LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3I8_LEIMU
TriTrypDb:
LmxM.32.0110
Length:
352

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3I8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 115 117 PF00675 0.486
CLV_NRD_NRD_1 125 127 PF00675 0.528
CLV_NRD_NRD_1 267 269 PF00675 0.590
CLV_NRD_NRD_1 338 340 PF00675 0.624
CLV_NRD_NRD_1 35 37 PF00675 0.766
CLV_PCSK_FUR_1 140 144 PF00082 0.601
CLV_PCSK_FUR_1 336 340 PF00082 0.577
CLV_PCSK_KEX2_1 125 127 PF00082 0.611
CLV_PCSK_KEX2_1 142 144 PF00082 0.487
CLV_PCSK_KEX2_1 267 269 PF00082 0.643
CLV_PCSK_KEX2_1 338 340 PF00082 0.636
CLV_PCSK_PC1ET2_1 142 144 PF00082 0.487
CLV_PCSK_SKI1_1 220 224 PF00082 0.512
CLV_PCSK_SKI1_1 267 271 PF00082 0.626
DEG_SPOP_SBC_1 27 31 PF00917 0.479
DOC_CKS1_1 151 156 PF01111 0.569
DOC_CYCLIN_RxL_1 101 114 PF00134 0.610
DOC_PP1_RVXF_1 105 112 PF00149 0.610
DOC_PP2B_LxvP_1 149 152 PF13499 0.630
DOC_USP7_MATH_1 240 244 PF00917 0.613
DOC_USP7_MATH_1 28 32 PF00917 0.645
DOC_USP7_MATH_1 74 78 PF00917 0.616
DOC_USP7_MATH_1 91 95 PF00917 0.711
DOC_USP7_MATH_2 207 213 PF00917 0.625
DOC_USP7_UBL2_3 172 176 PF12436 0.681
DOC_USP7_UBL2_3 216 220 PF12436 0.633
DOC_WW_Pin1_4 150 155 PF00397 0.678
DOC_WW_Pin1_4 232 237 PF00397 0.609
LIG_14-3-3_CanoR_1 13 17 PF00244 0.617
LIG_14-3-3_CanoR_1 132 138 PF00244 0.550
LIG_14-3-3_CanoR_1 346 352 PF00244 0.721
LIG_14-3-3_CanoR_1 49 58 PF00244 0.622
LIG_FHA_1 198 204 PF00498 0.708
LIG_FHA_1 264 270 PF00498 0.531
LIG_FHA_1 312 318 PF00498 0.561
LIG_FHA_1 53 59 PF00498 0.708
LIG_FHA_1 79 85 PF00498 0.740
LIG_FHA_2 225 231 PF00498 0.623
LIG_FHA_2 274 280 PF00498 0.518
LIG_FHA_2 38 44 PF00498 0.560
LIG_LIR_Gen_1 177 183 PF02991 0.663
LIG_LIR_Nem_3 153 159 PF02991 0.571
LIG_LIR_Nem_3 177 182 PF02991 0.737
LIG_LIR_Nem_3 329 334 PF02991 0.621
LIG_SH2_NCK_1 198 202 PF00017 0.659
LIG_SH2_NCK_1 42 46 PF00017 0.614
LIG_SH2_SRC 179 182 PF00017 0.603
LIG_SH2_STAP1 42 46 PF00017 0.579
LIG_SH2_STAT5 179 182 PF00017 0.574
LIG_SH2_STAT5 238 241 PF00017 0.490
LIG_SH2_STAT5 46 49 PF00017 0.464
LIG_SH2_STAT5 82 85 PF00017 0.698
LIG_SH3_1 148 154 PF00018 0.645
LIG_SH3_3 148 154 PF00018 0.551
LIG_SH3_3 155 161 PF00018 0.562
LIG_SH3_3 44 50 PF00018 0.477
LIG_SUMO_SIM_anti_2 285 292 PF11976 0.668
MOD_CDK_SPK_2 232 237 PF00069 0.590
MOD_CK1_1 15 21 PF00069 0.663
MOD_CK1_1 273 279 PF00069 0.538
MOD_CK1_1 292 298 PF00069 0.394
MOD_CK1_1 52 58 PF00069 0.691
MOD_CK2_1 224 230 PF00069 0.625
MOD_CK2_1 273 279 PF00069 0.518
MOD_CK2_1 87 93 PF00069 0.561
MOD_DYRK1A_RPxSP_1 150 154 PF00069 0.628
MOD_GlcNHglycan 113 116 PF01048 0.603
MOD_GlcNHglycan 58 61 PF01048 0.655
MOD_GlcNHglycan 76 79 PF01048 0.551
MOD_GlcNHglycan 89 92 PF01048 0.684
MOD_GSK3_1 197 204 PF00069 0.680
MOD_GSK3_1 216 223 PF00069 0.429
MOD_GSK3_1 26 33 PF00069 0.590
MOD_GSK3_1 271 278 PF00069 0.576
MOD_GSK3_1 288 295 PF00069 0.481
MOD_GSK3_1 326 333 PF00069 0.514
MOD_GSK3_1 5 12 PF00069 0.580
MOD_GSK3_1 52 59 PF00069 0.640
MOD_GSK3_1 74 81 PF00069 0.689
MOD_GSK3_1 87 94 PF00069 0.599
MOD_LATS_1 35 41 PF00433 0.672
MOD_N-GLC_1 255 260 PF02516 0.573
MOD_N-GLC_1 317 322 PF02516 0.608
MOD_NEK2_1 111 116 PF00069 0.488
MOD_NEK2_1 239 244 PF00069 0.543
MOD_NEK2_1 270 275 PF00069 0.551
MOD_NEK2_1 326 331 PF00069 0.515
MOD_NEK2_1 54 59 PF00069 0.600
MOD_PIKK_1 183 189 PF00454 0.557
MOD_PIKK_1 209 215 PF00454 0.563
MOD_PIKK_1 220 226 PF00454 0.534
MOD_PKA_2 12 18 PF00069 0.631
MOD_PKA_2 345 351 PF00069 0.716
MOD_Plk_1 183 189 PF00069 0.581
MOD_Plk_1 240 246 PF00069 0.657
MOD_Plk_1 255 261 PF00069 0.512
MOD_Plk_1 317 323 PF00069 0.554
MOD_Plk_1 38 44 PF00069 0.672
MOD_Plk_1 78 84 PF00069 0.635
MOD_Plk_4 242 248 PF00069 0.613
MOD_Plk_4 289 295 PF00069 0.427
MOD_Plk_4 326 332 PF00069 0.513
MOD_Plk_4 78 84 PF00069 0.685
MOD_ProDKin_1 150 156 PF00069 0.680
MOD_ProDKin_1 232 238 PF00069 0.605
MOD_SUMO_rev_2 209 217 PF00179 0.640
TRG_ENDOCYTIC_2 156 159 PF00928 0.567
TRG_ENDOCYTIC_2 179 182 PF00928 0.658
TRG_ENDOCYTIC_2 331 334 PF00928 0.623
TRG_ER_diArg_1 148 151 PF00400 0.501
TRG_ER_diArg_1 267 269 PF00400 0.656
TRG_ER_diArg_1 338 340 PF00400 0.581
TRG_Pf-PMV_PEXEL_1 101 106 PF00026 0.621
TRG_Pf-PMV_PEXEL_1 324 328 PF00026 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYS1 Leptomonas seymouri 56% 95%
A0A3Q8IGM9 Leishmania donovani 94% 100%
A0A422NYD6 Trypanosoma rangeli 40% 88%
A4HL47 Leishmania braziliensis 79% 100%
A4I8M6 Leishmania infantum 94% 100%
C9ZPV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 91%
Q4Q4L2 Leishmania major 92% 100%
V5BJG4 Trypanosoma cruzi 40% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS