DUF4520 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3E8_LEIMU

TriTrypDb:

LmxM.31.3700

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.369
CLV_C14_Caspase3-7	312	316	PF00656	0.646
CLV_C14_Caspase3-7	379	383	PF00656	0.547
CLV_NRD_NRD_1	172	174	PF00675	0.507
CLV_NRD_NRD_1	250	252	PF00675	0.500
CLV_NRD_NRD_1	514	516	PF00675	0.465
CLV_NRD_NRD_1	518	520	PF00675	0.424
CLV_NRD_NRD_1	629	631	PF00675	0.529
CLV_NRD_NRD_1	700	702	PF00675	0.603
CLV_PCSK_KEX2_1	172	174	PF00082	0.603
CLV_PCSK_KEX2_1	250	252	PF00082	0.551
CLV_PCSK_KEX2_1	518	520	PF00082	0.444
CLV_PCSK_SKI1_1	124	128	PF00082	0.633
CLV_PCSK_SKI1_1	165	169	PF00082	0.505
CLV_PCSK_SKI1_1	251	255	PF00082	0.413
CLV_PCSK_SKI1_1	290	294	PF00082	0.591
CLV_PCSK_SKI1_1	297	301	PF00082	0.524
CLV_PCSK_SKI1_1	439	443	PF00082	0.639
CLV_PCSK_SKI1_1	494	498	PF00082	0.478
CLV_PCSK_SKI1_1	510	514	PF00082	0.417
CLV_PCSK_SKI1_1	518	522	PF00082	0.426
CLV_PCSK_SKI1_1	590	594	PF00082	0.510
CLV_PCSK_SKI1_1	668	672	PF00082	0.609
CLV_PCSK_SKI1_1	687	691	PF00082	0.318
DEG_APCC_DBOX_1	25	33	PF00400	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.560
DEG_SCF_FBW7_1	520	527	PF00400	0.502
DEG_SPOP_SBC_1	572	576	PF00917	0.617
DOC_AGCK_PIF_3	712	715	PF00069	0.639
DOC_CYCLIN_yCln2_LP_2	647	653	PF00134	0.533
DOC_MAPK_gen_1	38	45	PF00069	0.557
DOC_MAPK_gen_1	515	522	PF00069	0.447
DOC_MAPK_MEF2A_6	38	45	PF00069	0.581
DOC_MAPK_MEF2A_6	553	561	PF00069	0.689
DOC_PP1_RVXF_1	248	255	PF00149	0.410
DOC_PP1_RVXF_1	516	523	PF00149	0.397
DOC_PP1_RVXF_1	629	636	PF00149	0.637
DOC_PP1_RVXF_1	71	78	PF00149	0.484
DOC_USP7_MATH_1	236	240	PF00917	0.563
DOC_USP7_MATH_1	282	286	PF00917	0.647
DOC_USP7_MATH_1	345	349	PF00917	0.744
DOC_USP7_MATH_1	458	462	PF00917	0.539
DOC_USP7_MATH_1	524	528	PF00917	0.579
DOC_USP7_MATH_2	337	343	PF00917	0.618
DOC_USP7_UBL2_3	293	297	PF12436	0.504
DOC_USP7_UBL2_3	664	668	PF12436	0.481
DOC_WW_Pin1_4	27	32	PF00397	0.592
DOC_WW_Pin1_4	415	420	PF00397	0.565
DOC_WW_Pin1_4	453	458	PF00397	0.734
DOC_WW_Pin1_4	520	525	PF00397	0.531
DOC_WW_Pin1_4	568	573	PF00397	0.526
LIG_14-3-3_CanoR_1	16	25	PF00244	0.604
LIG_14-3-3_CanoR_1	676	684	PF00244	0.461
LIG_Actin_WH2_2	390	408	PF00022	0.573
LIG_BRCT_BRCA1_1	131	135	PF00533	0.589
LIG_EVH1_2	41	45	PF00568	0.648
LIG_FHA_1	121	127	PF00498	0.631
LIG_FHA_1	178	184	PF00498	0.392
LIG_FHA_1	225	231	PF00498	0.454
LIG_FHA_1	526	532	PF00498	0.472
LIG_FHA_1	587	593	PF00498	0.504
LIG_FHA_2	432	438	PF00498	0.617
LIG_FHA_2	69	75	PF00498	0.635
LIG_Integrin_RGD_1	67	69	PF01839	0.495
LIG_LIR_Apic_2	52	56	PF02991	0.490
LIG_LIR_Apic_2	623	629	PF02991	0.511
LIG_LIR_Gen_1	393	398	PF02991	0.448
LIG_LIR_Gen_1	445	455	PF02991	0.741
LIG_LIR_Gen_1	475	484	PF02991	0.479
LIG_LIR_Nem_3	393	397	PF02991	0.428
LIG_LIR_Nem_3	445	450	PF02991	0.736
LIG_LIR_Nem_3	709	715	PF02991	0.495
LIG_MYND_3	283	287	PF01753	0.591
LIG_PCNA_yPIPBox_3	361	370	PF02747	0.431
LIG_PDZ_Class_2	710	715	PF00595	0.647
LIG_SH2_CRK	365	369	PF00017	0.369
LIG_SH2_STAP1	267	271	PF00017	0.450
LIG_SH2_STAP1	421	425	PF00017	0.499
LIG_SH2_STAP1	696	700	PF00017	0.480
LIG_SH2_STAT3	259	262	PF00017	0.501
LIG_SH2_STAT5	142	145	PF00017	0.530
LIG_SH2_STAT5	387	390	PF00017	0.412
LIG_SH2_STAT5	495	498	PF00017	0.418
LIG_SH2_STAT5	507	510	PF00017	0.447
LIG_SH3_3	116	122	PF00018	0.606
LIG_SH3_3	331	337	PF00018	0.505
LIG_SH3_3	551	557	PF00018	0.752
LIG_SH3_3	566	572	PF00018	0.571
LIG_SH3_3	630	636	PF00018	0.650
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.494
LIG_SUMO_SIM_par_1	269	276	PF11976	0.494
LIG_SUMO_SIM_par_1	534	541	PF11976	0.510
LIG_SUMO_SIM_par_1	95	101	PF11976	0.436
LIG_TRAF2_1	285	288	PF00917	0.600
LIG_TRAF2_1	337	340	PF00917	0.619
LIG_TYR_ITIM	363	368	PF00017	0.462
MOD_CDK_SPK_2	415	420	PF00069	0.565
MOD_CDK_SPxxK_3	453	460	PF00069	0.444
MOD_CK1_1	475	481	PF00069	0.546
MOD_CK1_1	571	577	PF00069	0.508
MOD_CK1_1	638	644	PF00069	0.503
MOD_CK1_1	675	681	PF00069	0.616
MOD_CK2_1	282	288	PF00069	0.591
MOD_CK2_1	431	437	PF00069	0.593
MOD_CK2_1	458	464	PF00069	0.516
MOD_CK2_1	474	480	PF00069	0.477
MOD_CK2_1	68	74	PF00069	0.687
MOD_Cter_Amidation	516	519	PF01082	0.462
MOD_GlcNHglycan	110	113	PF01048	0.633
MOD_GlcNHglycan	18	21	PF01048	0.574
MOD_GlcNHglycan	187	190	PF01048	0.439
MOD_GlcNHglycan	192	195	PF01048	0.386
MOD_GlcNHglycan	238	241	PF01048	0.618
MOD_GlcNHglycan	259	262	PF01048	0.612
MOD_GlcNHglycan	371	374	PF01048	0.484
MOD_GlcNHglycan	389	392	PF01048	0.471
MOD_GSK3_1	108	115	PF00069	0.643
MOD_GSK3_1	236	243	PF00069	0.487
MOD_GSK3_1	426	433	PF00069	0.485
MOD_GSK3_1	45	52	PF00069	0.498
MOD_GSK3_1	520	527	PF00069	0.507
MOD_GSK3_1	568	575	PF00069	0.512
MOD_GSK3_1	98	105	PF00069	0.504
MOD_NEK2_1	129	134	PF00069	0.603
MOD_NEK2_1	185	190	PF00069	0.404
MOD_NEK2_1	45	50	PF00069	0.608
MOD_NEK2_1	474	479	PF00069	0.430
MOD_NEK2_1	525	530	PF00069	0.493
MOD_NEK2_1	573	578	PF00069	0.630
MOD_PIKK_1	102	108	PF00454	0.557
MOD_PIKK_1	241	247	PF00454	0.623
MOD_PKA_2	108	114	PF00069	0.662
MOD_PKA_2	129	135	PF00069	0.579
MOD_PKA_2	369	375	PF00069	0.433
MOD_PKA_2	675	681	PF00069	0.488
MOD_Plk_1	224	230	PF00069	0.405
MOD_Plk_1	338	344	PF00069	0.529
MOD_Plk_1	97	103	PF00069	0.500
MOD_Plk_4	346	352	PF00069	0.524
MOD_Plk_4	45	51	PF00069	0.400
MOD_Plk_4	469	475	PF00069	0.490
MOD_Plk_4	573	579	PF00069	0.616
MOD_Plk_4	649	655	PF00069	0.515
MOD_Plk_4	708	714	PF00069	0.562
MOD_ProDKin_1	27	33	PF00069	0.588
MOD_ProDKin_1	415	421	PF00069	0.560
MOD_ProDKin_1	453	459	PF00069	0.725
MOD_ProDKin_1	520	526	PF00069	0.541
MOD_ProDKin_1	568	574	PF00069	0.522
MOD_SUMO_for_1	694	697	PF00179	0.467
MOD_SUMO_rev_2	436	441	PF00179	0.632
MOD_SUMO_rev_2	588	595	PF00179	0.459
TRG_DiLeu_BaEn_2	608	614	PF01217	0.643
TRG_DiLeu_LyEn_5	437	442	PF01217	0.576
TRG_ENDOCYTIC_2	142	145	PF00928	0.530
TRG_ENDOCYTIC_2	365	368	PF00928	0.369
TRG_ER_diArg_1	171	173	PF00400	0.567
TRG_ER_diArg_1	25	28	PF00400	0.530
TRG_ER_diArg_1	250	252	PF00400	0.551
TRG_ER_diArg_1	37	40	PF00400	0.598
TRG_ER_diArg_1	518	520	PF00400	0.444
TRG_NLS_MonoExtC_3	514	519	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P501	Leptomonas seymouri	65%	85%
A0A0S4JJK2	Bodo saltans	34%	87%
A0A1X0NRY5	Trypanosomatidae	41%	98%
A0A3S5H7T3	Leishmania donovani	88%	98%
A4HL07	Leishmania braziliensis	79%	100%
A4I8I8	Leishmania infantum	88%	98%
D0AAM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	96%
Q4Q4Q2	Leishmania major	88%	100%
V5BLC8	Trypanosoma cruzi	41%	96%