Putative kinetoplast DNA-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein 3, putative

Species:

Leishmania mexicana

UniProt:

E9B3F6_LEIMU

TriTrypDb:

LmxM.31.3780

Length:

131

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.749
CLV_NRD_NRD_1	123	125	PF00675	0.561
CLV_NRD_NRD_1	3	5	PF00675	0.710
CLV_NRD_NRD_1	48	50	PF00675	0.534
CLV_NRD_NRD_1	87	89	PF00675	0.625
CLV_NRD_NRD_1	9	11	PF00675	0.529
CLV_PCSK_KEX2_1	110	112	PF00082	0.671
CLV_PCSK_KEX2_1	123	125	PF00082	0.533
CLV_PCSK_KEX2_1	3	5	PF00082	0.710
CLV_PCSK_KEX2_1	9	11	PF00082	0.529
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.671
CLV_PCSK_SKI1_1	107	111	PF00082	0.580
CLV_PCSK_SKI1_1	115	119	PF00082	0.611
CLV_PCSK_SKI1_1	28	32	PF00082	0.699
CLV_PCSK_SKI1_1	4	8	PF00082	0.685
CLV_PCSK_SKI1_1	49	53	PF00082	0.462
CLV_PCSK_SKI1_1	57	61	PF00082	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.736
DOC_CKS1_1	44	49	PF01111	0.470
DOC_MAPK_gen_1	98	105	PF00069	0.516
DOC_PP2B_LxvP_1	79	82	PF13499	0.562
DOC_USP7_MATH_1	122	126	PF00917	0.686
DOC_USP7_MATH_1	34	38	PF00917	0.445
DOC_USP7_UBL2_3	110	114	PF12436	0.627
DOC_USP7_UBL2_3	115	119	PF12436	0.613
DOC_USP7_UBL2_3	31	35	PF12436	0.534
DOC_WW_Pin1_4	118	123	PF00397	0.545
DOC_WW_Pin1_4	43	48	PF00397	0.571
DOC_WW_Pin1_4	9	14	PF00397	0.614
LIG_14-3-3_CanoR_1	123	127	PF00244	0.743
LIG_14-3-3_CanoR_1	3	9	PF00244	0.681
LIG_14-3-3_CanoR_1	57	62	PF00244	0.605
LIG_FHA_1	100	106	PF00498	0.526
LIG_FHA_1	22	28	PF00498	0.686
LIG_LIR_Gen_1	12	21	PF02991	0.607
LIG_LIR_Gen_1	65	75	PF02991	0.452
LIG_LIR_Gen_1	76	83	PF02991	0.477
LIG_LIR_Nem_3	12	17	PF02991	0.595
LIG_LIR_Nem_3	60	64	PF02991	0.528
LIG_LIR_Nem_3	65	70	PF02991	0.454
LIG_LIR_Nem_3	76	81	PF02991	0.478
LIG_LYPXL_yS_3	61	64	PF13949	0.528
LIG_PCNA_PIPBox_1	87	96	PF02747	0.433
LIG_PCNA_yPIPBox_3	84	94	PF02747	0.453
LIG_SH2_CRK	41	45	PF00017	0.465
LIG_SH2_STAP1	74	78	PF00017	0.377
LIG_SH3_3	100	106	PF00018	0.526
LIG_SH3_3	56	62	PF00018	0.497
LIG_TYR_ITIM	59	64	PF00017	0.521
MOD_CDK_SPK_2	118	123	PF00069	0.504
MOD_CDK_SPxK_1	118	124	PF00069	0.516
MOD_CDK_SPxK_1	43	49	PF00069	0.570
MOD_CDK_SPxxK_3	43	50	PF00069	0.476
MOD_CK1_1	12	18	PF00069	0.599
MOD_CK2_1	42	48	PF00069	0.478
MOD_GlcNHglycan	107	110	PF01048	0.541
MOD_GlcNHglycan	36	39	PF01048	0.538
MOD_GSK3_1	118	125	PF00069	0.651
MOD_N-GLC_1	99	104	PF02516	0.516
MOD_NEK2_1	2	7	PF00069	0.701
MOD_NEK2_1	21	26	PF00069	0.357
MOD_PKA_2	122	128	PF00069	0.686
MOD_PKA_2	2	8	PF00069	0.698
MOD_PKB_1	55	63	PF00069	0.661
MOD_ProDKin_1	118	124	PF00069	0.546
MOD_ProDKin_1	43	49	PF00069	0.570
MOD_ProDKin_1	9	15	PF00069	0.615
MOD_SUMO_rev_2	45	52	PF00179	0.463
TRG_ENDOCYTIC_2	41	44	PF00928	0.466
TRG_ENDOCYTIC_2	61	64	PF00928	0.358
TRG_ENDOCYTIC_2	67	70	PF00928	0.438
TRG_ER_diArg_1	122	124	PF00400	0.599
TRG_ER_diArg_1	2	4	PF00400	0.726
TRG_ER_diArg_1	8	10	PF00400	0.560
TRG_NLS_Bipartite_1	98	115	PF00514	0.676
TRG_NLS_MonoExtC_3	109	114	PF00514	0.669
TRG_NLS_MonoExtN_4	107	114	PF00514	0.696
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W1	Leptomonas seymouri	32%	97%
A0A0N1IIB3	Leptomonas seymouri	67%	100%
A0A1X0NSD7	Trypanosomatidae	44%	72%
A0A3Q8IGK7	Leishmania donovani	40%	99%
A0A3Q8ITR1	Leishmania donovani	90%	96%
A0A422P329	Trypanosoma rangeli	45%	69%
A4HL14	Leishmania braziliensis	32%	100%
A4HL15	Leishmania braziliensis	83%	100%
A4I8J5	Leishmania infantum	40%	99%
A4I8J6	Leishmania infantum	90%	96%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4Q4P4	Leishmania major	90%	100%
Q4Q4P5	Leishmania major	39%	100%
Q8IS98	Crithidia fasciculata	65%	98%
Q9TY83	Crithidia fasciculata	34%	100%
Q9TY84	Crithidia fasciculata	34%	100%