ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B3J2_LEIMU

TriTrypDb:

LmxM.32.0140

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3J2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.640
CLV_NRD_NRD_1	377	379	PF00675	0.560
CLV_NRD_NRD_1	384	386	PF00675	0.587
CLV_NRD_NRD_1	388	390	PF00675	0.607
CLV_PCSK_KEX2_1	365	367	PF00082	0.432
CLV_PCSK_KEX2_1	377	379	PF00082	0.555
CLV_PCSK_KEX2_1	384	386	PF00082	0.585
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.353
CLV_PCSK_SKI1_1	21	25	PF00082	0.546
CLV_PCSK_SKI1_1	272	276	PF00082	0.588
DEG_APCC_DBOX_1	20	28	PF00400	0.521
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.493
DOC_MAPK_MEF2A_6	225	233	PF00069	0.483
DOC_PP2B_LxvP_1	193	196	PF13499	0.569
DOC_USP7_MATH_1	334	338	PF00917	0.607
DOC_USP7_MATH_1	364	368	PF00917	0.635
DOC_USP7_MATH_1	9	13	PF00917	0.465
DOC_WW_Pin1_4	398	403	PF00397	0.590
DOC_WW_Pin1_4	45	50	PF00397	0.630
LIG_14-3-3_CanoR_1	207	215	PF00244	0.622
LIG_14-3-3_CanoR_1	306	316	PF00244	0.585
LIG_14-3-3_CanoR_1	377	382	PF00244	0.648
LIG_14-3-3_CanoR_1	384	388	PF00244	0.515
LIG_14-3-3_CterR_2	404	408	PF00244	0.777
LIG_APCC_ABBA_1	195	200	PF00400	0.588
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_BIR_III_4	92	96	PF00653	0.513
LIG_BRCT_BRCA1_1	246	250	PF00533	0.694
LIG_Clathr_ClatBox_1	279	283	PF01394	0.384
LIG_EH_1	42	46	PF12763	0.609
LIG_FHA_1	176	182	PF00498	0.550
LIG_FHA_1	2	8	PF00498	0.497
LIG_FHA_1	209	215	PF00498	0.354
LIG_FHA_1	27	33	PF00498	0.535
LIG_FHA_1	292	298	PF00498	0.641
LIG_FHA_1	308	314	PF00498	0.432
LIG_FHA_1	82	88	PF00498	0.485
LIG_FHA_2	208	214	PF00498	0.622
LIG_FHA_2	237	243	PF00498	0.384
LIG_FHA_2	260	266	PF00498	0.295
LIG_FHA_2	300	306	PF00498	0.493
LIG_Integrin_RGD_1	340	342	PF01839	0.651
LIG_Integrin_RGD_1	40	42	PF01839	0.577
LIG_LIR_Apic_2	159	164	PF02991	0.516
LIG_LIR_Gen_1	254	264	PF02991	0.507
LIG_LIR_Nem_3	254	260	PF02991	0.509
LIG_LIR_Nem_3	386	391	PF02991	0.536
LIG_NRBOX	226	232	PF00104	0.452
LIG_PCNA_yPIPBox_3	17	27	PF02747	0.653
LIG_Pex14_2	180	184	PF04695	0.369
LIG_PTAP_UEV_1	10	15	PF05743	0.457
LIG_SH2_CRK	16	20	PF00017	0.697
LIG_SH2_STAT5	290	293	PF00017	0.506
LIG_SH2_STAT5	358	361	PF00017	0.592
LIG_SH2_STAT5	368	371	PF00017	0.514
LIG_SH2_STAT5	73	76	PF00017	0.724
LIG_SH3_3	152	158	PF00018	0.513
LIG_SH3_3	2	8	PF00018	0.750
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.556
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.554
LIG_SUMO_SIM_anti_2	239	245	PF11976	0.534
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.478
LIG_SUMO_SIM_par_1	228	235	PF11976	0.506
LIG_SUMO_SIM_par_1	244	249	PF11976	0.489
MOD_CDC14_SPxK_1	401	404	PF00782	0.729
MOD_CDK_SPxK_1	398	404	PF00069	0.704
MOD_CK1_1	128	134	PF00069	0.513
MOD_CK1_1	299	305	PF00069	0.549
MOD_CK1_1	376	382	PF00069	0.371
MOD_CK1_1	94	100	PF00069	0.513
MOD_CK2_1	207	213	PF00069	0.633
MOD_CK2_1	259	265	PF00069	0.569
MOD_CK2_1	299	305	PF00069	0.538
MOD_CK2_1	341	347	PF00069	0.617
MOD_CK2_1	364	370	PF00069	0.636
MOD_GlcNHglycan	11	14	PF01048	0.545
MOD_GlcNHglycan	127	130	PF01048	0.478
MOD_GlcNHglycan	165	168	PF01048	0.587
MOD_GlcNHglycan	92	96	PF01048	0.513
MOD_GSK3_1	125	132	PF00069	0.410
MOD_GSK3_1	259	266	PF00069	0.523
MOD_GSK3_1	268	275	PF00069	0.521
MOD_GSK3_1	292	299	PF00069	0.504
MOD_GSK3_1	373	380	PF00069	0.389
MOD_LATS_1	375	381	PF00433	0.596
MOD_N-GLC_1	125	130	PF02516	0.513
MOD_NEK2_1	105	110	PF00069	0.411
MOD_NEK2_1	201	206	PF00069	0.466
MOD_NEK2_2	129	134	PF00069	0.222
MOD_NEK2_2	175	180	PF00069	0.454
MOD_PKA_1	377	383	PF00069	0.649
MOD_PKA_2	376	382	PF00069	0.659
MOD_PKA_2	383	389	PF00069	0.534
MOD_PKB_1	89	97	PF00069	0.436
MOD_Plk_1	291	297	PF00069	0.616
MOD_Plk_4	175	181	PF00069	0.461
MOD_Plk_4	225	231	PF00069	0.412
MOD_Plk_4	236	242	PF00069	0.476
MOD_Plk_4	259	265	PF00069	0.527
MOD_Plk_4	292	298	PF00069	0.571
MOD_Plk_4	299	305	PF00069	0.481
MOD_Plk_4	31	37	PF00069	0.512
MOD_Plk_4	377	383	PF00069	0.596
MOD_ProDKin_1	398	404	PF00069	0.602
MOD_ProDKin_1	45	51	PF00069	0.624
MOD_SUMO_rev_2	353	357	PF00179	0.588
TRG_DiLeu_BaEn_1	347	352	PF01217	0.506
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.436
TRG_ENDOCYTIC_2	198	201	PF00928	0.429
TRG_ER_diArg_1	88	91	PF00400	0.527
TRG_NES_CRM1_1	278	292	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF8	Leptomonas seymouri	52%	100%
A0A3Q8IHJ7	Leishmania donovani	88%	100%
A4HL51	Leishmania braziliensis	73%	100%
A4I8N0	Leishmania infantum	88%	100%
Q4Q4K9	Leishmania major	87%	100%