Tetraspanin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tetraspanin

Gene product:

Tetraspanin family, putative

Species:

Leishmania mexicana

UniProt:

E9B3J5_LEIMU

TriTrypDb:

LmxM.32.0170

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B3J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.752
CLV_NRD_NRD_1	230	232	PF00675	0.377
CLV_PCSK_KEX2_1	126	128	PF00082	0.369
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.261
CLV_PCSK_SKI1_1	8	12	PF00082	0.560
DOC_CDC14_PxL_1	43	51	PF14671	0.570
DOC_MAPK_gen_1	126	134	PF00069	0.574
DOC_MAPK_gen_1	265	274	PF00069	0.386
DOC_MAPK_gen_1	57	67	PF00069	0.638
DOC_PP1_RVXF_1	230	237	PF00149	0.256
DOC_USP7_MATH_1	18	22	PF00917	0.750
DOC_USP7_MATH_1	89	93	PF00917	0.334
DOC_WW_Pin1_4	126	131	PF00397	0.377
LIG_14-3-3_CanoR_1	244	252	PF00244	0.349
LIG_14-3-3_CanoR_1	8	16	PF00244	0.760
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BRCT_BRCA1_1	83	87	PF00533	0.496
LIG_FHA_1	112	118	PF00498	0.419
LIG_FHA_1	223	229	PF00498	0.347
LIG_FHA_1	259	265	PF00498	0.354
LIG_FHA_1	97	103	PF00498	0.308
LIG_FHA_2	222	228	PF00498	0.305
LIG_GBD_Chelix_1	177	185	PF00786	0.553
LIG_LIR_Gen_1	140	149	PF02991	0.432
LIG_LIR_Gen_1	153	160	PF02991	0.287
LIG_LIR_Gen_1	279	290	PF02991	0.471
LIG_LIR_Gen_1	52	63	PF02991	0.636
LIG_LIR_Nem_3	140	144	PF02991	0.450
LIG_LIR_Nem_3	150	154	PF02991	0.378
LIG_LIR_Nem_3	266	272	PF02991	0.316
LIG_LIR_Nem_3	279	285	PF02991	0.447
LIG_LIR_Nem_3	38	43	PF02991	0.628
LIG_LIR_Nem_3	52	58	PF02991	0.592
LIG_LIR_Nem_3	84	90	PF02991	0.390
LIG_NRBOX	259	265	PF00104	0.386
LIG_Pex14_2	83	87	PF04695	0.480
LIG_SH2_CRK	141	145	PF00017	0.415
LIG_SH2_CRK	154	158	PF00017	0.298
LIG_SH2_CRK	40	44	PF00017	0.668
LIG_SH2_CRK	61	65	PF00017	0.530
LIG_SH2_SRC	217	220	PF00017	0.330
LIG_SH2_STAT5	217	220	PF00017	0.308
LIG_SH2_STAT5	270	273	PF00017	0.340
LIG_SH3_3	207	213	PF00018	0.353
LIG_SH3_3	231	237	PF00018	0.310
LIG_SUMO_SIM_par_1	108	114	PF11976	0.448
LIG_WRC_WIRS_1	90	95	PF05994	0.330
MOD_CK1_1	243	249	PF00069	0.341
MOD_CK1_1	276	282	PF00069	0.457
MOD_CK1_1	286	292	PF00069	0.424
MOD_CK2_1	227	233	PF00069	0.334
MOD_GlcNHglycan	186	190	PF01048	0.465
MOD_GlcNHglycan	20	23	PF01048	0.578
MOD_GlcNHglycan	245	248	PF01048	0.502
MOD_GlcNHglycan	285	288	PF01048	0.383
MOD_GlcNHglycan	5	8	PF01048	0.545
MOD_GlcNHglycan	68	71	PF01048	0.445
MOD_GlcNHglycan	99	102	PF01048	0.544
MOD_GSK3_1	236	243	PF00069	0.308
MOD_GSK3_1	259	266	PF00069	0.368
MOD_GSK3_1	66	73	PF00069	0.377
MOD_GSK3_1	89	96	PF00069	0.346
MOD_N-GLC_1	221	226	PF02516	0.515
MOD_N-GLC_1	49	54	PF02516	0.464
MOD_NEK2_1	137	142	PF00069	0.438
MOD_NEK2_1	144	149	PF00069	0.462
MOD_NEK2_1	185	190	PF00069	0.292
MOD_NEK2_1	240	245	PF00069	0.330
MOD_NEK2_1	263	268	PF00069	0.327
MOD_NEK2_1	283	288	PF00069	0.303
MOD_NEK2_1	49	54	PF00069	0.700
MOD_NEK2_1	93	98	PF00069	0.356
MOD_NEK2_2	70	75	PF00069	0.463
MOD_NEK2_2	82	87	PF00069	0.492
MOD_PKA_2	243	249	PF00069	0.362
MOD_Plk_1	49	55	PF00069	0.690
MOD_Plk_4	144	150	PF00069	0.371
MOD_Plk_4	259	265	PF00069	0.367
MOD_Plk_4	276	282	PF00069	0.262
MOD_Plk_4	50	56	PF00069	0.674
MOD_Plk_4	70	76	PF00069	0.268
MOD_ProDKin_1	126	132	PF00069	0.377
MOD_SUMO_rev_2	180	185	PF00179	0.330
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.738
TRG_ENDOCYTIC_2	141	144	PF00928	0.403
TRG_ENDOCYTIC_2	154	157	PF00928	0.264
TRG_ENDOCYTIC_2	269	272	PF00928	0.330
TRG_ENDOCYTIC_2	40	43	PF00928	0.630
TRG_ENDOCYTIC_2	61	64	PF00928	0.599
TRG_ER_diArg_1	264	267	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P684	Leptomonas seymouri	44%	98%
A0A0S4JPS2	Bodo saltans	24%	100%
A0A3Q8IEM4	Leishmania donovani	90%	100%
A0A422NDS8	Trypanosoma rangeli	27%	100%
A4HL54	Leishmania braziliensis	75%	100%
A4I8N3	Leishmania infantum	90%	100%
D0A4K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q4K6	Leishmania major	85%	100%
V5BBB3	Trypanosoma cruzi	27%	100%