WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3G6_LEIMU

TriTrypDb:

LmxM.31.3880

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.571
CLV_NRD_NRD_1	84	86	PF00675	0.498
CLV_PCSK_SKI1_1	182	186	PF00082	0.524
CLV_PCSK_SKI1_1	206	210	PF00082	0.596
DEG_Nend_UBRbox_2	1	3	PF02207	0.450
DEG_ODPH_VHL_1	172	185	PF01847	0.522
DEG_SPOP_SBC_1	19	23	PF00917	0.470
DOC_PP1_RVXF_1	180	186	PF00149	0.546
DOC_PP1_RVXF_1	204	210	PF00149	0.599
DOC_PP4_FxxP_1	48	51	PF00568	0.521
DOC_USP7_MATH_1	109	113	PF00917	0.386
DOC_USP7_MATH_1	15	19	PF00917	0.449
DOC_USP7_MATH_1	302	306	PF00917	0.600
DOC_WW_Pin1_4	146	151	PF00397	0.425
DOC_WW_Pin1_4	214	219	PF00397	0.688
DOC_WW_Pin1_4	261	266	PF00397	0.526
DOC_WW_Pin1_4	276	281	PF00397	0.386
LIG_14-3-3_CanoR_1	49	57	PF00244	0.410
LIG_14-3-3_CanoR_1	85	94	PF00244	0.510
LIG_FHA_1	111	117	PF00498	0.440
LIG_FHA_1	179	185	PF00498	0.568
LIG_FHA_1	283	289	PF00498	0.364
LIG_FHA_1	30	36	PF00498	0.441
LIG_FHA_1	76	82	PF00498	0.474
LIG_FHA_2	32	38	PF00498	0.320
LIG_LIR_Apic_2	276	280	PF02991	0.491
LIG_LIR_Gen_1	153	160	PF02991	0.279
LIG_LIR_Nem_3	153	157	PF02991	0.448
LIG_LIR_Nem_3	21	27	PF02991	0.393
LIG_LIR_Nem_3	245	251	PF02991	0.494
LIG_PDZ_Class_2	356	361	PF00595	0.521
LIG_SH2_NCK_1	127	131	PF00017	0.477
LIG_SH2_SRC	137	140	PF00017	0.439
LIG_SH2_STAT5	137	140	PF00017	0.443
LIG_SH2_STAT5	141	144	PF00017	0.417
LIG_SH2_STAT5	163	166	PF00017	0.391
LIG_SH2_STAT5	274	277	PF00017	0.472
LIG_SH2_STAT5	345	348	PF00017	0.459
LIG_SH2_STAT5	64	67	PF00017	0.490
LIG_SH3_3	212	218	PF00018	0.609
LIG_SH3_3	221	227	PF00018	0.517
LIG_SH3_3	35	41	PF00018	0.562
LIG_SUMO_SIM_par_1	111	121	PF11976	0.436
LIG_SUMO_SIM_par_1	31	37	PF11976	0.474
LIG_TRAF2_1	308	311	PF00917	0.560
MOD_CK1_1	112	118	PF00069	0.523
MOD_CK1_1	17	23	PF00069	0.453
MOD_CK1_1	29	35	PF00069	0.336
MOD_CK1_1	89	95	PF00069	0.525
MOD_CK2_1	246	252	PF00069	0.458
MOD_CK2_1	93	99	PF00069	0.490
MOD_GlcNHglycan	164	167	PF01048	0.474
MOD_GlcNHglycan	17	20	PF01048	0.529
MOD_GlcNHglycan	196	199	PF01048	0.553
MOD_GlcNHglycan	254	258	PF01048	0.480
MOD_GlcNHglycan	304	307	PF01048	0.693
MOD_GlcNHglycan	52	55	PF01048	0.629
MOD_GSK3_1	10	17	PF00069	0.412
MOD_GSK3_1	158	165	PF00069	0.546
MOD_GSK3_1	19	26	PF00069	0.425
MOD_GSK3_1	89	96	PF00069	0.510
MOD_N-GLC_1	229	234	PF02516	0.490
MOD_N-GLC_2	162	164	PF02516	0.394
MOD_N-GLC_2	98	100	PF02516	0.242
MOD_NEK2_1	110	115	PF00069	0.321
MOD_NEK2_1	284	289	PF00069	0.385
MOD_NEK2_1	301	306	PF00069	0.449
MOD_NEK2_1	81	86	PF00069	0.497
MOD_NEK2_2	246	251	PF00069	0.525
MOD_PKA_2	158	164	PF00069	0.336
MOD_PKA_2	5	11	PF00069	0.452
MOD_Plk_1	152	158	PF00069	0.354
MOD_Plk_1	202	208	PF00069	0.452
MOD_Plk_1	229	235	PF00069	0.491
MOD_Plk_2-3	93	99	PF00069	0.470
MOD_Plk_4	112	118	PF00069	0.446
MOD_Plk_4	246	252	PF00069	0.450
MOD_Plk_4	31	37	PF00069	0.395
MOD_ProDKin_1	146	152	PF00069	0.430
MOD_ProDKin_1	214	220	PF00069	0.691
MOD_ProDKin_1	261	267	PF00069	0.525
MOD_ProDKin_1	276	282	PF00069	0.383
TRG_DiLeu_BaEn_2	98	104	PF01217	0.390
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.542
TRG_ENDOCYTIC_2	154	157	PF00928	0.403
TRG_ENDOCYTIC_2	45	48	PF00928	0.432
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3G5	Leptomonas seymouri	59%	99%
A0A1X0NS90	Trypanosomatidae	34%	98%
A0A3S5IR82	Trypanosoma rangeli	34%	100%
A0A3S7X6A3	Leishmania donovani	90%	100%
A4HL25	Leishmania braziliensis	82%	100%
A4I8K6	Leishmania infantum	90%	100%
D0AAK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q4N4	Leishmania major	87%	99%
V5DE80	Trypanosoma cruzi	33%	100%