3-hydroxyisobutyryl-coenzyme a hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyisobutyryl-coenzyme a hydrolase-like protein

Species:

Leishmania mexicana

UniProt:

E9B3E5_LEIMU

TriTrypDb:

LmxM.32.3670

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	6	2
GO:0016289	CoA hydrolase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016790	thiolester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	135	137	PF00082	0.549
CLV_PCSK_KEX2_1	92	94	PF00082	0.549
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.549
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.549
DEG_Nend_UBRbox_2	1	2	PF02207	0.695
DOC_CKS1_1	94	99	PF01111	0.549
DOC_MAPK_gen_1	53	60	PF00069	0.549
DOC_USP7_MATH_1	6	10	PF00917	0.549
DOC_USP7_MATH_1	63	67	PF00917	0.549
DOC_WW_Pin1_4	46	51	PF00397	0.549
DOC_WW_Pin1_4	77	82	PF00397	0.549
DOC_WW_Pin1_4	93	98	PF00397	0.269
LIG_14-3-3_CanoR_1	136	142	PF00244	0.549
LIG_14-3-3_CanoR_1	162	166	PF00244	0.793
LIG_14-3-3_CanoR_1	21	30	PF00244	0.549
LIG_Actin_WH2_2	41	57	PF00022	0.549
LIG_FHA_1	70	76	PF00498	0.549
LIG_FHA_1	83	89	PF00498	0.322
LIG_FHA_2	155	161	PF00498	0.719
LIG_FHA_2	31	37	PF00498	0.549
LIG_FHA_2	99	105	PF00498	0.549
LIG_Integrin_RGD_1	107	109	PF01839	0.549
LIG_LIR_Gen_1	109	117	PF02991	0.549
LIG_LIR_Nem_3	109	113	PF02991	0.549
LIG_SH2_CRK	110	114	PF00017	0.549
LIG_SH2_NCK_1	110	114	PF00017	0.549
LIG_SH2_STAT5	110	113	PF00017	0.549
LIG_SH3_3	24	30	PF00018	0.549
LIG_SUMO_SIM_anti_2	148	153	PF11976	0.549
LIG_SUMO_SIM_anti_2	72	77	PF11976	0.549
LIG_SUMO_SIM_par_1	71	77	PF11976	0.549
LIG_SUMO_SIM_par_1	84	89	PF11976	0.322
LIG_WRC_WIRS_1	103	108	PF05994	0.549
MOD_CDK_SPxxK_3	46	53	PF00069	0.549
MOD_CK1_1	164	170	PF00069	0.805
MOD_CK1_1	9	15	PF00069	0.549
MOD_CK2_1	140	146	PF00069	0.549
MOD_CK2_1	154	160	PF00069	0.462
MOD_CK2_1	30	36	PF00069	0.549
MOD_CK2_1	98	104	PF00069	0.549
MOD_GlcNHglycan	12	15	PF01048	0.549
MOD_GlcNHglycan	64	68	PF01048	0.549
MOD_GSK3_1	108	115	PF00069	0.375
MOD_GSK3_1	44	51	PF00069	0.549
MOD_GSK3_1	6	13	PF00069	0.549
MOD_GSK3_1	98	105	PF00069	0.549
MOD_NEK2_1	112	117	PF00069	0.549
MOD_NEK2_2	161	166	PF00069	0.791
MOD_PKA_2	161	167	PF00069	0.791
MOD_Plk_1	108	114	PF00069	0.549
MOD_Plk_4	108	114	PF00069	0.375
MOD_Plk_4	161	167	PF00069	0.791
MOD_Plk_4	98	104	PF00069	0.549
MOD_ProDKin_1	46	52	PF00069	0.549
MOD_ProDKin_1	77	83	PF00069	0.549
MOD_ProDKin_1	93	99	PF00069	0.269
TRG_ENDOCYTIC_2	110	113	PF00928	0.549
TRG_NES_CRM1_1	120	134	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A2VDC2	XENLA	25%	44%
Q2HJ73	BOVIN	30%	44%
Q58EB4	DANRE	28%	45%
Q5XIE6	RAT	30%	44%
Q5ZJ60	CHICK	28%	44%
Q6NVY1	HUMAN	26%	44%
Q9SHJ8	ARATH	24%	44%