Adenosine deaminase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenosine deaminase-like protein

Species:

Leishmania mexicana

UniProt:

E9B3K2_LEIMU

TriTrypDb:

LmxM.32.0235

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0004000	adenosine deaminase activity	4	8
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	8
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	8
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	8
GO:0019239	deaminase activity	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0008251	tRNA-specific adenosine deaminase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.555
CLV_NRD_NRD_1	114	116	PF00675	0.558
CLV_NRD_NRD_1	143	145	PF00675	0.383
CLV_NRD_NRD_1	158	160	PF00675	0.236
CLV_NRD_NRD_1	16	18	PF00675	0.406
CLV_NRD_NRD_1	187	189	PF00675	0.355
CLV_NRD_NRD_1	325	327	PF00675	0.317
CLV_NRD_NRD_1	368	370	PF00675	0.627
CLV_NRD_NRD_1	372	374	PF00675	0.718
CLV_NRD_NRD_1	430	432	PF00675	0.715
CLV_NRD_NRD_1	483	485	PF00675	0.656
CLV_NRD_NRD_1	589	591	PF00675	0.598
CLV_PCSK_FUR_1	366	370	PF00082	0.616
CLV_PCSK_KEX2_1	114	116	PF00082	0.558
CLV_PCSK_KEX2_1	143	145	PF00082	0.383
CLV_PCSK_KEX2_1	158	160	PF00082	0.236
CLV_PCSK_KEX2_1	16	18	PF00082	0.406
CLV_PCSK_KEX2_1	186	188	PF00082	0.406
CLV_PCSK_KEX2_1	324	326	PF00082	0.317
CLV_PCSK_KEX2_1	368	370	PF00082	0.646
CLV_PCSK_KEX2_1	432	434	PF00082	0.672
CLV_PCSK_KEX2_1	483	485	PF00082	0.656
CLV_PCSK_KEX2_1	589	591	PF00082	0.516
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.672
CLV_PCSK_PC7_1	12	18	PF00082	0.438
CLV_PCSK_PC7_1	479	485	PF00082	0.676
CLV_PCSK_SKI1_1	143	147	PF00082	0.404
CLV_PCSK_SKI1_1	385	389	PF00082	0.513
DEG_APCC_DBOX_1	560	568	PF00400	0.552
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_CYCLIN_RxL_1	141	150	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.547
DOC_MAPK_DCC_7	324	334	PF00069	0.555
DOC_MAPK_gen_1	114	121	PF00069	0.481
DOC_MAPK_gen_1	158	164	PF00069	0.463
DOC_MAPK_gen_1	312	321	PF00069	0.517
DOC_MAPK_gen_1	373	380	PF00069	0.406
DOC_MAPK_gen_1	76	84	PF00069	0.600
DOC_MAPK_MEF2A_6	114	121	PF00069	0.419
DOC_PP1_RVXF_1	573	579	PF00149	0.754
DOC_PP2B_LxvP_1	342	345	PF13499	0.562
DOC_PP2B_LxvP_1	89	92	PF13499	0.450
DOC_PP4_FxxP_1	330	333	PF00568	0.517
DOC_USP7_MATH_1	169	173	PF00917	0.566
DOC_USP7_MATH_1	230	234	PF00917	0.563
DOC_USP7_MATH_1	402	406	PF00917	0.703
DOC_USP7_MATH_1	408	412	PF00917	0.770
DOC_USP7_MATH_1	443	447	PF00917	0.692
DOC_USP7_MATH_1	520	524	PF00917	0.786
DOC_USP7_MATH_1	579	583	PF00917	0.711
DOC_USP7_MATH_1	6	10	PF00917	0.549
DOC_USP7_MATH_1	66	70	PF00917	0.686
DOC_WW_Pin1_4	200	205	PF00397	0.562
DOC_WW_Pin1_4	24	29	PF00397	0.367
DOC_WW_Pin1_4	279	284	PF00397	0.562
DOC_WW_Pin1_4	395	400	PF00397	0.697
DOC_WW_Pin1_4	518	523	PF00397	0.763
LIG_14-3-3_CanoR_1	174	180	PF00244	0.520
LIG_14-3-3_CanoR_1	264	270	PF00244	0.448
LIG_14-3-3_CanoR_1	274	278	PF00244	0.448
LIG_14-3-3_CanoR_1	302	308	PF00244	0.545
LIG_14-3-3_CanoR_1	335	342	PF00244	0.510
LIG_14-3-3_CanoR_1	483	493	PF00244	0.689
LIG_BIR_III_2	132	136	PF00653	0.562
LIG_BIR_III_2	193	197	PF00653	0.400
LIG_BRCT_BRCA1_1	390	394	PF00533	0.597
LIG_deltaCOP1_diTrp_1	311	316	PF00928	0.555
LIG_EVH1_1	380	384	PF00568	0.426
LIG_FHA_1	209	215	PF00498	0.560
LIG_FHA_1	308	314	PF00498	0.555
LIG_FHA_1	395	401	PF00498	0.563
LIG_FHA_1	439	445	PF00498	0.501
LIG_FHA_1	592	598	PF00498	0.546
LIG_FHA_1	66	72	PF00498	0.481
LIG_FHA_2	136	142	PF00498	0.400
LIG_FHA_2	454	460	PF00498	0.508
LIG_FHA_2	485	491	PF00498	0.642
LIG_FHA_2	567	573	PF00498	0.697
LIG_FHA_2	6	12	PF00498	0.770
LIG_LIR_Apic_2	328	333	PF02991	0.491
LIG_LIR_Gen_1	177	185	PF02991	0.562
LIG_LIR_Gen_1	419	429	PF02991	0.646
LIG_LIR_Nem_3	177	183	PF02991	0.562
LIG_LIR_Nem_3	311	317	PF02991	0.474
LIG_LIR_Nem_3	419	424	PF02991	0.681
LIG_LIR_Nem_3	448	454	PF02991	0.698
LIG_SH2_CRK	281	285	PF00017	0.606
LIG_SH2_CRK	504	508	PF00017	0.324
LIG_SH2_NCK_1	533	537	PF00017	0.817
LIG_SH2_PTP2	116	119	PF00017	0.539
LIG_SH2_STAP1	180	184	PF00017	0.606
LIG_SH2_STAT5	116	119	PF00017	0.468
LIG_SH2_STAT5	93	96	PF00017	0.411
LIG_SH3_3	338	344	PF00018	0.484
LIG_SH3_3	375	381	PF00018	0.607
LIG_SUMO_SIM_par_1	144	150	PF11976	0.562
LIG_SUMO_SIM_par_1	440	446	PF11976	0.495
LIG_SxIP_EBH_1	483	497	PF03271	0.452
LIG_TRAF2_1	138	141	PF00917	0.400
LIG_TRAF2_1	8	11	PF00917	0.711
MOD_CDK_SPxxK_3	518	525	PF00069	0.502
MOD_CK1_1	120	126	PF00069	0.517
MOD_CK1_1	136	142	PF00069	0.517
MOD_CK1_1	233	239	PF00069	0.590
MOD_CK1_1	255	261	PF00069	0.584
MOD_CK1_1	267	273	PF00069	0.498
MOD_CK1_1	411	417	PF00069	0.655
MOD_CK1_1	486	492	PF00069	0.555
MOD_CK1_1	532	538	PF00069	0.691
MOD_CK2_1	135	141	PF00069	0.400
MOD_CK2_1	255	261	PF00069	0.562
MOD_CK2_1	4	10	PF00069	0.776
MOD_CK2_1	484	490	PF00069	0.702
MOD_CK2_1	510	516	PF00069	0.607
MOD_CK2_1	66	72	PF00069	0.646
MOD_Cter_Amidation	322	325	PF01082	0.317
MOD_GlcNHglycan	122	125	PF01048	0.272
MOD_GlcNHglycan	170	174	PF01048	0.406
MOD_GlcNHglycan	188	191	PF01048	0.171
MOD_GlcNHglycan	200	203	PF01048	0.406
MOD_GlcNHglycan	232	235	PF01048	0.336
MOD_GlcNHglycan	256	260	PF01048	0.384
MOD_GlcNHglycan	390	393	PF01048	0.609
MOD_GlcNHglycan	425	428	PF01048	0.701
MOD_GlcNHglycan	445	448	PF01048	0.710
MOD_GSK3_1	169	176	PF00069	0.608
MOD_GSK3_1	263	270	PF00069	0.616
MOD_GSK3_1	303	310	PF00069	0.555
MOD_GSK3_1	423	430	PF00069	0.725
MOD_GSK3_1	443	450	PF00069	0.728
MOD_GSK3_1	566	573	PF00069	0.764
MOD_N-GLC_1	303	308	PF02516	0.355
MOD_N-GLC_1	414	419	PF02516	0.597
MOD_NEK2_1	208	213	PF00069	0.580
MOD_NEK2_1	216	221	PF00069	0.600
MOD_NEK2_1	222	227	PF00069	0.508
MOD_NEK2_1	305	310	PF00069	0.517
MOD_NEK2_1	334	339	PF00069	0.552
MOD_NEK2_1	388	393	PF00069	0.486
MOD_NEK2_1	394	399	PF00069	0.581
MOD_NEK2_1	510	515	PF00069	0.591
MOD_NEK2_1	553	558	PF00069	0.637
MOD_NEK2_1	577	582	PF00069	0.653
MOD_NEK2_1	71	76	PF00069	0.740
MOD_NEK2_1	87	92	PF00069	0.438
MOD_NEK2_2	359	364	PF00069	0.307
MOD_NEK2_2	570	575	PF00069	0.709
MOD_PIKK_1	553	559	PF00454	0.680
MOD_PK_1	325	331	PF00069	0.524
MOD_PK_1	335	341	PF00069	0.513
MOD_PKA_1	186	192	PF00069	0.550
MOD_PKA_1	325	331	PF00069	0.491
MOD_PKA_1	483	489	PF00069	0.699
MOD_PKA_2	173	179	PF00069	0.532
MOD_PKA_2	186	192	PF00069	0.477
MOD_PKA_2	208	214	PF00069	0.606
MOD_PKA_2	263	269	PF00069	0.448
MOD_PKA_2	273	279	PF00069	0.448
MOD_PKA_2	325	331	PF00069	0.512
MOD_PKA_2	334	340	PF00069	0.525
MOD_PKA_2	483	489	PF00069	0.699
MOD_Plk_1	303	309	PF00069	0.555
MOD_Plk_1	460	466	PF00069	0.634
MOD_Plk_1	551	557	PF00069	0.682
MOD_Plk_1	570	576	PF00069	0.773
MOD_Plk_4	325	331	PF00069	0.530
MOD_Plk_4	460	466	PF00069	0.594
MOD_ProDKin_1	200	206	PF00069	0.562
MOD_ProDKin_1	24	30	PF00069	0.367
MOD_ProDKin_1	279	285	PF00069	0.562
MOD_ProDKin_1	395	401	PF00069	0.703
MOD_ProDKin_1	518	524	PF00069	0.766
MOD_SUMO_rev_2	106	112	PF00179	0.389
TRG_DiLeu_BaEn_1	141	146	PF01217	0.400
TRG_DiLeu_BaEn_4	437	443	PF01217	0.508
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.562
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.689
TRG_DiLeu_LyEn_5	141	146	PF01217	0.444
TRG_ENDOCYTIC_2	116	119	PF00928	0.468
TRG_ENDOCYTIC_2	180	183	PF00928	0.606
TRG_ENDOCYTIC_2	281	284	PF00928	0.530
TRG_ENDOCYTIC_2	504	507	PF00928	0.317
TRG_ER_diArg_1	113	115	PF00400	0.573
TRG_ER_diArg_1	142	144	PF00400	0.565
TRG_ER_diArg_1	16	18	PF00400	0.406
TRG_ER_diArg_1	185	188	PF00400	0.606
TRG_ER_diArg_1	324	326	PF00400	0.517
TRG_ER_diArg_1	365	368	PF00400	0.605
TRG_ER_diArg_1	418	421	PF00400	0.612
TRG_ER_diArg_1	589	591	PF00400	0.640
TRG_NLS_MonoExtC_3	430	435	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P680	Leptomonas seymouri	40%	100%
A0A3Q8IGD9	Leishmania donovani	86%	100%
A0A422NGA7	Trypanosoma rangeli	32%	98%
A4HJ19	Leishmania braziliensis	71%	100%
A4I8P1	Leishmania infantum	86%	100%
Q4Q4J9	Leishmania major	86%	100%