Transmembrane protein 18

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 18, putative

Species:

Leishmania mexicana

UniProt:

E9B3F1_LEIMU

TriTrypDb:

LmxM.31.3730

Length:

205

Annotations

LeishMANIAdb annotations

Part of the eukaryotic TMEM18 family, consisting of conserved 3TM nuclear membrane proteins.. Localization: Perinuclear (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1

Expansion

Sequence features

E9B3F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3F1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.482
CLV_NRD_NRD_1	178	180	PF00675	0.298
CLV_NRD_NRD_1	185	187	PF00675	0.459
CLV_NRD_NRD_1	53	55	PF00675	0.558
CLV_PCSK_KEX2_1	172	174	PF00082	0.275
CLV_PCSK_KEX2_1	177	179	PF00082	0.279
CLV_PCSK_KEX2_1	185	187	PF00082	0.453
CLV_PCSK_KEX2_1	53	55	PF00082	0.510
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.267
CLV_PCSK_PC7_1	173	179	PF00082	0.310
CLV_PCSK_PC7_1	181	187	PF00082	0.472
CLV_PCSK_SKI1_1	96	100	PF00082	0.188
DOC_MAPK_MEF2A_6	163	171	PF00069	0.546
DOC_PP4_FxxP_1	126	129	PF00568	0.346
DOC_USP7_MATH_1	113	117	PF00917	0.357
DOC_USP7_MATH_1	198	202	PF00917	0.753
DOC_USP7_MATH_1	38	42	PF00917	0.513
LIG_14-3-3_CanoR_1	163	168	PF00244	0.587
LIG_14-3-3_CanoR_1	96	101	PF00244	0.326
LIG_Actin_WH2_2	145	161	PF00022	0.426
LIG_BIR_II_1	1	5	PF00653	0.411
LIG_BRCT_BRCA1_1	65	69	PF00533	0.285
LIG_CaM_NSCaTE_8	81	88	PF13499	0.422
LIG_deltaCOP1_diTrp_1	123	126	PF00928	0.286
LIG_EH1_1	161	169	PF00400	0.578
LIG_eIF4E_1	162	168	PF01652	0.406
LIG_LIR_Apic_2	123	129	PF02991	0.346
LIG_LIR_Nem_3	55	60	PF02991	0.422
LIG_LIR_Nem_3	66	72	PF02991	0.271
LIG_LIR_Nem_3	86	92	PF02991	0.233
LIG_NRBOX	103	109	PF00104	0.338
LIG_Pex14_1	65	69	PF04695	0.267
LIG_REV1ctd_RIR_1	67	75	PF16727	0.346
LIG_RPA_C_Fungi	27	39	PF08784	0.448
LIG_SH2_CRK	162	166	PF00017	0.489
LIG_SH2_CRK	60	64	PF00017	0.395
LIG_SH2_NCK_1	60	64	PF00017	0.438
LIG_SH2_STAT5	133	136	PF00017	0.371
LIG_SH2_STAT5	145	148	PF00017	0.446
LIG_SH2_STAT5	155	158	PF00017	0.477
LIG_SH2_STAT5	60	63	PF00017	0.391
LIG_SH2_STAT5	72	75	PF00017	0.292
LIG_SUMO_SIM_par_1	105	110	PF11976	0.438
LIG_TRAF2_1	6	9	PF00917	0.621
LIG_TYR_ITIM	153	158	PF00017	0.372
LIG_UBA3_1	167	172	PF00899	0.351
MOD_CK1_1	41	47	PF00069	0.649
MOD_CK2_1	3	9	PF00069	0.600
MOD_CK2_1	44	50	PF00069	0.610
MOD_GlcNHglycan	109	112	PF01048	0.471
MOD_N-GLC_1	63	68	PF02516	0.369
MOD_NEK2_1	107	112	PF00069	0.500
MOD_NEK2_1	26	31	PF00069	0.572
MOD_NEK2_1	3	8	PF00069	0.558
MOD_PKA_1	185	191	PF00069	0.652
MOD_PKA_2	185	191	PF00069	0.677
MOD_Plk_4	163	169	PF00069	0.471
MOD_SUMO_rev_2	194	204	PF00179	0.761
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.443
TRG_ENDOCYTIC_2	155	158	PF00928	0.491
TRG_ENDOCYTIC_2	162	165	PF00928	0.349
TRG_ENDOCYTIC_2	60	63	PF00928	0.354
TRG_ER_diArg_1	176	179	PF00400	0.422
TRG_ER_diArg_1	52	54	PF00400	0.376
TRG_ER_diLys_1	202	205	PF00400	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIZ0	Leptomonas seymouri	48%	100%
A0A1X0NRY6	Trypanosomatidae	42%	100%
A0A3R7KYB3	Trypanosoma rangeli	40%	100%
A0A3S7X686	Leishmania donovani	92%	100%
A4HL10	Leishmania braziliensis	77%	100%
A4I8J1	Leishmania infantum	92%	100%
D0AAM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q4P9	Leishmania major	92%	100%