LIR_Nem_3 598 602 PF02991 0.286
LIG_LYPXL_S_1 492 496 PF13949 0.320
LIG_LYPXL_yS_3 493 496 PF13949 0.261
LIG_Pex14_2 286 290 PF04695 0.406
LIG_Pex14_2 324 328 PF04695 0.298
LIG_Pex14_2 534 538 PF04695 0.469
LIG_Pex14_2 601 605 PF04695 0.366
LIG_PTB_Apo_2 166 173 PF02174 0.166
LIG_PTB_Apo_2 555 562 PF02174 0.308
LIG_PTB_Phospho_1 166 172 PF10480 0.166
LIG_PTB_Phospho_1 555 561 PF10480 0.351
LIG_REV1ctd_RIR_1 100 110 PF16727 0.614
LIG_SH2_CRK 215 219 PF00017 0.177
LIG_SH2_NCK_1 215 219 PF00017 0.192
LIG_SH2_STAP1 131 135 PF00017 0.302
LIG_SH2_STAP1 188 192 PF00017 0.344
LIG_SH2_STAP1 298 302 PF00017 0.526
LIG_SH2_STAT5 166 169 PF00017 0.321
LIG_SH2_STAT5 240 243 PF00017 0.367
LIG_SH2_STAT5 247 250 PF00017 0.483
LIG_SH2_STAT5 298 301 PF00017 0.438
LIG_SH2_STAT5 400 403 PF00017 0.550
LIG_SH2_STAT5 527 530 PF00017 0.357
LIG_SH2_STAT5 599 602 PF00017 0.240
LIG_SH3_3 107 113 PF00018 0.573
LIG_SH3_3 363 369 PF00018 0.182
LIG_SH3_3 488 494 PF00018 0.297
LIG_SH3_3 76 82 PF00018 0.777
LIG_SH3_3 95 101 PF00018 0.705
LIG_SUMO_SIM_par_1 111 117 PF11976 0.193
LIG_SUMO_SIM_par_1 353 359 PF11976 0.339
LIG_SUMO_SIM_par_1 527 532 PF11976 0.406
LIG_TRAF2_1 396 399 PF00917 0.366
LIG_TRAF2_1 604 607 PF00917 0.482
LIG_TRFH_1 600 604 PF08558 0.341
LIG_TYR_ITIM 213 218 PF00017 0.226
LIG_TYR_ITIM 597 602 PF00017 0.294
LIG_TYR_ITSM 168 175 PF00017 0.176
LIG_WRC_WIRS_1 325 330 PF05994 0.266
LIG_WRC_WIRS_1 455 460 PF05994 0.412
MOD_CK1_1 149 155 PF00069 0.241
MOD_CK1_1 168 174 PF00069 0.268
MOD_CK1_1 193 199 PF00069 0.222
MOD_CK1_1 205 211 PF00069 0.280
MOD_CK1_1 217 223 PF00069 0.282
MOD_CK1_1 29 35 PF00069 0.757
MOD_CK1_1 292 298 PF00069 0.441
MOD_CK1_1 318 324 PF00069 0.456
MOD_CK1_1 356 362 PF00069 0.382
MOD_CK1_1 468 474 PF00069 0.454
MOD_CK1_1 543 549 PF00069 0.235
MOD_CK2_1 168 174 PF00069 0.299
MOD_CK2_1 37 43 PF00069 0.613
MOD_CK2_1 74 80 PF00069 0.794
MOD_CK2_1 81 87 PF00069 0.774
MOD_GlcNHglycan 144 147 PF01048 0.430
MOD_GlcNHglycan 197 200 PF01048 0.508
MOD_GlcNHglycan 204 207 PF01048 0.489
MOD_GlcNHglycan 219 222 PF01048 0.419
MOD_GlcNHglycan 28 31 PF01048 0.398
MOD_GlcNHglycan 503 506 PF01048 0.436
MOD_GlcNHglycan 568 571 PF01048 0.439
MOD_GlcNHglycan 572 575 PF01048 0.438
MOD_GlcNHglycan 76 79 PF01048 0.468
MOD_GSK3_1 142 149 PF00069 0.187
MOD_GSK3_1 161 168 PF00069 0.236
MOD_GSK3_1 186 193 PF00069 0.256
MOD_GSK3_1 213 220 PF00069 0.257
MOD_GSK3_1 26 33 PF00069 0.753
MOD_GSK3_1 262 269 PF00069 0.242
MOD_GSK3_1 289 296 PF00069 0.371
MOD_GSK3_1 355 362 PF00069 0.341
MOD_GSK3_1 386 393 PF00069 0.447
MOD_GSK3_1 43 50 PF00069 0.790
MOD_GSK3_1 461 468 PF00069 0.302
MOD_GSK3_1 5 12 PF00069 0.658
MOD_GSK3_1 562 569 PF00069 0.309
MOD_GSK3_1 64 71 PF00069 0.757
MOD_N-GLC_1 161 166 PF02516 0.503
MOD_N-GLC_1 168 173 PF02516 0.487
MOD_N-GLC_1 37 42 PF02516 0.411
MOD_N-GLC_2 207 209 PF02516 0.526
MOD_N-GLC_2 558 560 PF02516 0.371
MOD_NEK2_1 108 113 PF00069 0.424
MOD_NEK2_1 161 166 PF00069 0.354
MOD_NEK2_1 195 200 PF00069 0.269
MOD_NEK2_1 223 228 PF00069 0.314
MOD_NEK2_1 315 320 PF00069 0.316
MOD_NEK2_1 324 329 PF00069 0.306
MOD_NEK2_1 333 338 PF00069 0.263
MOD_NEK2_1 454 459 PF00069 0.337
MOD_NEK2_1 478 483 PF00069 0.305
MOD_NEK2_2 101 106 PF00069 0.482
MOD_NEK2_2 130 135 PF00069 0.326
MOD_NEK2_2 68 73 PF00069 0.587
MOD_PIKK_1 400 406 PF00454 0.555
MOD_PIKK_1 416 422 PF00454 0.194
MOD_PIKK_1 49 55 PF00454 0.599
MOD_PKA_1 465 471 PF00069 0.526
MOD_PKA_1 73 79 PF00069 0.638
MOD_PKA_2 180 186 PF00069 0.344
MOD_PKA_2 465 471 PF00069 0.417
MOD_PKA_2 74 80 PF00069 0.778
MOD_Plk_1 161 167 PF00069 0.279
MOD_Plk_1 168 174 PF00069 0.236
MOD_Plk_1 190 196 PF00069 0.217
MOD_Plk_1 398 404 PF00069 0.439
MOD_Plk_2-3 386 392 PF00069 0.489
MOD_Plk_4 130 136 PF00069 0.265
MOD_Plk_4 162 168 PF00069 0.353
MOD_Plk_4 223 229 PF00069 0.330
MOD_Plk_4 247 253 PF00069 0.441
MOD_Plk_4 255 261 PF00069 0.292
MOD_Plk_4 310 316 PF00069 0.452
MOD_Plk_4 324 330 PF00069 0.360
MOD_Plk_4 356 362 PF00069 0.310
MOD_Plk_4 430 436 PF00069 0.269
MOD_ProDKin_1 109 115 PF00069 0.323
MOD_ProDKin_1 37 43 PF00069 0.813
MOD_ProDKin_1 64 70 PF00069 0.597
MOD_SUMO_rev_2 606 613 PF00179 0.490
MOD_SUMO_rev_2 617 627 PF00179 0.567
TRG_DiLeu_BaLyEn_6 115 120 PF01217 0.196
TRG_DiLeu_BaLyEn_6 366 371 PF01217 0.196
TRG_DiLeu_BaLyEn_6 56 61 PF01217 0.586
TRG_ENDOCYTIC_2 131 134 PF00928 0.254
TRG_ENDOCYTIC_2 172 175 PF00928 0.320
TRG_ENDOCYTIC_2 215 218 PF00928 0.199
TRG_ENDOCYTIC_2 274 277 PF00928 0.202
TRG_ENDOCYTIC_2 493 496 PF00928 0.261
TRG_ENDOCYTIC_2 599 602 PF00928 0.264
TRG_ER_diArg_1 465 467 PF00400 0.451
TRG_ER_diArg_1 72 75 PF00400 0.790

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VG78 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 24% 100%
A0A0N0P2E1 Leptomonas seymouri 41% 100%
A0A0N0P3Z7 Leptomonas seymouri 35% 82%
A0A0N0P4D8 Leptomonas seymouri 37% 85%
A0A0N1IG16 Leptomonas seymouri 44% 100%
A0A0N1P9H5 Leptomonas seymouri 63% 100%
A0A0S4J363 Bodo saltans 26% 100%
A0A0S4JDF9 Bodo saltans 37% 100%
A0A0S4JEY7 Bodo saltans 37% 100%
A0A0S4JH90 Bodo saltans 35% 100%
A0A0S4JS00 Bodo saltans 32% 100%
A0A1X0NLE0 Trypanosomatidae 43% 100%
A0A1X0NM05 Trypanosomatidae 43% 100%
A0A1X0NN62 Trypanosomatidae 43% 100%
A0A1X0P9L7 Trypanosomatidae 32% 100%
A0A381N054 Leishmania infantum 44% 100%
A0A3Q8IDK1 Leishmania donovani 95% 100%
A0A3Q8IK60 Leishmania donovani 44% 100%
A0A3Q8IWJ4 Leishmania donovani 43% 96%
A0A3R7KPU3 Trypanosoma rangeli 32% 100%
A0A3S7WY58 Leishmania donovani 22% 100%
A0A3S7XC27 Leishmania donovani 44% 100%
A0A422MNQ4 Trypanosoma rangeli 43% 100%
A4HDC6 Leishmania braziliensis 22% 100%
A4HL65 Leishmania braziliensis 82% 100%
A4HQD6 Leishmania braziliensis 45% 100%
A4HQD7 Leishmania braziliensis 46% 100%
A4HQE7 Leishmania braziliensis 48% 100%
A4I0Q6 Leishmania infantum 22% 100%
A4I8N6 Leishmania infantum 95% 100%
A4IC83 Leishmania infantum 43% 96%
C0SPB2 Bacillus subtilis (strain 168) 24% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
O04249 Arabidopsis thaliana 23% 100%
O34718 Bacillus subtilis (strain 168) 23% 100%
P0AGF4 Escherichia coli (strain K12) 23% 100%
P0AGF5 Escherichia coli O157:H7 23% 100%
P13865 Leishmania enriettii 44% 100%
P14672 Homo sapiens 24% 100%
P40885 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P46333 Bacillus subtilis (strain 168) 23% 100%
P54862 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P78831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
P94493 Bacillus subtilis (strain 168) 23% 100%
Q01441 Leishmania donovani 96% 100%
Q06221 Trypanosoma brucei brucei 35% 100%
Q06222 Trypanosoma brucei brucei 37% 100%
Q09037 Trypanosoma brucei brucei 35% 100%
Q27115 Trypanosoma vivax 39% 100%
Q4Q0D0 Leishmania major 41% 100%
Q4Q0D1 Leishmania major 45% 100%
Q4Q0D2 Leishmania major 45% 100%
Q4Q4J1 Leishmania major 93% 100%
Q4QAR5 Leishmania major 22% 100%
Q8VZ80 Arabidopsis thaliana 22% 100%
Q92253 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 23% 100%
Q94EC4 Oryza sativa subsp. japonica 24% 100%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
Q9P3U7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q9SFG0 Arabidopsis thaliana 23% 100%
Q9SX48 Arabidopsis thaliana 24% 100%
Q9XIH6 Arabidopsis thaliana 24% 100%
Q9XIH7 Arabidopsis thaliana 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS