BT1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

BT1 family protein

Gene product:

BT1 family, putative

Species:

Leishmania mexicana

UniProt:

E9B3F0_LEIMU

TriTrypDb:

LmxM.31.3720

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9B3F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3F0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.392
CLV_NRD_NRD_1	290	292	PF00675	0.247
CLV_NRD_NRD_1	436	438	PF00675	0.241
CLV_NRD_NRD_1	66	68	PF00675	0.305
CLV_PCSK_KEX2_1	217	219	PF00082	0.427
CLV_PCSK_KEX2_1	290	292	PF00082	0.247
CLV_PCSK_KEX2_1	436	438	PF00082	0.241
CLV_PCSK_KEX2_1	65	67	PF00082	0.318
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.312
CLV_PCSK_SKI1_1	169	173	PF00082	0.498
CLV_PCSK_SKI1_1	191	195	PF00082	0.390
CLV_PCSK_SKI1_1	290	294	PF00082	0.224
CLV_PCSK_SKI1_1	354	358	PF00082	0.403
CLV_PCSK_SKI1_1	67	71	PF00082	0.298
DEG_APCC_DBOX_1	300	308	PF00400	0.439
DEG_APCC_DBOX_1	65	73	PF00400	0.498
DOC_CKS1_1	187	192	PF01111	0.429
DOC_CYCLIN_RxL_1	188	199	PF00134	0.481
DOC_CYCLIN_RxL_1	23	34	PF00134	0.239
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.192
DOC_MAPK_DCC_7	26	35	PF00069	0.239
DOC_MAPK_FxFP_2	259	262	PF00069	0.318
DOC_MAPK_gen_1	65	71	PF00069	0.493
DOC_MAPK_HePTP_8	351	363	PF00069	0.303
DOC_MAPK_MEF2A_6	297	306	PF00069	0.519
DOC_MAPK_MEF2A_6	354	363	PF00069	0.366
DOC_MAPK_RevD_3	422	437	PF00069	0.238
DOC_PP2B_LxvP_1	111	114	PF13499	0.353
DOC_PP2B_LxvP_1	334	337	PF13499	0.192
DOC_PP4_FxxP_1	259	262	PF00568	0.324
DOC_USP7_MATH_1	130	134	PF00917	0.498
DOC_USP7_MATH_1	135	139	PF00917	0.485
DOC_USP7_MATH_1	245	249	PF00917	0.253
DOC_WW_Pin1_4	186	191	PF00397	0.434
LIG_14-3-3_CanoR_1	196	204	PF00244	0.668
LIG_14-3-3_CanoR_1	301	305	PF00244	0.498
LIG_Actin_WH2_2	180	198	PF00022	0.423
LIG_APCC_ABBA_1	59	64	PF00400	0.482
LIG_BRCT_BRCA1_1	103	107	PF00533	0.216
LIG_BRCT_BRCA1_1	302	306	PF00533	0.498
LIG_eIF4E_1	319	325	PF01652	0.353
LIG_eIF4E_1	81	87	PF01652	0.303
LIG_FHA_1	1	7	PF00498	0.512
LIG_FHA_1	106	112	PF00498	0.415
LIG_FHA_1	148	154	PF00498	0.393
LIG_FHA_1	158	164	PF00498	0.321
LIG_FHA_1	319	325	PF00498	0.347
LIG_FHA_1	329	335	PF00498	0.281
LIG_FHA_1	347	353	PF00498	0.348
LIG_FHA_1	374	380	PF00498	0.480
LIG_FHA_2	127	133	PF00498	0.498
LIG_FHA_2	373	379	PF00498	0.498
LIG_FHA_2	403	409	PF00498	0.263
LIG_GBD_Chelix_1	174	182	PF00786	0.281
LIG_GBD_Chelix_1	416	424	PF00786	0.249
LIG_IRF3_LxIS_1	389	396	PF10401	0.303
LIG_LIR_Apic_2	45	50	PF02991	0.275
LIG_LIR_Gen_1	236	245	PF02991	0.441
LIG_LIR_Gen_1	252	262	PF02991	0.353
LIG_LIR_Gen_1	303	314	PF02991	0.304
LIG_LIR_Gen_1	345	356	PF02991	0.298
LIG_LIR_Gen_1	375	385	PF02991	0.498
LIG_LIR_Gen_1	407	417	PF02991	0.301
LIG_LIR_Gen_1	82	90	PF02991	0.367
LIG_LIR_Nem_3	236	240	PF02991	0.441
LIG_LIR_Nem_3	248	254	PF02991	0.359
LIG_LIR_Nem_3	303	308	PF02991	0.378
LIG_LIR_Nem_3	345	351	PF02991	0.283
LIG_LIR_Nem_3	375	380	PF02991	0.507
LIG_LIR_Nem_3	407	412	PF02991	0.329
LIG_LIR_Nem_3	78	84	PF02991	0.359
LIG_LIR_Nem_3	91	97	PF02991	0.298
LIG_MLH1_MIPbox_1	103	107	PF16413	0.216
LIG_MLH1_MIPbox_1	302	306	PF16413	0.498
LIG_NRBOX	161	167	PF00104	0.249
LIG_Pex14_1	315	319	PF04695	0.303
LIG_Pex14_2	261	265	PF04695	0.284
LIG_PTB_Apo_2	260	267	PF02174	0.361
LIG_PTB_Phospho_1	260	266	PF10480	0.349
LIG_SH2_PTP2	112	115	PF00017	0.353
LIG_SH2_PTP2	341	344	PF00017	0.298
LIG_SH2_SRC	254	257	PF00017	0.326
LIG_SH2_SRC	341	344	PF00017	0.298
LIG_SH2_STAP1	251	255	PF00017	0.341
LIG_SH2_STAP1	409	413	PF00017	0.263
LIG_SH2_STAT5	112	115	PF00017	0.294
LIG_SH2_STAT5	241	244	PF00017	0.361
LIG_SH2_STAT5	254	257	PF00017	0.344
LIG_SH2_STAT5	282	285	PF00017	0.433
LIG_SH2_STAT5	319	322	PF00017	0.300
LIG_SH2_STAT5	341	344	PF00017	0.298
LIG_SH2_STAT5	41	44	PF00017	0.319
LIG_SH2_STAT5	431	434	PF00017	0.273
LIG_SH2_STAT5	54	57	PF00017	0.387
LIG_SH2_STAT5	81	84	PF00017	0.345
LIG_SH3_3	178	184	PF00018	0.337
LIG_SH3_3	337	343	PF00018	0.342
LIG_SUMO_SIM_anti_2	3	10	PF11976	0.249
LIG_SUMO_SIM_par_1	160	167	PF11976	0.249
LIG_SUMO_SIM_par_1	183	189	PF11976	0.345
LIG_SUMO_SIM_par_1	231	236	PF11976	0.183
LIG_SUMO_SIM_par_1	3	10	PF11976	0.339
LIG_SUMO_SIM_par_1	414	419	PF11976	0.358
LIG_TRAF2_1	129	132	PF00917	0.498
LIG_TRAF2_1	292	295	PF00917	0.498
LIG_TRFH_1	84	88	PF08558	0.303
LIG_UBA3_1	394	400	PF00899	0.249
LIG_WRC_WIRS_1	234	239	PF05994	0.183
LIG_WRC_WIRS_1	344	349	PF05994	0.270
MOD_CDK_SPK_2	186	191	PF00069	0.434
MOD_CK1_1	101	107	PF00069	0.353
MOD_CK1_1	149	155	PF00069	0.357
MOD_CK1_1	18	24	PF00069	0.399
MOD_CK1_1	381	387	PF00069	0.331
MOD_CK1_1	388	394	PF00069	0.352
MOD_CK2_1	126	132	PF00069	0.366
MOD_CK2_1	372	378	PF00069	0.353
MOD_CMANNOS	213	216	PF00535	0.333
MOD_GlcNHglycan	137	140	PF01048	0.353
MOD_GlcNHglycan	15	18	PF01048	0.221
MOD_GlcNHglycan	390	393	PF01048	0.422
MOD_GlcNHglycan	437	440	PF01048	0.490
MOD_GlcNHglycan	91	94	PF01048	0.183
MOD_GSK3_1	101	108	PF00069	0.310
MOD_GSK3_1	126	133	PF00069	0.366
MOD_GSK3_1	135	142	PF00069	0.366
MOD_GSK3_1	196	203	PF00069	0.548
MOD_GSK3_1	324	331	PF00069	0.358
MOD_GSK3_1	343	350	PF00069	0.406
MOD_GSK3_1	381	388	PF00069	0.379
MOD_GSK3_1	75	82	PF00069	0.414
MOD_N-GLC_2	269	271	PF02516	0.353
MOD_NEK2_1	141	146	PF00069	0.332
MOD_NEK2_1	15	20	PF00069	0.362
MOD_NEK2_1	194	199	PF00069	0.584
MOD_NEK2_1	233	238	PF00069	0.400
MOD_NEK2_1	239	244	PF00069	0.365
MOD_NEK2_1	274	279	PF00069	0.224
MOD_NEK2_1	308	313	PF00069	0.298
MOD_NEK2_1	324	329	PF00069	0.426
MOD_NEK2_1	347	352	PF00069	0.391
MOD_NEK2_1	372	377	PF00069	0.414
MOD_NEK2_1	380	385	PF00069	0.365
MOD_NEK2_1	393	398	PF00069	0.341
MOD_NEK2_1	402	407	PF00069	0.360
MOD_NEK2_1	6	11	PF00069	0.330
MOD_NEK2_2	164	169	PF00069	0.432
MOD_NEK2_2	343	348	PF00069	0.336
MOD_NEK2_2	79	84	PF00069	0.211
MOD_PIKK_1	101	107	PF00454	0.353
MOD_PIKK_1	196	202	PF00454	0.443
MOD_PIKK_1	290	296	PF00454	0.270
MOD_PIKK_1	407	413	PF00454	0.281
MOD_PKA_1	290	296	PF00069	0.249
MOD_PKA_2	135	141	PF00069	0.324
MOD_PKA_2	147	153	PF00069	0.252
MOD_PKA_2	195	201	PF00069	0.601
MOD_PKA_2	290	296	PF00069	0.400
MOD_PKA_2	300	306	PF00069	0.311
MOD_PKA_2	435	441	PF00069	0.569
MOD_Plk_1	200	206	PF00069	0.443
MOD_Plk_1	245	251	PF00069	0.319
MOD_Plk_1	372	378	PF00069	0.294
MOD_Plk_1	407	413	PF00069	0.303
MOD_Plk_2-3	373	379	PF00069	0.311
MOD_Plk_4	141	147	PF00069	0.398
MOD_Plk_4	15	21	PF00069	0.353
MOD_Plk_4	233	239	PF00069	0.352
MOD_Plk_4	245	251	PF00069	0.396
MOD_Plk_4	300	306	PF00069	0.364
MOD_Plk_4	343	349	PF00069	0.373
MOD_Plk_4	357	363	PF00069	0.346
MOD_Plk_4	385	391	PF00069	0.304
MOD_Plk_4	416	422	PF00069	0.353
MOD_Plk_4	42	48	PF00069	0.355
MOD_Plk_4	7	13	PF00069	0.353
MOD_Plk_4	79	85	PF00069	0.384
MOD_Plk_4	98	104	PF00069	0.306
MOD_ProDKin_1	186	192	PF00069	0.442
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.303
TRG_ENDOCYTIC_2	112	115	PF00928	0.356
TRG_ENDOCYTIC_2	241	244	PF00928	0.366
TRG_ENDOCYTIC_2	254	257	PF00928	0.405
TRG_ENDOCYTIC_2	341	344	PF00928	0.365
TRG_ENDOCYTIC_2	409	412	PF00928	0.353
TRG_ENDOCYTIC_2	84	87	PF00928	0.442
TRG_ER_diArg_1	216	218	PF00400	0.404
TRG_ER_diArg_1	66	68	PF00400	0.361
TRG_NES_CRM1_1	49	64	PF08389	0.281
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	24%	83%
A0A0N1I3H1	Leptomonas seymouri	65%	67%
A0A3Q8IF44	Leishmania donovani	25%	84%
A0A3Q8ILR5	Leishmania donovani	88%	97%
A4HIW8	Leishmania braziliensis	25%	100%
A4HL09	Leishmania braziliensis	79%	100%
A4I8J0	Leishmania infantum	88%	97%
E9AHK6	Leishmania infantum	25%	84%
E9B1F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
F4KIL8	Arabidopsis thaliana	22%	93%
Q4Q4Q0	Leishmania major	87%	100%
Q4Q6R0	Leishmania major	26%	100%
Q55721	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	93%
Q5FV41	Arabidopsis thaliana	22%	92%
Q9SKZ5	Arabidopsis thaliana	23%	82%
Q9SQN2	Arabidopsis thaliana	22%	92%