LeishMANIAdb
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SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SET domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3G4_LEIMU
TriTrypDb:
LmxM.31.3860
Length:
916

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3G4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3G4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 408 412 PF00656 0.609
CLV_C14_Caspase3-7 585 589 PF00656 0.685
CLV_NRD_NRD_1 228 230 PF00675 0.580
CLV_NRD_NRD_1 25 27 PF00675 0.554
CLV_NRD_NRD_1 357 359 PF00675 0.506
CLV_NRD_NRD_1 392 394 PF00675 0.541
CLV_NRD_NRD_1 607 609 PF00675 0.657
CLV_NRD_NRD_1 735 737 PF00675 0.706
CLV_PCSK_KEX2_1 218 220 PF00082 0.490
CLV_PCSK_KEX2_1 228 230 PF00082 0.496
CLV_PCSK_KEX2_1 356 358 PF00082 0.531
CLV_PCSK_KEX2_1 605 607 PF00082 0.609
CLV_PCSK_KEX2_1 735 737 PF00082 0.672
CLV_PCSK_KEX2_1 87 89 PF00082 0.483
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.606
CLV_PCSK_PC1ET2_1 356 358 PF00082 0.510
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.609
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.483
CLV_PCSK_SKI1_1 260 264 PF00082 0.637
CLV_PCSK_SKI1_1 379 383 PF00082 0.459
CLV_PCSK_SKI1_1 472 476 PF00082 0.479
CLV_PCSK_SKI1_1 523 527 PF00082 0.430
CLV_PCSK_SKI1_1 645 649 PF00082 0.452
CLV_PCSK_SKI1_1 670 674 PF00082 0.467
CLV_PCSK_SKI1_1 96 100 PF00082 0.485
DEG_APCC_DBOX_1 95 103 PF00400 0.403
DEG_COP1_1 429 438 PF00400 0.416
DEG_SCF_FBW7_1 861 868 PF00400 0.576
DEG_SPOP_SBC_1 170 174 PF00917 0.579
DOC_CKS1_1 690 695 PF01111 0.522
DOC_CKS1_1 862 867 PF01111 0.703
DOC_CYCLIN_RxL_1 104 112 PF00134 0.513
DOC_CYCLIN_RxL_1 212 223 PF00134 0.605
DOC_CYCLIN_RxL_1 323 334 PF00134 0.365
DOC_CYCLIN_yCln2_LP_2 3 9 PF00134 0.480
DOC_MAPK_gen_1 218 224 PF00069 0.526
DOC_MAPK_gen_1 23 31 PF00069 0.548
DOC_MAPK_gen_1 854 862 PF00069 0.616
DOC_MAPK_gen_1 92 101 PF00069 0.413
DOC_MAPK_MEF2A_6 43 51 PF00069 0.459
DOC_MAPK_MEF2A_6 717 725 PF00069 0.423
DOC_MAPK_MEF2A_6 854 862 PF00069 0.728
DOC_PP2B_LxvP_1 111 114 PF13499 0.584
DOC_PP2B_LxvP_1 628 631 PF13499 0.459
DOC_PP2B_LxvP_1 675 678 PF13499 0.527
DOC_PP2B_LxvP_1 753 756 PF13499 0.544
DOC_PP2B_LxvP_1 884 887 PF13499 0.477
DOC_USP7_MATH_1 164 168 PF00917 0.475
DOC_USP7_MATH_1 240 244 PF00917 0.485
DOC_USP7_MATH_1 486 490 PF00917 0.545
DOC_USP7_MATH_1 513 517 PF00917 0.574
DOC_USP7_MATH_1 62 66 PF00917 0.507
DOC_USP7_MATH_1 759 763 PF00917 0.647
DOC_USP7_MATH_1 865 869 PF00917 0.567
DOC_USP7_UBL2_3 23 27 PF12436 0.561
DOC_USP7_UBL2_3 378 382 PF12436 0.427
DOC_USP7_UBL2_3 876 880 PF12436 0.573
DOC_WW_Pin1_4 2 7 PF00397 0.626
DOC_WW_Pin1_4 600 605 PF00397 0.705
DOC_WW_Pin1_4 689 694 PF00397 0.558
DOC_WW_Pin1_4 725 730 PF00397 0.675
DOC_WW_Pin1_4 824 829 PF00397 0.579
DOC_WW_Pin1_4 861 866 PF00397 0.585
LIG_14-3-3_CanoR_1 107 112 PF00244 0.607
LIG_14-3-3_CanoR_1 163 169 PF00244 0.711
LIG_14-3-3_CanoR_1 219 225 PF00244 0.566
LIG_14-3-3_CanoR_1 627 631 PF00244 0.443
LIG_14-3-3_CanoR_1 63 70 PF00244 0.397
LIG_14-3-3_CanoR_1 670 678 PF00244 0.591
LIG_14-3-3_CanoR_1 854 859 PF00244 0.626
LIG_BIR_III_2 103 107 PF00653 0.577
LIG_BRCT_BRCA1_1 515 519 PF00533 0.541
LIG_CaM_IQ_9 29 45 PF13499 0.298
LIG_CSK_EPIYA_1 295 299 PF00017 0.467
LIG_FHA_1 190 196 PF00498 0.692
LIG_FHA_1 411 417 PF00498 0.536
LIG_FHA_1 486 492 PF00498 0.504
LIG_FHA_1 546 552 PF00498 0.581
LIG_FHA_1 620 626 PF00498 0.402
LIG_FHA_2 370 376 PF00498 0.503
LIG_FHA_2 403 409 PF00498 0.480
LIG_FHA_2 576 582 PF00498 0.627
LIG_FHA_2 631 637 PF00498 0.347
LIG_FHA_2 771 777 PF00498 0.461
LIG_FHA_2 801 807 PF00498 0.431
LIG_FHA_2 844 850 PF00498 0.534
LIG_LIR_Apic_2 139 145 PF02991 0.429
LIG_LIR_Gen_1 295 305 PF02991 0.392
LIG_LIR_Gen_1 429 438 PF02991 0.510
LIG_LIR_Gen_1 643 652 PF02991 0.523
LIG_LIR_Gen_1 691 702 PF02991 0.426
LIG_LIR_LC3C_4 762 767 PF02991 0.453
LIG_LIR_Nem_3 295 301 PF02991 0.457
LIG_LIR_Nem_3 422 428 PF02991 0.476
LIG_LIR_Nem_3 443 449 PF02991 0.523
LIG_LIR_Nem_3 643 649 PF02991 0.525
LIG_LIR_Nem_3 691 697 PF02991 0.445
LIG_NRBOX 366 372 PF00104 0.469
LIG_NRP_CendR_1 915 916 PF00754 0.494
LIG_Pex14_1 151 155 PF04695 0.538
LIG_SH2_CRK 298 302 PF00017 0.447
LIG_SH2_CRK 305 309 PF00017 0.452
LIG_SH2_CRK 694 698 PF00017 0.533
LIG_SH2_CRK 838 842 PF00017 0.475
LIG_SH2_CRK 95 99 PF00017 0.487
LIG_SH2_PTP2 646 649 PF00017 0.518
LIG_SH2_STAT3 531 534 PF00017 0.511
LIG_SH2_STAT5 100 103 PF00017 0.353
LIG_SH2_STAT5 184 187 PF00017 0.572
LIG_SH2_STAT5 531 534 PF00017 0.380
LIG_SH2_STAT5 646 649 PF00017 0.613
LIG_SH2_STAT5 770 773 PF00017 0.621
LIG_SH2_STAT5 910 913 PF00017 0.482
LIG_SH3_3 188 194 PF00018 0.556
LIG_SH3_3 463 469 PF00018 0.602
LIG_SH3_3 646 652 PF00018 0.457
LIG_SH3_3 653 659 PF00018 0.437
LIG_SH3_3 684 690 PF00018 0.561
LIG_SH3_3 696 702 PF00018 0.335
LIG_SH3_3 763 769 PF00018 0.342
LIG_SH3_3 859 865 PF00018 0.591
LIG_SUMO_SIM_anti_2 405 411 PF11976 0.588
LIG_SUMO_SIM_anti_2 762 768 PF11976 0.375
LIG_SUMO_SIM_par_1 495 500 PF11976 0.580
LIG_SUMO_SIM_par_1 553 558 PF11976 0.439
LIG_TRAF2_1 542 545 PF00917 0.515
LIG_TYR_ITSM 690 697 PF00017 0.545
LIG_UBA3_1 286 291 PF00899 0.455
LIG_WRC_WIRS_1 435 440 PF05994 0.492
LIG_WRC_WIRS_1 446 451 PF05994 0.493
MOD_CDC14_SPxK_1 728 731 PF00782 0.517
MOD_CDK_SPK_2 600 605 PF00069 0.622
MOD_CDK_SPxK_1 600 606 PF00069 0.706
MOD_CDK_SPxK_1 725 731 PF00069 0.515
MOD_CDK_SPxxK_3 600 607 PF00069 0.706
MOD_CK1_1 243 249 PF00069 0.584
MOD_CK1_1 319 325 PF00069 0.511
MOD_CK1_1 489 495 PF00069 0.562
MOD_CK1_1 575 581 PF00069 0.686
MOD_CK1_1 676 682 PF00069 0.627
MOD_CK2_1 331 337 PF00069 0.351
MOD_CK2_1 369 375 PF00069 0.509
MOD_CK2_1 402 408 PF00069 0.642
MOD_CK2_1 630 636 PF00069 0.386
MOD_CK2_1 647 653 PF00069 0.559
MOD_CK2_1 776 782 PF00069 0.533
MOD_CK2_1 800 806 PF00069 0.425
MOD_GlcNHglycan 111 114 PF01048 0.637
MOD_GlcNHglycan 469 472 PF01048 0.669
MOD_GlcNHglycan 515 518 PF01048 0.507
MOD_GlcNHglycan 560 563 PF01048 0.455
MOD_GlcNHglycan 588 591 PF01048 0.720
MOD_GlcNHglycan 593 596 PF01048 0.726
MOD_GlcNHglycan 64 67 PF01048 0.461
MOD_GlcNHglycan 649 652 PF01048 0.600
MOD_GlcNHglycan 761 764 PF01048 0.520
MOD_GSK3_1 164 171 PF00069 0.532
MOD_GSK3_1 369 376 PF00069 0.420
MOD_GSK3_1 485 492 PF00069 0.506
MOD_GSK3_1 596 603 PF00069 0.696
MOD_GSK3_1 626 633 PF00069 0.310
MOD_GSK3_1 861 868 PF00069 0.521
MOD_N-GLC_1 107 112 PF02516 0.576
MOD_N-GLC_1 489 494 PF02516 0.559
MOD_N-GLC_1 600 605 PF02516 0.705
MOD_NEK2_1 109 114 PF00069 0.641
MOD_NEK2_1 195 200 PF00069 0.525
MOD_NEK2_1 220 225 PF00069 0.613
MOD_NEK2_1 245 250 PF00069 0.617
MOD_NEK2_1 331 336 PF00069 0.330
MOD_NEK2_1 385 390 PF00069 0.526
MOD_NEK2_1 497 502 PF00069 0.571
MOD_NEK2_2 234 239 PF00069 0.624
MOD_NEK2_2 910 915 PF00069 0.552
MOD_PIKK_1 171 177 PF00454 0.566
MOD_PIKK_1 373 379 PF00454 0.585
MOD_PIKK_1 489 495 PF00454 0.538
MOD_PKA_2 16 22 PF00069 0.433
MOD_PKA_2 572 578 PF00069 0.551
MOD_PKA_2 62 68 PF00069 0.325
MOD_PKA_2 626 632 PF00069 0.418
MOD_Plk_1 107 113 PF00069 0.511
MOD_Plk_1 240 246 PF00069 0.514
MOD_Plk_1 673 679 PF00069 0.647
MOD_Plk_1 799 805 PF00069 0.334
MOD_Plk_2-3 369 375 PF00069 0.353
MOD_Plk_2-3 776 782 PF00069 0.533
MOD_Plk_2-3 800 806 PF00069 0.293
MOD_Plk_4 184 190 PF00069 0.494
MOD_Plk_4 220 226 PF00069 0.558
MOD_Plk_4 434 440 PF00069 0.514
MOD_Plk_4 445 451 PF00069 0.470
MOD_Plk_4 692 698 PF00069 0.482
MOD_ProDKin_1 2 8 PF00069 0.623
MOD_ProDKin_1 600 606 PF00069 0.706
MOD_ProDKin_1 689 695 PF00069 0.552
MOD_ProDKin_1 725 731 PF00069 0.677
MOD_ProDKin_1 824 830 PF00069 0.576
MOD_ProDKin_1 861 867 PF00069 0.577
MOD_SUMO_for_1 157 160 PF00179 0.476
MOD_SUMO_for_1 381 384 PF00179 0.461
MOD_SUMO_for_1 663 666 PF00179 0.337
TRG_DiLeu_BaEn_1 461 466 PF01217 0.489
TRG_ENDOCYTIC_2 152 155 PF00928 0.545
TRG_ENDOCYTIC_2 298 301 PF00928 0.385
TRG_ENDOCYTIC_2 305 308 PF00928 0.389
TRG_ENDOCYTIC_2 446 449 PF00928 0.538
TRG_ENDOCYTIC_2 646 649 PF00928 0.518
TRG_ENDOCYTIC_2 694 697 PF00928 0.529
TRG_ENDOCYTIC_2 95 98 PF00928 0.381
TRG_ER_diArg_1 228 230 PF00400 0.580
TRG_ER_diArg_1 606 608 PF00400 0.605
TRG_ER_diArg_1 914 916 PF00400 0.476
TRG_NES_CRM1_1 125 139 PF08389 0.448
TRG_NES_CRM1_1 545 558 PF08389 0.523
TRG_NES_CRM1_1 666 680 PF08389 0.607
TRG_NES_CRM1_1 800 814 PF08389 0.370
TRG_NLS_MonoCore_2 604 609 PF00514 0.628
TRG_NLS_MonoExtC_3 377 382 PF00514 0.504
TRG_NLS_MonoExtC_3 604 610 PF00514 0.581
TRG_NLS_MonoExtN_4 378 383 PF00514 0.559
TRG_NLS_MonoExtN_4 604 609 PF00514 0.669
TRG_Pf-PMV_PEXEL_1 260 264 PF00026 0.466
TRG_Pf-PMV_PEXEL_1 365 369 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 387 392 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 607 611 PF00026 0.469
TRG_Pf-PMV_PEXEL_1 670 674 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P499 Leptomonas seymouri 68% 94%
A0A1X0NSE3 Trypanosomatidae 44% 98%
A0A3R7L0F4 Trypanosoma rangeli 42% 97%
A0A3S5H7T5 Leishmania donovani 94% 100%
A4HL23 Leishmania braziliensis 84% 100%
A4I8K4 Leishmania infantum 94% 100%
D0AAL2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 97%
Q4Q4N6 Leishmania major 94% 100%
V5BMI7 Trypanosoma cruzi 44% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS