Enoyl-CoA hydratase/isomerase family protein,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/isomerase family protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3E6_LEIMU

TriTrypDb:

LmxM.31.3680

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006573	valine metabolic process	5	1
GO:0006574	valine catabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009081	branched-chain amino acid metabolic process	4	1
GO:0009083	branched-chain amino acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016054	organic acid catabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901606	alpha-amino acid catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	6	12
GO:0016289	CoA hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016790	thiolester hydrolase activity	4	12
GO:0016829	lyase activity	2	6
GO:0016853	isomerase activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.413
CLV_C14_Caspase3-7	250	254	PF00656	0.321
CLV_C14_Caspase3-7	344	348	PF00656	0.321
CLV_PCSK_KEX2_1	288	290	PF00082	0.279
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.321
CLV_PCSK_SKI1_1	21	25	PF00082	0.253
CLV_PCSK_SKI1_1	321	325	PF00082	0.260
CLV_PCSK_SKI1_1	86	90	PF00082	0.299
DOC_AGCK_PIF_2	88	93	PF00069	0.272
DOC_ANK_TNKS_1	156	163	PF00023	0.308
DOC_CKS1_1	217	222	PF01111	0.321
DOC_CKS1_1	293	298	PF01111	0.321
DOC_CKS1_1	352	357	PF01111	0.561
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.321
DOC_MAPK_DCC_7	157	165	PF00069	0.308
DOC_MAPK_MEF2A_6	157	165	PF00069	0.273
DOC_PP2B_LxvP_1	158	161	PF13499	0.384
DOC_PP4_FxxP_1	136	139	PF00568	0.224
DOC_USP7_MATH_1	192	196	PF00917	0.385
DOC_USP7_MATH_1	200	204	PF00917	0.433
DOC_USP7_MATH_1	6	10	PF00917	0.482
DOC_USP7_UBL2_3	288	292	PF12436	0.426
DOC_WW_Pin1_4	216	221	PF00397	0.321
DOC_WW_Pin1_4	273	278	PF00397	0.245
DOC_WW_Pin1_4	292	297	PF00397	0.321
DOC_WW_Pin1_4	351	356	PF00397	0.500
LIG_14-3-3_CanoR_1	128	136	PF00244	0.245
LIG_14-3-3_CanoR_1	157	161	PF00244	0.388
LIG_14-3-3_CanoR_1	21	26	PF00244	0.235
LIG_14-3-3_CanoR_1	27	32	PF00244	0.284
LIG_14-3-3_CanoR_1	44	50	PF00244	0.418
LIG_14-3-3_CanoR_1	7	13	PF00244	0.448
LIG_14-3-3_CterR_2	369	371	PF00244	0.426
LIG_APCC_ABBA_1	143	148	PF00400	0.260
LIG_DLG_GKlike_1	27	34	PF00625	0.272
LIG_FHA_1	184	190	PF00498	0.245
LIG_FHA_1	219	225	PF00498	0.423
LIG_FHA_1	241	247	PF00498	0.303
LIG_FHA_1	259	265	PF00498	0.378
LIG_FHA_1	279	285	PF00498	0.348
LIG_FHA_1	37	43	PF00498	0.248
LIG_FHA_1	97	103	PF00498	0.391
LIG_FHA_2	293	299	PF00498	0.388
LIG_IRF3_LxIS_1	242	249	PF10401	0.200
LIG_LIR_Apic_2	152	156	PF02991	0.245
LIG_LIR_Apic_2	215	220	PF02991	0.321
LIG_LIR_Apic_2	347	352	PF02991	0.304
LIG_LIR_Gen_1	232	240	PF02991	0.289
LIG_LIR_Nem_3	232	236	PF02991	0.195
LIG_LIR_Nem_3	87	93	PF02991	0.278
LIG_SH2_CRK	166	170	PF00017	0.321
LIG_SH2_CRK	217	221	PF00017	0.321
LIG_SH2_NCK_1	217	221	PF00017	0.359
LIG_SH2_STAT5	113	116	PF00017	0.256
LIG_SH2_STAT5	217	220	PF00017	0.297
LIG_SH2_STAT5	239	242	PF00017	0.188
LIG_SH2_STAT5	304	307	PF00017	0.304
LIG_SH2_STAT5	349	352	PF00017	0.367
LIG_SH2_STAT5	46	49	PF00017	0.291
LIG_SH2_STAT5	57	60	PF00017	0.185
LIG_SH3_1	349	355	PF00018	0.384
LIG_SH3_3	349	355	PF00018	0.404
LIG_SH3_3	356	362	PF00018	0.387
LIG_SH3_3	44	50	PF00018	0.391
LIG_SH3_4	330	337	PF00018	0.272
LIG_SUMO_SIM_par_1	280	285	PF11976	0.406
LIG_SxIP_EBH_1	98	108	PF03271	0.272
LIG_ULM_U2AF65_1	329	334	PF00076	0.272
LIG_WRC_WIRS_1	272	277	PF05994	0.321
MOD_CK1_1	122	128	PF00069	0.370
MOD_CK1_1	232	238	PF00069	0.321
MOD_CK1_1	291	297	PF00069	0.450
MOD_CK2_1	192	198	PF00069	0.226
MOD_CK2_1	292	298	PF00069	0.304
MOD_DYRK1A_RPxSP_1	351	355	PF00069	0.406
MOD_GlcNHglycan	124	127	PF01048	0.272
MOD_GlcNHglycan	190	193	PF01048	0.404
MOD_GlcNHglycan	8	11	PF01048	0.466
MOD_GlcNHglycan	81	84	PF01048	0.139
MOD_GSK3_1	188	195	PF00069	0.202
MOD_GSK3_1	215	222	PF00069	0.411
MOD_GSK3_1	225	232	PF00069	0.309
MOD_GSK3_1	240	247	PF00069	0.139
MOD_GSK3_1	258	265	PF00069	0.303
MOD_GSK3_1	271	278	PF00069	0.365
MOD_GSK3_1	288	295	PF00069	0.324
MOD_GSK3_1	364	371	PF00069	0.499
MOD_GSK3_1	57	64	PF00069	0.369
MOD_GSK3_1	75	82	PF00069	0.168
MOD_LATS_1	19	25	PF00433	0.388
MOD_N-GLC_1	244	249	PF02516	0.139
MOD_NEK2_1	1	6	PF00069	0.565
MOD_NEK2_1	167	172	PF00069	0.245
MOD_NEK2_1	240	245	PF00069	0.252
MOD_NEK2_1	246	251	PF00069	0.293
MOD_PIKK_1	219	225	PF00454	0.236
MOD_PIKK_1	304	310	PF00454	0.379
MOD_PKA_1	288	294	PF00069	0.175
MOD_PKA_2	156	162	PF00069	0.388
MOD_PKA_2	288	294	PF00069	0.175
MOD_PKA_2	350	356	PF00069	0.576
MOD_PKA_2	6	12	PF00069	0.376
MOD_Plk_1	244	250	PF00069	0.257
MOD_Plk_4	149	155	PF00069	0.272
MOD_Plk_4	247	253	PF00069	0.313
MOD_Plk_4	52	58	PF00069	0.388
MOD_Plk_4	8	14	PF00069	0.370
MOD_Plk_4	97	103	PF00069	0.370
MOD_ProDKin_1	216	222	PF00069	0.321
MOD_ProDKin_1	273	279	PF00069	0.245
MOD_ProDKin_1	292	298	PF00069	0.321
MOD_ProDKin_1	351	357	PF00069	0.493
MOD_SUMO_rev_2	326	331	PF00179	0.385
MOD_SUMO_rev_2	92	100	PF00179	0.318
TRG_ENDOCYTIC_2	166	169	PF00928	0.260
TRG_ENDOCYTIC_2	239	242	PF00928	0.188
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P500	Leptomonas seymouri	40%	100%
A0A0N0P5E1	Leptomonas seymouri	64%	100%
A0A1X0NSC5	Trypanosomatidae	44%	100%
A0A1X0NTE8	Trypanosomatidae	46%	100%
A0A1X0NTM5	Trypanosomatidae	47%	100%
A0A381MRJ9	Leishmania infantum	38%	100%
A0A3Q8IDG7	Leishmania donovani	39%	100%
A0A3Q8IHF8	Leishmania donovani	92%	100%
A0A3Q8ITQ0	Leishmania donovani	38%	100%
A2VDC2	Xenopus laevis	41%	96%
A4HHN0	Leishmania braziliensis	27%	100%
A4HL04	Leishmania braziliensis	39%	100%
A4HL05	Leishmania braziliensis	38%	100%
A4HL06	Leishmania braziliensis	84%	100%
A4I8I5	Leishmania infantum	38%	100%
A4I8I6	Leishmania infantum	93%	100%
D0AAN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	99%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O74802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	86%
P28817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	74%
Q1PEY5	Arabidopsis thaliana	36%	98%
Q28FR6	Xenopus tropicalis	41%	96%
Q2HJ73	Bos taurus	38%	96%
Q4Q4Q4	Leishmania major	94%	100%
Q4Q4Q5	Leishmania major	38%	100%
Q4Q4Q6	Leishmania major	38%	98%
Q55GS6	Dictyostelium discoideum	32%	97%
Q58EB4	Danio rerio	38%	97%
Q5XF59	Arabidopsis thaliana	35%	93%
Q5XIE6	Rattus norvegicus	39%	96%
Q5ZJ60	Gallus gallus	38%	96%
Q6NMB0	Arabidopsis thaliana	37%	98%
Q6NVY1	Homo sapiens	39%	96%
Q8QZS1	Mus musculus	39%	96%
Q8RXN4	Arabidopsis thaliana	31%	91%
Q9LK08	Arabidopsis thaliana	29%	89%
Q9LKJ1	Arabidopsis thaliana	36%	98%
Q9SHJ8	Arabidopsis thaliana	33%	96%
Q9T0K7	Arabidopsis thaliana	31%	88%
V5BQZ7	Trypanosoma cruzi	43%	96%