LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3K1_LEIMU
TriTrypDb:
LmxM.32.0230
Length:
571

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic ZDHHC-type palmitoyltransferases (e.g animal ZDHHC20).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005737 cytoplasm 2 1
GO:0005783 endoplasmic reticulum 5 1
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9B3K1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3K1

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 1
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006897 endocytosis 5 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016192 vesicle-mediated transport 4 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018198 peptidyl-cysteine modification 6 1
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 1
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 1
GO:0018345 protein palmitoylation 6 1
GO:0019538 protein metabolic process 3 1
GO:0033036 macromolecule localization 2 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0044238 primary metabolic process 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016409 palmitoyltransferase activity 5 9
GO:0016417 S-acyltransferase activity 5 9
GO:0016740 transferase activity 2 9
GO:0016746 acyltransferase activity 3 9
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 9
GO:0019707 protein-cysteine S-acyltransferase activity 3 9
GO:0140096 catalytic activity, acting on a protein 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 306 308 PF00675 0.430
CLV_NRD_NRD_1 384 386 PF00675 0.449
CLV_NRD_NRD_1 422 424 PF00675 0.481
CLV_NRD_NRD_1 457 459 PF00675 0.557
CLV_PCSK_KEX2_1 305 307 PF00082 0.419
CLV_PCSK_KEX2_1 362 364 PF00082 0.337
CLV_PCSK_KEX2_1 384 386 PF00082 0.449
CLV_PCSK_KEX2_1 422 424 PF00082 0.481
CLV_PCSK_KEX2_1 457 459 PF00082 0.557
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.382
CLV_PCSK_SKI1_1 363 367 PF00082 0.335
CLV_PCSK_SKI1_1 384 388 PF00082 0.496
CLV_PCSK_SKI1_1 432 436 PF00082 0.425
CLV_PCSK_SKI1_1 477 481 PF00082 0.383
DEG_APCC_KENBOX_2 296 300 PF00400 0.275
DOC_CKS1_1 400 405 PF01111 0.605
DOC_MAPK_gen_1 128 137 PF00069 0.649
DOC_MAPK_gen_1 422 430 PF00069 0.643
DOC_MAPK_MEF2A_6 265 272 PF00069 0.484
DOC_PP4_FxxP_1 140 143 PF00568 0.702
DOC_PP4_FxxP_1 205 208 PF00568 0.732
DOC_PP4_FxxP_1 45 48 PF00568 0.416
DOC_USP7_MATH_1 129 133 PF00917 0.678
DOC_USP7_MATH_1 504 508 PF00917 0.716
DOC_USP7_MATH_1 558 562 PF00917 0.728
DOC_USP7_MATH_1 63 67 PF00917 0.511
DOC_WW_Pin1_4 146 151 PF00397 0.766
DOC_WW_Pin1_4 314 319 PF00397 0.355
DOC_WW_Pin1_4 399 404 PF00397 0.776
DOC_WW_Pin1_4 75 80 PF00397 0.395
LIG_14-3-3_CanoR_1 128 137 PF00244 0.626
LIG_14-3-3_CanoR_1 168 173 PF00244 0.727
LIG_14-3-3_CanoR_1 305 314 PF00244 0.185
LIG_14-3-3_CanoR_1 363 368 PF00244 0.505
LIG_14-3-3_CanoR_1 369 379 PF00244 0.461
LIG_14-3-3_CanoR_1 413 418 PF00244 0.703
LIG_14-3-3_CanoR_1 502 510 PF00244 0.721
LIG_14-3-3_CanoR_1 513 519 PF00244 0.565
LIG_14-3-3_CanoR_1 7 15 PF00244 0.526
LIG_APCC_ABBA_1 435 440 PF00400 0.636
LIG_BIR_III_2 406 410 PF00653 0.692
LIG_BRCT_BRCA1_1 349 353 PF00533 0.437
LIG_Clathr_ClatBox_1 102 106 PF01394 0.474
LIG_EH1_1 109 117 PF00400 0.474
LIG_eIF4E_1 264 270 PF01652 0.484
LIG_FHA_1 109 115 PF00498 0.474
LIG_FHA_1 14 20 PF00498 0.369
LIG_FHA_1 272 278 PF00498 0.351
LIG_FHA_1 288 294 PF00498 0.289
LIG_FHA_1 355 361 PF00498 0.392
LIG_FHA_1 409 415 PF00498 0.624
LIG_FHA_1 41 47 PF00498 0.432
LIG_FHA_2 137 143 PF00498 0.692
LIG_FHA_2 371 377 PF00498 0.484
LIG_LIR_Apic_2 138 143 PF02991 0.700
LIG_LIR_Apic_2 202 208 PF02991 0.736
LIG_LIR_Apic_2 229 233 PF02991 0.555
LIG_LIR_Apic_2 31 35 PF02991 0.447
LIG_LIR_Apic_2 43 48 PF02991 0.396
LIG_LIR_Gen_1 212 221 PF02991 0.677
LIG_LIR_Gen_1 28 38 PF02991 0.395
LIG_LIR_Gen_1 493 499 PF02991 0.779
LIG_LIR_Gen_1 6 17 PF02991 0.548
LIG_LIR_Gen_1 71 82 PF02991 0.489
LIG_LIR_Gen_1 98 109 PF02991 0.359
LIG_LIR_Nem_3 138 144 PF02991 0.704
LIG_LIR_Nem_3 212 216 PF02991 0.663
LIG_LIR_Nem_3 28 33 PF02991 0.351
LIG_LIR_Nem_3 493 497 PF02991 0.779
LIG_LIR_Nem_3 6 12 PF02991 0.628
LIG_LIR_Nem_3 71 77 PF02991 0.509
LIG_LIR_Nem_3 98 104 PF02991 0.356
LIG_NRBOX 267 273 PF00104 0.425
LIG_Pex14_1 478 482 PF04695 0.463
LIG_Pex14_2 45 49 PF04695 0.388
LIG_Pex14_2 474 478 PF04695 0.580
LIG_REV1ctd_RIR_1 477 483 PF16727 0.600
LIG_SH2_CRK 166 170 PF00017 0.579
LIG_SH2_CRK 213 217 PF00017 0.669
LIG_SH2_CRK 230 234 PF00017 0.555
LIG_SH2_CRK 30 34 PF00017 0.394
LIG_SH2_GRB2like 220 223 PF00017 0.492
LIG_SH2_GRB2like 380 383 PF00017 0.650
LIG_SH2_NCK_1 213 217 PF00017 0.669
LIG_SH2_SRC 248 251 PF00017 0.484
LIG_SH2_STAP1 110 114 PF00017 0.474
LIG_SH2_STAP1 273 277 PF00017 0.362
LIG_SH2_STAP1 30 34 PF00017 0.394
LIG_SH2_STAP1 460 464 PF00017 0.719
LIG_SH2_STAT3 488 491 PF00017 0.598
LIG_SH2_STAT5 110 113 PF00017 0.337
LIG_SH2_STAT5 213 216 PF00017 0.665
LIG_SH2_STAT5 220 223 PF00017 0.555
LIG_SH2_STAT5 267 270 PF00017 0.337
LIG_SH2_STAT5 273 276 PF00017 0.337
LIG_SH2_STAT5 292 295 PF00017 0.284
LIG_SH2_STAT5 30 33 PF00017 0.363
LIG_SH2_STAT5 359 362 PF00017 0.383
LIG_SH2_STAT5 460 463 PF00017 0.721
LIG_SH3_3 111 117 PF00018 0.507
LIG_SH3_3 333 339 PF00018 0.295
LIG_SH3_3 397 403 PF00018 0.704
LIG_SUMO_SIM_anti_2 10 16 PF11976 0.503
LIG_SUMO_SIM_par_1 10 16 PF11976 0.503
LIG_SUMO_SIM_par_1 268 274 PF11976 0.394
LIG_SUMO_SIM_par_1 280 286 PF11976 0.394
LIG_SUMO_SIM_par_1 292 298 PF11976 0.354
LIG_TYR_ITIM 271 276 PF00017 0.337
LIG_WRC_WIRS_1 137 142 PF05994 0.686
LIG_WRC_WIRS_1 169 174 PF05994 0.726
LIG_WW_3 231 235 PF00397 0.555
LIG_WW_3 318 322 PF00397 0.377
MOD_CDK_SPK_2 399 404 PF00069 0.712
MOD_CDK_SPxxK_3 314 321 PF00069 0.355
MOD_CK1_1 156 162 PF00069 0.760
MOD_CK1_1 212 218 PF00069 0.671
MOD_CK1_1 25 31 PF00069 0.427
MOD_CK1_1 391 397 PF00069 0.744
MOD_CK1_1 500 506 PF00069 0.696
MOD_CK1_1 511 517 PF00069 0.560
MOD_CK1_1 540 546 PF00069 0.699
MOD_CK1_1 59 65 PF00069 0.525
MOD_CK1_1 68 74 PF00069 0.524
MOD_CK1_1 75 81 PF00069 0.456
MOD_CK2_1 136 142 PF00069 0.681
MOD_CK2_1 391 397 PF00069 0.745
MOD_CK2_1 50 56 PF00069 0.464
MOD_DYRK1A_RPxSP_1 146 150 PF00069 0.764
MOD_GlcNHglycan 131 134 PF01048 0.421
MOD_GlcNHglycan 155 158 PF01048 0.525
MOD_GlcNHglycan 184 187 PF01048 0.575
MOD_GlcNHglycan 24 27 PF01048 0.420
MOD_GlcNHglycan 302 305 PF01048 0.423
MOD_GlcNHglycan 390 393 PF01048 0.360
MOD_GlcNHglycan 502 505 PF01048 0.509
MOD_GlcNHglycan 510 513 PF01048 0.491
MOD_GlcNHglycan 52 55 PF01048 0.665
MOD_GlcNHglycan 560 563 PF01048 0.558
MOD_GlcNHglycan 61 64 PF01048 0.702
MOD_GlcNHglycan 67 70 PF01048 0.668
MOD_GSK3_1 127 134 PF00069 0.661
MOD_GSK3_1 142 149 PF00069 0.663
MOD_GSK3_1 18 25 PF00069 0.437
MOD_GSK3_1 271 278 PF00069 0.337
MOD_GSK3_1 283 290 PF00069 0.337
MOD_GSK3_1 398 405 PF00069 0.770
MOD_GSK3_1 498 505 PF00069 0.680
MOD_GSK3_1 59 66 PF00069 0.512
MOD_GSK3_1 68 75 PF00069 0.526
MOD_GSK3_1 77 84 PF00069 0.492
MOD_N-GLC_1 370 375 PF02516 0.284
MOD_N-GLC_1 50 55 PF02516 0.691
MOD_N-GLC_2 222 224 PF02516 0.355
MOD_N-GLC_2 242 244 PF02516 0.150
MOD_NEK2_1 135 140 PF00069 0.646
MOD_NEK2_1 18 23 PF00069 0.362
MOD_NEK2_1 226 231 PF00069 0.555
MOD_NEK2_1 271 276 PF00069 0.351
MOD_NEK2_1 300 305 PF00069 0.226
MOD_NEK2_1 354 359 PF00069 0.345
MOD_NEK2_1 95 100 PF00069 0.298
MOD_NEK2_2 136 141 PF00069 0.674
MOD_NEK2_2 504 509 PF00069 0.748
MOD_PIKK_1 180 186 PF00454 0.681
MOD_PKA_1 306 312 PF00069 0.185
MOD_PKA_2 127 133 PF00069 0.681
MOD_PKA_2 306 312 PF00069 0.267
MOD_PKA_2 534 540 PF00069 0.771
MOD_PKA_2 72 78 PF00069 0.543
MOD_PKB_1 305 313 PF00069 0.185
MOD_Plk_1 370 376 PF00069 0.484
MOD_Plk_1 5 11 PF00069 0.654
MOD_Plk_4 136 142 PF00069 0.660
MOD_Plk_4 19 25 PF00069 0.377
MOD_Plk_4 271 277 PF00069 0.337
MOD_Plk_4 28 34 PF00069 0.391
MOD_Plk_4 280 286 PF00069 0.337
MOD_Plk_4 287 293 PF00069 0.337
MOD_Plk_4 347 353 PF00069 0.345
MOD_Plk_4 355 361 PF00069 0.290
MOD_Plk_4 416 422 PF00069 0.519
MOD_Plk_4 537 543 PF00069 0.716
MOD_Plk_4 96 102 PF00069 0.371
MOD_ProDKin_1 146 152 PF00069 0.768
MOD_ProDKin_1 314 320 PF00069 0.355
MOD_ProDKin_1 399 405 PF00069 0.775
MOD_ProDKin_1 75 81 PF00069 0.387
TRG_DiLeu_BaEn_1 548 553 PF01217 0.689
TRG_DiLeu_BaEn_4 548 554 PF01217 0.689
TRG_ENDOCYTIC_2 141 144 PF00928 0.718
TRG_ENDOCYTIC_2 166 169 PF00928 0.578
TRG_ENDOCYTIC_2 213 216 PF00928 0.665
TRG_ENDOCYTIC_2 220 223 PF00928 0.555
TRG_ENDOCYTIC_2 267 270 PF00928 0.337
TRG_ENDOCYTIC_2 273 276 PF00928 0.337
TRG_ENDOCYTIC_2 30 33 PF00928 0.345
TRG_ENDOCYTIC_2 518 521 PF00928 0.713
TRG_ER_diArg_1 125 128 PF00400 0.671
TRG_ER_diArg_1 305 307 PF00400 0.257
TRG_ER_diArg_1 384 386 PF00400 0.658
TRG_ER_diArg_1 412 415 PF00400 0.722
TRG_ER_diArg_1 421 423 PF00400 0.578
TRG_ER_diArg_1 456 458 PF00400 0.766
TRG_ER_diArg_1 469 472 PF00400 0.579
TRG_Pf-PMV_PEXEL_1 423 427 PF00026 0.453
TRG_Pf-PMV_PEXEL_1 432 436 PF00026 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5U1 Leptomonas seymouri 61% 98%
A0A1X0P0I7 Trypanosomatidae 34% 100%
A0A3R7KZF6 Trypanosoma rangeli 32% 100%
A0A3S7X6D2 Leishmania donovani 92% 100%
A4I8P0 Leishmania infantum 92% 100%
D0A4L6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
Q4Q4K0 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS