Cyclin-dependent kinases regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-dependent kinase regulatory subunit

Species:

Leishmania mexicana

UniProt:

E9B3F7_LEIMU

TriTrypDb:

LmxM.31.3790

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1

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Expansion

Sequence features

E9B3F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3F7

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0007049	cell cycle	2	7
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008047	enzyme activator activity	3	1
GO:0016301	kinase activity	4	6
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	7
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0019207	kinase regulator activity	3	7
GO:0019209	kinase activator activity	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	95	97	PF00082	0.316
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.363
CLV_PCSK_SKI1_1	18	22	PF00082	0.451
DEG_APCC_DBOX_1	17	25	PF00400	0.446
DOC_MAPK_MEF2A_6	86	93	PF00069	0.363
DOC_PP4_FxxP_1	94	97	PF00568	0.363
DOC_USP7_UBL2_3	26	30	PF12436	0.440
LIG_14-3-3_CanoR_1	61	68	PF00244	0.318
LIG_14-3-3_CterR_2	96	99	PF00244	0.491
LIG_BIR_III_4	13	17	PF00653	0.457

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTV2	Leptomonas seymouri	97%	99%
A0A0S4ISU5	Bodo saltans	67%	97%
A0A0S4J117	Bodo saltans	53%	91%
A0A3Q8IDH6	Leishmania donovani	99%	100%
A2XCH8	Oryza sativa subsp. indica	65%	100%
A4HL16	Leishmania braziliensis	99%	100%
A4I8J7	Leishmania infantum	99%	100%
B0G102	Dictyostelium discoideum	60%	100%
D0AAM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
O23249	Arabidopsis thaliana	65%	100%

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