Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3H3_LEIMU

TriTrypDb:

LmxM.31.3950

Length:

994

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3H3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.569
CLV_NRD_NRD_1	315	317	PF00675	0.533
CLV_NRD_NRD_1	345	347	PF00675	0.426
CLV_NRD_NRD_1	348	350	PF00675	0.395
CLV_NRD_NRD_1	472	474	PF00675	0.523
CLV_NRD_NRD_1	51	53	PF00675	0.466
CLV_NRD_NRD_1	542	544	PF00675	0.559
CLV_NRD_NRD_1	644	646	PF00675	0.406
CLV_NRD_NRD_1	873	875	PF00675	0.770
CLV_NRD_NRD_1	881	883	PF00675	0.746
CLV_NRD_NRD_1	9	11	PF00675	0.676
CLV_PCSK_FUR_1	470	474	PF00082	0.424
CLV_PCSK_KEX2_1	130	132	PF00082	0.535
CLV_PCSK_KEX2_1	190	192	PF00082	0.558
CLV_PCSK_KEX2_1	315	317	PF00082	0.531
CLV_PCSK_KEX2_1	344	346	PF00082	0.431
CLV_PCSK_KEX2_1	350	352	PF00082	0.400
CLV_PCSK_KEX2_1	393	395	PF00082	0.561
CLV_PCSK_KEX2_1	472	474	PF00082	0.523
CLV_PCSK_KEX2_1	51	53	PF00082	0.440
CLV_PCSK_KEX2_1	542	544	PF00082	0.515
CLV_PCSK_KEX2_1	873	875	PF00082	0.731
CLV_PCSK_KEX2_1	881	883	PF00082	0.735
CLV_PCSK_KEX2_1	9	11	PF00082	0.676
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.571
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.498
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.577
CLV_PCSK_PC7_1	311	317	PF00082	0.510
CLV_PCSK_PC7_1	340	346	PF00082	0.555
CLV_PCSK_SKI1_1	111	115	PF00082	0.583
CLV_PCSK_SKI1_1	12	16	PF00082	0.543
CLV_PCSK_SKI1_1	435	439	PF00082	0.525
CLV_PCSK_SKI1_1	473	477	PF00082	0.526
CLV_PCSK_SKI1_1	567	571	PF00082	0.405
CLV_PCSK_SKI1_1	645	649	PF00082	0.470
CLV_PCSK_SKI1_1	682	686	PF00082	0.524
CLV_PCSK_SKI1_1	696	700	PF00082	0.377
CLV_PCSK_SKI1_1	767	771	PF00082	0.502
CLV_PCSK_SKI1_1	788	792	PF00082	0.613
CLV_PCSK_SKI1_1	811	815	PF00082	0.740
CLV_PCSK_SKI1_1	874	878	PF00082	0.647
CLV_PCSK_SKI1_1	943	947	PF00082	0.732
CLV_PCSK_SKI1_1	985	989	PF00082	0.484
DEG_APCC_DBOX_1	681	689	PF00400	0.537
DEG_COP1_1	897	906	PF00400	0.594
DEG_MDM2_SWIB_1	666	673	PF02201	0.371
DEG_SPOP_SBC_1	322	326	PF00917	0.539
DOC_CDC14_PxL_1	200	208	PF14671	0.241
DOC_CKS1_1	19	24	PF01111	0.738
DOC_CKS1_1	653	658	PF01111	0.555
DOC_CYCLIN_RxL_1	274	284	PF00134	0.391
DOC_CYCLIN_RxL_1	642	650	PF00134	0.538
DOC_CYCLIN_RxL_1	805	819	PF00134	0.746
DOC_CYCLIN_RxL_1	982	991	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.464
DOC_MAPK_DCC_7	355	364	PF00069	0.475
DOC_MAPK_FxFP_2	411	414	PF00069	0.534
DOC_MAPK_gen_1	542	549	PF00069	0.385
DOC_MAPK_gen_1	567	576	PF00069	0.498
DOC_MAPK_gen_1	679	688	PF00069	0.516
DOC_MAPK_gen_1	762	772	PF00069	0.350
DOC_MAPK_MEF2A_6	355	364	PF00069	0.494
DOC_MAPK_MEF2A_6	542	551	PF00069	0.501
DOC_MIT_MIM_1	5	14	PF04212	0.673
DOC_PIKK_1	710	717	PF02985	0.526
DOC_PP2B_LxvP_1	176	179	PF13499	0.552
DOC_PP2B_LxvP_1	357	360	PF13499	0.466
DOC_PP2B_LxvP_1	789	792	PF13499	0.676
DOC_PP2B_LxvP_1	813	816	PF13499	0.636
DOC_PP4_FxxP_1	411	414	PF00568	0.534
DOC_PP4_FxxP_1	659	662	PF00568	0.517
DOC_PP4_FxxP_1	804	807	PF00568	0.752
DOC_USP7_MATH_1	181	185	PF00917	0.456
DOC_USP7_MATH_1	213	217	PF00917	0.486
DOC_USP7_MATH_1	419	423	PF00917	0.594
DOC_USP7_MATH_1	442	446	PF00917	0.699
DOC_USP7_MATH_1	728	732	PF00917	0.544
DOC_USP7_MATH_1	816	820	PF00917	0.476
DOC_USP7_MATH_1	884	888	PF00917	0.731
DOC_USP7_MATH_1	906	910	PF00917	0.755
DOC_USP7_MATH_1	912	916	PF00917	0.630
DOC_USP7_MATH_1	976	980	PF00917	0.427
DOC_USP7_UBL2_3	943	947	PF12436	0.732
DOC_WW_Pin1_4	18	23	PF00397	0.738
DOC_WW_Pin1_4	24	29	PF00397	0.644
DOC_WW_Pin1_4	652	657	PF00397	0.435
DOC_WW_Pin1_4	677	682	PF00397	0.378
DOC_WW_Pin1_4	820	825	PF00397	0.761
DOC_WW_Pin1_4	843	848	PF00397	0.747
LIG_14-3-3_CanoR_1	270	276	PF00244	0.436
LIG_14-3-3_CanoR_1	335	340	PF00244	0.542
LIG_14-3-3_CanoR_1	397	405	PF00244	0.511
LIG_14-3-3_CanoR_1	435	440	PF00244	0.563
LIG_14-3-3_CanoR_1	490	496	PF00244	0.414
LIG_14-3-3_CanoR_1	526	531	PF00244	0.496
LIG_14-3-3_CanoR_1	679	688	PF00244	0.513
LIG_14-3-3_CanoR_1	867	872	PF00244	0.703
LIG_14-3-3_CanoR_1	9	15	PF00244	0.683
LIG_14-3-3_CanoR_1	985	993	PF00244	0.390
LIG_Actin_WH2_2	634	651	PF00022	0.529
LIG_Actin_WH2_2	681	698	PF00022	0.474
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BRCT_BRCA1_1	335	339	PF00533	0.546
LIG_BRCT_BRCA1_1	753	757	PF00533	0.532
LIG_Clathr_ClatBox_1	361	365	PF01394	0.510
LIG_CSL_BTD_1	201	204	PF09270	0.236
LIG_deltaCOP1_diTrp_1	459	464	PF00928	0.404
LIG_deltaCOP1_diTrp_1	981	984	PF00928	0.544
LIG_FHA_1	123	129	PF00498	0.392
LIG_FHA_1	13	19	PF00498	0.661
LIG_FHA_1	180	186	PF00498	0.521
LIG_FHA_1	187	193	PF00498	0.460
LIG_FHA_1	259	265	PF00498	0.508
LIG_FHA_1	428	434	PF00498	0.489
LIG_FHA_1	441	447	PF00498	0.522
LIG_FHA_1	778	784	PF00498	0.614
LIG_FHA_1	820	826	PF00498	0.764
LIG_FHA_1	91	97	PF00498	0.489
LIG_FHA_1	978	984	PF00498	0.606
LIG_FHA_2	153	159	PF00498	0.452
LIG_FHA_2	248	254	PF00498	0.519
LIG_FHA_2	398	404	PF00498	0.545
LIG_FHA_2	737	743	PF00498	0.573
LIG_FHA_2	771	777	PF00498	0.661
LIG_FHA_2	851	857	PF00498	0.777
LIG_FHA_2	920	926	PF00498	0.668
LIG_FHA_2	936	942	PF00498	0.644
LIG_LIR_Apic_2	145	150	PF02991	0.529
LIG_LIR_Apic_2	297	301	PF02991	0.391
LIG_LIR_Apic_2	801	807	PF02991	0.748
LIG_LIR_Gen_1	196	205	PF02991	0.398
LIG_LIR_Gen_1	286	296	PF02991	0.462
LIG_LIR_Gen_1	369	379	PF02991	0.420
LIG_LIR_Gen_1	462	471	PF02991	0.453
LIG_LIR_Gen_1	505	515	PF02991	0.411
LIG_LIR_Gen_1	525	534	PF02991	0.520
LIG_LIR_Gen_1	635	644	PF02991	0.431
LIG_LIR_Nem_3	126	132	PF02991	0.476
LIG_LIR_Nem_3	199	205	PF02991	0.389
LIG_LIR_Nem_3	263	268	PF02991	0.338
LIG_LIR_Nem_3	274	279	PF02991	0.397
LIG_LIR_Nem_3	286	292	PF02991	0.305
LIG_LIR_Nem_3	325	331	PF02991	0.380
LIG_LIR_Nem_3	369	374	PF02991	0.407
LIG_LIR_Nem_3	462	467	PF02991	0.429
LIG_LIR_Nem_3	505	510	PF02991	0.411
LIG_LIR_Nem_3	525	530	PF02991	0.513
LIG_LIR_Nem_3	563	569	PF02991	0.533
LIG_LIR_Nem_3	635	639	PF02991	0.448
LIG_LIR_Nem_3	93	97	PF02991	0.515
LIG_LIR_Nem_3	981	987	PF02991	0.643
LIG_MYND_1	658	662	PF01753	0.465
LIG_MYND_1	812	816	PF01753	0.531
LIG_NRBOX	643	649	PF00104	0.546
LIG_PCNA_PIPBox_1	493	502	PF02747	0.413
LIG_Pex14_2	659	663	PF04695	0.406
LIG_Pex14_2	666	670	PF04695	0.329
LIG_Pex14_2	768	772	PF04695	0.425
LIG_PTB_Apo_2	191	198	PF02174	0.272
LIG_PTB_Apo_2	270	277	PF02174	0.357
LIG_PTB_Phospho_1	270	276	PF10480	0.468
LIG_SH2_CRK	226	230	PF00017	0.472
LIG_SH2_CRK	353	357	PF00017	0.424
LIG_SH2_CRK	799	803	PF00017	0.711
LIG_SH2_GRB2like	331	334	PF00017	0.525
LIG_SH2_NCK_1	799	803	PF00017	0.711
LIG_SH2_PTP2	238	241	PF00017	0.458
LIG_SH2_PTP2	298	301	PF00017	0.425
LIG_SH2_SRC	298	301	PF00017	0.238
LIG_SH2_STAP1	371	375	PF00017	0.400
LIG_SH2_STAP1	779	783	PF00017	0.533
LIG_SH2_STAT5	17	20	PF00017	0.699
LIG_SH2_STAT5	238	241	PF00017	0.338
LIG_SH2_STAT5	268	271	PF00017	0.296
LIG_SH2_STAT5	289	292	PF00017	0.455
LIG_SH2_STAT5	298	301	PF00017	0.392
LIG_SH2_STAT5	331	334	PF00017	0.435
LIG_SH2_STAT5	410	413	PF00017	0.541
LIG_SH2_STAT5	432	435	PF00017	0.394
LIG_SH2_STAT5	779	782	PF00017	0.557
LIG_SH3_1	844	850	PF00018	0.802
LIG_SH3_1	898	904	PF00018	0.754
LIG_SH3_3	16	22	PF00018	0.661
LIG_SH3_3	422	428	PF00018	0.553
LIG_SH3_3	436	442	PF00018	0.648
LIG_SH3_3	468	474	PF00018	0.555
LIG_SH3_3	650	656	PF00018	0.448
LIG_SH3_3	806	812	PF00018	0.749
LIG_SH3_3	844	850	PF00018	0.784
LIG_SH3_3	898	904	PF00018	0.749
LIG_SH3_3	915	921	PF00018	0.616
LIG_Sin3_3	787	794	PF02671	0.585
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.500
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.504
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.423
LIG_SUMO_SIM_anti_2	909	916	PF11976	0.722
LIG_SUMO_SIM_par_1	152	158	PF11976	0.416
LIG_SUMO_SIM_par_1	435	440	PF11976	0.578
LIG_TRAF2_1	101	104	PF00917	0.546
LIG_TRAF2_1	586	589	PF00917	0.628
LIG_TRAF2_1	708	711	PF00917	0.486
LIG_UBA3_1	70	79	PF00899	0.567
LIG_UBA3_1	771	777	PF00899	0.530
LIG_WRC_WIRS_1	272	277	PF05994	0.459
LIG_WRC_WIRS_1	291	296	PF05994	0.376
MOD_CDK_SPK_2	677	682	PF00069	0.378
MOD_CK1_1	451	457	PF00069	0.535
MOD_CK1_1	680	686	PF00069	0.471
MOD_CK1_1	819	825	PF00069	0.565
MOD_CK2_1	152	158	PF00069	0.447
MOD_CK2_1	247	253	PF00069	0.515
MOD_CK2_1	444	450	PF00069	0.561
MOD_CK2_1	451	457	PF00069	0.441
MOD_CK2_1	519	525	PF00069	0.458
MOD_CK2_1	583	589	PF00069	0.576
MOD_CK2_1	59	65	PF00069	0.430
MOD_CK2_1	705	711	PF00069	0.536
MOD_CK2_1	728	734	PF00069	0.582
MOD_CK2_1	770	776	PF00069	0.637
MOD_CK2_1	850	856	PF00069	0.738
MOD_CK2_1	935	941	PF00069	0.718
MOD_CK2_1	960	966	PF00069	0.577
MOD_CMANNOS	461	464	PF00535	0.400
MOD_GlcNHglycan	144	147	PF01048	0.602
MOD_GlcNHglycan	302	305	PF01048	0.518
MOD_GlcNHglycan	335	338	PF01048	0.486
MOD_GlcNHglycan	421	424	PF01048	0.580
MOD_GlcNHglycan	649	652	PF01048	0.599
MOD_GlcNHglycan	682	685	PF01048	0.490
MOD_GlcNHglycan	700	703	PF01048	0.276
MOD_GlcNHglycan	862	865	PF01048	0.677
MOD_GlcNHglycan	869	872	PF01048	0.645
MOD_GlcNHglycan	894	897	PF01048	0.531
MOD_GSK3_1	208	215	PF00069	0.441
MOD_GSK3_1	419	426	PF00069	0.399
MOD_GSK3_1	440	447	PF00069	0.624
MOD_GSK3_1	459	466	PF00069	0.482
MOD_GSK3_1	724	731	PF00069	0.518
MOD_GSK3_1	816	823	PF00069	0.601
MOD_GSK3_1	855	862	PF00069	0.667
MOD_GSK3_1	902	909	PF00069	0.725
MOD_N-GLC_1	179	184	PF02516	0.552
MOD_N-GLC_1	193	198	PF02516	0.533
MOD_N-GLC_1	677	682	PF02516	0.378
MOD_N-GLC_1	867	872	PF02516	0.713
MOD_N-GLC_2	544	546	PF02516	0.495
MOD_NEK2_1	114	119	PF00069	0.430
MOD_NEK2_1	186	191	PF00069	0.584
MOD_NEK2_1	271	276	PF00069	0.516
MOD_NEK2_1	290	295	PF00069	0.310
MOD_NEK2_1	309	314	PF00069	0.488
MOD_NEK2_1	448	453	PF00069	0.579
MOD_NEK2_1	46	51	PF00069	0.500
MOD_NEK2_1	463	468	PF00069	0.336
MOD_NEK2_1	484	489	PF00069	0.476
MOD_NEK2_1	59	64	PF00069	0.488
MOD_NEK2_1	637	642	PF00069	0.496
MOD_NEK2_1	647	652	PF00069	0.545
MOD_NEK2_1	770	775	PF00069	0.474
MOD_NEK2_1	826	831	PF00069	0.791
MOD_NEK2_1	859	864	PF00069	0.683
MOD_NEK2_2	213	218	PF00069	0.449
MOD_NEK2_2	926	931	PF00069	0.737
MOD_PIKK_1	751	757	PF00454	0.557
MOD_PIKK_1	829	835	PF00454	0.772
MOD_PK_1	355	361	PF00069	0.353
MOD_PKA_2	448	454	PF00069	0.390
MOD_PKA_2	866	872	PF00069	0.741
MOD_PKB_1	10	18	PF00069	0.551
MOD_Plk_1	193	199	PF00069	0.423
MOD_Plk_1	39	45	PF00069	0.461
MOD_Plk_1	403	409	PF00069	0.518
MOD_Plk_1	855	861	PF00069	0.710
MOD_Plk_2-3	302	308	PF00069	0.429
MOD_Plk_4	152	158	PF00069	0.476
MOD_Plk_4	181	187	PF00069	0.458
MOD_Plk_4	271	277	PF00069	0.459
MOD_Plk_4	323	329	PF00069	0.433
MOD_Plk_4	39	45	PF00069	0.514
MOD_Plk_4	427	433	PF00069	0.536
MOD_Plk_4	448	454	PF00069	0.554
MOD_Plk_4	463	469	PF00069	0.299
MOD_Plk_4	491	497	PF00069	0.395
MOD_Plk_4	502	508	PF00069	0.349
MOD_Plk_4	855	861	PF00069	0.675
MOD_Plk_4	919	925	PF00069	0.629
MOD_Plk_4	960	966	PF00069	0.660
MOD_ProDKin_1	18	24	PF00069	0.738
MOD_ProDKin_1	652	658	PF00069	0.436
MOD_ProDKin_1	677	683	PF00069	0.376
MOD_ProDKin_1	820	826	PF00069	0.763
MOD_ProDKin_1	843	849	PF00069	0.748
MOD_SUMO_for_1	367	370	PF00179	0.424
MOD_SUMO_for_1	398	401	PF00179	0.523
MOD_SUMO_rev_2	258	264	PF00179	0.419
MOD_SUMO_rev_2	936	945	PF00179	0.685
TRG_DiLeu_BaEn_1	3	8	PF01217	0.605
TRG_DiLeu_BaEn_1	40	45	PF01217	0.452
TRG_DiLeu_BaEn_1	621	626	PF01217	0.563
TRG_DiLeu_BaEn_2	369	375	PF01217	0.517
TRG_DiLeu_BaEn_3	40	46	PF01217	0.451
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.226
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.496
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.519
TRG_DiLeu_BaLyEn_6	809	814	PF01217	0.656
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.552
TRG_ENDOCYTIC_2	238	241	PF00928	0.449
TRG_ENDOCYTIC_2	268	271	PF00928	0.331
TRG_ENDOCYTIC_2	276	279	PF00928	0.389
TRG_ENDOCYTIC_2	288	291	PF00928	0.456
TRG_ENDOCYTIC_2	353	356	PF00928	0.376
TRG_ENDOCYTIC_2	371	374	PF00928	0.432
TRG_ENDOCYTIC_2	610	613	PF00928	0.545
TRG_ENDOCYTIC_2	799	802	PF00928	0.709
TRG_ER_diArg_1	129	131	PF00400	0.567
TRG_ER_diArg_1	314	316	PF00400	0.527
TRG_ER_diArg_1	343	346	PF00400	0.480
TRG_ER_diArg_1	348	351	PF00400	0.445
TRG_ER_diArg_1	379	382	PF00400	0.470
TRG_ER_diArg_1	470	473	PF00400	0.481
TRG_ER_diArg_1	50	52	PF00400	0.467
TRG_ER_diArg_1	676	679	PF00400	0.544
TRG_ER_diArg_1	764	767	PF00400	0.493
TRG_ER_diArg_1	8	10	PF00400	0.547
TRG_ER_diArg_1	872	874	PF00400	0.773
TRG_NLS_MonoExtC_3	247	253	PF00514	0.534
TRG_NLS_MonoExtN_4	346	353	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTN3	Leptomonas seymouri	62%	99%
A0A1X0NSF8	Trypanosomatidae	33%	100%
A0A3Q8ITR9	Leishmania donovani	92%	100%
A0A422NHV7	Trypanosoma rangeli	36%	100%
A4HL32	Leishmania braziliensis	83%	100%
A4I8L3	Leishmania infantum	92%	100%
D0AAK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q4M7	Leishmania major	91%	100%
V5AXZ4	Trypanosoma cruzi	36%	100%