Thiol-dependent reductase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thiol-dependent reductase 1

Species:

Leishmania mexicana

UniProt:

E9B3K3_LEIMU

TriTrypDb:

LmxM.32.0240

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K3

PDB structure(s): 4ags_A , 4ags_B , 4ags_C

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	2
GO:0015035	protein-disulfide reductase activity	3	5
GO:0015036	disulfide oxidoreductase activity	4	5
GO:0015038	glutathione disulfide oxidoreductase activity	5	2
GO:0016209	antioxidant activity	1	2
GO:0016491	oxidoreductase activity	2	5
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	5
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	5
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	2
GO:0019153	protein-disulfide reductase (glutathione) activity	4	5
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0045174	glutathione dehydrogenase (ascorbate) activity	2	2
GO:0050661	NADP binding	4	1
GO:0070402	NADPH binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1
GO:0005515	protein binding	2	1
GO:0042802	identical protein binding	3	1
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.435
CLV_NRD_NRD_1	404	406	PF00675	0.512
CLV_NRD_NRD_1	84	86	PF00675	0.349
CLV_PCSK_FUR_1	402	406	PF00082	0.512
CLV_PCSK_KEX2_1	336	338	PF00082	0.356
CLV_PCSK_KEX2_1	404	406	PF00082	0.542
CLV_PCSK_KEX2_1	84	86	PF00082	0.372
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.356
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.372
CLV_PCSK_PC7_1	400	406	PF00082	0.500
CLV_PCSK_SKI1_1	129	133	PF00082	0.393
CLV_PCSK_SKI1_1	262	266	PF00082	0.493
CLV_PCSK_SKI1_1	386	390	PF00082	0.440
DEG_SCF_FBW7_2	242	248	PF00400	0.405
DOC_CKS1_1	242	247	PF01111	0.401
DOC_CKS1_1	380	385	PF01111	0.344
DOC_MAPK_DCC_7	11	19	PF00069	0.372
DOC_MAPK_gen_1	212	218	PF00069	0.386
DOC_MAPK_MEF2A_6	11	19	PF00069	0.372
DOC_WW_Pin1_4	161	166	PF00397	0.544
DOC_WW_Pin1_4	241	246	PF00397	0.407
DOC_WW_Pin1_4	379	384	PF00397	0.344
LIG_14-3-3_CanoR_1	157	161	PF00244	0.482
LIG_14-3-3_CanoR_1	262	271	PF00244	0.304
LIG_14-3-3_CanoR_1	295	300	PF00244	0.290
LIG_APCC_ABBA_1	198	203	PF00400	0.460
LIG_BRCT_BRCA1_1	194	198	PF00533	0.356
LIG_BRCT_BRCA1_1	297	301	PF00533	0.272
LIG_EH1_1	290	298	PF00400	0.405
LIG_eIF4E_1	291	297	PF01652	0.405
LIG_FHA_1	14	20	PF00498	0.434
LIG_FHA_1	266	272	PF00498	0.536
LIG_FHA_2	113	119	PF00498	0.470
LIG_FHA_2	389	395	PF00498	0.584
LIG_LIR_Gen_1	360	371	PF02991	0.380
LIG_LIR_Nem_3	172	177	PF02991	0.560
LIG_LIR_Nem_3	195	201	PF02991	0.356
LIG_LIR_Nem_3	228	233	PF02991	0.397
LIG_LIR_Nem_3	360	366	PF02991	0.363
LIG_MYND_3	14	18	PF01753	0.405
LIG_PCNA_TLS_4	55	62	PF02747	0.405
LIG_PTB_Apo_2	285	292	PF02174	0.405
LIG_PTB_Phospho_1	285	291	PF10480	0.405
LIG_REV1ctd_RIR_1	330	341	PF16727	0.405
LIG_SH2_CRK	230	234	PF00017	0.356
LIG_SH2_CRK	5	9	PF00017	0.269
LIG_SH2_GRB2like	194	197	PF00017	0.407
LIG_SH2_GRB2like	232	235	PF00017	0.356
LIG_SH2_PTP2	232	235	PF00017	0.356
LIG_SH2_SRC	232	235	PF00017	0.356
LIG_SH2_SRC	94	97	PF00017	0.349
LIG_SH2_STAP1	194	198	PF00017	0.405
LIG_SH2_STAP1	363	367	PF00017	0.436
LIG_SH2_STAT5	109	112	PF00017	0.428
LIG_SH2_STAT5	191	194	PF00017	0.308
LIG_SH2_STAT5	232	235	PF00017	0.356
LIG_SH2_STAT5	259	262	PF00017	0.364
LIG_SH2_STAT5	291	294	PF00017	0.414
LIG_SH2_STAT5	355	358	PF00017	0.351
LIG_SH2_STAT5	36	39	PF00017	0.329
LIG_SH2_STAT5	94	97	PF00017	0.355
LIG_SH3_3	216	222	PF00018	0.479
LIG_SH3_3	266	272	PF00018	0.351
LIG_SH3_3	364	370	PF00018	0.223
LIG_SUMO_SIM_anti_2	342	347	PF11976	0.383
LIG_TRAF2_1	391	394	PF00917	0.558
LIG_UBA3_1	345	353	PF00899	0.382
MOD_CDK_SPxxK_3	379	386	PF00069	0.344
MOD_CK2_1	388	394	PF00069	0.537
MOD_Cter_Amidation	334	337	PF01082	0.356
MOD_GlcNHglycan	180	183	PF01048	0.488
MOD_GlcNHglycan	245	248	PF01048	0.525
MOD_GlcNHglycan	358	362	PF01048	0.434
MOD_GlcNHglycan	38	42	PF01048	0.560
MOD_GlcNHglycan	50	53	PF01048	0.519
MOD_GlcNHglycan	69	72	PF01048	0.456
MOD_GlcNHglycan	80	83	PF01048	0.511
MOD_GSK3_1	156	163	PF00069	0.364
MOD_N-GLC_1	101	106	PF02516	0.405
MOD_NEK2_1	37	42	PF00069	0.499
MOD_NEK2_1	48	53	PF00069	0.395
MOD_PIKK_1	250	256	PF00454	0.372
MOD_PKA_2	10	16	PF00069	0.361
MOD_PKA_2	156	162	PF00069	0.329
MOD_PKA_2	235	241	PF00069	0.316
MOD_Plk_1	112	118	PF00069	0.416
MOD_Plk_4	265	271	PF00069	0.358
MOD_Plk_4	27	33	PF00069	0.507
MOD_Plk_4	295	301	PF00069	0.484
MOD_ProDKin_1	161	167	PF00069	0.542
MOD_ProDKin_1	241	247	PF00069	0.407
MOD_ProDKin_1	379	385	PF00069	0.344
MOD_SUMO_for_1	307	310	PF00179	0.407
MOD_SUMO_rev_2	305	309	PF00179	0.435
TRG_DiLeu_BaEn_1	266	271	PF01217	0.365
TRG_DiLeu_BaEn_2	280	286	PF01217	0.405
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.405
TRG_ENDOCYTIC_2	138	141	PF00928	0.368
TRG_ENDOCYTIC_2	174	177	PF00928	0.477
TRG_ENDOCYTIC_2	230	233	PF00928	0.407
TRG_ENDOCYTIC_2	363	366	PF00928	0.335
TRG_ENDOCYTIC_2	5	8	PF00928	0.270
TRG_ER_diArg_1	204	207	PF00400	0.375
TRG_ER_diArg_1	402	405	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IX62	Bodo saltans	40%	85%
A0A0S4KHM5	Bodo saltans	41%	85%
A0A1X0P247	Trypanosomatidae	46%	92%
A0A3S7X699	Leishmania donovani	91%	91%
A0A422NGA2	Trypanosoma rangeli	51%	92%
A4HJ18	Leishmania braziliensis	79%	100%
A4I8P2	Leishmania infantum	91%	91%
Q70GE8	Leishmania major	92%	100%
V5DBY4	Trypanosoma cruzi	47%	92%