FOP_dimer domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3I2_LEIMU

TriTrypDb:

LmxM.32.0050

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	114	118	PF00082	0.574
CLV_PCSK_SKI1_1	70	74	PF00082	0.504
DEG_Nend_UBRbox_2	1	3	PF02207	0.652
DEG_SPOP_SBC_1	155	159	PF00917	0.652
DOC_ANK_TNKS_1	122	129	PF00023	0.603
DOC_CYCLIN_RxL_1	67	76	PF00134	0.511
DOC_MIT_MIM_1	127	137	PF04212	0.521
DOC_PP4_FxxP_1	68	71	PF00568	0.602
DOC_USP7_MATH_1	147	151	PF00917	0.712
DOC_USP7_MATH_1	156	160	PF00917	0.627
DOC_USP7_MATH_1	161	165	PF00917	0.655
DOC_USP7_MATH_1	174	178	PF00917	0.662
DOC_USP7_MATH_1	28	32	PF00917	0.540
DOC_USP7_MATH_1	78	82	PF00917	0.433
DOC_WW_Pin1_4	170	175	PF00397	0.667
DOC_WW_Pin1_4	189	194	PF00397	0.576
LIG_14-3-3_CanoR_1	47	54	PF00244	0.568
LIG_14-3-3_CanoR_1	70	75	PF00244	0.595
LIG_BRCT_BRCA1_1	207	211	PF00533	0.670
LIG_FHA_1	160	166	PF00498	0.700
LIG_FHA_1	7	13	PF00498	0.670
LIG_FHA_1	95	101	PF00498	0.458
LIG_FHA_2	8	14	PF00498	0.686
LIG_Integrin_RGD_1	55	57	PF01839	0.529
LIG_Rb_pABgroove_1	80	88	PF01858	0.313
LIG_SH2_CRK	86	90	PF00017	0.427
LIG_SH2_SRC	205	208	PF00017	0.555
LIG_SH2_STAP1	205	209	PF00017	0.575
LIG_SH2_STAT3	92	95	PF00017	0.494
LIG_SH3_3	168	174	PF00018	0.563
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.572
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.431
LIG_SUMO_SIM_par_1	70	76	PF11976	0.535
LIG_SUMO_SIM_par_1	81	87	PF11976	0.380
LIG_TRAF2_1	182	185	PF00917	0.776
LIG_TYR_ITIM	84	89	PF00017	0.426
MOD_CK1_1	150	156	PF00069	0.736
MOD_CK1_1	159	165	PF00069	0.746
MOD_CK1_1	177	183	PF00069	0.747
MOD_CK1_1	31	37	PF00069	0.531
MOD_CK2_1	178	184	PF00069	0.687
MOD_CK2_1	209	215	PF00069	0.692
MOD_CK2_1	7	13	PF00069	0.715
MOD_GlcNHglycan	104	107	PF01048	0.321
MOD_GlcNHglycan	176	179	PF01048	0.679
MOD_GlcNHglycan	180	183	PF01048	0.690
MOD_GlcNHglycan	30	33	PF01048	0.530
MOD_GlcNHglycan	35	38	PF01048	0.505
MOD_GSK3_1	150	157	PF00069	0.718
MOD_GSK3_1	170	177	PF00069	0.662
MOD_GSK3_1	180	187	PF00069	0.695
MOD_GSK3_1	205	212	PF00069	0.550
MOD_GSK3_1	31	38	PF00069	0.525
MOD_N-GLC_1	150	155	PF02516	0.732
MOD_NEK2_1	33	38	PF00069	0.469
MOD_NEK2_1	46	51	PF00069	0.549
MOD_NEK2_1	72	77	PF00069	0.557
MOD_NEK2_1	94	99	PF00069	0.443
MOD_PIKK_1	156	162	PF00454	0.783
MOD_PIKK_1	7	13	PF00454	0.647
MOD_PKA_2	46	52	PF00069	0.543
MOD_Plk_1	112	118	PF00069	0.487
MOD_Plk_1	150	156	PF00069	0.594
MOD_Plk_1	205	211	PF00069	0.562
MOD_Plk_1	7	13	PF00069	0.705
MOD_Plk_4	150	156	PF00069	0.579
MOD_Plk_4	78	84	PF00069	0.469
MOD_ProDKin_1	170	176	PF00069	0.670
MOD_ProDKin_1	189	195	PF00069	0.566
TRG_DiLeu_BaEn_1	113	118	PF01217	0.504
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.395
TRG_ENDOCYTIC_2	86	89	PF00928	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX52	Leptomonas seymouri	52%	100%
A0A0S4JQ70	Bodo saltans	34%	90%
A0A3Q8ILV2	Leishmania donovani	85%	100%
A0A3R7NRD8	Trypanosoma rangeli	35%	100%
A4HL41	Leishmania braziliensis	70%	100%
A4I8M1	Leishmania infantum	85%	100%
C9ZPU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	96%
Q4Q4L8	Leishmania major	87%	100%
V5BAE5	Trypanosoma cruzi	35%	100%