Cornichon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cornichon

Gene product:

Cornichon protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3G2_LEIMU

TriTrypDb:

LmxM.31.3840

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B3G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3G2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.505
CLV_NRD_NRD_1	32	34	PF00675	0.342
CLV_PCSK_KEX2_1	34	36	PF00082	0.321
CLV_PCSK_KEX2_1	5	7	PF00082	0.415
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.356
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.415
CLV_PCSK_SKI1_1	143	147	PF00082	0.290
CLV_PCSK_SKI1_1	35	39	PF00082	0.361
DEG_APCC_DBOX_1	34	42	PF00400	0.537
DOC_CDC14_PxL_1	15	23	PF14671	0.616
DOC_CYCLIN_RxL_1	140	150	PF00134	0.535
DOC_MAPK_gen_1	31	40	PF00069	0.585
DOC_MAPK_MEF2A_6	33	42	PF00069	0.496
DOC_PP1_RVXF_1	10	16	PF00149	0.594
LIG_14-3-3_CanoR_1	110	116	PF00244	0.505
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	121	125	PF00533	0.442
LIG_EH1_1	52	60	PF00400	0.338
LIG_EH1_1	96	104	PF00400	0.353
LIG_FHA_1	2	8	PF00498	0.663
LIG_LIR_Gen_1	120	131	PF02991	0.534
LIG_LIR_Gen_1	45	54	PF02991	0.346
LIG_LIR_Nem_3	120	126	PF02991	0.524
LIG_LIR_Nem_3	150	156	PF02991	0.484
LIG_LIR_Nem_3	177	183	PF02991	0.390
LIG_LIR_Nem_3	45	49	PF02991	0.362
LIG_NRBOX	37	43	PF00104	0.409
LIG_OCRL_FandH_1	38	50	PF00620	0.422
LIG_PDZ_Class_2	183	188	PF00595	0.436
LIG_Pex14_1	61	65	PF04695	0.353
LIG_Pex14_2	11	15	PF04695	0.633
LIG_Pex14_2	175	179	PF04695	0.218
LIG_SH2_CRK	169	173	PF00017	0.384
LIG_SH2_SRC	85	88	PF00017	0.505
LIG_SH2_STAP1	135	139	PF00017	0.476
LIG_SH2_STAP1	85	89	PF00017	0.483
LIG_SH2_STAT3	135	138	PF00017	0.495
LIG_SH2_STAT5	180	183	PF00017	0.382
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.455
LIG_SUMO_SIM_par_1	18	24	PF11976	0.596
LIG_WRC_WIRS_1	156	161	PF05994	0.436
LIG_WRC_WIRS_1	182	187	PF05994	0.261
MOD_CK1_1	26	32	PF00069	0.575
MOD_CK2_1	26	32	PF00069	0.594
MOD_GlcNHglycan	28	31	PF01048	0.328
MOD_GlcNHglycan	68	71	PF01048	0.396
MOD_GSK3_1	53	60	PF00069	0.430
MOD_GSK3_1	66	73	PF00069	0.344
MOD_GSK3_1	98	105	PF00069	0.353
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	119	124	PF00069	0.473
MOD_NEK2_1	181	186	PF00069	0.287
MOD_NEK2_1	42	47	PF00069	0.365
MOD_Plk_1	147	153	PF00069	0.430
MOD_Plk_4	119	125	PF00069	0.459
MOD_Plk_4	148	154	PF00069	0.484
MOD_Plk_4	181	187	PF00069	0.214
MOD_Plk_4	42	48	PF00069	0.382
MOD_Plk_4	53	59	PF00069	0.365
MOD_Plk_4	98	104	PF00069	0.353
MOD_SUMO_rev_2	26	36	PF00179	0.580
TRG_ENDOCYTIC_2	169	172	PF00928	0.320
TRG_NES_CRM1_1	94	106	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W0	Leptomonas seymouri	70%	99%
A0A0N1HVI2	Leptomonas seymouri	25%	100%
A0A0S4IRN3	Bodo saltans	24%	86%
A0A1X0P478	Trypanosomatidae	41%	99%
A0A3Q8IH86	Leishmania donovani	88%	100%
A0A3Q8IHH3	Leishmania donovani	24%	100%
A0A3R7KL43	Trypanosoma rangeli	41%	99%
A4HL20	Leishmania braziliensis	24%	100%
A4HL21	Leishmania braziliensis	68%	100%
A4I8K1	Leishmania infantum	24%	100%
A4I8K2	Leishmania infantum	88%	100%
E9B3G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q4N8	Leishmania major	82%	100%
Q4Q4N9	Leishmania major	24%	100%
Q84W04	Arabidopsis thaliana	25%	100%
V5BLE0	Trypanosoma cruzi	25%	100%