Zinc/iron permease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Zinc/iron permease

Gene product:

ZIP Zinc transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B3I7_LEIMU

TriTrypDb:

LmxM.32.0100

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9B3I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I7

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006829	zinc ion transport	8	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071577	zinc ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005385	zinc ion transmembrane transporter activity	7	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0046915	transition metal ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.242
CLV_NRD_NRD_1	32	34	PF00675	0.527
CLV_PCSK_FUR_1	30	34	PF00082	0.435
CLV_PCSK_KEX2_1	216	218	PF00082	0.246
CLV_PCSK_KEX2_1	32	34	PF00082	0.532
CLV_PCSK_SKI1_1	100	104	PF00082	0.394
CLV_PCSK_SKI1_1	245	249	PF00082	0.473
DEG_SCF_TRCP1_1	123	129	PF00400	0.534
DEG_SPOP_SBC_1	266	270	PF00917	0.374
DOC_CKS1_1	228	233	PF01111	0.413
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.362
DOC_MAPK_MEF2A_6	171	180	PF00069	0.497
DOC_PP2B_LxvP_1	24	27	PF13499	0.553
DOC_USP7_MATH_1	121	125	PF00917	0.708
DOC_USP7_MATH_1	207	211	PF00917	0.601
DOC_USP7_MATH_1	250	254	PF00917	0.454
DOC_USP7_MATH_1	262	266	PF00917	0.480
DOC_USP7_MATH_1	284	288	PF00917	0.255
DOC_USP7_MATH_1	83	87	PF00917	0.374
DOC_WW_Pin1_4	227	232	PF00397	0.360
DOC_WW_Pin1_4	245	250	PF00397	0.411
DOC_WW_Pin1_4	75	80	PF00397	0.401
LIG_14-3-3_CanoR_1	20	27	PF00244	0.750
LIG_14-3-3_CanoR_1	32	40	PF00244	0.643
LIG_Actin_WH2_2	230	247	PF00022	0.174
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	210	214	PF00533	0.603
LIG_BRCT_BRCA1_1	252	256	PF00533	0.422
LIG_BRCT_BRCA1_1	286	290	PF00533	0.300
LIG_Clathr_ClatBox_1	150	154	PF01394	0.519
LIG_CSL_BTD_1	6	9	PF09270	0.606
LIG_FHA_1	111	117	PF00498	0.664
LIG_FHA_1	130	136	PF00498	0.593
LIG_FHA_1	144	150	PF00498	0.528
LIG_FHA_1	162	168	PF00498	0.451
LIG_FHA_1	20	26	PF00498	0.736
LIG_FHA_1	246	252	PF00498	0.504
LIG_FHA_1	271	277	PF00498	0.391
LIG_FHA_1	308	314	PF00498	0.174
LIG_FHA_1	317	323	PF00498	0.317
LIG_FHA_1	40	46	PF00498	0.437
LIG_FHA_1	58	64	PF00498	0.326
LIG_LIR_Gen_1	185	195	PF02991	0.513
LIG_LIR_Gen_1	287	298	PF02991	0.397
LIG_LIR_Gen_1	43	53	PF02991	0.538
LIG_LIR_Gen_1	86	95	PF02991	0.249
LIG_LIR_Nem_3	185	190	PF02991	0.450
LIG_LIR_Nem_3	287	293	PF02991	0.326
LIG_LIR_Nem_3	43	49	PF02991	0.555
LIG_LIR_Nem_3	86	90	PF02991	0.399
LIG_Pex14_1	7	11	PF04695	0.651
LIG_Rb_LxCxE_1	296	310	PF01857	0.237
LIG_SH2_NCK_1	187	191	PF00017	0.466
LIG_SH2_PTP2	292	295	PF00017	0.362
LIG_SH2_STAT5	292	295	PF00017	0.416
LIG_SH2_STAT5	324	327	PF00017	0.414
LIG_SH3_3	258	264	PF00018	0.390
LIG_SH3_3	3	9	PF00018	0.591
LIG_SH3_3	89	95	PF00018	0.348
LIG_SUMO_SIM_anti_2	131	139	PF11976	0.563
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.174
LIG_SUMO_SIM_anti_2	268	280	PF11976	0.387
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.312
MOD_CK1_1	128	134	PF00069	0.650
MOD_CK1_1	265	271	PF00069	0.508
MOD_CK1_1	274	280	PF00069	0.368
MOD_CK1_1	75	81	PF00069	0.460
MOD_CK2_1	185	191	PF00069	0.587
MOD_Cter_Amidation	30	33	PF01082	0.498
MOD_GlcNHglycan	123	126	PF01048	0.488
MOD_GlcNHglycan	161	164	PF01048	0.369
MOD_GlcNHglycan	167	170	PF01048	0.358
MOD_GlcNHglycan	195	198	PF01048	0.341
MOD_GlcNHglycan	252	255	PF01048	0.686
MOD_GlcNHglycan	286	289	PF01048	0.328
MOD_GlcNHglycan	53	56	PF01048	0.331
MOD_GlcNHglycan	74	77	PF01048	0.662
MOD_GSK3_1	106	113	PF00069	0.699
MOD_GSK3_1	121	128	PF00069	0.764
MOD_GSK3_1	161	168	PF00069	0.624
MOD_GSK3_1	245	252	PF00069	0.441
MOD_GSK3_1	262	269	PF00069	0.457
MOD_GSK3_1	270	277	PF00069	0.419
MOD_GSK3_1	34	41	PF00069	0.592
MOD_N-GLC_1	207	212	PF02516	0.425
MOD_NEK2_1	161	166	PF00069	0.521
MOD_NEK2_1	322	327	PF00069	0.462
MOD_NEK2_1	40	45	PF00069	0.557
MOD_NEK2_1	57	62	PF00069	0.225
MOD_NEK2_1	98	103	PF00069	0.576
MOD_PKA_2	19	25	PF00069	0.697
MOD_PKA_2	208	214	PF00069	0.623
MOD_Plk_1	98	104	PF00069	0.577
MOD_Plk_2-3	185	191	PF00069	0.622
MOD_Plk_4	274	280	PF00069	0.406
MOD_Plk_4	286	292	PF00069	0.303
MOD_Plk_4	293	299	PF00069	0.217
MOD_Plk_4	83	89	PF00069	0.341
MOD_ProDKin_1	227	233	PF00069	0.360
MOD_ProDKin_1	245	251	PF00069	0.415
MOD_ProDKin_1	75	81	PF00069	0.396
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.557
TRG_ENDOCYTIC_2	187	190	PF00928	0.507
TRG_ENDOCYTIC_2	292	295	PF00928	0.362
TRG_ER_diArg_1	215	217	PF00400	0.489
TRG_ER_diArg_1	30	33	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U6	Leptomonas seymouri	48%	95%
A0A1X0P3V2	Trypanosomatidae	29%	75%
A0A3R7MSD3	Trypanosoma rangeli	31%	100%
A0A3S7X6D4	Leishmania donovani	88%	100%
A4HL46	Leishmania braziliensis	69%	100%
A4I8M5	Leishmania infantum	88%	100%
C9ZPV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
Q4Q4L3	Leishmania major	85%	100%
V5BAE0	Trypanosoma cruzi	37%	92%