LeishMANIAdb
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DUF4283 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4283 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B3E9_LEIMU
TriTrypDb:
LmxM.31.3710
Length:
135

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3E9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 132 134 PF00675 0.700
CLV_NRD_NRD_1 5 7 PF00675 0.548
CLV_NRD_NRD_1 65 67 PF00675 0.547
CLV_PCSK_KEX2_1 132 134 PF00082 0.704
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.544
CLV_PCSK_SKI1_1 127 131 PF00082 0.563
CLV_PCSK_SKI1_1 67 71 PF00082 0.453
DOC_CYCLIN_RxL_1 78 88 PF00134 0.291
DOC_CYCLIN_yCln2_LP_2 53 59 PF00134 0.645
DOC_MAPK_gen_1 123 131 PF00069 0.620
DOC_MAPK_gen_1 44 53 PF00069 0.586
DOC_MAPK_MEF2A_6 44 53 PF00069 0.578
DOC_MAPK_NFAT4_5 46 54 PF00069 0.647
DOC_MAPK_RevD_3 24 38 PF00069 0.555
DOC_PP1_RVXF_1 65 72 PF00149 0.494
DOC_PP1_RVXF_1 79 86 PF00149 0.440
DOC_USP7_UBL2_3 119 123 PF12436 0.706
DOC_USP7_UBL2_3 130 134 PF12436 0.603
DOC_USP7_UBL2_3 44 48 PF12436 0.601
DOC_USP7_UBL2_3 7 11 PF12436 0.622
DOC_WW_Pin1_4 52 57 PF00397 0.565
LIG_FHA_2 106 112 PF00498 0.744
LIG_LIR_Nem_3 58 63 PF02991 0.516
LIG_SH3_3 19 25 PF00018 0.515
LIG_SUMO_SIM_par_1 54 61 PF11976 0.408
MOD_CK2_1 105 111 PF00069 0.700
MOD_CK2_1 58 64 PF00069 0.629
MOD_GlcNHglycan 60 63 PF01048 0.375
MOD_GlcNHglycan 90 93 PF01048 0.493
MOD_GSK3_1 26 33 PF00069 0.593
MOD_GSK3_1 88 95 PF00069 0.467
MOD_NEK2_1 36 41 PF00069 0.585
MOD_PKA_2 104 110 PF00069 0.648
MOD_ProDKin_1 52 58 PF00069 0.561
MOD_SUMO_rev_2 61 69 PF00179 0.525
TRG_ENDOCYTIC_2 60 63 PF00928 0.519
TRG_ER_diLys_1 130 135 PF00400 0.538
TRG_NLS_MonoExtC_3 36 41 PF00514 0.611
TRG_NLS_MonoExtN_4 4 10 PF00514 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HXE6 Leptomonas seymouri 76% 100%
A0A0S4IS54 Bodo saltans 67% 84%
A0A1X0NSL1 Trypanosomatidae 70% 100%
A0A3S5H7T4 Leishmania donovani 89% 100%
A0A422P317 Trypanosoma rangeli 68% 100%
A4HL08 Leishmania braziliensis 80% 100%
A4I8I9 Leishmania infantum 89% 100%
D0AAM8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
Q4Q4Q1 Leishmania major 88% 100%
V5DME8 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS