Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3K4_LEIMU

TriTrypDb:

LmxM.32.0250

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.557
CLV_C14_Caspase3-7	294	298	PF00656	0.490
CLV_C14_Caspase3-7	308	312	PF00656	0.433
CLV_MEL_PAP_1	38	44	PF00089	0.417
CLV_NRD_NRD_1	328	330	PF00675	0.495
CLV_NRD_NRD_1	86	88	PF00675	0.647
CLV_NRD_NRD_1	89	91	PF00675	0.612
CLV_PCSK_FUR_1	87	91	PF00082	0.696
CLV_PCSK_KEX2_1	328	330	PF00082	0.495
CLV_PCSK_KEX2_1	86	88	PF00082	0.663
CLV_PCSK_KEX2_1	89	91	PF00082	0.651
CLV_PCSK_SKI1_1	117	121	PF00082	0.321
CLV_PCSK_SKI1_1	128	132	PF00082	0.339
CLV_PCSK_SKI1_1	205	209	PF00082	0.554
CLV_PCSK_SKI1_1	45	49	PF00082	0.369
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DOC_MAPK_gen_1	13	21	PF00069	0.407
DOC_MAPK_gen_1	153	163	PF00069	0.262
DOC_MAPK_MEF2A_6	15	23	PF00069	0.450
DOC_PP1_RVXF_1	4	10	PF00149	0.438
DOC_PP2B_LxvP_1	193	196	PF13499	0.640
DOC_PP4_FxxP_1	242	245	PF00568	0.396
DOC_SPAK_OSR1_1	241	245	PF12202	0.410
DOC_USP7_MATH_1	180	184	PF00917	0.563
DOC_USP7_MATH_1	245	249	PF00917	0.355
DOC_USP7_MATH_1	31	35	PF00917	0.497
DOC_USP7_MATH_1	52	56	PF00917	0.435
DOC_WW_Pin1_4	184	189	PF00397	0.692
DOC_WW_Pin1_4	268	273	PF00397	0.423
DOC_WW_Pin1_4	50	55	PF00397	0.483
DOC_WW_Pin1_4	95	100	PF00397	0.655
LIG_14-3-3_CanoR_1	147	155	PF00244	0.481
LIG_14-3-3_CanoR_1	209	217	PF00244	0.362
LIG_14-3-3_CanoR_1	283	289	PF00244	0.399
LIG_14-3-3_CanoR_1	41	48	PF00244	0.403
LIG_14-3-3_CanoR_1	6	12	PF00244	0.488
LIG_14-3-3_CanoR_1	89	99	PF00244	0.639
LIG_eIF4E_1	321	327	PF01652	0.381
LIG_FHA_1	317	323	PF00498	0.417
LIG_FHA_1	91	97	PF00498	0.669
LIG_GBD_Chelix_1	322	330	PF00786	0.402
LIG_LIR_Gen_1	164	174	PF02991	0.492
LIG_LIR_LC3C_4	158	163	PF02991	0.421
LIG_LIR_Nem_3	109	113	PF02991	0.330
LIG_LIR_Nem_3	164	169	PF02991	0.462
LIG_SH2_STAT5	264	267	PF00017	0.390
LIG_SH2_STAT5	321	324	PF00017	0.384
LIG_SH3_3	131	137	PF00018	0.389
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.474
LIG_SUMO_SIM_par_1	157	164	PF11976	0.429
LIG_TYR_ITIM	108	113	PF00017	0.401
LIG_WRC_WIRS_1	246	251	PF05994	0.308
MOD_CK1_1	212	218	PF00069	0.446
MOD_CK1_1	98	104	PF00069	0.655
MOD_CK2_1	161	167	PF00069	0.409
MOD_Cter_Amidation	87	90	PF01082	0.519
MOD_GlcNHglycan	163	166	PF01048	0.475
MOD_GlcNHglycan	182	185	PF01048	0.524
MOD_GlcNHglycan	211	214	PF01048	0.480
MOD_GlcNHglycan	297	300	PF01048	0.429
MOD_GlcNHglycan	301	304	PF01048	0.388
MOD_GSK3_1	180	187	PF00069	0.548
MOD_GSK3_1	205	212	PF00069	0.453
MOD_GSK3_1	264	271	PF00069	0.519
MOD_GSK3_1	291	298	PF00069	0.361
MOD_GSK3_1	312	319	PF00069	0.433
MOD_GSK3_1	98	105	PF00069	0.654
MOD_N-GLC_1	184	189	PF02516	0.683
MOD_N-GLC_1	316	321	PF02516	0.525
MOD_NEK2_1	161	166	PF00069	0.379
MOD_NEK2_1	207	212	PF00069	0.535
MOD_NEK2_1	284	289	PF00069	0.369
MOD_NEK2_1	322	327	PF00069	0.376
MOD_NEK2_1	9	14	PF00069	0.499
MOD_PIKK_1	40	46	PF00454	0.482
MOD_PKA_2	208	214	PF00069	0.536
MOD_PKA_2	295	301	PF00069	0.391
MOD_PKA_2	312	318	PF00069	0.368
MOD_PKA_2	40	46	PF00069	0.505
MOD_PKB_1	90	98	PF00069	0.583
MOD_Plk_1	102	108	PF00069	0.594
MOD_Plk_1	316	322	PF00069	0.521
MOD_Plk_4	245	251	PF00069	0.445
MOD_Plk_4	322	328	PF00069	0.381
MOD_ProDKin_1	184	190	PF00069	0.693
MOD_ProDKin_1	268	274	PF00069	0.420
MOD_ProDKin_1	50	56	PF00069	0.479
MOD_ProDKin_1	95	101	PF00069	0.646
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.319
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.329
TRG_ENDOCYTIC_2	110	113	PF00928	0.369
TRG_ER_diArg_1	327	329	PF00400	0.510
TRG_ER_diArg_1	86	89	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRG0	Leptomonas seymouri	55%	98%
A0A0S4JMI8	Bodo saltans	29%	100%
A0A1X0P0V8	Trypanosomatidae	43%	100%
A0A3Q8IJV7	Leishmania donovani	91%	100%
A0A422NG71	Trypanosoma rangeli	46%	100%
A4HJ17	Leishmania braziliensis	83%	100%
A4I8P3	Leishmania infantum	90%	100%
D0A4L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q4J5	Leishmania major	91%	100%
V5BFZ0	Trypanosoma cruzi	44%	100%