Tetraspanin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tetraspanin

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B3J4_LEIMU

TriTrypDb:

LmxM.32.0160

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B3J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3J4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.456
CLV_NRD_NRD_1	202	204	PF00675	0.720
CLV_NRD_NRD_1	334	336	PF00675	0.517
CLV_NRD_NRD_1	91	93	PF00675	0.404
CLV_PCSK_KEX2_1	200	202	PF00082	0.660
CLV_PCSK_KEX2_1	336	338	PF00082	0.484
CLV_PCSK_KEX2_1	90	92	PF00082	0.404
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.586
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.484
CLV_PCSK_SKI1_1	117	121	PF00082	0.580
CLV_PCSK_SKI1_1	197	201	PF00082	0.584
DEG_SPOP_SBC_1	254	258	PF00917	0.426
DOC_CDC14_PxL_1	21	29	PF14671	0.541
DOC_MAPK_gen_1	299	308	PF00069	0.677
DOC_PP1_RVXF_1	115	121	PF00149	0.403
DOC_PP2B_LxvP_1	70	73	PF13499	0.317
DOC_PP4_FxxP_1	22	25	PF00568	0.463
DOC_USP7_MATH_1	245	249	PF00917	0.517
DOC_USP7_MATH_1	253	257	PF00917	0.428
DOC_USP7_MATH_1	311	315	PF00917	0.633
DOC_WW_Pin1_4	249	254	PF00397	0.496
DOC_WW_Pin1_4	307	312	PF00397	0.687
LIG_14-3-3_CanoR_1	299	308	PF00244	0.706
LIG_14-3-3_CterR_2	335	338	PF00244	0.721
LIG_APCC_ABBA_1	132	137	PF00400	0.466
LIG_BIR_II_1	1	5	PF00653	0.479
LIG_BRCT_BRCA1_1	186	190	PF00533	0.433
LIG_BRCT_BRCA1_1	301	305	PF00533	0.657
LIG_deltaCOP1_diTrp_1	181	190	PF00928	0.438
LIG_eIF4E_1	100	106	PF01652	0.317
LIG_FHA_1	119	125	PF00498	0.404
LIG_FHA_1	166	172	PF00498	0.533
LIG_FHA_1	213	219	PF00498	0.389
LIG_FHA_1	224	230	PF00498	0.434
LIG_FHA_1	26	32	PF00498	0.423
LIG_FHA_2	128	134	PF00498	0.374
LIG_FHA_2	255	261	PF00498	0.477
LIG_FHA_2	31	37	PF00498	0.421
LIG_GBD_Chelix_1	31	39	PF00786	0.658
LIG_GBD_Chelix_1	59	67	PF00786	0.538
LIG_LIR_Apic_2	152	156	PF02991	0.444
LIG_LIR_Apic_2	19	25	PF02991	0.564
LIG_LIR_Gen_1	133	142	PF02991	0.353
LIG_LIR_Gen_1	182	193	PF02991	0.355
LIG_LIR_Nem_3	133	138	PF02991	0.411
LIG_LIR_Nem_3	182	188	PF02991	0.398
LIG_LIR_Nem_3	233	238	PF02991	0.469
LIG_LIR_Nem_3	302	308	PF02991	0.654
LIG_NRBOX	111	117	PF00104	0.290
LIG_NRBOX	66	72	PF00104	0.317
LIG_Pex14_1	151	155	PF04695	0.432
LIG_Pex14_1	96	100	PF04695	0.452
LIG_Pex14_2	10	14	PF04695	0.317
LIG_SH2_CRK	100	104	PF00017	0.371
LIG_SH2_CRK	153	157	PF00017	0.434
LIG_SH2_SRC	153	156	PF00017	0.481
LIG_SH2_STAT5	113	116	PF00017	0.506
LIG_SH2_STAT5	262	265	PF00017	0.395
LIG_SUMO_SIM_par_1	41	47	PF11976	0.418
LIG_SUMO_SIM_par_1	68	74	PF11976	0.335
LIG_TRAF2_1	174	177	PF00917	0.433
LIG_TYR_ITIM	111	116	PF00017	0.371
MOD_CK1_1	158	164	PF00069	0.472
MOD_CK1_1	26	32	PF00069	0.428
MOD_CK1_1	300	306	PF00069	0.647
MOD_CK1_1	310	316	PF00069	0.678
MOD_CK2_1	127	133	PF00069	0.349
MOD_CK2_1	171	177	PF00069	0.474
MOD_CK2_1	254	260	PF00069	0.483
MOD_CK2_1	30	36	PF00069	0.435
MOD_CK2_1	311	317	PF00069	0.697
MOD_CK2_1	41	47	PF00069	0.505
MOD_GlcNHglycan	157	160	PF01048	0.624
MOD_GlcNHglycan	267	270	PF01048	0.542
MOD_GlcNHglycan	313	316	PF01048	0.428
MOD_GlcNHglycan	317	320	PF01048	0.416
MOD_GSK3_1	155	162	PF00069	0.442
MOD_GSK3_1	163	170	PF00069	0.439
MOD_GSK3_1	23	30	PF00069	0.426
MOD_GSK3_1	245	252	PF00069	0.499
MOD_GSK3_1	307	314	PF00069	0.665
MOD_GSK3_1	43	50	PF00069	0.482
MOD_LATS_1	297	303	PF00433	0.643
MOD_N-GLC_1	128	133	PF02516	0.632
MOD_N-GLC_1	171	176	PF02516	0.629
MOD_N-GLC_1	245	250	PF02516	0.655
MOD_NEK2_1	10	15	PF00069	0.434
MOD_NEK2_1	237	242	PF00069	0.487
MOD_NEK2_1	267	272	PF00069	0.395
MOD_NEK2_1	27	32	PF00069	0.444
MOD_NEK2_1	279	284	PF00069	0.305
MOD_NEK2_2	16	21	PF00069	0.486
MOD_OFUCOSY	157	163	PF10250	0.673
MOD_PIKK_1	144	150	PF00454	0.417
MOD_PKA_2	300	306	PF00069	0.696
MOD_Plk_1	128	134	PF00069	0.432
MOD_Plk_1	245	251	PF00069	0.455
MOD_Plk_1	35	41	PF00069	0.423
MOD_Plk_1	46	52	PF00069	0.375
MOD_Plk_4	282	288	PF00069	0.323
MOD_Plk_4	51	57	PF00069	0.439
MOD_Plk_4	71	77	PF00069	0.269
MOD_ProDKin_1	249	255	PF00069	0.495
MOD_ProDKin_1	307	313	PF00069	0.685
MOD_SUMO_for_1	322	325	PF00179	0.682
TRG_ENDOCYTIC_2	100	103	PF00928	0.371
TRG_ENDOCYTIC_2	113	116	PF00928	0.371
TRG_ER_diArg_1	201	203	PF00400	0.459
TRG_ER_diArg_1	90	92	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK0	Leptomonas seymouri	36%	81%
A0A3Q8IHA4	Leishmania donovani	87%	100%
A4HL53	Leishmania braziliensis	69%	100%
A4I8N2	Leishmania infantum	87%	100%
Q4Q4K7	Leishmania major	84%	100%