Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3J7_LEIMU

TriTrypDb:

LmxM.32.0190

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B3J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.555
CLV_C14_Caspase3-7	472	476	PF00656	0.666
CLV_NRD_NRD_1	105	107	PF00675	0.543
CLV_NRD_NRD_1	145	147	PF00675	0.473
CLV_NRD_NRD_1	210	212	PF00675	0.688
CLV_NRD_NRD_1	93	95	PF00675	0.486
CLV_PCSK_KEX2_1	145	147	PF00082	0.563
CLV_PCSK_KEX2_1	150	152	PF00082	0.549
CLV_PCSK_KEX2_1	210	212	PF00082	0.688
CLV_PCSK_KEX2_1	243	245	PF00082	0.492
CLV_PCSK_KEX2_1	93	95	PF00082	0.486
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.577
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.425
CLV_PCSK_PC7_1	146	152	PF00082	0.527
CLV_PCSK_SKI1_1	124	128	PF00082	0.490
CLV_PCSK_SKI1_1	151	155	PF00082	0.446
CLV_PCSK_SKI1_1	39	43	PF00082	0.519
CLV_PCSK_SKI1_1	462	466	PF00082	0.622
CLV_PCSK_SKI1_1	474	478	PF00082	0.603
CLV_PCSK_SKI1_1	94	98	PF00082	0.473
DEG_APCC_DBOX_1	38	46	PF00400	0.479
DEG_SPOP_SBC_1	218	222	PF00917	0.569
DEG_SPOP_SBC_1	466	470	PF00917	0.647
DOC_AGCK_PIF_3	513	516	PF00069	0.632
DOC_CKS1_1	276	281	PF01111	0.662
DOC_CKS1_1	32	37	PF01111	0.424
DOC_CKS1_1	447	452	PF01111	0.635
DOC_CYCLIN_RxL_1	295	306	PF00134	0.381
DOC_CYCLIN_RxL_1	453	463	PF00134	0.619
DOC_MIT_MIM_1	411	420	PF04212	0.469
DOC_PP2B_LxvP_1	391	394	PF13499	0.361
DOC_PP2B_LxvP_1	458	461	PF13499	0.452
DOC_USP7_MATH_1	15	19	PF00917	0.704
DOC_USP7_MATH_1	219	223	PF00917	0.613
DOC_USP7_MATH_1	228	232	PF00917	0.686
DOC_USP7_MATH_1	257	261	PF00917	0.390
DOC_USP7_MATH_1	314	318	PF00917	0.500
DOC_USP7_MATH_1	337	341	PF00917	0.505
DOC_USP7_MATH_1	342	346	PF00917	0.516
DOC_USP7_MATH_1	439	443	PF00917	0.732
DOC_USP7_MATH_1	464	468	PF00917	0.646
DOC_WW_Pin1_4	220	225	PF00397	0.669
DOC_WW_Pin1_4	247	252	PF00397	0.526
DOC_WW_Pin1_4	275	280	PF00397	0.629
DOC_WW_Pin1_4	303	308	PF00397	0.630
DOC_WW_Pin1_4	31	36	PF00397	0.544
DOC_WW_Pin1_4	363	368	PF00397	0.649
DOC_WW_Pin1_4	446	451	PF00397	0.739
DOC_WW_Pin1_4	497	502	PF00397	0.409
LIG_14-3-3_CanoR_1	190	198	PF00244	0.608
LIG_14-3-3_CanoR_1	211	219	PF00244	0.635
LIG_14-3-3_CanoR_1	263	273	PF00244	0.456
LIG_14-3-3_CanoR_1	303	307	PF00244	0.482
LIG_14-3-3_CanoR_1	324	334	PF00244	0.526
LIG_14-3-3_CanoR_1	416	421	PF00244	0.603
LIG_14-3-3_CanoR_1	483	493	PF00244	0.719
LIG_Actin_WH2_2	290	305	PF00022	0.495
LIG_BRCT_BRCA1_1	326	330	PF00533	0.527
LIG_CORNRBOX	400	408	PF00104	0.389
LIG_CSL_BTD_1	458	461	PF09270	0.452
LIG_DLG_GKlike_1	416	424	PF00625	0.543
LIG_eIF4E_1	4	10	PF01652	0.617
LIG_FHA_1	228	234	PF00498	0.514
LIG_FHA_1	275	281	PF00498	0.684
LIG_FHA_1	303	309	PF00498	0.556
LIG_FHA_1	327	333	PF00498	0.492
LIG_FHA_1	342	348	PF00498	0.557
LIG_FHA_1	385	391	PF00498	0.651
LIG_FHA_1	399	405	PF00498	0.553
LIG_FHA_1	441	447	PF00498	0.707
LIG_FHA_1	450	456	PF00498	0.526
LIG_FHA_1	497	503	PF00498	0.609
LIG_FHA_2	125	131	PF00498	0.496
LIG_FHA_2	468	474	PF00498	0.665
LIG_FHA_2	498	504	PF00498	0.439
LIG_FHA_2	73	79	PF00498	0.576
LIG_HP1_1	38	42	PF01393	0.520
LIG_LIR_Apic_2	444	450	PF02991	0.643
LIG_LIR_Gen_1	327	337	PF02991	0.486
LIG_LIR_Gen_1	411	420	PF02991	0.499
LIG_LIR_Gen_1	510	516	PF02991	0.567
LIG_LIR_Nem_3	327	333	PF02991	0.490
LIG_LIR_Nem_3	411	415	PF02991	0.496
LIG_LIR_Nem_3	510	516	PF02991	0.567
LIG_LIR_Nem_3	68	74	PF02991	0.488
LIG_PDZ_Class_1	511	516	PF00595	0.563
LIG_SH2_CRK	201	205	PF00017	0.624
LIG_SH2_STAT3	11	14	PF00017	0.676
LIG_SH2_STAT5	354	357	PF00017	0.343
LIG_SH2_STAT5	4	7	PF00017	0.634
LIG_SH3_3	221	227	PF00018	0.666
LIG_SH3_3	273	279	PF00018	0.579
LIG_SH3_3	29	35	PF00018	0.712
LIG_SH3_3	431	437	PF00018	0.476
LIG_SH3_3	66	72	PF00018	0.356
LIG_SUMO_SIM_anti_2	327	335	PF11976	0.592
LIG_SUMO_SIM_par_1	277	283	PF11976	0.472
LIG_SUMO_SIM_par_1	327	335	PF11976	0.460
MOD_CDC14_SPxK_1	366	369	PF00782	0.635
MOD_CDK_SPxK_1	31	37	PF00069	0.431
MOD_CDK_SPxK_1	363	369	PF00069	0.610
MOD_CK1_1	205	211	PF00069	0.599
MOD_CK1_1	220	226	PF00069	0.674
MOD_CK1_1	287	293	PF00069	0.649
MOD_CK1_1	371	377	PF00069	0.512
MOD_CK1_1	467	473	PF00069	0.644
MOD_CK2_1	122	128	PF00069	0.463
MOD_CK2_1	332	338	PF00069	0.467
MOD_CK2_1	497	503	PF00069	0.439
MOD_CK2_1	72	78	PF00069	0.524
MOD_Cter_Amidation	148	151	PF01082	0.603
MOD_Cter_Amidation	241	244	PF01082	0.440
MOD_GlcNHglycan	204	207	PF01048	0.673
MOD_GlcNHglycan	214	217	PF01048	0.671
MOD_GlcNHglycan	284	287	PF01048	0.671
MOD_GlcNHglycan	289	292	PF01048	0.576
MOD_GlcNHglycan	338	342	PF01048	0.585
MOD_GlcNHglycan	462	465	PF01048	0.700
MOD_GlcNHglycan	512	516	PF01048	0.583
MOD_GSK3_1	189	196	PF00069	0.584
MOD_GSK3_1	280	287	PF00069	0.638
MOD_GSK3_1	337	344	PF00069	0.479
MOD_GSK3_1	363	370	PF00069	0.544
MOD_GSK3_1	460	467	PF00069	0.639
MOD_GSK3_1	475	482	PF00069	0.608
MOD_N-GLC_1	264	269	PF02516	0.430
MOD_NEK2_1	302	307	PF00069	0.452
MOD_NEK2_1	326	331	PF00069	0.576
MOD_NEK2_1	368	373	PF00069	0.573
MOD_NEK2_1	465	470	PF00069	0.670
MOD_NEK2_1	479	484	PF00069	0.654
MOD_NMyristoyl	1	7	PF02799	0.485
MOD_PIKK_1	15	21	PF00454	0.662
MOD_PIKK_1	280	286	PF00454	0.703
MOD_PIKK_1	485	491	PF00454	0.737
MOD_PKA_2	189	195	PF00069	0.617
MOD_PKA_2	212	218	PF00069	0.548
MOD_PKA_2	302	308	PF00069	0.493
MOD_PKA_2	314	320	PF00069	0.523
MOD_PKA_2	479	485	PF00069	0.645
MOD_PKB_1	322	330	PF00069	0.618
MOD_Plk_1	474	480	PF00069	0.515
MOD_Plk_4	193	199	PF00069	0.472
MOD_Plk_4	228	234	PF00069	0.699
MOD_Plk_4	257	263	PF00069	0.535
MOD_Plk_4	289	295	PF00069	0.710
MOD_Plk_4	326	332	PF00069	0.567
MOD_Plk_4	403	409	PF00069	0.460
MOD_Plk_4	441	447	PF00069	0.622
MOD_Plk_4	72	78	PF00069	0.536
MOD_ProDKin_1	220	226	PF00069	0.668
MOD_ProDKin_1	247	253	PF00069	0.524
MOD_ProDKin_1	275	281	PF00069	0.627
MOD_ProDKin_1	303	309	PF00069	0.634
MOD_ProDKin_1	31	37	PF00069	0.532
MOD_ProDKin_1	363	369	PF00069	0.655
MOD_ProDKin_1	446	452	PF00069	0.735
MOD_ProDKin_1	497	503	PF00069	0.411
MOD_SUMO_rev_2	102	109	PF00179	0.405
MOD_SUMO_rev_2	110	118	PF00179	0.457
MOD_SUMO_rev_2	161	167	PF00179	0.575
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.488
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.422
TRG_ENDOCYTIC_2	7	10	PF00928	0.554
TRG_ER_diArg_1	144	146	PF00400	0.497
TRG_ER_diArg_1	209	211	PF00400	0.673
TRG_ER_diArg_1	36	39	PF00400	0.578
TRG_ER_diArg_1	92	94	PF00400	0.483
TRG_NES_CRM1_1	325	339	PF08389	0.565
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z6	Leptomonas seymouri	37%	93%
A0A3R7MER9	Trypanosoma rangeli	23%	97%
A0A3S5H7T7	Leishmania donovani	87%	76%
A4HL56	Leishmania braziliensis	72%	100%
A4I8N5	Leishmania infantum	87%	93%
Q4Q4K4	Leishmania major	87%	100%