Iwr1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3J3_LEIMU

TriTrypDb:

LmxM.32.0150

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3J3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.616
CLV_C14_Caspase3-7	168	172	PF00656	0.647
CLV_C14_Caspase3-7	223	227	PF00656	0.695
CLV_C14_Caspase3-7	239	243	PF00656	0.545
CLV_C14_Caspase3-7	68	72	PF00656	0.601
CLV_C14_Caspase3-7	93	97	PF00656	0.384
CLV_NRD_NRD_1	140	142	PF00675	0.618
CLV_NRD_NRD_1	203	205	PF00675	0.638
CLV_NRD_NRD_1	21	23	PF00675	0.578
CLV_NRD_NRD_1	247	249	PF00675	0.659
CLV_PCSK_KEX2_1	121	123	PF00082	0.651
CLV_PCSK_KEX2_1	139	141	PF00082	0.586
CLV_PCSK_KEX2_1	21	23	PF00082	0.578
CLV_PCSK_KEX2_1	247	249	PF00082	0.664
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.693
CLV_PCSK_PC7_1	117	123	PF00082	0.737
CLV_PCSK_SKI1_1	17	21	PF00082	0.551
DOC_PP4_FxxP_1	135	138	PF00568	0.719
DOC_USP7_MATH_1	240	244	PF00917	0.755
DOC_USP7_MATH_1	28	32	PF00917	0.665
DOC_USP7_MATH_1	40	44	PF00917	0.615
DOC_USP7_MATH_1	50	54	PF00917	0.488
DOC_USP7_UBL2_3	41	45	PF12436	0.489
DOC_WW_Pin1_4	156	161	PF00397	0.715
LIG_14-3-3_CanoR_1	117	121	PF00244	0.679
LIG_14-3-3_CanoR_1	140	146	PF00244	0.704
LIG_14-3-3_CanoR_1	255	259	PF00244	0.647
LIG_BIR_III_4	169	173	PF00653	0.647
LIG_BIR_III_4	224	228	PF00653	0.643
LIG_Clathr_ClatBox_1	184	188	PF01394	0.616
LIG_Clathr_ClatBox_1	85	89	PF01394	0.672
LIG_FHA_1	14	20	PF00498	0.570
LIG_FHA_1	140	146	PF00498	0.726
LIG_FHA_1	192	198	PF00498	0.677
LIG_FHA_1	33	39	PF00498	0.698
LIG_FHA_2	166	172	PF00498	0.666
LIG_FHA_2	91	97	PF00498	0.616
LIG_LIR_Apic_2	196	201	PF02991	0.658
LIG_LIR_Gen_1	180	189	PF02991	0.734
LIG_LIR_Gen_1	48	59	PF02991	0.429
LIG_LIR_Nem_3	100	105	PF02991	0.557
LIG_LIR_Nem_3	161	166	PF02991	0.591
LIG_LIR_Nem_3	180	184	PF02991	0.444
LIG_LIR_Nem_3	256	261	PF02991	0.555
LIG_LIR_Nem_3	48	54	PF02991	0.457
LIG_Rb_LxCxE_1	180	202	PF01857	0.633
LIG_SH2_STAP1	181	185	PF00017	0.624
LIG_SH2_STAT5	111	114	PF00017	0.457
LIG_SH2_STAT5	134	137	PF00017	0.611
LIG_SH2_STAT5	198	201	PF00017	0.660
LIG_SH2_STAT5	266	269	PF00017	0.423
LIG_SH3_3	34	40	PF00018	0.614
LIG_TRFH_1	134	138	PF08558	0.734
LIG_UBA3_1	85	91	PF00899	0.500
MOD_CDC14_SPxK_1	159	162	PF00782	0.738
MOD_CDK_SPxK_1	156	162	PF00069	0.754
MOD_CK1_1	13	19	PF00069	0.683
MOD_CK1_1	229	235	PF00069	0.789
MOD_CK1_1	241	247	PF00069	0.639
MOD_CK1_1	254	260	PF00069	0.636
MOD_CK1_1	270	276	PF00069	0.641
MOD_CK1_1	90	96	PF00069	0.688
MOD_CK2_1	208	214	PF00069	0.657
MOD_CK2_1	50	56	PF00069	0.623
MOD_Cter_Amidation	245	248	PF01082	0.649
MOD_GlcNHglycan	149	152	PF01048	0.668
MOD_GlcNHglycan	214	219	PF01048	0.684
MOD_GlcNHglycan	228	231	PF01048	0.639
MOD_GlcNHglycan	272	275	PF01048	0.612
MOD_GlcNHglycan	60	63	PF01048	0.662
MOD_GSK3_1	152	159	PF00069	0.663
MOD_GSK3_1	238	245	PF00069	0.780
MOD_GSK3_1	269	276	PF00069	0.617
MOD_GSK3_1	28	35	PF00069	0.654
MOD_GSK3_1	41	48	PF00069	0.775
MOD_NEK2_1	58	63	PF00069	0.434
MOD_NEK2_1	8	13	PF00069	0.642
MOD_NEK2_2	10	15	PF00069	0.645
MOD_PIKK_1	45	51	PF00454	0.623
MOD_PK_1	141	147	PF00069	0.648
MOD_PKA_1	139	145	PF00069	0.626
MOD_PKA_2	116	122	PF00069	0.769
MOD_PKA_2	139	145	PF00069	0.627
MOD_PKA_2	254	260	PF00069	0.634
MOD_PKB_1	139	147	PF00069	0.762
MOD_Plk_1	267	273	PF00069	0.622
MOD_Plk_4	152	158	PF00069	0.641
MOD_Plk_4	50	56	PF00069	0.482
MOD_ProDKin_1	156	162	PF00069	0.707
MOD_SUMO_rev_2	84	93	PF00179	0.496
TRG_DiLeu_BaEn_1	180	185	PF01217	0.662
TRG_DiLeu_BaEn_4	126	132	PF01217	0.765
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.625
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.399
TRG_ENDOCYTIC_2	181	184	PF00928	0.634
TRG_ENDOCYTIC_2	258	261	PF00928	0.616
TRG_ER_diArg_1	138	141	PF00400	0.608
TRG_ER_diArg_1	20	22	PF00400	0.516
TRG_NES_CRM1_1	96	110	PF08389	0.572
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U4	Leptomonas seymouri	44%	82%
A0A3S7X690	Leishmania donovani	86%	100%
A4HL52	Leishmania braziliensis	70%	100%
A4I8N1	Leishmania infantum	86%	100%
Q4Q4K8	Leishmania major	86%	100%