Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3K7_LEIMU

TriTrypDb:

LmxM.32.0280

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0005848	mRNA cleavage stimulating factor complex	4	12
GO:0005849	mRNA cleavage factor complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

E9B3K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031124	mRNA 3'-end processing	8	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.456
CLV_NRD_NRD_1	113	115	PF00675	0.594
CLV_NRD_NRD_1	212	214	PF00675	0.354
CLV_NRD_NRD_1	409	411	PF00675	0.423
CLV_NRD_NRD_1	78	80	PF00675	0.595
CLV_NRD_NRD_1	8	10	PF00675	0.542
CLV_PCSK_KEX2_1	10	12	PF00082	0.533
CLV_PCSK_KEX2_1	113	115	PF00082	0.594
CLV_PCSK_KEX2_1	212	214	PF00082	0.354
CLV_PCSK_KEX2_1	409	411	PF00082	0.425
CLV_PCSK_KEX2_1	78	80	PF00082	0.511
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.533
CLV_PCSK_SKI1_1	253	257	PF00082	0.550
CLV_PCSK_SKI1_1	294	298	PF00082	0.465
CLV_PCSK_SKI1_1	438	442	PF00082	0.474
CLV_Separin_Metazoa	222	226	PF03568	0.467
DEG_SCF_FBW7_1	295	301	PF00400	0.624
DOC_CKS1_1	295	300	PF01111	0.502
DOC_CKS1_1	503	508	PF01111	0.371
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.509
DOC_MAPK_gen_1	9	18	PF00069	0.563
DOC_MAPK_MEF2A_6	98	105	PF00069	0.492
DOC_MAPK_NFAT4_5	98	106	PF00069	0.533
DOC_PP1_RVXF_1	130	137	PF00149	0.380
DOC_PP2B_LxvP_1	296	299	PF13499	0.617
DOC_PP2B_LxvP_1	99	102	PF13499	0.486
DOC_PP4_FxxP_1	426	429	PF00568	0.387
DOC_USP7_MATH_1	194	198	PF00917	0.565
DOC_USP7_MATH_1	2	6	PF00917	0.653
DOC_USP7_MATH_1	332	336	PF00917	0.547
DOC_USP7_MATH_1	337	341	PF00917	0.466
DOC_USP7_MATH_1	381	385	PF00917	0.455
DOC_USP7_MATH_1	40	44	PF00917	0.470
DOC_USP7_MATH_1	443	447	PF00917	0.417
DOC_USP7_MATH_1	457	461	PF00917	0.245
DOC_USP7_MATH_1	467	471	PF00917	0.439
DOC_USP7_UBL2_3	253	257	PF12436	0.388
DOC_WW_Pin1_4	134	139	PF00397	0.311
DOC_WW_Pin1_4	246	251	PF00397	0.269
DOC_WW_Pin1_4	294	299	PF00397	0.498
DOC_WW_Pin1_4	417	422	PF00397	0.568
DOC_WW_Pin1_4	483	488	PF00397	0.457
DOC_WW_Pin1_4	502	507	PF00397	0.353
LIG_14-3-3_CanoR_1	108	112	PF00244	0.518
LIG_14-3-3_CanoR_1	121	130	PF00244	0.285
LIG_14-3-3_CanoR_1	410	418	PF00244	0.545
LIG_14-3-3_CanoR_1	438	448	PF00244	0.382
LIG_14-3-3_CanoR_1	92	101	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_4	47	51	PF00653	0.419
LIG_BRCT_BRCA1_1	339	343	PF00533	0.467
LIG_CSL_BTD_1	503	506	PF09270	0.352
LIG_CSL_BTD_1	507	510	PF09270	0.432
LIG_CtBP_PxDLS_1	102	106	PF00389	0.618
LIG_FHA_1	146	152	PF00498	0.307
LIG_FHA_1	216	222	PF00498	0.355
LIG_FHA_1	259	265	PF00498	0.400
LIG_FHA_1	290	296	PF00498	0.427
LIG_FHA_1	356	362	PF00498	0.465
LIG_FHA_1	381	387	PF00498	0.476
LIG_FHA_1	388	394	PF00498	0.470
LIG_FHA_1	400	406	PF00498	0.461
LIG_FHA_1	463	469	PF00498	0.473
LIG_FHA_1	47	53	PF00498	0.425
LIG_FHA_1	85	91	PF00498	0.510
LIG_FHA_2	157	163	PF00498	0.344
LIG_FHA_2	351	357	PF00498	0.451
LIG_FHA_2	428	434	PF00498	0.485
LIG_FHA_2	492	498	PF00498	0.434
LIG_LIR_Apic_2	415	421	PF02991	0.514
LIG_LIR_Apic_2	424	429	PF02991	0.392
LIG_LIR_Gen_1	24	33	PF02991	0.480
LIG_LIR_Gen_1	272	279	PF02991	0.425
LIG_LIR_Gen_1	83	94	PF02991	0.536
LIG_LIR_Nem_3	272	278	PF02991	0.331
LIG_LIR_Nem_3	356	362	PF02991	0.464
LIG_LIR_Nem_3	460	464	PF02991	0.374
LIG_LIR_Nem_3	83	89	PF02991	0.488
LIG_LIR_Nem_3	97	103	PF02991	0.472
LIG_SH2_CRK	100	104	PF00017	0.548
LIG_SH2_CRK	362	366	PF00017	0.364
LIG_SH2_NCK_1	247	251	PF00017	0.280
LIG_SH2_PTP2	275	278	PF00017	0.378
LIG_SH2_STAT5	142	145	PF00017	0.409
LIG_SH2_STAT5	243	246	PF00017	0.324
LIG_SH2_STAT5	275	278	PF00017	0.328
LIG_SH2_STAT5	461	464	PF00017	0.378
LIG_SH3_1	225	231	PF00018	0.451
LIG_SH3_3	225	231	PF00018	0.373
LIG_SH3_3	292	298	PF00018	0.553
LIG_SUMO_SIM_anti_2	220	225	PF11976	0.466
LIG_SUMO_SIM_par_1	101	107	PF11976	0.616
LIG_SUMO_SIM_par_1	452	460	PF11976	0.375
LIG_TRAF2_1	80	83	PF00917	0.628
LIG_Vh1_VBS_1	38	56	PF01044	0.539
LIG_WRC_WIRS_1	423	428	PF05994	0.382
MOD_CDK_SPxxK_3	246	253	PF00069	0.271
MOD_CK1_1	104	110	PF00069	0.574
MOD_CK1_1	156	162	PF00069	0.330
MOD_CK1_1	249	255	PF00069	0.289
MOD_CK1_1	315	321	PF00069	0.705
MOD_CK1_1	339	345	PF00069	0.290
MOD_CK1_1	470	476	PF00069	0.391
MOD_CK2_1	422	428	PF00069	0.385
MOD_CK2_1	439	445	PF00069	0.430
MOD_CK2_1	69	75	PF00069	0.611
MOD_Cter_Amidation	111	114	PF01082	0.602
MOD_GlcNHglycan	123	126	PF01048	0.449
MOD_GlcNHglycan	161	166	PF01048	0.492
MOD_GlcNHglycan	196	199	PF01048	0.562
MOD_GlcNHglycan	234	237	PF01048	0.438
MOD_GlcNHglycan	271	274	PF01048	0.396
MOD_GlcNHglycan	316	320	PF01048	0.647
MOD_GlcNHglycan	334	337	PF01048	0.445
MOD_GlcNHglycan	365	368	PF01048	0.481
MOD_GlcNHglycan	377	380	PF01048	0.295
MOD_GlcNHglycan	42	45	PF01048	0.449
MOD_GlcNHglycan	441	444	PF01048	0.465
MOD_GlcNHglycan	94	97	PF01048	0.508
MOD_GSK3_1	103	110	PF00069	0.448
MOD_GSK3_1	265	272	PF00069	0.456
MOD_GSK3_1	294	301	PF00069	0.521
MOD_GSK3_1	302	309	PF00069	0.563
MOD_GSK3_1	317	324	PF00069	0.670
MOD_GSK3_1	332	339	PF00069	0.430
MOD_GSK3_1	346	353	PF00069	0.367
MOD_GSK3_1	381	388	PF00069	0.472
MOD_GSK3_1	417	424	PF00069	0.522
MOD_GSK3_1	439	446	PF00069	0.353
MOD_GSK3_1	467	474	PF00069	0.383
MOD_N-GLC_1	443	448	PF02516	0.368
MOD_NEK2_1	103	108	PF00069	0.371
MOD_NEK2_1	123	128	PF00069	0.462
MOD_NEK2_1	232	237	PF00069	0.321
MOD_NEK2_1	350	355	PF00069	0.353
MOD_NEK2_1	399	404	PF00069	0.469
MOD_NEK2_1	411	416	PF00069	0.597
MOD_NEK2_1	84	89	PF00069	0.514
MOD_NEK2_1	94	99	PF00069	0.424
MOD_PIKK_1	2	8	PF00454	0.680
MOD_PIKK_1	215	221	PF00454	0.375
MOD_PIKK_1	471	477	PF00454	0.431
MOD_PIKK_1	84	90	PF00454	0.595
MOD_PKA_2	107	113	PF00069	0.519
MOD_PKA_2	325	331	PF00069	0.616
MOD_PKB_1	119	127	PF00069	0.354
MOD_Plk_1	132	138	PF00069	0.414
MOD_Plk_1	161	167	PF00069	0.506
MOD_Plk_1	265	271	PF00069	0.385
MOD_Plk_1	421	427	PF00069	0.420
MOD_Plk_1	443	449	PF00069	0.362
MOD_Plk_1	451	457	PF00069	0.381
MOD_Plk_1	468	474	PF00069	0.452
MOD_Plk_1	496	502	PF00069	0.390
MOD_Plk_2-3	422	428	PF00069	0.400
MOD_Plk_4	355	361	PF00069	0.321
MOD_Plk_4	381	387	PF00069	0.533
MOD_Plk_4	451	457	PF00069	0.343
MOD_Plk_4	474	480	PF00069	0.446
MOD_ProDKin_1	134	140	PF00069	0.312
MOD_ProDKin_1	246	252	PF00069	0.269
MOD_ProDKin_1	294	300	PF00069	0.508
MOD_ProDKin_1	417	423	PF00069	0.561
MOD_ProDKin_1	483	489	PF00069	0.465
MOD_ProDKin_1	502	508	PF00069	0.364
MOD_SUMO_rev_2	249	255	PF00179	0.373
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.351
TRG_ENDOCYTIC_2	100	103	PF00928	0.496
TRG_ENDOCYTIC_2	26	29	PF00928	0.386
TRG_ENDOCYTIC_2	275	278	PF00928	0.407
TRG_ENDOCYTIC_2	362	365	PF00928	0.395
TRG_ER_diArg_1	116	119	PF00400	0.397
TRG_ER_diArg_1	211	213	PF00400	0.374
TRG_ER_diArg_1	408	410	PF00400	0.416
TRG_ER_diArg_1	500	503	PF00400	0.327
TRG_ER_diArg_1	9	12	PF00400	0.555
TRG_NES_CRM1_1	19	32	PF08389	0.465
TRG_NES_CRM1_1	61	77	PF08389	0.482
TRG_NLS_MonoCore_2	9	14	PF00514	0.564
TRG_NLS_MonoExtC_3	8	13	PF00514	0.551
TRG_NLS_MonoExtN_4	7	14	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHC2	Leptomonas seymouri	81%	94%
A0A0S4IHN1	Bodo saltans	39%	92%
A0A0S4JL38	Bodo saltans	23%	95%
A0A1X0P742	Trypanosomatidae	54%	100%
A0A3Q8ITT7	Leishmania donovani	97%	100%
A0A422NAT5	Trypanosoma rangeli	53%	97%
A4HL64	Leishmania braziliensis	94%	100%
A4I8P5	Leishmania infantum	98%	100%
D0A0R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
Q4Q4J2	Leishmania major	97%	100%
Q8L4J2	Arabidopsis thaliana	24%	100%
V5BJ28	Trypanosoma cruzi	52%	94%