Centrosomal protein of 104 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3I4_LEIMU

TriTrypDb:

LmxM.32.0070

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B3I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.518
CLV_NRD_NRD_1	123	125	PF00675	0.472
CLV_NRD_NRD_1	185	187	PF00675	0.773
CLV_NRD_NRD_1	274	276	PF00675	0.399
CLV_NRD_NRD_1	600	602	PF00675	0.544
CLV_PCSK_KEX2_1	184	186	PF00082	0.743
CLV_PCSK_KEX2_1	199	201	PF00082	0.683
CLV_PCSK_KEX2_1	215	217	PF00082	0.506
CLV_PCSK_KEX2_1	274	276	PF00082	0.386
CLV_PCSK_KEX2_1	600	602	PF00082	0.514
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.614
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.468
CLV_PCSK_SKI1_1	102	106	PF00082	0.578
CLV_PCSK_SKI1_1	137	141	PF00082	0.399
CLV_PCSK_SKI1_1	215	219	PF00082	0.467
CLV_PCSK_SKI1_1	301	305	PF00082	0.439
CLV_PCSK_SKI1_1	473	477	PF00082	0.439
CLV_PCSK_SKI1_1	553	557	PF00082	0.399
CLV_PCSK_SKI1_1	642	646	PF00082	0.428
CLV_PCSK_SKI1_1	74	78	PF00082	0.488
CLV_PCSK_SKI1_1	82	86	PF00082	0.524
DEG_APCC_DBOX_1	298	306	PF00400	0.465
DEG_APCC_DBOX_1	613	621	PF00400	0.470
DOC_CKS1_1	179	184	PF01111	0.759
DOC_CKS1_1	356	361	PF01111	0.459
DOC_CKS1_1	577	582	PF01111	0.403
DOC_CYCLIN_RxL_1	134	141	PF00134	0.479
DOC_CYCLIN_RxL_1	639	647	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.531
DOC_MAPK_gen_1	102	111	PF00069	0.493
DOC_MAPK_gen_1	120	129	PF00069	0.462
DOC_MAPK_gen_1	274	282	PF00069	0.405
DOC_MAPK_gen_1	45	55	PF00069	0.501
DOC_MAPK_gen_1	476	485	PF00069	0.407
DOC_MAPK_MEF2A_6	48	57	PF00069	0.477
DOC_MAPK_MEF2A_6	74	83	PF00069	0.408
DOC_PP1_RVXF_1	135	141	PF00149	0.429
DOC_PP1_RVXF_1	262	269	PF00149	0.501
DOC_PP1_RVXF_1	97	104	PF00149	0.523
DOC_PP2B_LxvP_1	643	646	PF13499	0.483
DOC_PP4_FxxP_1	140	143	PF00568	0.449
DOC_USP7_MATH_1	208	212	PF00917	0.591
DOC_USP7_MATH_1	232	236	PF00917	0.718
DOC_USP7_MATH_1	357	361	PF00917	0.566
DOC_USP7_MATH_1	461	465	PF00917	0.445
DOC_USP7_MATH_1	583	587	PF00917	0.495
DOC_USP7_UBL2_3	677	681	PF12436	0.588
DOC_USP7_UBL2_3	74	78	PF12436	0.448
DOC_WW_Pin1_4	178	183	PF00397	0.750
DOC_WW_Pin1_4	235	240	PF00397	0.699
DOC_WW_Pin1_4	32	37	PF00397	0.753
DOC_WW_Pin1_4	350	355	PF00397	0.594
DOC_WW_Pin1_4	380	385	PF00397	0.651
DOC_WW_Pin1_4	387	392	PF00397	0.582
DOC_WW_Pin1_4	46	51	PF00397	0.490
DOC_WW_Pin1_4	491	496	PF00397	0.476
DOC_WW_Pin1_4	542	547	PF00397	0.413
DOC_WW_Pin1_4	576	581	PF00397	0.454
LIG_14-3-3_CanoR_1	124	128	PF00244	0.515
LIG_14-3-3_CanoR_1	184	189	PF00244	0.779
LIG_14-3-3_CanoR_1	200	209	PF00244	0.606
LIG_14-3-3_CanoR_1	216	221	PF00244	0.513
LIG_14-3-3_CanoR_1	243	247	PF00244	0.610
LIG_14-3-3_CanoR_1	274	282	PF00244	0.503
LIG_14-3-3_CanoR_1	337	342	PF00244	0.560
LIG_14-3-3_CanoR_1	375	381	PF00244	0.579
LIG_14-3-3_CanoR_1	557	565	PF00244	0.470
LIG_14-3-3_CanoR_1	614	618	PF00244	0.457
LIG_14-3-3_CanoR_1	67	75	PF00244	0.398
LIG_Actin_WH2_2	259	276	PF00022	0.558
LIG_Actin_WH2_2	463	480	PF00022	0.482
LIG_AP2alpha_1	268	272	PF02296	0.516
LIG_APCC_ABBA_1	618	623	PF00400	0.226
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	107	111	PF00533	0.481
LIG_BRCT_BRCA1_1	471	475	PF00533	0.434
LIG_Clathr_ClatBox_1	209	213	PF01394	0.638
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.584
LIG_eIF4E_1	134	140	PF01652	0.420
LIG_FHA_1	124	130	PF00498	0.458
LIG_FHA_1	50	56	PF00498	0.473
LIG_FHA_1	570	576	PF00498	0.440
LIG_FHA_1	577	583	PF00498	0.454
LIG_FHA_2	11	17	PF00498	0.503
LIG_FHA_2	338	344	PF00498	0.404
LIG_FHA_2	496	502	PF00498	0.344
LIG_FHA_2	594	600	PF00498	0.591
LIG_FHA_2	75	81	PF00498	0.419
LIG_GBD_Chelix_1	658	666	PF00786	0.463
LIG_HP1_1	546	550	PF01393	0.477
LIG_Integrin_isoDGR_2	624	626	PF01839	0.385
LIG_LIR_Apic_2	90	95	PF02991	0.601
LIG_LIR_Gen_1	132	143	PF02991	0.439
LIG_LIR_Gen_1	267	273	PF02991	0.489
LIG_LIR_Gen_1	527	533	PF02991	0.324
LIG_LIR_Gen_1	616	622	PF02991	0.484
LIG_LIR_Nem_3	132	138	PF02991	0.434
LIG_LIR_Nem_3	267	271	PF02991	0.444
LIG_LIR_Nem_3	616	621	PF02991	0.454
LIG_LIR_Nem_3	97	101	PF02991	0.434
LIG_NRBOX	639	645	PF00104	0.525
LIG_NRP_CendR_1	694	695	PF00754	0.504
LIG_PCNA_PIPBox_1	321	330	PF02747	0.435
LIG_PCNA_yPIPBox_3	333	346	PF02747	0.453
LIG_Pex14_2	140	144	PF04695	0.394
LIG_Pex14_2	268	272	PF04695	0.474
LIG_Pex14_2	453	457	PF04695	0.545
LIG_Pex14_2	471	475	PF04695	0.434
LIG_PTB_Apo_2	447	454	PF02174	0.454
LIG_PTB_Apo_2	517	524	PF02174	0.487
LIG_PTB_Apo_2	628	635	PF02174	0.359
LIG_PTB_Apo_2	97	104	PF02174	0.499
LIG_Rb_pABgroove_1	134	142	PF01858	0.380
LIG_REV1ctd_RIR_1	269	279	PF16727	0.492
LIG_SH2_CRK	7	11	PF00017	0.481
LIG_SH2_STAP1	7	11	PF00017	0.481
LIG_SH2_STAT3	512	515	PF00017	0.471
LIG_SH2_STAT5	134	137	PF00017	0.373
LIG_SH2_STAT5	164	167	PF00017	0.439
LIG_SH2_STAT5	576	579	PF00017	0.500
LIG_SH3_3	14	20	PF00018	0.559
LIG_SH3_3	176	182	PF00018	0.651
LIG_SH3_3	189	195	PF00018	0.610
LIG_SH3_3	30	36	PF00018	0.705
LIG_SH3_3	353	359	PF00018	0.668
LIG_SH3_3	540	546	PF00018	0.390
LIG_SH3_3	574	580	PF00018	0.445
LIG_SH3_3	645	651	PF00018	0.505
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.540
LIG_SUMO_SIM_par_1	208	213	PF11976	0.592
LIG_SUMO_SIM_par_1	481	487	PF11976	0.471
LIG_SxIP_EBH_1	32	43	PF03271	0.488
LIG_TYR_ITIM	5	10	PF00017	0.469
LIG_UBA3_1	482	488	PF00899	0.357
LIG_WRC_WIRS_1	462	467	PF05994	0.327
LIG_WW_3	181	185	PF00397	0.548
MOD_CDC14_SPxK_1	238	241	PF00782	0.565
MOD_CDK_SPxK_1	178	184	PF00069	0.774
MOD_CDK_SPxK_1	235	241	PF00069	0.552
MOD_CDK_SPxxK_3	178	185	PF00069	0.638
MOD_CDK_SPxxK_3	355	362	PF00069	0.473
MOD_CK1_1	187	193	PF00069	0.766
MOD_CK1_1	235	241	PF00069	0.707
MOD_CK1_1	350	356	PF00069	0.680
MOD_CK1_1	360	366	PF00069	0.711
MOD_CK1_1	379	385	PF00069	0.675
MOD_CK1_1	402	408	PF00069	0.634
MOD_CK1_1	581	587	PF00069	0.363
MOD_CK1_1	633	639	PF00069	0.562
MOD_CK2_1	24	30	PF00069	0.586
MOD_CK2_1	337	343	PF00069	0.404
MOD_CK2_1	593	599	PF00069	0.586
MOD_CK2_1	74	80	PF00069	0.364
MOD_Cter_Amidation	213	216	PF01082	0.468
MOD_GlcNHglycan	160	164	PF01048	0.495
MOD_GlcNHglycan	359	362	PF01048	0.726
MOD_GlcNHglycan	42	45	PF01048	0.472
MOD_GlcNHglycan	588	591	PF01048	0.382
MOD_GSK3_1	110	117	PF00069	0.489
MOD_GSK3_1	155	162	PF00069	0.428
MOD_GSK3_1	333	340	PF00069	0.411
MOD_GSK3_1	346	353	PF00069	0.631
MOD_GSK3_1	376	383	PF00069	0.626
MOD_GSK3_1	433	440	PF00069	0.431
MOD_GSK3_1	491	498	PF00069	0.374
MOD_GSK3_1	578	585	PF00069	0.433
MOD_N-GLC_1	376	381	PF02516	0.723
MOD_N-GLC_1	630	635	PF02516	0.402
MOD_NEK2_1	159	164	PF00069	0.435
MOD_NEK2_1	24	29	PF00069	0.640
MOD_NEK2_1	346	351	PF00069	0.533
MOD_NEK2_1	471	476	PF00069	0.365
MOD_NEK2_1	514	519	PF00069	0.392
MOD_NEK2_1	533	538	PF00069	0.369
MOD_NEK2_1	658	663	PF00069	0.369
MOD_NEK2_2	613	618	PF00069	0.474
MOD_PIKK_1	187	193	PF00454	0.680
MOD_PK_1	105	111	PF00069	0.537
MOD_PK_1	216	222	PF00069	0.505
MOD_PK_1	578	584	PF00069	0.302
MOD_PKA_1	184	190	PF00069	0.774
MOD_PKA_1	199	205	PF00069	0.672
MOD_PKA_2	123	129	PF00069	0.457
MOD_PKA_2	184	190	PF00069	0.755
MOD_PKA_2	199	205	PF00069	0.684
MOD_PKA_2	242	248	PF00069	0.615
MOD_PKA_2	273	279	PF00069	0.488
MOD_PKA_2	556	562	PF00069	0.459
MOD_PKA_2	613	619	PF00069	0.478
MOD_PKA_2	687	693	PF00069	0.618
MOD_Plk_1	114	120	PF00069	0.509
MOD_Plk_1	227	233	PF00069	0.528
MOD_Plk_1	346	352	PF00069	0.448
MOD_Plk_1	376	382	PF00069	0.701
MOD_Plk_1	630	636	PF00069	0.415
MOD_Plk_4	337	343	PF00069	0.581
MOD_Plk_4	49	55	PF00069	0.474
MOD_Plk_4	524	530	PF00069	0.428
MOD_Plk_4	571	577	PF00069	0.398
MOD_Plk_4	583	589	PF00069	0.424
MOD_Plk_4	613	619	PF00069	0.414
MOD_Plk_4	658	664	PF00069	0.405
MOD_ProDKin_1	178	184	PF00069	0.755
MOD_ProDKin_1	235	241	PF00069	0.700
MOD_ProDKin_1	32	38	PF00069	0.744
MOD_ProDKin_1	350	356	PF00069	0.603
MOD_ProDKin_1	380	386	PF00069	0.651
MOD_ProDKin_1	387	393	PF00069	0.582
MOD_ProDKin_1	46	52	PF00069	0.481
MOD_ProDKin_1	491	497	PF00069	0.476
MOD_ProDKin_1	542	548	PF00069	0.413
MOD_ProDKin_1	576	582	PF00069	0.448
MOD_SUMO_for_1	129	132	PF00179	0.489
MOD_SUMO_rev_2	117	127	PF00179	0.504
MOD_SUMO_rev_2	211	217	PF00179	0.466
MOD_SUMO_rev_2	221	231	PF00179	0.543
MOD_SUMO_rev_2	27	33	PF00179	0.515
MOD_SUMO_rev_2	70	76	PF00179	0.366
TRG_AP2beta_CARGO_1	132	142	PF09066	0.481
TRG_DiLeu_BaEn_4	277	283	PF01217	0.500
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.335
TRG_ENDOCYTIC_2	7	10	PF00928	0.473
TRG_ER_diArg_1	183	186	PF00400	0.731
TRG_ER_diArg_1	273	275	PF00400	0.420
TRG_NLS_Bipartite_1	199	219	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	401	406	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U7	Leptomonas seymouri	61%	98%
A0A0N0P8K1	Leptomonas seymouri	25%	79%
A0A0S4ILQ6	Bodo saltans	25%	70%
A0A1X0P6E5	Trypanosomatidae	25%	82%
A0A3R7MW28	Trypanosoma rangeli	26%	81%
A0A3S7WVF9	Leishmania donovani	24%	79%
A0A3S7X6A2	Leishmania donovani	92%	100%
A0A422NYA4	Trypanosoma rangeli	40%	86%
A4HL43	Leishmania braziliensis	74%	99%
A4HY47	Leishmania infantum	24%	79%
A4I8M3	Leishmania infantum	92%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	77%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q4L6	Leishmania major	92%	100%
V5DTJ3	Trypanosoma cruzi	26%	82%