Enolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Enolase

Gene product:

enolase, putative

Species:

Leishmania mexicana

UniProt:

E9B3F4_LEIMU

TriTrypDb:

LmxM.31.3760

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0000015	phosphopyruvate hydratase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:1902494	catalytic complex	2	4

Expansion

Sequence features

E9B3F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3F4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	4
GO:0006082	organic acid metabolic process	3	4
GO:0006090	pyruvate metabolic process	7	4
GO:0006091	generation of precursor metabolites and energy	3	4
GO:0006096	glycolytic process	5	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006163	purine nucleotide metabolic process	5	4
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006753	nucleoside phosphate metabolic process	4	4
GO:0006757	obsolete ATP generation from ADP	4	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009117	nucleotide metabolic process	5	4
GO:0009132	nucleoside diphosphate metabolic process	5	4
GO:0009135	purine nucleoside diphosphate metabolic process	6	4
GO:0009141	nucleoside triphosphate metabolic process	5	4
GO:0009144	purine nucleoside triphosphate metabolic process	6	4
GO:0009150	purine ribonucleotide metabolic process	6	4
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	4
GO:0009185	ribonucleoside diphosphate metabolic process	6	4
GO:0009199	ribonucleoside triphosphate metabolic process	6	4
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	4
GO:0009259	ribonucleotide metabolic process	5	4
GO:0009987	cellular process	1	4
GO:0016052	carbohydrate catabolic process	4	4
GO:0016310	phosphorylation	5	4
GO:0019637	organophosphate metabolic process	3	4
GO:0019693	ribose phosphate metabolic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044281	small molecule metabolic process	2	4
GO:0046031	ADP metabolic process	7	4
GO:0046034	ATP metabolic process	7	4
GO:0046483	heterocycle metabolic process	3	4
GO:0046939	obsolete nucleotide phosphorylation	6	4
GO:0055086	nucleobase-containing small molecule metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0072521	purine-containing compound metabolic process	4	4
GO:1901135	carbohydrate derivative metabolic process	3	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901575	organic substance catabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004634	phosphopyruvate hydratase activity	5	8
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0000287	magnesium ion binding	5	4
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.476
CLV_C14_Caspase3-7	271	275	PF00656	0.537
CLV_NRD_NRD_1	501	503	PF00675	0.547
CLV_NRD_NRD_1	590	592	PF00675	0.564
CLV_NRD_NRD_1	605	607	PF00675	0.634
CLV_PCSK_KEX2_1	501	503	PF00082	0.547
CLV_PCSK_KEX2_1	590	592	PF00082	0.561
CLV_PCSK_SKI1_1	149	153	PF00082	0.413
CLV_PCSK_SKI1_1	332	336	PF00082	0.559
CLV_PCSK_SKI1_1	36	40	PF00082	0.622
CLV_PCSK_SKI1_1	502	506	PF00082	0.552
DEG_SIAH_1	581	589	PF03145	0.584
DEG_SPOP_SBC_1	267	271	PF00917	0.451
DEG_SPOP_SBC_1	308	312	PF00917	0.627
DOC_ANK_TNKS_1	43	50	PF00023	0.335
DOC_CYCLIN_RxL_1	128	139	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	460	466	PF00134	0.556
DOC_MAPK_DCC_7	229	238	PF00069	0.519
DOC_MAPK_gen_1	430	437	PF00069	0.491
DOC_MAPK_gen_1	501	508	PF00069	0.573
DOC_MAPK_MEF2A_6	229	238	PF00069	0.519
DOC_MAPK_MEF2A_6	257	265	PF00069	0.497
DOC_MAPK_MEF2A_6	501	508	PF00069	0.573
DOC_PP2B_LxvP_1	464	467	PF13499	0.572
DOC_PP4_FxxP_1	231	234	PF00568	0.263
DOC_USP7_MATH_1	127	131	PF00917	0.549
DOC_USP7_MATH_1	156	160	PF00917	0.498
DOC_USP7_MATH_1	212	216	PF00917	0.472
DOC_USP7_MATH_1	252	256	PF00917	0.525
DOC_USP7_MATH_1	26	30	PF00917	0.518
DOC_USP7_MATH_1	308	312	PF00917	0.543
DOC_USP7_MATH_1	546	550	PF00917	0.524
DOC_USP7_MATH_1	566	570	PF00917	0.321
DOC_USP7_MATH_1	79	83	PF00917	0.501
DOC_USP7_UBL2_3	404	408	PF12436	0.508
DOC_USP7_UBL2_3	592	596	PF12436	0.575
DOC_USP7_UBL2_3	598	602	PF12436	0.601
DOC_WW_Pin1_4	150	155	PF00397	0.559
DOC_WW_Pin1_4	459	464	PF00397	0.589
LIG_14-3-3_CanoR_1	101	105	PF00244	0.743
LIG_14-3-3_CanoR_1	229	234	PF00244	0.483
LIG_14-3-3_CanoR_1	243	253	PF00244	0.427
LIG_14-3-3_CanoR_1	25	35	PF00244	0.634
LIG_14-3-3_CanoR_1	257	265	PF00244	0.407
LIG_14-3-3_CanoR_1	302	308	PF00244	0.518
LIG_14-3-3_CanoR_1	501	507	PF00244	0.494
LIG_Actin_WH2_2	486	503	PF00022	0.284
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BIR_III_4	112	116	PF00653	0.595
LIG_BIR_III_4	274	278	PF00653	0.674
LIG_BIR_III_4	375	379	PF00653	0.515
LIG_BRCT_BRCA1_1	254	258	PF00533	0.367
LIG_BRCT_BRCA1_1	39	43	PF00533	0.553
LIG_EH1_1	13	21	PF00400	0.387
LIG_EVH1_1	578	582	PF00568	0.553
LIG_FHA_1	237	243	PF00498	0.467
LIG_FHA_1	267	273	PF00498	0.662
LIG_FHA_1	326	332	PF00498	0.470
LIG_FHA_1	333	339	PF00498	0.462
LIG_FHA_1	357	363	PF00498	0.632
LIG_FHA_1	455	461	PF00498	0.553
LIG_FHA_1	503	509	PF00498	0.446
LIG_FHA_1	553	559	PF00498	0.557
LIG_FHA_1	581	587	PF00498	0.575
LIG_FHA_1	68	74	PF00498	0.443
LIG_FHA_1	83	89	PF00498	0.413
LIG_FHA_2	109	115	PF00498	0.707
LIG_FHA_2	483	489	PF00498	0.430
LIG_FHA_2	82	88	PF00498	0.530
LIG_LIR_Gen_1	117	126	PF02991	0.463
LIG_LIR_Gen_1	255	265	PF02991	0.488
LIG_LIR_Gen_1	531	540	PF02991	0.430
LIG_LIR_Nem_3	117	121	PF02991	0.626
LIG_LIR_Nem_3	255	261	PF02991	0.510
LIG_LIR_Nem_3	37	42	PF02991	0.594
LIG_LIR_Nem_3	4	10	PF02991	0.483
LIG_LIR_Nem_3	531	535	PF02991	0.460
LIG_LIR_Nem_3	577	581	PF02991	0.659
LIG_MLH1_MIPbox_1	39	43	PF16413	0.553
LIG_MYND_1	463	467	PF01753	0.386
LIG_Pex14_2	39	43	PF04695	0.598
LIG_REV1ctd_RIR_1	36	45	PF16727	0.632
LIG_SH2_CRK	118	122	PF00017	0.604
LIG_SH2_NCK_1	118	122	PF00017	0.604
LIG_SH2_NCK_1	137	141	PF00017	0.356
LIG_SH2_PTP2	262	265	PF00017	0.473
LIG_SH2_PTP2	532	535	PF00017	0.430
LIG_SH2_SRC	137	140	PF00017	0.440
LIG_SH2_STAP1	10	14	PF00017	0.567
LIG_SH2_STAT5	187	190	PF00017	0.414
LIG_SH2_STAT5	262	265	PF00017	0.473
LIG_SH2_STAT5	402	405	PF00017	0.452
LIG_SH2_STAT5	42	45	PF00017	0.490
LIG_SH2_STAT5	492	495	PF00017	0.360
LIG_SH2_STAT5	532	535	PF00017	0.472
LIG_SH3_1	576	582	PF00018	0.621
LIG_SH3_3	474	480	PF00018	0.495
LIG_SH3_3	576	582	PF00018	0.528
LIG_SUMO_SIM_par_1	504	510	PF11976	0.569
LIG_UBA3_1	170	178	PF00899	0.476
LIG_WRC_WIRS_1	237	242	PF05994	0.509
LIG_WRC_WIRS_1	88	93	PF05994	0.394
LIG_WW_2	579	582	PF00397	0.628
MOD_CK1_1	159	165	PF00069	0.386
MOD_CK1_1	215	221	PF00069	0.765
MOD_CK1_1	224	230	PF00069	0.539
MOD_CK1_1	3	9	PF00069	0.570
MOD_CK1_1	306	312	PF00069	0.578
MOD_CK1_1	455	461	PF00069	0.706
MOD_CK1_1	541	547	PF00069	0.477
MOD_CK1_1	82	88	PF00069	0.486
MOD_CK2_1	108	114	PF00069	0.720
MOD_GlcNHglycan	145	148	PF01048	0.550
MOD_GlcNHglycan	158	161	PF01048	0.523
MOD_GlcNHglycan	16	19	PF01048	0.475
MOD_GlcNHglycan	196	199	PF01048	0.660
MOD_GlcNHglycan	214	217	PF01048	0.765
MOD_GlcNHglycan	225	229	PF01048	0.620
MOD_GlcNHglycan	28	31	PF01048	0.536
MOD_GlcNHglycan	284	287	PF01048	0.598
MOD_GlcNHglycan	338	341	PF01048	0.495
MOD_GlcNHglycan	375	379	PF01048	0.597
MOD_GlcNHglycan	452	455	PF01048	0.637
MOD_GlcNHglycan	457	460	PF01048	0.708
MOD_GlcNHglycan	535	538	PF01048	0.534
MOD_GlcNHglycan	540	543	PF01048	0.463
MOD_GlcNHglycan	568	571	PF01048	0.635
MOD_GlcNHglycan	61	64	PF01048	0.577
MOD_GSK3_1	100	107	PF00069	0.747
MOD_GSK3_1	116	123	PF00069	0.602
MOD_GSK3_1	14	21	PF00069	0.440
MOD_GSK3_1	143	150	PF00069	0.468
MOD_GSK3_1	152	159	PF00069	0.477
MOD_GSK3_1	166	173	PF00069	0.404
MOD_GSK3_1	252	259	PF00069	0.551
MOD_GSK3_1	26	33	PF00069	0.480
MOD_GSK3_1	278	285	PF00069	0.588
MOD_GSK3_1	303	310	PF00069	0.535
MOD_GSK3_1	332	339	PF00069	0.563
MOD_GSK3_1	351	358	PF00069	0.526
MOD_GSK3_1	370	377	PF00069	0.421
MOD_GSK3_1	437	444	PF00069	0.464
MOD_GSK3_1	450	457	PF00069	0.620
MOD_GSK3_1	546	553	PF00069	0.520
MOD_N-GLC_1	325	330	PF02516	0.466
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	14	19	PF00069	0.537
MOD_NEK2_1	236	241	PF00069	0.408
MOD_NEK2_1	268	273	PF00069	0.635
MOD_NEK2_1	303	308	PF00069	0.563
MOD_NEK2_1	355	360	PF00069	0.584
MOD_NEK2_1	418	423	PF00069	0.517
MOD_NEK2_1	437	442	PF00069	0.271
MOD_NEK2_1	507	512	PF00069	0.584
MOD_NEK2_2	252	257	PF00069	0.615
MOD_PK_1	229	235	PF00069	0.471
MOD_PKA_2	100	106	PF00069	0.575
MOD_PKA_2	256	262	PF00069	0.529
MOD_PKA_2	450	456	PF00069	0.662
MOD_PKA_2	566	572	PF00069	0.624
MOD_Plk_1	278	284	PF00069	0.474
MOD_Plk_1	79	85	PF00069	0.482
MOD_Plk_2-3	108	114	PF00069	0.642
MOD_Plk_2-3	482	488	PF00069	0.506
MOD_Plk_2-3	87	93	PF00069	0.651
MOD_Plk_4	116	122	PF00069	0.536
MOD_Plk_4	166	172	PF00069	0.398
MOD_Plk_4	236	242	PF00069	0.484
MOD_Plk_4	284	290	PF00069	0.374
MOD_Plk_4	382	388	PF00069	0.483
MOD_Plk_4	437	443	PF00069	0.495
MOD_Plk_4	473	479	PF00069	0.490
MOD_Plk_4	502	508	PF00069	0.530
MOD_Plk_4	528	534	PF00069	0.490
MOD_ProDKin_1	150	156	PF00069	0.568
MOD_ProDKin_1	459	465	PF00069	0.587
MOD_SUMO_rev_2	29	38	PF00179	0.646
MOD_SUMO_rev_2	373	383	PF00179	0.615
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.416
TRG_ENDOCYTIC_2	118	121	PF00928	0.622
TRG_ENDOCYTIC_2	262	265	PF00928	0.473
TRG_ENDOCYTIC_2	384	387	PF00928	0.411
TRG_ENDOCYTIC_2	532	535	PF00928	0.523
TRG_ER_diArg_1	289	292	PF00400	0.498
TRG_ER_diArg_1	430	433	PF00400	0.439
TRG_ER_diArg_1	500	502	PF00400	0.413
TRG_ER_diArg_1	589	591	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A1	Leptomonas seymouri	39%	94%
A0A0S4IQJ6	Bodo saltans	25%	100%
A0A1X0NS02	Trypanosomatidae	26%	100%
A0A3Q8IJR5	Leishmania donovani	86%	100%
A4HL13	Leishmania braziliensis	75%	100%
A4I8J4	Leishmania infantum	86%	100%
D0AAM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q4P6	Leishmania major	88%	100%
V5DME2	Trypanosoma cruzi	27%	100%