SHQ1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SHQ1 protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3F9_LEIMU

TriTrypDb:

LmxM.31.3810

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3F9

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	12
GO:0000493	box H/ACA snoRNP assembly	8	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.628
CLV_C14_Caspase3-7	181	185	PF00656	0.428
CLV_C14_Caspase3-7	87	91	PF00656	0.406
CLV_NRD_NRD_1	194	196	PF00675	0.387
CLV_NRD_NRD_1	439	441	PF00675	0.237
CLV_PCSK_KEX2_1	194	196	PF00082	0.391
CLV_PCSK_KEX2_1	439	441	PF00082	0.237
CLV_PCSK_SKI1_1	286	290	PF00082	0.585
CLV_PCSK_SKI1_1	374	378	PF00082	0.248
CLV_PCSK_SKI1_1	439	443	PF00082	0.237
CLV_PCSK_SKI1_1	463	467	PF00082	0.251
CLV_PCSK_SKI1_1	473	477	PF00082	0.221
CLV_PCSK_SKI1_1	479	483	PF00082	0.205
CLV_PCSK_SKI1_1	488	492	PF00082	0.237
CLV_PCSK_SKI1_1	515	519	PF00082	0.288
CLV_PCSK_SKI1_1	548	552	PF00082	0.394
DEG_APCC_DBOX_1	101	109	PF00400	0.505
DEG_APCC_DBOX_1	368	376	PF00400	0.491
DEG_Nend_Nbox_1	1	3	PF02207	0.382
DEG_SCF_FBW7_2	1	7	PF00400	0.490
DOC_CKS1_1	1	6	PF01111	0.377
DOC_CYCLIN_RxL_1	369	380	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.396
DOC_MAPK_DCC_7	369	377	PF00069	0.504
DOC_MAPK_DCC_7	548	557	PF00069	0.372
DOC_MAPK_gen_1	100	108	PF00069	0.472
DOC_MAPK_gen_1	352	359	PF00069	0.495
DOC_MAPK_gen_1	369	377	PF00069	0.514
DOC_MAPK_gen_1	512	520	PF00069	0.446
DOC_MAPK_MEF2A_6	352	359	PF00069	0.530
DOC_MAPK_MEF2A_6	369	377	PF00069	0.394
DOC_MAPK_MEF2A_6	473	482	PF00069	0.564
DOC_MAPK_MEF2A_6	512	520	PF00069	0.446
DOC_PP1_RVXF_1	372	378	PF00149	0.460
DOC_PP1_RVXF_1	47	53	PF00149	0.327
DOC_PP2B_LxvP_1	348	351	PF13499	0.378
DOC_PP2B_LxvP_1	376	379	PF13499	0.421
DOC_PP2B_LxvP_1	560	563	PF13499	0.360
DOC_PP4_FxxP_1	298	301	PF00568	0.496
DOC_USP7_MATH_1	112	116	PF00917	0.696
DOC_USP7_MATH_1	144	148	PF00917	0.709
DOC_USP7_MATH_1	201	205	PF00917	0.297
DOC_USP7_MATH_1	316	320	PF00917	0.731
DOC_USP7_MATH_1	326	330	PF00917	0.600
DOC_USP7_MATH_1	334	338	PF00917	0.560
DOC_USP7_MATH_2	152	158	PF00917	0.433
DOC_WW_Pin1_4	377	382	PF00397	0.502
DOC_WW_Pin1_4	41	46	PF00397	0.473
DOC_WW_Pin1_4	415	420	PF00397	0.437
LIG_14-3-3_CanoR_1	102	106	PF00244	0.499
LIG_14-3-3_CanoR_1	286	291	PF00244	0.577
LIG_14-3-3_CanoR_1	63	67	PF00244	0.404
LIG_Actin_WH2_2	226	243	PF00022	0.283
LIG_BIR_III_2	284	288	PF00653	0.598
LIG_BIR_III_4	217	221	PF00653	0.375
LIG_BRCT_BRCA1_1	156	160	PF00533	0.392
LIG_BRCT_BRCA1_1	164	168	PF00533	0.328
LIG_BRCT_BRCA1_1	355	359	PF00533	0.372
LIG_BRCT_BRCA1_2	164	170	PF00533	0.511
LIG_Clathr_ClatBox_1	212	216	PF01394	0.403
LIG_EH1_1	13	21	PF00400	0.346
LIG_EH1_1	205	213	PF00400	0.438
LIG_EH1_1	469	477	PF00400	0.445
LIG_eIF4E_1	447	453	PF01652	0.527
LIG_eIF4E_1	470	476	PF01652	0.448
LIG_FHA_1	362	368	PF00498	0.591
LIG_FHA_1	386	392	PF00498	0.441
LIG_FHA_1	460	466	PF00498	0.555
LIG_FHA_1	491	497	PF00498	0.462
LIG_FHA_1	63	69	PF00498	0.396
LIG_FHA_1	72	78	PF00498	0.343
LIG_FHA_2	187	193	PF00498	0.426
LIG_FHA_2	427	433	PF00498	0.539
LIG_FHA_2	85	91	PF00498	0.397
LIG_LIR_Apic_2	297	301	PF02991	0.519
LIG_LIR_Apic_2	40	45	PF02991	0.424
LIG_LIR_Apic_2	422	426	PF02991	0.462
LIG_LIR_Apic_2	492	498	PF02991	0.450
LIG_LIR_Gen_1	11	21	PF02991	0.346
LIG_LIR_Gen_1	165	176	PF02991	0.388
LIG_LIR_Gen_1	394	401	PF02991	0.439
LIG_LIR_Gen_1	44	52	PF02991	0.435
LIG_LIR_Gen_1	83	94	PF02991	0.384
LIG_LIR_Nem_3	11	17	PF02991	0.347
LIG_LIR_Nem_3	165	171	PF02991	0.382
LIG_LIR_Nem_3	36	42	PF02991	0.414
LIG_LIR_Nem_3	394	400	PF02991	0.439
LIG_LIR_Nem_3	44	50	PF02991	0.421
LIG_LIR_Nem_3	83	89	PF02991	0.375
LIG_MYND_3	562	566	PF01753	0.312
LIG_OCRL_FandH_1	13	25	PF00620	0.226
LIG_PCNA_yPIPBox_3	463	476	PF02747	0.474
LIG_Pex14_2	160	164	PF04695	0.356
LIG_PTB_Apo_2	26	33	PF02174	0.382
LIG_PTB_Apo_2	88	95	PF02174	0.398
LIG_PTB_Phospho_1	88	94	PF10480	0.406
LIG_SH2_CRK	42	46	PF00017	0.431
LIG_SH2_SRC	228	231	PF00017	0.480
LIG_SH2_SRC	423	426	PF00017	0.539
LIG_SH2_SRC	495	498	PF00017	0.491
LIG_SH2_SRC	94	97	PF00017	0.357
LIG_SH2_STAP1	397	401	PF00017	0.448
LIG_SH2_STAP1	431	435	PF00017	0.437
LIG_SH2_STAP1	470	474	PF00017	0.539
LIG_SH2_STAP1	66	70	PF00017	0.445
LIG_SH2_STAT5	130	133	PF00017	0.542
LIG_SH2_STAT5	228	231	PF00017	0.357
LIG_SH2_STAT5	42	45	PF00017	0.357
LIG_SH2_STAT5	423	426	PF00017	0.539
LIG_SH2_STAT5	47	50	PF00017	0.292
LIG_SH2_STAT5	470	473	PF00017	0.448
LIG_SH2_STAT5	495	498	PF00017	0.491
LIG_SH2_STAT5	76	79	PF00017	0.341
LIG_SH2_STAT5	94	97	PF00017	0.279
LIG_SH3_3	338	344	PF00018	0.700
LIG_SH3_3	367	373	PF00018	0.588
LIG_SH3_3	375	381	PF00018	0.472
LIG_SH3_3	72	78	PF00018	0.325
LIG_SUMO_SIM_par_1	178	184	PF11976	0.412
LIG_SUMO_SIM_par_1	286	292	PF11976	0.578
LIG_TRAF2_1	121	124	PF00917	0.590
LIG_TRAF2_1	247	250	PF00917	0.687
LIG_TRAF2_1	271	274	PF00917	0.669
LIG_TRAF2_1	360	363	PF00917	0.432
MOD_CK1_1	319	325	PF00069	0.656
MOD_CK1_1	329	335	PF00069	0.519
MOD_CK1_1	405	411	PF00069	0.507
MOD_CK1_1	535	541	PF00069	0.595
MOD_CK2_1	186	192	PF00069	0.410
MOD_CK2_1	257	263	PF00069	0.473
MOD_CK2_1	357	363	PF00069	0.448
MOD_CK2_1	377	383	PF00069	0.539
MOD_CK2_1	480	486	PF00069	0.539
MOD_CK2_1	522	528	PF00069	0.511
MOD_Cter_Amidation	192	195	PF01082	0.274
MOD_GlcNHglycan	164	167	PF01048	0.414
MOD_GlcNHglycan	21	24	PF01048	0.367
MOD_GlcNHglycan	237	240	PF01048	0.576
MOD_GlcNHglycan	263	266	PF01048	0.505
MOD_GlcNHglycan	291	294	PF01048	0.670
MOD_GlcNHglycan	403	407	PF01048	0.339
MOD_GlcNHglycan	534	537	PF01048	0.652
MOD_GSK3_1	107	114	PF00069	0.641
MOD_GSK3_1	257	264	PF00069	0.365
MOD_GSK3_1	353	360	PF00069	0.381
MOD_GSK3_1	37	44	PF00069	0.423
MOD_GSK3_1	415	422	PF00069	0.437
MOD_GSK3_1	524	531	PF00069	0.470
MOD_GSK3_1	80	87	PF00069	0.337
MOD_N-GLC_1	112	117	PF02516	0.542
MOD_N-GLC_1	412	417	PF02516	0.291
MOD_N-GLC_1	468	473	PF02516	0.274
MOD_NEK2_1	19	24	PF00069	0.445
MOD_NEK2_1	240	245	PF00069	0.651
MOD_NEK2_1	490	495	PF00069	0.506
MOD_NEK2_1	530	535	PF00069	0.547
MOD_NEK2_2	426	431	PF00069	0.491
MOD_PIKK_1	329	335	PF00454	0.646
MOD_PIKK_1	34	40	PF00454	0.518
MOD_PIKK_1	412	418	PF00454	0.566
MOD_PIKK_1	6	12	PF00454	0.409
MOD_PKA_1	548	554	PF00069	0.389
MOD_PKA_2	101	107	PF00069	0.503
MOD_PKA_2	240	246	PF00069	0.390
MOD_PKA_2	353	359	PF00069	0.313
MOD_PKA_2	62	68	PF00069	0.408
MOD_Plk_1	275	281	PF00069	0.689
MOD_Plk_1	412	418	PF00069	0.513
MOD_Plk_1	468	474	PF00069	0.474
MOD_Plk_2-3	178	184	PF00069	0.533
MOD_Plk_2-3	62	68	PF00069	0.487
MOD_Plk_4	101	107	PF00069	0.503
MOD_Plk_4	275	281	PF00069	0.704
MOD_Plk_4	286	292	PF00069	0.645
MOD_Plk_4	407	413	PF00069	0.454
MOD_Plk_4	419	425	PF00069	0.437
MOD_Plk_4	426	432	PF00069	0.437
MOD_Plk_4	490	496	PF00069	0.448
MOD_Plk_4	548	554	PF00069	0.389
MOD_Plk_4	71	77	PF00069	0.335
MOD_ProDKin_1	377	383	PF00069	0.502
MOD_ProDKin_1	41	47	PF00069	0.473
MOD_ProDKin_1	415	421	PF00069	0.437
MOD_SUMO_rev_2	292	301	PF00179	0.574
MOD_SUMO_rev_2	483	490	PF00179	0.518
TRG_DiLeu_BaEn_1	249	254	PF01217	0.412
TRG_DiLeu_BaEn_1	275	280	PF01217	0.703
TRG_DiLeu_BaEn_1	363	368	PF01217	0.480
TRG_DiLeu_BaEn_1	486	491	PF01217	0.539
TRG_DiLeu_BaEn_4	249	255	PF01217	0.535
TRG_DiLeu_BaEn_4	275	281	PF01217	0.624
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.541
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.440
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.448
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.437
TRG_ENDOCYTIC_2	397	400	PF00928	0.437
TRG_ENDOCYTIC_2	447	450	PF00928	0.362
TRG_ENDOCYTIC_2	47	50	PF00928	0.307
TRG_ER_diArg_1	344	347	PF00400	0.531
TRG_ER_diArg_1	351	354	PF00400	0.434
TRG_ER_diArg_1	476	479	PF00400	0.469
TRG_ER_diArg_1	48	51	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y0	Leptomonas seymouri	66%	99%
A0A0S4IU29	Bodo saltans	39%	100%
A0A1X0NS82	Trypanosomatidae	47%	100%
A0A3S7X679	Leishmania donovani	90%	99%
A0A422P315	Trypanosoma rangeli	49%	100%
A4HL18	Leishmania braziliensis	81%	100%
A4I8J9	Leishmania infantum	90%	99%
D0AAM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4Q4P1	Leishmania major	89%	100%
V5BR05	Trypanosoma cruzi	50%	100%