LeishMANIAdb
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Transcriptional regulator

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transcriptional regulator
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3H9_LEIMU
TriTrypDb:
LmxM.32.0020
Length:
109

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3H9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3H9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 44 48 PF00082 0.387
DOC_MAPK_gen_1 38 47 PF00069 0.447
DOC_PP2B_LxvP_1 73 76 PF13499 0.458
LIG_14-3-3_CanoR_1 100 104 PF00244 0.279
LIG_14-3-3_CanoR_1 49 58 PF00244 0.492
LIG_FHA_1 13 19 PF00498 0.495
LIG_FHA_1 35 41 PF00498 0.547
LIG_PALB2_WD40_1 53 61 PF16756 0.534
LIG_SUMO_SIM_par_1 14 19 PF11976 0.480
MOD_CK1_1 12 18 PF00069 0.480
MOD_CK1_1 66 72 PF00069 0.559
MOD_CK1_1 78 84 PF00069 0.570
MOD_GlcNHglycan 11 14 PF01048 0.448
MOD_GlcNHglycan 19 23 PF01048 0.413
MOD_GlcNHglycan 65 68 PF01048 0.494
MOD_GSK3_1 2 9 PF00069 0.492
MOD_NEK2_1 36 41 PF00069 0.471
MOD_NEK2_1 4 9 PF00069 0.375
MOD_NEK2_1 96 101 PF00069 0.367
MOD_PKA_2 99 105 PF00069 0.407
MOD_Plk_1 2 8 PF00069 0.571
MOD_Plk_4 99 105 PF00069 0.293
TRG_ENDOCYTIC_2 92 95 PF00928 0.507
TRG_Pf-PMV_PEXEL_1 49 53 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKZ7 Leptomonas seymouri 69% 100%
A0A0S4KHD0 Bodo saltans 54% 100%
A0A1X0P3H9 Trypanosomatidae 57% 100%
A0A3Q8IEL8 Leishmania donovani 88% 100%
A0A3R7KVB4 Trypanosoma rangeli 62% 100%
A4HL38 Leishmania braziliensis 79% 100%
A4I8L8 Leishmania infantum 88% 100%
C9ZPU1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
Q4Q4M1 Leishmania major 89% 100%
V5DB11 Trypanosoma cruzi 64% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS