Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3I6_LEIMU

TriTrypDb:

LmxM.32.0090

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.654
CLV_C14_Caspase3-7	563	567	PF00656	0.562
CLV_NRD_NRD_1	227	229	PF00675	0.484
CLV_NRD_NRD_1	335	337	PF00675	0.535
CLV_NRD_NRD_1	385	387	PF00675	0.467
CLV_PCSK_KEX2_1	227	229	PF00082	0.519
CLV_PCSK_KEX2_1	335	337	PF00082	0.466
CLV_PCSK_KEX2_1	385	387	PF00082	0.467
CLV_PCSK_PC7_1	381	387	PF00082	0.476
CLV_PCSK_SKI1_1	283	287	PF00082	0.385
CLV_PCSK_SKI1_1	381	385	PF00082	0.466
CLV_PCSK_SKI1_1	389	393	PF00082	0.446
CLV_PCSK_SKI1_1	482	486	PF00082	0.418
CLV_PCSK_SKI1_1	505	509	PF00082	0.376
CLV_PCSK_SKI1_1	55	59	PF00082	0.284
DEG_APCC_DBOX_1	384	392	PF00400	0.385
DEG_APCC_DBOX_1	456	464	PF00400	0.398
DEG_SCF_FBW7_1	539	546	PF00400	0.538
DEG_SPOP_SBC_1	176	180	PF00917	0.446
DOC_ANK_TNKS_1	187	194	PF00023	0.542
DOC_CYCLIN_yCln2_LP_2	568	574	PF00134	0.540
DOC_MAPK_gen_1	10	17	PF00069	0.532
DOC_MAPK_gen_1	227	235	PF00069	0.382
DOC_MAPK_MEF2A_6	10	17	PF00069	0.600
DOC_MAPK_MEF2A_6	300	309	PF00069	0.441
DOC_MAPK_MEF2A_6	569	576	PF00069	0.470
DOC_MAPK_MEF2A_6	588	597	PF00069	0.287
DOC_PP2B_LxvP_1	568	571	PF13499	0.568
DOC_PP4_FxxP_1	182	185	PF00568	0.411
DOC_PP4_FxxP_1	284	287	PF00568	0.328
DOC_SPAK_OSR1_1	140	144	PF12202	0.265
DOC_USP7_MATH_1	13	17	PF00917	0.487
DOC_USP7_MATH_1	131	135	PF00917	0.383
DOC_USP7_MATH_1	174	178	PF00917	0.556
DOC_USP7_MATH_1	217	221	PF00917	0.406
DOC_USP7_MATH_1	323	327	PF00917	0.477
DOC_USP7_MATH_1	349	353	PF00917	0.636
DOC_USP7_MATH_1	355	359	PF00917	0.619
DOC_WW_Pin1_4	39	44	PF00397	0.422
DOC_WW_Pin1_4	511	516	PF00397	0.602
DOC_WW_Pin1_4	539	544	PF00397	0.601
DOC_WW_Pin1_4	548	553	PF00397	0.480
DOC_WW_Pin1_4	610	615	PF00397	0.447
DOC_WW_Pin1_4	71	76	PF00397	0.354
DOC_WW_Pin1_4	92	97	PF00397	0.346
LIG_14-3-3_CanoR_1	101	109	PF00244	0.373
LIG_14-3-3_CanoR_1	12	18	PF00244	0.487
LIG_14-3-3_CanoR_1	123	132	PF00244	0.428
LIG_14-3-3_CanoR_1	213	222	PF00244	0.491
LIG_14-3-3_CanoR_1	227	233	PF00244	0.383
LIG_14-3-3_CanoR_1	252	257	PF00244	0.394
LIG_14-3-3_CanoR_1	300	307	PF00244	0.446
LIG_14-3-3_CanoR_1	335	343	PF00244	0.390
LIG_14-3-3_CanoR_1	482	487	PF00244	0.445
LIG_Actin_WH2_2	307	323	PF00022	0.362
LIG_Actin_WH2_2	376	391	PF00022	0.414
LIG_Actin_WH2_2	466	484	PF00022	0.415
LIG_APCC_ABBA_1	367	372	PF00400	0.441
LIG_APCC_ABBAyCdc20_2	165	171	PF00400	0.372
LIG_BRCT_BRCA1_1	178	182	PF00533	0.390
LIG_Clathr_ClatBox_1	436	440	PF01394	0.278
LIG_deltaCOP1_diTrp_1	251	256	PF00928	0.399
LIG_deltaCOP1_diTrp_1	605	610	PF00928	0.468
LIG_eIF4E_1	229	235	PF01652	0.328
LIG_EVH1_1	207	211	PF00568	0.391
LIG_FHA_1	12	18	PF00498	0.532
LIG_FHA_1	154	160	PF00498	0.310
LIG_FHA_1	229	235	PF00498	0.328
LIG_FHA_1	300	306	PF00498	0.453
LIG_FHA_1	511	517	PF00498	0.603
LIG_FHA_1	527	533	PF00498	0.384
LIG_FHA_1	553	559	PF00498	0.665
LIG_FHA_1	594	600	PF00498	0.395
LIG_FHA_2	260	266	PF00498	0.415
LIG_FHA_2	544	550	PF00498	0.627
LIG_GBD_Chelix_1	466	474	PF00786	0.275
LIG_LIR_Apic_2	179	185	PF02991	0.476
LIG_LIR_Apic_2	281	287	PF02991	0.320
LIG_LIR_Apic_2	38	43	PF02991	0.321
LIG_LIR_Gen_1	432	441	PF02991	0.376
LIG_LIR_Gen_1	445	456	PF02991	0.364
LIG_LIR_Gen_1	489	499	PF02991	0.557
LIG_LIR_Nem_3	251	256	PF02991	0.395
LIG_LIR_Nem_3	34	40	PF02991	0.451
LIG_LIR_Nem_3	373	379	PF02991	0.496
LIG_LIR_Nem_3	432	437	PF02991	0.366
LIG_LIR_Nem_3	445	451	PF02991	0.351
LIG_LIR_Nem_3	489	494	PF02991	0.420
LIG_LIR_Nem_3	52	57	PF02991	0.341
LIG_LIR_Nem_3	92	97	PF02991	0.443
LIG_MAD2	123	131	PF02301	0.456
LIG_NRBOX	465	471	PF00104	0.364
LIG_PCNA_yPIPBox_3	292	304	PF02747	0.402
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.384
LIG_Pex14_1	434	438	PF04695	0.339
LIG_Pex14_2	444	448	PF04695	0.416
LIG_PTB_Apo_2	88	95	PF02174	0.385
LIG_SH2_CRK	229	233	PF00017	0.331
LIG_SH2_PTP2	40	43	PF00017	0.325
LIG_SH2_SRC	438	441	PF00017	0.295
LIG_SH2_STAP1	170	174	PF00017	0.326
LIG_SH2_STAP1	229	233	PF00017	0.392
LIG_SH2_STAP1	301	305	PF00017	0.451
LIG_SH2_STAP1	591	595	PF00017	0.395
LIG_SH2_STAT5	301	304	PF00017	0.462
LIG_SH2_STAT5	40	43	PF00017	0.325
LIG_SH2_STAT5	438	441	PF00017	0.370
LIG_SH2_STAT5	84	87	PF00017	0.364
LIG_SH3_2	208	213	PF14604	0.367
LIG_SH3_3	110	116	PF00018	0.412
LIG_SH3_3	180	186	PF00018	0.472
LIG_SH3_3	205	211	PF00018	0.389
LIG_SH3_3	567	573	PF00018	0.441
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.335
LIG_SUMO_SIM_anti_2	596	601	PF11976	0.403
LIG_SUMO_SIM_par_1	230	237	PF11976	0.396
LIG_SUMO_SIM_par_1	465	471	PF11976	0.376
LIG_SUMO_SIM_par_1	513	520	PF11976	0.590
LIG_SUMO_SIM_par_1	594	601	PF11976	0.368
LIG_UBA3_1	50	55	PF00899	0.429
MOD_CDK_SPxxK_3	71	78	PF00069	0.345
MOD_CK1_1	177	183	PF00069	0.409
MOD_CK1_1	362	368	PF00069	0.538
MOD_CK1_1	489	495	PF00069	0.431
MOD_CK1_1	603	609	PF00069	0.498
MOD_CK2_1	252	258	PF00069	0.428
MOD_CK2_1	259	265	PF00069	0.351
MOD_CK2_1	411	417	PF00069	0.468
MOD_CK2_1	609	615	PF00069	0.451
MOD_CK2_1	80	86	PF00069	0.431
MOD_GlcNHglycan	215	218	PF01048	0.408
MOD_GlcNHglycan	219	222	PF01048	0.404
MOD_GlcNHglycan	267	270	PF01048	0.348
MOD_GlcNHglycan	352	355	PF01048	0.557
MOD_GlcNHglycan	413	416	PF01048	0.368
MOD_GlcNHglycan	47	50	PF01048	0.450
MOD_GlcNHglycan	600	603	PF01048	0.498
MOD_GSK3_1	126	133	PF00069	0.314
MOD_GSK3_1	213	220	PF00069	0.418
MOD_GSK3_1	299	306	PF00069	0.289
MOD_GSK3_1	315	322	PF00069	0.404
MOD_GSK3_1	330	337	PF00069	0.584
MOD_GSK3_1	35	42	PF00069	0.531
MOD_GSK3_1	350	357	PF00069	0.399
MOD_GSK3_1	368	375	PF00069	0.445
MOD_GSK3_1	425	432	PF00069	0.397
MOD_GSK3_1	45	52	PF00069	0.567
MOD_GSK3_1	482	489	PF00069	0.426
MOD_GSK3_1	510	517	PF00069	0.486
MOD_GSK3_1	539	546	PF00069	0.628
MOD_GSK3_1	548	555	PF00069	0.656
MOD_GSK3_1	606	613	PF00069	0.624
MOD_GSK3_1	64	71	PF00069	0.286
MOD_GSK3_1	76	83	PF00069	0.450
MOD_N-GLC_1	71	76	PF02516	0.362
MOD_N-GLC_1	90	95	PF02516	0.436
MOD_N-GLC_2	21	23	PF02516	0.481
MOD_NEK2_1	125	130	PF00069	0.544
MOD_NEK2_1	215	220	PF00069	0.415
MOD_NEK2_1	234	239	PF00069	0.474
MOD_NEK2_1	299	304	PF00069	0.399
MOD_NEK2_1	370	375	PF00069	0.459
MOD_NEK2_1	451	456	PF00069	0.567
MOD_NEK2_1	486	491	PF00069	0.528
MOD_NEK2_1	516	521	PF00069	0.581
MOD_NEK2_1	532	537	PF00069	0.426
MOD_NEK2_1	68	73	PF00069	0.449
MOD_NEK2_1	76	81	PF00069	0.427
MOD_NEK2_2	49	54	PF00069	0.383
MOD_PIKK_1	288	294	PF00454	0.438
MOD_PIKK_1	334	340	PF00454	0.427
MOD_PIKK_1	489	495	PF00454	0.605
MOD_PIKK_1	76	82	PF00454	0.368
MOD_PKA_1	227	233	PF00069	0.483
MOD_PKA_2	100	106	PF00069	0.304
MOD_PKA_2	11	17	PF00069	0.595
MOD_PKA_2	227	233	PF00069	0.367
MOD_PKA_2	299	305	PF00069	0.390
MOD_PKA_2	315	321	PF00069	0.414
MOD_PKA_2	334	340	PF00069	0.430
MOD_PKA_2	350	356	PF00069	0.466
MOD_Plk_1	400	406	PF00069	0.493
MOD_Plk_1	591	597	PF00069	0.392
MOD_Plk_1	90	96	PF00069	0.452
MOD_Plk_4	228	234	PF00069	0.349
MOD_Plk_4	294	300	PF00069	0.376
MOD_Plk_4	429	435	PF00069	0.342
MOD_Plk_4	482	488	PF00069	0.467
MOD_Plk_4	49	55	PF00069	0.424
MOD_Plk_4	494	500	PF00069	0.394
MOD_Plk_4	64	70	PF00069	0.292
MOD_Plk_4	80	86	PF00069	0.576
MOD_ProDKin_1	39	45	PF00069	0.416
MOD_ProDKin_1	511	517	PF00069	0.603
MOD_ProDKin_1	539	545	PF00069	0.605
MOD_ProDKin_1	548	554	PF00069	0.473
MOD_ProDKin_1	71	77	PF00069	0.346
MOD_ProDKin_1	92	98	PF00069	0.341
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.407
TRG_ENDOCYTIC_2	197	200	PF00928	0.339
TRG_ENDOCYTIC_2	229	232	PF00928	0.331
TRG_ER_diArg_1	226	228	PF00400	0.391
TRG_ER_diArg_1	384	386	PF00400	0.469
TRG_ER_diArg_1	9	12	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P687	Leptomonas seymouri	43%	67%
A0A3S7X6C3	Leishmania donovani	85%	100%
A4HL45	Leishmania braziliensis	74%	100%
A4I8M4	Leishmania infantum	85%	100%
Q4Q4L4	Leishmania major	86%	100%