WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3G0_LEIMU

TriTrypDb:

LmxM.31.3820

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0034708	methyltransferase complex	4	11
GO:0035097	histone methyltransferase complex	3	11
GO:0048188	Set1C/COMPASS complex	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Expansion

Sequence features

E9B3G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3G0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018023	peptidyl-lysine trimethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051568	histone H3-K4 methylation	7	1
GO:0071704	organic substance metabolic process	2	4
GO:0080182	histone H3-K4 trimethylation	7	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.413
CLV_PCSK_KEX2_1	180	182	PF00082	0.534
CLV_PCSK_KEX2_1	247	249	PF00082	0.433
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.483
CLV_PCSK_SKI1_1	131	135	PF00082	0.361
CLV_PCSK_SKI1_1	149	153	PF00082	0.427
CLV_PCSK_SKI1_1	174	178	PF00082	0.423
CLV_PCSK_SKI1_1	181	185	PF00082	0.404
CLV_PCSK_SKI1_1	194	198	PF00082	0.383
CLV_PCSK_SKI1_1	217	221	PF00082	0.474
CLV_PCSK_SKI1_1	248	252	PF00082	0.494
CLV_PCSK_SKI1_1	282	286	PF00082	0.387
CLV_PCSK_SKI1_1	332	336	PF00082	0.438
DEG_APCC_DBOX_1	184	192	PF00400	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.601
DEG_SCF_FBW7_1	104	111	PF00400	0.476
DEG_SCF_FBW7_1	143	150	PF00400	0.491
DEG_SPOP_SBC_1	196	200	PF00917	0.563
DOC_CYCLIN_RxL_1	204	214	PF00134	0.525
DOC_MAPK_MEF2A_6	310	318	PF00069	0.443
DOC_PP1_RVXF_1	129	136	PF00149	0.232
DOC_PP1_RVXF_1	205	212	PF00149	0.516
DOC_PP1_RVXF_1	330	337	PF00149	0.432
DOC_PP4_FxxP_1	184	187	PF00568	0.458
DOC_USP7_MATH_1	147	151	PF00917	0.553
DOC_USP7_MATH_1	213	217	PF00917	0.405
DOC_USP7_MATH_1	291	295	PF00917	0.574
DOC_USP7_MATH_1	330	334	PF00917	0.460
DOC_USP7_MATH_1	338	342	PF00917	0.525
DOC_WW_Pin1_4	104	109	PF00397	0.480
DOC_WW_Pin1_4	143	148	PF00397	0.487
DOC_WW_Pin1_4	266	271	PF00397	0.489
LIG_14-3-3_CanoR_1	217	227	PF00244	0.500
LIG_14-3-3_CanoR_1	332	337	PF00244	0.437
LIG_14-3-3_CanoR_1	57	67	PF00244	0.403
LIG_BIR_III_4	255	259	PF00653	0.413
LIG_BIR_III_4	49	53	PF00653	0.520
LIG_BRCT_BRCA1_1	84	88	PF00533	0.542
LIG_FHA_1	117	123	PF00498	0.463
LIG_FHA_1	41	47	PF00498	0.407
LIG_FHA_2	347	353	PF00498	0.672
LIG_FHA_2	39	45	PF00498	0.537
LIG_LIR_Gen_1	107	118	PF02991	0.420
LIG_LIR_Gen_1	345	355	PF02991	0.592
LIG_LIR_Nem_3	107	113	PF02991	0.418
LIG_LIR_Nem_3	17	21	PF02991	0.492
LIG_LIR_Nem_3	333	339	PF02991	0.391
LIG_LIR_Nem_3	345	350	PF02991	0.500
LIG_MLH1_MIPbox_1	84	88	PF16413	0.557
LIG_PTB_Apo_2	52	59	PF02174	0.507
LIG_PTB_Phospho_1	52	58	PF10480	0.509
LIG_SH2_CRK	110	114	PF00017	0.383
LIG_SH2_CRK	3	7	PF00017	0.621
LIG_SH2_CRK	347	351	PF00017	0.665
LIG_SH2_GRB2like	93	96	PF00017	0.605
LIG_SH2_STAP1	110	114	PF00017	0.461
LIG_SH2_STAT3	305	308	PF00017	0.477
LIG_SH2_STAT5	241	244	PF00017	0.418
LIG_SH2_STAT5	3	6	PF00017	0.594
LIG_SH2_STAT5	58	61	PF00017	0.495
LIG_SH2_STAT5	93	96	PF00017	0.561
LIG_SUMO_SIM_par_1	174	179	PF11976	0.414
LIG_SUMO_SIM_par_1	186	192	PF11976	0.427
LIG_TYR_ITIM	228	233	PF00017	0.434
LIG_UBA3_1	303	310	PF00899	0.564
MOD_CDK_SPxK_1	143	149	PF00069	0.529
MOD_CK1_1	25	31	PF00069	0.454
MOD_CK1_1	276	282	PF00069	0.545
MOD_CK1_1	292	298	PF00069	0.476
MOD_CK1_1	309	315	PF00069	0.491
MOD_CK2_1	220	226	PF00069	0.396
MOD_CK2_1	339	345	PF00069	0.605
MOD_CK2_1	346	352	PF00069	0.661
MOD_GlcNHglycan	139	142	PF01048	0.439
MOD_GlcNHglycan	210	214	PF01048	0.455
MOD_GlcNHglycan	223	226	PF01048	0.377
MOD_GlcNHglycan	24	27	PF01048	0.464
MOD_GlcNHglycan	252	255	PF01048	0.587
MOD_GSK3_1	104	111	PF00069	0.475
MOD_GSK3_1	143	150	PF00069	0.405
MOD_GSK3_1	195	202	PF00069	0.538
MOD_GSK3_1	209	216	PF00069	0.305
MOD_GSK3_1	272	279	PF00069	0.550
MOD_GSK3_1	291	298	PF00069	0.568
MOD_GSK3_1	326	333	PF00069	0.458
MOD_GSK3_1	56	63	PF00069	0.496
MOD_N-GLC_1	14	19	PF02516	0.520
MOD_N-GLC_1	292	297	PF02516	0.342
MOD_N-GLC_1	38	43	PF02516	0.516
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	197	202	PF00069	0.504
MOD_NEK2_1	218	223	PF00069	0.372
MOD_NEK2_1	272	277	PF00069	0.481
MOD_NEK2_1	326	331	PF00069	0.378
MOD_NEK2_1	339	344	PF00069	0.580
MOD_PIKK_1	82	88	PF00454	0.556
MOD_PKA_2	56	62	PF00069	0.402
MOD_PKA_2	9	15	PF00069	0.435
MOD_Plk_1	14	20	PF00069	0.371
MOD_Plk_1	147	153	PF00069	0.432
MOD_Plk_1	213	219	PF00069	0.498
MOD_Plk_1	82	88	PF00069	0.556
MOD_Plk_4	339	345	PF00069	0.510
MOD_Plk_4	60	66	PF00069	0.522
MOD_ProDKin_1	104	110	PF00069	0.467
MOD_ProDKin_1	143	149	PF00069	0.494
MOD_ProDKin_1	266	272	PF00069	0.484
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.425
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.520
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.559
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.378
TRG_ENDOCYTIC_2	110	113	PF00928	0.386
TRG_ENDOCYTIC_2	230	233	PF00928	0.443
TRG_ENDOCYTIC_2	3	6	PF00928	0.620
TRG_ENDOCYTIC_2	347	350	PF00928	0.585
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC17	Leptomonas seymouri	72%	93%
A0A0S4IL54	Bodo saltans	30%	82%
A0A1X0NRZ4	Trypanosomatidae	52%	100%
A0A3S7X6A1	Leishmania donovani	95%	100%
A0A422P323	Trypanosoma rangeli	53%	99%
A4HL19	Leishmania braziliensis	91%	100%
A4I8K0	Leishmania infantum	96%	100%
D0AAL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q4P0	Leishmania major	96%	100%
V5BR02	Trypanosoma cruzi	52%	89%