Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3I1_LEIMU

TriTrypDb:

LmxM.32.0040

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	516	520	PF00656	0.659
CLV_C14_Caspase3-7	68	72	PF00656	0.523
CLV_NRD_NRD_1	339	341	PF00675	0.671
CLV_NRD_NRD_1	412	414	PF00675	0.739
CLV_NRD_NRD_1	88	90	PF00675	0.589
CLV_PCSK_KEX2_1	338	340	PF00082	0.679
CLV_PCSK_KEX2_1	412	414	PF00082	0.705
CLV_PCSK_KEX2_1	454	456	PF00082	0.506
CLV_PCSK_KEX2_1	88	90	PF00082	0.589
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.477
CLV_PCSK_SKI1_1	18	22	PF00082	0.484
CLV_PCSK_SKI1_1	217	221	PF00082	0.545
CLV_PCSK_SKI1_1	307	311	PF00082	0.669
CLV_PCSK_SKI1_1	451	455	PF00082	0.583
CLV_PCSK_SKI1_1	89	93	PF00082	0.610
DEG_APCC_DBOX_1	17	25	PF00400	0.508
DEG_Nend_UBRbox_1	1	4	PF02207	0.728
DEG_SPOP_SBC_1	319	323	PF00917	0.574
DEG_SPOP_SBC_1	359	363	PF00917	0.703
DOC_CYCLIN_RxL_1	112	121	PF00134	0.424
DOC_CYCLIN_RxL_1	213	224	PF00134	0.547
DOC_MAPK_MEF2A_6	213	222	PF00069	0.447
DOC_PP1_RVXF_1	114	121	PF00149	0.413
DOC_PP4_MxPP_1	273	276	PF00568	0.502
DOC_USP7_MATH_1	159	163	PF00917	0.579
DOC_USP7_MATH_1	253	257	PF00917	0.740
DOC_USP7_MATH_1	282	286	PF00917	0.654
DOC_USP7_MATH_1	319	323	PF00917	0.691
DOC_USP7_MATH_1	359	363	PF00917	0.703
DOC_USP7_MATH_1	486	490	PF00917	0.459
DOC_WW_Pin1_4	147	152	PF00397	0.660
DOC_WW_Pin1_4	259	264	PF00397	0.553
DOC_WW_Pin1_4	297	302	PF00397	0.651
DOC_WW_Pin1_4	315	320	PF00397	0.649
DOC_WW_Pin1_4	390	395	PF00397	0.684
DOC_WW_Pin1_4	49	54	PF00397	0.453
LIG_14-3-3_CanoR_1	11	20	PF00244	0.508
LIG_14-3-3_CanoR_1	2	8	PF00244	0.660
LIG_14-3-3_CanoR_1	338	345	PF00244	0.671
LIG_14-3-3_CanoR_1	375	379	PF00244	0.574
LIG_14-3-3_CanoR_1	88	94	PF00244	0.594
LIG_Actin_WH2_2	457	475	PF00022	0.538
LIG_BIR_III_4	510	514	PF00653	0.541
LIG_BRCT_BRCA1_1	51	55	PF00533	0.504
LIG_EVH1_2	141	145	PF00568	0.502
LIG_FHA_1	148	154	PF00498	0.686
LIG_FHA_1	194	200	PF00498	0.452
LIG_FHA_1	288	294	PF00498	0.678
LIG_FHA_1	339	345	PF00498	0.709
LIG_FHA_1	444	450	PF00498	0.678
LIG_FHA_2	438	444	PF00498	0.633
LIG_FHA_2	483	489	PF00498	0.592
LIG_FHA_2	55	61	PF00498	0.610
LIG_FHA_2	66	72	PF00498	0.388
LIG_HCF-1_HBM_1	200	203	PF13415	0.537
LIG_LIR_Gen_1	117	125	PF02991	0.447
LIG_LIR_Gen_1	393	400	PF02991	0.558
LIG_LIR_Nem_3	14	20	PF02991	0.552
LIG_Pex14_2	51	55	PF04695	0.422
LIG_SH2_SRC	31	34	PF00017	0.541
LIG_SH2_STAT5	245	248	PF00017	0.596
LIG_SH2_STAT5	448	451	PF00017	0.534
LIG_SH2_STAT5	483	486	PF00017	0.497
LIG_SH2_STAT5	77	80	PF00017	0.466
LIG_SH2_STAT5	85	88	PF00017	0.502
LIG_SH3_3	136	142	PF00018	0.667
LIG_SH3_3	206	212	PF00018	0.498
LIG_SH3_3	30	36	PF00018	0.578
LIG_SH3_3	417	423	PF00018	0.623
LIG_SH3_3	47	53	PF00018	0.574
LIG_SUMO_SIM_anti_2	289	297	PF11976	0.637
LIG_TRAF2_1	126	129	PF00917	0.692
LIG_TRAF2_1	371	374	PF00917	0.673
MOD_CDK_SPK_2	259	264	PF00069	0.643
MOD_CDK_SPxxK_3	147	154	PF00069	0.646
MOD_CK1_1	256	262	PF00069	0.727
MOD_CK1_1	3	9	PF00069	0.557
MOD_CK1_1	323	329	PF00069	0.698
MOD_CK1_1	392	398	PF00069	0.643
MOD_CK2_1	123	129	PF00069	0.606
MOD_CK2_1	310	316	PF00069	0.587
MOD_CK2_1	368	374	PF00069	0.670
MOD_CK2_1	400	406	PF00069	0.680
MOD_CK2_1	437	443	PF00069	0.579
MOD_CK2_1	482	488	PF00069	0.564
MOD_GlcNHglycan	13	16	PF01048	0.427
MOD_GlcNHglycan	2	5	PF01048	0.531
MOD_GlcNHglycan	241	244	PF01048	0.402
MOD_GlcNHglycan	257	261	PF01048	0.743
MOD_GlcNHglycan	270	273	PF01048	0.636
MOD_GlcNHglycan	325	328	PF01048	0.692
MOD_GlcNHglycan	370	373	PF01048	0.644
MOD_GlcNHglycan	488	491	PF01048	0.466
MOD_GlcNHglycan	515	518	PF01048	0.609
MOD_GlcNHglycan	78	81	PF01048	0.510
MOD_GSK3_1	131	138	PF00069	0.677
MOD_GSK3_1	239	246	PF00069	0.525
MOD_GSK3_1	297	304	PF00069	0.688
MOD_GSK3_1	3	10	PF00069	0.657
MOD_GSK3_1	315	322	PF00069	0.516
MOD_GSK3_1	359	366	PF00069	0.743
MOD_GSK3_1	39	46	PF00069	0.573
MOD_GSK3_1	477	484	PF00069	0.528
MOD_GSK3_1	486	493	PF00069	0.469
MOD_GSK3_1	49	56	PF00069	0.393
MOD_GSK3_1	501	508	PF00069	0.427
MOD_GSK3_1	92	99	PF00069	0.507
MOD_NEK2_1	320	325	PF00069	0.657
MOD_NEK2_1	399	404	PF00069	0.497
MOD_NEK2_1	43	48	PF00069	0.598
MOD_NEK2_1	460	465	PF00069	0.486
MOD_NEK2_1	54	59	PF00069	0.502
MOD_NEK2_1	7	12	PF00069	0.621
MOD_PIKK_1	152	158	PF00454	0.621
MOD_PIKK_1	338	344	PF00454	0.671
MOD_PIKK_1	54	60	PF00454	0.624
MOD_PKA_1	338	344	PF00069	0.712
MOD_PKA_2	338	344	PF00069	0.679
MOD_PKA_2	374	380	PF00069	0.635
MOD_PKA_2	411	417	PF00069	0.697
MOD_PKA_2	481	487	PF00069	0.486
MOD_PKA_2	7	13	PF00069	0.620
MOD_Plk_1	307	313	PF00069	0.641
MOD_Plk_1	460	466	PF00069	0.487
MOD_Plk_2-3	287	293	PF00069	0.488
MOD_ProDKin_1	147	153	PF00069	0.656
MOD_ProDKin_1	259	265	PF00069	0.555
MOD_ProDKin_1	297	303	PF00069	0.655
MOD_ProDKin_1	315	321	PF00069	0.652
MOD_ProDKin_1	390	396	PF00069	0.674
MOD_ProDKin_1	49	55	PF00069	0.451
MOD_SUMO_rev_2	466	475	PF00179	0.443
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.650
TRG_ENDOCYTIC_2	17	20	PF00928	0.509
TRG_ENDOCYTIC_2	426	429	PF00928	0.699
TRG_ER_diArg_1	248	251	PF00400	0.693
TRG_ER_diArg_1	337	340	PF00400	0.640
TRG_ER_diArg_1	411	413	PF00400	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK4	Leptomonas seymouri	59%	99%
A0A0S4JPU3	Bodo saltans	34%	95%
A0A3S7X6B5	Leishmania donovani	90%	100%
A0A422NYF9	Trypanosoma rangeli	45%	100%
A4HL40	Leishmania braziliensis	78%	100%
A4I8M0	Leishmania infantum	90%	100%
C9ZPU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
Q4Q4L9	Leishmania major	88%	100%
V5AUZ3	Trypanosoma cruzi	45%	100%