Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3I5_LEIMU

TriTrypDb:

LmxM.32.0080

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I5

PDB structure(s): 7aih_At , 7am2_At , 7ane_At

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.549
CLV_NRD_NRD_1	137	139	PF00675	0.669
CLV_NRD_NRD_1	65	67	PF00675	0.605
CLV_NRD_NRD_1	91	93	PF00675	0.591
CLV_PCSK_KEX2_1	117	119	PF00082	0.549
CLV_PCSK_KEX2_1	136	138	PF00082	0.490
CLV_PCSK_KEX2_1	21	23	PF00082	0.566
CLV_PCSK_KEX2_1	65	67	PF00082	0.605
CLV_PCSK_KEX2_1	91	93	PF00082	0.610
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.637
CLV_PCSK_PC7_1	133	139	PF00082	0.671
CLV_PCSK_PC7_1	87	93	PF00082	0.626
CLV_PCSK_SKI1_1	65	69	PF00082	0.708
CLV_PCSK_SKI1_1	82	86	PF00082	0.592
DEG_Nend_UBRbox_3	1	3	PF02207	0.467
DEG_SPOP_SBC_1	100	104	PF00917	0.557
DOC_MAPK_JIP1_4	7	13	PF00069	0.513
DOC_USP7_MATH_1	128	132	PF00917	0.728
DOC_USP7_MATH_1	67	71	PF00917	0.662
DOC_WW_Pin1_4	171	176	PF00397	0.601
LIG_14-3-3_CanoR_1	155	161	PF00244	0.556
LIG_14-3-3_CanoR_1	66	72	PF00244	0.695
LIG_CtBP_PxDLS_1	151	155	PF00389	0.368
LIG_FHA_1	163	169	PF00498	0.591
LIG_LIR_Gen_1	162	172	PF02991	0.674
LIG_LIR_Nem_3	162	167	PF02991	0.638
LIG_SH2_CRK	164	168	PF00017	0.654
LIG_SH2_STAP1	164	168	PF00017	0.522
LIG_SH2_STAT5	164	167	PF00017	0.637
LIG_SH2_STAT5	40	43	PF00017	0.542
LIG_SH3_3	169	175	PF00018	0.572
MOD_CK1_1	159	165	PF00069	0.539
MOD_CK1_1	174	180	PF00069	0.621
MOD_CK1_1	42	48	PF00069	0.672
MOD_GlcNHglycan	41	44	PF01048	0.586
MOD_GlcNHglycan	79	82	PF01048	0.599
MOD_GlcNHglycan	8	11	PF01048	0.510
MOD_GSK3_1	162	169	PF00069	0.564
MOD_GSK3_1	170	177	PF00069	0.547
MOD_N-GLC_1	162	167	PF02516	0.608
MOD_NEK2_1	101	106	PF00069	0.539
MOD_NEK2_1	156	161	PF00069	0.528
MOD_NEK2_1	77	82	PF00069	0.572
MOD_NEK2_2	14	19	PF00069	0.555
MOD_PIKK_1	128	134	PF00454	0.732
MOD_PIKK_1	162	168	PF00454	0.637
MOD_PIKK_1	65	71	PF00454	0.601
MOD_PKA_1	21	27	PF00069	0.542
MOD_PKA_1	65	71	PF00069	0.601
MOD_PKA_2	21	27	PF00069	0.504
MOD_PKA_2	58	64	PF00069	0.552
MOD_PKA_2	6	12	PF00069	0.606
MOD_PKA_2	65	71	PF00069	0.611
MOD_Plk_1	162	168	PF00069	0.619
MOD_ProDKin_1	171	177	PF00069	0.599
TRG_ENDOCYTIC_2	164	167	PF00928	0.672
TRG_ENDOCYTIC_2	50	53	PF00928	0.535
TRG_ER_diArg_1	116	118	PF00400	0.552
TRG_ER_diArg_1	136	138	PF00400	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I402	Leptomonas seymouri	81%	100%
A0A0S4JQA3	Bodo saltans	57%	100%
A0A1X0P2R8	Trypanosomatidae	65%	100%
A0A3Q8IJU1	Leishmania donovani	91%	100%
A0A422NYD9	Trypanosoma rangeli	70%	95%
A4HL44	Leishmania braziliensis	92%	100%
C9ZPU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	94%
E9AHM6	Leishmania infantum	91%	100%
Q4Q4L5	Leishmania major	96%	100%
V5DB04	Trypanosoma cruzi	70%	83%