LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9B3J9_LEIMU
TriTrypDb:
LmxM.32.0210
Length:
920

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9B3J9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3J9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.789
CLV_C14_Caspase3-7 652 656 PF00656 0.627
CLV_C14_Caspase3-7 800 804 PF00656 0.618
CLV_C14_Caspase3-7 892 896 PF00656 0.677
CLV_NRD_NRD_1 267 269 PF00675 0.531
CLV_NRD_NRD_1 341 343 PF00675 0.365
CLV_NRD_NRD_1 35 37 PF00675 0.608
CLV_NRD_NRD_1 689 691 PF00675 0.402
CLV_NRD_NRD_1 752 754 PF00675 0.406
CLV_NRD_NRD_1 759 761 PF00675 0.438
CLV_NRD_NRD_1 815 817 PF00675 0.470
CLV_PCSK_FUR_1 813 817 PF00082 0.460
CLV_PCSK_KEX2_1 267 269 PF00082 0.531
CLV_PCSK_KEX2_1 35 37 PF00082 0.608
CLV_PCSK_KEX2_1 752 754 PF00082 0.406
CLV_PCSK_KEX2_1 759 761 PF00082 0.433
CLV_PCSK_KEX2_1 76 78 PF00082 0.493
CLV_PCSK_KEX2_1 815 817 PF00082 0.470
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.505
CLV_PCSK_SKI1_1 242 246 PF00082 0.450
CLV_PCSK_SKI1_1 288 292 PF00082 0.297
CLV_PCSK_SKI1_1 342 346 PF00082 0.576
CLV_PCSK_SKI1_1 428 432 PF00082 0.433
CLV_PCSK_SKI1_1 559 563 PF00082 0.515
CLV_PCSK_SKI1_1 592 596 PF00082 0.379
CLV_PCSK_SKI1_1 816 820 PF00082 0.459
CLV_PCSK_SKI1_1 903 907 PF00082 0.373
DEG_APCC_DBOX_1 814 822 PF00400 0.652
DOC_CDC14_PxL_1 585 593 PF14671 0.636
DOC_CKS1_1 390 395 PF01111 0.464
DOC_CYCLIN_RxL_1 554 565 PF00134 0.711
DOC_CYCLIN_RxL_1 810 823 PF00134 0.650
DOC_CYCLIN_RxL_1 900 910 PF00134 0.574
DOC_CYCLIN_yClb5_NLxxxL_5 422 431 PF00134 0.516
DOC_CYCLIN_yCln2_LP_2 156 162 PF00134 0.751
DOC_MAPK_gen_1 285 295 PF00069 0.526
DOC_MAPK_gen_1 32 40 PF00069 0.366
DOC_MAPK_gen_1 688 696 PF00069 0.511
DOC_MAPK_gen_1 813 821 PF00069 0.732
DOC_MAPK_gen_1 824 833 PF00069 0.600
DOC_MAPK_MEF2A_6 688 696 PF00069 0.529
DOC_MAPK_MEF2A_6 813 821 PF00069 0.690
DOC_MAPK_RevD_3 327 343 PF00069 0.383
DOC_PP1_RVXF_1 286 292 PF00149 0.572
DOC_PP1_RVXF_1 34 41 PF00149 0.435
DOC_PP1_RVXF_1 732 739 PF00149 0.631
DOC_PP2B_LxvP_1 191 194 PF13499 0.673
DOC_PP2B_LxvP_1 329 332 PF13499 0.418
DOC_PP2B_LxvP_1 509 512 PF13499 0.719
DOC_PP4_FxxP_1 234 237 PF00568 0.662
DOC_PP4_FxxP_1 291 294 PF00568 0.294
DOC_PP4_FxxP_1 738 741 PF00568 0.623
DOC_SPAK_OSR1_1 100 104 PF12202 0.665
DOC_USP7_MATH_1 125 129 PF00917 0.730
DOC_USP7_MATH_1 281 285 PF00917 0.665
DOC_USP7_MATH_1 294 298 PF00917 0.392
DOC_USP7_MATH_1 43 47 PF00917 0.279
DOC_USP7_MATH_1 479 483 PF00917 0.750
DOC_USP7_MATH_1 538 542 PF00917 0.713
DOC_USP7_MATH_1 549 553 PF00917 0.671
DOC_USP7_MATH_1 610 614 PF00917 0.717
DOC_USP7_MATH_1 676 680 PF00917 0.626
DOC_USP7_MATH_1 695 699 PF00917 0.619
DOC_USP7_MATH_1 716 720 PF00917 0.564
DOC_USP7_MATH_1 886 890 PF00917 0.655
DOC_USP7_MATH_2 523 529 PF00917 0.743
DOC_USP7_UBL2_3 242 246 PF12436 0.739
DOC_WW_Pin1_4 105 110 PF00397 0.716
DOC_WW_Pin1_4 155 160 PF00397 0.862
DOC_WW_Pin1_4 170 175 PF00397 0.729
DOC_WW_Pin1_4 189 194 PF00397 0.697
DOC_WW_Pin1_4 323 328 PF00397 0.433
DOC_WW_Pin1_4 389 394 PF00397 0.486
DOC_WW_Pin1_4 398 403 PF00397 0.439
DOC_WW_Pin1_4 453 458 PF00397 0.723
DOC_WW_Pin1_4 464 469 PF00397 0.815
DOC_WW_Pin1_4 477 482 PF00397 0.720
DOC_WW_Pin1_4 512 517 PF00397 0.688
DOC_WW_Pin1_4 82 87 PF00397 0.698
DOC_WW_Pin1_4 914 919 PF00397 0.708
LIG_14-3-3_CanoR_1 150 154 PF00244 0.794
LIG_14-3-3_CanoR_1 267 272 PF00244 0.799
LIG_14-3-3_CanoR_1 352 356 PF00244 0.648
LIG_14-3-3_CanoR_1 358 363 PF00244 0.624
LIG_14-3-3_CanoR_1 406 411 PF00244 0.303
LIG_14-3-3_CanoR_1 783 793 PF00244 0.628
LIG_Actin_WH2_2 481 497 PF00022 0.665
LIG_Actin_WH2_2 826 843 PF00022 0.586
LIG_BIR_III_2 204 208 PF00653 0.808
LIG_BIR_III_4 647 651 PF00653 0.665
LIG_BRCT_BRCA1_1 59 63 PF00533 0.258
LIG_BRCT_BRCA1_1 611 615 PF00533 0.656
LIG_BRCT_BRCA1_1 634 638 PF00533 0.705
LIG_Clathr_ClatBox_1 683 687 PF01394 0.569
LIG_DLG_GKlike_1 760 768 PF00625 0.647
LIG_EH_1 772 776 PF12763 0.801
LIG_eIF4E_1 317 323 PF01652 0.324
LIG_eIF4E_1 410 416 PF01652 0.433
LIG_EVH1_2 702 706 PF00568 0.716
LIG_FHA_1 163 169 PF00498 0.677
LIG_FHA_1 186 192 PF00498 0.682
LIG_FHA_1 223 229 PF00498 0.737
LIG_FHA_1 299 305 PF00498 0.390
LIG_FHA_1 317 323 PF00498 0.398
LIG_FHA_1 346 352 PF00498 0.641
LIG_FHA_1 47 53 PF00498 0.332
LIG_FHA_1 826 832 PF00498 0.579
LIG_FHA_2 131 137 PF00498 0.856
LIG_FHA_2 519 525 PF00498 0.747
LIG_FHA_2 660 666 PF00498 0.668
LIG_GBD_Chelix_1 901 909 PF00786 0.469
LIG_HCF-1_HBM_1 198 201 PF13415 0.699
LIG_HP1_1 294 298 PF01393 0.383
LIG_LIR_Apic_2 231 237 PF02991 0.678
LIG_LIR_Apic_2 387 393 PF02991 0.495
LIG_LIR_Apic_2 409 413 PF02991 0.332
LIG_LIR_Gen_1 297 307 PF02991 0.372
LIG_LIR_Gen_1 49 59 PF02991 0.326
LIG_LIR_Gen_1 60 68 PF02991 0.247
LIG_LIR_Gen_1 635 645 PF02991 0.607
LIG_LIR_Gen_1 828 837 PF02991 0.745
LIG_LIR_Gen_1 844 851 PF02991 0.676
LIG_LIR_Gen_1 859 868 PF02991 0.613
LIG_LIR_LC3C_4 179 182 PF02991 0.764
LIG_LIR_LC3C_4 846 851 PF02991 0.670
LIG_LIR_Nem_3 297 302 PF02991 0.396
LIG_LIR_Nem_3 305 310 PF02991 0.278
LIG_LIR_Nem_3 364 370 PF02991 0.394
LIG_LIR_Nem_3 409 414 PF02991 0.320
LIG_LIR_Nem_3 434 438 PF02991 0.599
LIG_LIR_Nem_3 49 54 PF02991 0.326
LIG_LIR_Nem_3 595 601 PF02991 0.552
LIG_LIR_Nem_3 60 66 PF02991 0.247
LIG_LIR_Nem_3 635 641 PF02991 0.611
LIG_LIR_Nem_3 828 833 PF02991 0.678
LIG_LIR_Nem_3 844 850 PF02991 0.670
LIG_LIR_Nem_3 859 864 PF02991 0.615
LIG_LRP6_Inhibitor_1 400 406 PF00058 0.551
LIG_PALB2_WD40_1 362 370 PF16756 0.383
LIG_PCNA_PIPBox_1 292 301 PF02747 0.383
LIG_PCNA_yPIPBox_3 710 718 PF02747 0.602
LIG_Pex14_2 363 367 PF04695 0.265
LIG_Pex14_2 50 54 PF04695 0.258
LIG_PTB_Apo_2 344 351 PF02174 0.574
LIG_PTB_Phospho_1 344 350 PF10480 0.576
LIG_SH2_CRK 24 28 PF00017 0.258
LIG_SH2_CRK 299 303 PF00017 0.370
LIG_SH2_SRC 664 667 PF00017 0.640
LIG_SH2_STAP1 201 205 PF00017 0.743
LIG_SH2_STAP1 24 28 PF00017 0.258
LIG_SH2_STAP1 438 442 PF00017 0.615
LIG_SH2_STAP1 664 668 PF00017 0.632
LIG_SH2_STAT3 223 226 PF00017 0.755
LIG_SH2_STAT5 201 204 PF00017 0.743
LIG_SH2_STAT5 223 226 PF00017 0.665
LIG_SH2_STAT5 24 27 PF00017 0.360
LIG_SH2_STAT5 350 353 PF00017 0.623
LIG_SH2_STAT5 373 376 PF00017 0.335
LIG_SH2_STAT5 410 413 PF00017 0.401
LIG_SH2_STAT5 598 601 PF00017 0.555
LIG_SH2_STAT5 659 662 PF00017 0.628
LIG_SH3_3 178 184 PF00018 0.844
LIG_SH3_3 204 210 PF00018 0.737
LIG_SH3_3 211 217 PF00018 0.775
LIG_SH3_3 277 283 PF00018 0.711
LIG_SH3_3 451 457 PF00018 0.712
LIG_SH3_3 473 479 PF00018 0.715
LIG_SH3_3 510 516 PF00018 0.769
LIG_SH3_3 697 703 PF00018 0.654
LIG_SH3_3 715 721 PF00018 0.680
LIG_SH3_3 768 774 PF00018 0.719
LIG_SH3_3 806 812 PF00018 0.700
LIG_SUMO_SIM_anti_2 25 31 PF11976 0.263
LIG_SUMO_SIM_par_1 300 305 PF11976 0.332
LIG_SUMO_SIM_par_1 414 419 PF11976 0.383
LIG_SUMO_SIM_par_1 682 687 PF11976 0.566
LIG_TRAF2_1 143 146 PF00917 0.700
LIG_TRAF2_1 709 712 PF00917 0.643
LIG_TRAF2_1 842 845 PF00917 0.664
LIG_TYR_ITIM 599 604 PF00017 0.569
LIG_UBA3_1 338 343 PF00899 0.537
LIG_UBA3_1 683 691 PF00899 0.573
MOD_CDK_SPK_2 453 458 PF00069 0.658
MOD_CDK_SPK_2 464 469 PF00069 0.652
MOD_CDK_SPK_2 82 87 PF00069 0.660
MOD_CDK_SPxxK_3 170 177 PF00069 0.709
MOD_CDK_SPxxK_3 453 460 PF00069 0.658
MOD_CK1_1 112 118 PF00069 0.710
MOD_CK1_1 139 145 PF00069 0.805
MOD_CK1_1 149 155 PF00069 0.719
MOD_CK1_1 192 198 PF00069 0.839
MOD_CK1_1 222 228 PF00069 0.709
MOD_CK1_1 270 276 PF00069 0.748
MOD_CK1_1 361 367 PF00069 0.446
MOD_CK1_1 46 52 PF00069 0.376
MOD_CK1_1 489 495 PF00069 0.752
MOD_CK1_1 528 534 PF00069 0.815
MOD_CK1_1 565 571 PF00069 0.843
MOD_CK1_1 784 790 PF00069 0.753
MOD_CK1_1 82 88 PF00069 0.662
MOD_CK1_1 822 828 PF00069 0.752
MOD_CK1_1 889 895 PF00069 0.716
MOD_CK2_1 112 118 PF00069 0.721
MOD_CK2_1 130 136 PF00069 0.812
MOD_CK2_1 140 146 PF00069 0.679
MOD_CK2_1 192 198 PF00069 0.735
MOD_CK2_1 453 459 PF00069 0.658
MOD_CK2_1 518 524 PF00069 0.789
MOD_CK2_1 659 665 PF00069 0.674
MOD_CK2_1 764 770 PF00069 0.739
MOD_GlcNHglycan 234 237 PF01048 0.534
MOD_GlcNHglycan 269 272 PF01048 0.609
MOD_GlcNHglycan 45 48 PF01048 0.479
MOD_GlcNHglycan 481 484 PF01048 0.542
MOD_GlcNHglycan 488 491 PF01048 0.537
MOD_GlcNHglycan 500 503 PF01048 0.568
MOD_GlcNHglycan 551 554 PF01048 0.542
MOD_GlcNHglycan 634 637 PF01048 0.350
MOD_GlcNHglycan 652 655 PF01048 0.577
MOD_GlcNHglycan 718 721 PF01048 0.475
MOD_GlcNHglycan 729 732 PF01048 0.500
MOD_GlcNHglycan 73 76 PF01048 0.461
MOD_GlcNHglycan 799 802 PF01048 0.492
MOD_GSK3_1 105 112 PF00069 0.802
MOD_GSK3_1 120 127 PF00069 0.739
MOD_GSK3_1 135 142 PF00069 0.835
MOD_GSK3_1 145 152 PF00069 0.736
MOD_GSK3_1 185 192 PF00069 0.685
MOD_GSK3_1 215 222 PF00069 0.767
MOD_GSK3_1 267 274 PF00069 0.729
MOD_GSK3_1 294 301 PF00069 0.503
MOD_GSK3_1 486 493 PF00069 0.782
MOD_GSK3_1 514 521 PF00069 0.732
MOD_GSK3_1 525 532 PF00069 0.840
MOD_GSK3_1 549 556 PF00069 0.803
MOD_GSK3_1 562 569 PF00069 0.779
MOD_GSK3_1 655 662 PF00069 0.707
MOD_GSK3_1 67 74 PF00069 0.599
MOD_GSK3_1 716 723 PF00069 0.578
MOD_GSK3_1 75 82 PF00069 0.630
MOD_GSK3_1 760 767 PF00069 0.720
MOD_GSK3_1 781 788 PF00069 0.743
MOD_GSK3_1 819 826 PF00069 0.690
MOD_GSK3_1 886 893 PF00069 0.736
MOD_GSK3_1 95 102 PF00069 0.670
MOD_LATS_1 356 362 PF00433 0.645
MOD_LATS_1 758 764 PF00433 0.662
MOD_N-GLC_1 130 135 PF02516 0.584
MOD_N-GLC_1 136 141 PF02516 0.447
MOD_N-GLC_1 232 237 PF02516 0.468
MOD_N-GLC_1 346 351 PF02516 0.412
MOD_N-GLC_1 490 495 PF02516 0.490
MOD_N-GLC_1 569 574 PF02516 0.562
MOD_N-GLC_1 576 581 PF02516 0.561
MOD_N-GLC_1 615 620 PF02516 0.469
MOD_N-GLC_1 785 790 PF02516 0.400
MOD_N-GLC_1 819 824 PF02516 0.589
MOD_N-GLC_1 897 902 PF02516 0.420
MOD_NEK2_1 135 140 PF00069 0.768
MOD_NEK2_1 185 190 PF00069 0.752
MOD_NEK2_1 298 303 PF00069 0.550
MOD_NEK2_1 345 350 PF00069 0.622
MOD_NEK2_1 351 356 PF00069 0.649
MOD_NEK2_1 562 567 PF00069 0.736
MOD_NEK2_1 584 589 PF00069 0.683
MOD_NEK2_1 615 620 PF00069 0.684
MOD_NEK2_1 624 629 PF00069 0.699
MOD_NEK2_1 67 72 PF00069 0.660
MOD_NEK2_1 727 732 PF00069 0.769
MOD_NEK2_1 819 824 PF00069 0.664
MOD_NEK2_2 294 299 PF00069 0.360
MOD_NEK2_2 490 495 PF00069 0.706
MOD_NEK2_2 538 543 PF00069 0.721
MOD_NEK2_2 610 615 PF00069 0.652
MOD_NEK2_2 729 734 PF00069 0.683
MOD_PIKK_1 109 115 PF00454 0.751
MOD_PIKK_1 222 228 PF00454 0.753
MOD_PIKK_1 576 582 PF00454 0.705
MOD_PIKK_1 787 793 PF00454 0.650
MOD_PIKK_1 825 831 PF00454 0.580
MOD_PIKK_1 95 101 PF00454 0.698
MOD_PK_1 358 364 PF00069 0.532
MOD_PKA_1 267 273 PF00069 0.692
MOD_PKA_2 149 155 PF00069 0.826
MOD_PKA_2 185 191 PF00069 0.701
MOD_PKA_2 267 273 PF00069 0.781
MOD_PKA_2 351 357 PF00069 0.612
MOD_PKA_2 562 568 PF00069 0.745
MOD_PKA_2 99 105 PF00069 0.662
MOD_PKB_1 77 85 PF00069 0.642
MOD_Plk_1 130 136 PF00069 0.709
MOD_Plk_1 346 352 PF00069 0.576
MOD_Plk_1 490 496 PF00069 0.660
MOD_Plk_1 897 903 PF00069 0.622
MOD_Plk_4 192 198 PF00069 0.738
MOD_Plk_4 294 300 PF00069 0.360
MOD_Plk_4 346 352 PF00069 0.619
MOD_Plk_4 358 364 PF00069 0.631
MOD_Plk_4 406 412 PF00069 0.361
MOD_Plk_4 46 52 PF00069 0.460
MOD_Plk_4 529 535 PF00069 0.707
MOD_Plk_4 538 544 PF00069 0.705
MOD_Plk_4 57 63 PF00069 0.439
MOD_Plk_4 592 598 PF00069 0.551
MOD_Plk_4 610 616 PF00069 0.656
MOD_Plk_4 655 661 PF00069 0.646
MOD_Plk_4 720 726 PF00069 0.592
MOD_ProDKin_1 105 111 PF00069 0.714
MOD_ProDKin_1 155 161 PF00069 0.862
MOD_ProDKin_1 170 176 PF00069 0.729
MOD_ProDKin_1 189 195 PF00069 0.703
MOD_ProDKin_1 323 329 PF00069 0.433
MOD_ProDKin_1 389 395 PF00069 0.486
MOD_ProDKin_1 398 404 PF00069 0.440
MOD_ProDKin_1 453 459 PF00069 0.724
MOD_ProDKin_1 464 470 PF00069 0.814
MOD_ProDKin_1 477 483 PF00069 0.722
MOD_ProDKin_1 512 518 PF00069 0.689
MOD_ProDKin_1 82 88 PF00069 0.700
MOD_ProDKin_1 914 920 PF00069 0.714
MOD_SUMO_rev_2 767 774 PF00179 0.618
TRG_DiLeu_BaEn_1 845 850 PF01217 0.675
TRG_DiLeu_BaEn_1 866 871 PF01217 0.597
TRG_DiLeu_BaLyEn_6 814 819 PF01217 0.657
TRG_ENDOCYTIC_2 24 27 PF00928 0.360
TRG_ENDOCYTIC_2 299 302 PF00928 0.370
TRG_ENDOCYTIC_2 601 604 PF00928 0.576
TRG_ENDOCYTIC_2 834 837 PF00928 0.688
TRG_ER_diArg_1 751 753 PF00400 0.604
TRG_ER_diArg_1 759 761 PF00400 0.633
TRG_ER_diArg_1 812 815 PF00400 0.679
TRG_NES_CRM1_1 590 603 PF08389 0.625
TRG_Pf-PMV_PEXEL_1 602 606 PF00026 0.398
TRG_Pf-PMV_PEXEL_1 903 907 PF00026 0.373

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYR4 Leptomonas seymouri 36% 100%
A0A3S7X6B9 Leishmania donovani 80% 100%
A4HL58 Leishmania braziliensis 54% 100%
A4I8N8 Leishmania infantum 80% 100%
Q4Q4K2 Leishmania major 76% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS