Mpv17/PMP22 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mpv17 / PMP22 family, putative

Species:

Leishmania mexicana

UniProt:

E9B3K6_LEIMU

TriTrypDb:

LmxM.32.0270

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9B3K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.534
CLV_C14_Caspase3-7	191	195	PF00656	0.419
CLV_NRD_NRD_1	120	122	PF00675	0.280
CLV_NRD_NRD_1	197	199	PF00675	0.637
CLV_NRD_NRD_1	282	284	PF00675	0.545
CLV_PCSK_KEX2_1	120	122	PF00082	0.280
CLV_PCSK_KEX2_1	155	157	PF00082	0.602
CLV_PCSK_KEX2_1	196	198	PF00082	0.627
CLV_PCSK_KEX2_1	282	284	PF00082	0.590
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.590
CLV_PCSK_PC7_1	193	199	PF00082	0.639
CLV_PCSK_SKI1_1	161	165	PF00082	0.511
CLV_PCSK_SKI1_1	2	6	PF00082	0.398
CLV_PCSK_SKI1_1	235	239	PF00082	0.683
CLV_PCSK_SKI1_1	294	298	PF00082	0.590
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DEG_SPOP_SBC_1	103	107	PF00917	0.641
DOC_AGCK_PIF_1	125	130	PF00069	0.385
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.399
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.345
DOC_MAPK_gen_1	193	202	PF00069	0.415
DOC_MAPK_MEF2A_6	196	204	PF00069	0.468
DOC_PP4_FxxP_1	132	135	PF00568	0.385
DOC_USP7_MATH_1	103	107	PF00917	0.691
DOC_USP7_MATH_1	318	322	PF00917	0.354
DOC_USP7_MATH_1	55	59	PF00917	0.622
DOC_USP7_MATH_2	55	61	PF00917	0.475
DOC_WW_Pin1_4	170	175	PF00397	0.343
DOC_WW_Pin1_4	236	241	PF00397	0.437
DOC_WW_Pin1_4	58	63	PF00397	0.631
DOC_WW_Pin1_4	66	71	PF00397	0.543
DOC_WW_Pin1_4	88	93	PF00397	0.629
LIG_14-3-3_CanoR_1	120	124	PF00244	0.454
LIG_14-3-3_CanoR_1	18	24	PF00244	0.458
LIG_14-3-3_CanoR_1	316	326	PF00244	0.325
LIG_14-3-3_CanoR_1	95	103	PF00244	0.560
LIG_APCC_ABBA_1	186	191	PF00400	0.396
LIG_BRCT_BRCA1_1	121	125	PF00533	0.454
LIG_BRCT_BRCA1_1	126	130	PF00533	0.291
LIG_BRCT_BRCA1_1	59	63	PF00533	0.464
LIG_FHA_1	111	117	PF00498	0.572
LIG_FHA_1	170	176	PF00498	0.300
LIG_FHA_2	179	185	PF00498	0.309
LIG_FHA_2	35	41	PF00498	0.587
LIG_FXI_DFP_1	286	290	PF00024	0.465
LIG_LIR_Apic_2	129	135	PF02991	0.417
LIG_LIR_Gen_1	122	132	PF02991	0.317
LIG_LIR_Gen_1	272	281	PF02991	0.354
LIG_LIR_Nem_3	122	128	PF02991	0.317
LIG_LIR_Nem_3	173	179	PF02991	0.351
LIG_LIR_Nem_3	184	189	PF02991	0.246
LIG_LIR_Nem_3	231	237	PF02991	0.477
LIG_LIR_Nem_3	267	273	PF02991	0.328
LIG_LIR_Nem_3	288	292	PF02991	0.248
LIG_Pex14_1	304	308	PF04695	0.257
LIG_Pex14_2	128	132	PF04695	0.325
LIG_Pex14_2	234	238	PF04695	0.475
LIG_Pex14_2	270	274	PF04695	0.372
LIG_PTB_Apo_2	262	269	PF02174	0.412
LIG_REV1ctd_RIR_1	184	194	PF16727	0.396
LIG_SH2_NCK_1	295	299	PF00017	0.280
LIG_SH2_SRC	310	313	PF00017	0.321
LIG_SH2_STAP1	295	299	PF00017	0.330
LIG_SH2_STAT5	11	14	PF00017	0.556
LIG_SH2_STAT5	136	139	PF00017	0.413
LIG_SH2_STAT5	166	169	PF00017	0.322
LIG_SH2_STAT5	176	179	PF00017	0.260
LIG_SH2_STAT5	273	276	PF00017	0.439
LIG_SH2_STAT5	310	313	PF00017	0.255
LIG_SH2_STAT5	333	336	PF00017	0.378
LIG_SH3_3	234	240	PF00018	0.436
LIG_SH3_3	64	70	PF00018	0.574
LIG_SH3_3	86	92	PF00018	0.668
LIG_SUMO_SIM_par_1	113	118	PF11976	0.529
LIG_SUMO_SIM_par_1	63	69	PF11976	0.640
LIG_UBA3_1	330	339	PF00899	0.449
LIG_UBA3_1	4	13	PF00899	0.562
LIG_WRC_WIRS_1	125	130	PF05994	0.291
MOD_CDC14_SPxK_1	239	242	PF00782	0.382
MOD_CDK_SPxK_1	236	242	PF00069	0.387
MOD_CDK_SPxxK_3	88	95	PF00069	0.540
MOD_CK1_1	22	28	PF00069	0.523
MOD_CK1_1	58	64	PF00069	0.618
MOD_CK1_1	90	96	PF00069	0.582
MOD_CK2_1	34	40	PF00069	0.587
MOD_Cter_Amidation	194	197	PF01082	0.628
MOD_GlcNHglycan	106	109	PF01048	0.452
MOD_GlcNHglycan	156	159	PF01048	0.512
MOD_GlcNHglycan	320	323	PF01048	0.342
MOD_GlcNHglycan	327	330	PF01048	0.329
MOD_GSK3_1	19	26	PF00069	0.473
MOD_GSK3_1	325	332	PF00069	0.356
MOD_GSK3_1	84	91	PF00069	0.729
MOD_GSK3_1	94	101	PF00069	0.678
MOD_N-GLC_1	111	116	PF02516	0.307
MOD_N-GLC_1	19	24	PF02516	0.218
MOD_N-GLC_1	55	60	PF02516	0.411
MOD_N-GLC_1	98	103	PF02516	0.543
MOD_NEK2_1	119	124	PF00069	0.487
MOD_NEK2_1	21	26	PF00069	0.564
MOD_NEK2_1	248	253	PF00069	0.443
MOD_NEK2_1	317	322	PF00069	0.502
MOD_NEK2_1	63	68	PF00069	0.580
MOD_PIKK_1	94	100	PF00454	0.646
MOD_PKA_2	119	125	PF00069	0.454
MOD_PKA_2	84	90	PF00069	0.635
MOD_PKA_2	94	100	PF00069	0.558
MOD_Plk_1	111	117	PF00069	0.541
MOD_Plk_1	19	25	PF00069	0.420
MOD_Plk_1	248	254	PF00069	0.421
MOD_Plk_1	344	350	PF00069	0.639
MOD_Plk_1	98	104	PF00069	0.730
MOD_Plk_4	111	117	PF00069	0.526
MOD_Plk_4	162	168	PF00069	0.289
MOD_Plk_4	175	181	PF00069	0.344
MOD_Plk_4	329	335	PF00069	0.424
MOD_Plk_4	34	40	PF00069	0.548
MOD_Plk_4	6	12	PF00069	0.582
MOD_ProDKin_1	170	176	PF00069	0.342
MOD_ProDKin_1	236	242	PF00069	0.437
MOD_ProDKin_1	58	64	PF00069	0.624
MOD_ProDKin_1	66	72	PF00069	0.542
MOD_ProDKin_1	88	94	PF00069	0.633
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.369
TRG_ENDOCYTIC_2	141	144	PF00928	0.305
TRG_ENDOCYTIC_2	259	262	PF00928	0.421
TRG_ER_diArg_1	119	121	PF00400	0.485
TRG_ER_diArg_1	196	198	PF00400	0.416
TRG_ER_diArg_1	281	283	PF00400	0.390
TRG_ER_diArg_1	75	78	PF00400	0.576
TRG_ER_FFAT_2	267	278	PF00635	0.329
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA32	Leptomonas seymouri	68%	100%
A0A0S4JM85	Bodo saltans	30%	100%
A0A3Q8IGN8	Leishmania donovani	93%	100%
A0A3S5IR52	Trypanosoma rangeli	31%	100%
A4HL63	Leishmania braziliensis	82%	100%
E9AHM7	Leishmania infantum	93%	100%
Q4Q4J3	Leishmania major	90%	100%