Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3E4_LEIMU

TriTrypDb:

LmxM.31.3640

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.371
CLV_C14_Caspase3-7	235	239	PF00656	0.441
CLV_NRD_NRD_1	12	14	PF00675	0.343
CLV_NRD_NRD_1	163	165	PF00675	0.371
CLV_NRD_NRD_1	199	201	PF00675	0.429
CLV_NRD_NRD_1	246	248	PF00675	0.352
CLV_NRD_NRD_1	383	385	PF00675	0.656
CLV_PCSK_KEX2_1	12	14	PF00082	0.351
CLV_PCSK_KEX2_1	163	165	PF00082	0.508
CLV_PCSK_KEX2_1	201	203	PF00082	0.433
CLV_PCSK_KEX2_1	212	214	PF00082	0.307
CLV_PCSK_KEX2_1	383	385	PF00082	0.597
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.433
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.307
CLV_Separin_Metazoa	403	407	PF03568	0.439
DEG_COP1_1	27	36	PF00400	0.418
DEG_SPOP_SBC_1	18	22	PF00917	0.436
DOC_PP4_FxxP_1	122	125	PF00568	0.409
DOC_USP7_MATH_1	151	155	PF00917	0.487
DOC_USP7_MATH_1	185	189	PF00917	0.272
DOC_USP7_MATH_1	232	236	PF00917	0.448
DOC_USP7_MATH_1	349	353	PF00917	0.467
DOC_USP7_MATH_1	84	88	PF00917	0.347
DOC_WW_Pin1_4	384	389	PF00397	0.665
LIG_14-3-3_CanoR_1	101	105	PF00244	0.332
LIG_14-3-3_CanoR_1	12	18	PF00244	0.413
LIG_14-3-3_CanoR_1	355	360	PF00244	0.713
LIG_14-3-3_CanoR_1	406	413	PF00244	0.334
LIG_14-3-3_CterR_2	421	423	PF00244	0.475
LIG_Actin_WH2_2	88	103	PF00022	0.372
LIG_deltaCOP1_diTrp_1	66	72	PF00928	0.294
LIG_FHA_1	178	184	PF00498	0.542
LIG_FHA_1	19	25	PF00498	0.496
LIG_FHA_1	260	266	PF00498	0.457
LIG_FHA_1	294	300	PF00498	0.504
LIG_FHA_1	323	329	PF00498	0.331
LIG_FHA_1	333	339	PF00498	0.343
LIG_FHA_1	342	348	PF00498	0.509
LIG_FHA_2	157	163	PF00498	0.476
LIG_LIR_Apic_2	188	192	PF02991	0.358
LIG_LIR_Gen_1	267	275	PF02991	0.404
LIG_LIR_Nem_3	225	231	PF02991	0.408
LIG_LIR_Nem_3	267	271	PF02991	0.309
LIG_LIR_Nem_3	66	72	PF02991	0.380
LIG_Pex14_2	375	379	PF04695	0.468
LIG_SH2_CRK	189	193	PF00017	0.407
LIG_SH2_NCK_1	15	19	PF00017	0.417
LIG_SH2_NCK_1	189	193	PF00017	0.407
LIG_SH2_SRC	32	35	PF00017	0.326
LIG_SH2_STAT5	104	107	PF00017	0.320
LIG_SH2_STAT5	228	231	PF00017	0.382
LIG_SH2_STAT5	32	35	PF00017	0.427
LIG_SH3_3	243	249	PF00018	0.464
LIG_SH3_3	327	333	PF00018	0.378
LIG_SH3_3	374	380	PF00018	0.684
LIG_SH3_3	55	61	PF00018	0.349
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.354
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.411
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.503
LIG_SUMO_SIM_par_1	182	188	PF11976	0.318
LIG_SUMO_SIM_par_1	334	340	PF11976	0.356
LIG_SUMO_SIM_par_1	414	419	PF11976	0.398
LIG_TRAF2_1	393	396	PF00917	0.658
LIG_TRAF2_2	89	94	PF00917	0.295
LIG_WRC_WIRS_1	1	6	PF05994	0.519
MOD_CK1_1	284	290	PF00069	0.528
MOD_CK1_1	292	298	PF00069	0.506
MOD_CK1_1	311	317	PF00069	0.566
MOD_CK1_1	339	345	PF00069	0.520
MOD_CK1_1	41	47	PF00069	0.465
MOD_CK2_1	17	23	PF00069	0.476
MOD_CK2_1	217	223	PF00069	0.325
MOD_CK2_1	390	396	PF00069	0.594
MOD_GlcNHglycan	15	18	PF01048	0.420
MOD_GlcNHglycan	169	172	PF01048	0.320
MOD_GlcNHglycan	219	222	PF01048	0.374
MOD_GlcNHglycan	283	286	PF01048	0.488
MOD_GlcNHglycan	325	328	PF01048	0.413
MOD_GlcNHglycan	43	46	PF01048	0.474
MOD_GSK3_1	100	107	PF00069	0.197
MOD_GSK3_1	13	20	PF00069	0.543
MOD_GSK3_1	232	239	PF00069	0.513
MOD_GSK3_1	24	31	PF00069	0.424
MOD_GSK3_1	289	296	PF00069	0.388
MOD_GSK3_1	318	325	PF00069	0.413
MOD_GSK3_1	332	339	PF00069	0.366
MOD_GSK3_1	390	397	PF00069	0.640
MOD_GSK3_1	404	411	PF00069	0.521
MOD_GSK3_1	416	423	PF00069	0.366
MOD_GSK3_1	80	87	PF00069	0.317
MOD_N-GLC_1	107	112	PF02516	0.489
MOD_NEK2_1	100	105	PF00069	0.388
MOD_NEK2_1	254	259	PF00069	0.400
MOD_NEK2_1	290	295	PF00069	0.422
MOD_NEK2_1	416	421	PF00069	0.371
MOD_NEK2_2	371	376	PF00069	0.456
MOD_PIKK_1	139	145	PF00454	0.441
MOD_PIKK_1	151	157	PF00454	0.432
MOD_PIKK_1	232	238	PF00454	0.443
MOD_PIKK_1	416	422	PF00454	0.441
MOD_PIKK_1	84	90	PF00454	0.394
MOD_PKA_1	73	79	PF00069	0.423
MOD_PKA_2	100	106	PF00069	0.334
MOD_PKA_2	365	371	PF00069	0.472
MOD_PKA_2	405	411	PF00069	0.374
MOD_Plk_1	139	145	PF00069	0.397
MOD_Plk_1	28	34	PF00069	0.353
MOD_Plk_1	371	377	PF00069	0.709
MOD_Plk_1	394	400	PF00069	0.531
MOD_Plk_4	179	185	PF00069	0.359
MOD_Plk_4	28	34	PF00069	0.451
MOD_Plk_4	332	338	PF00069	0.369
MOD_Plk_4	355	361	PF00069	0.450
MOD_ProDKin_1	384	390	PF00069	0.666
MOD_SUMO_for_1	400	403	PF00179	0.467
TRG_ENDOCYTIC_2	135	138	PF00928	0.421
TRG_ER_diArg_1	11	13	PF00400	0.352
TRG_ER_diArg_1	383	386	PF00400	0.771
TRG_NLS_MonoExtC_3	199	204	PF00514	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I9	Leptomonas seymouri	55%	100%
A0A1X0NRZ3	Trypanosomatidae	36%	100%
A0A3Q8IGJ4	Leishmania donovani	93%	100%
A0A422P320	Trypanosoma rangeli	39%	100%
A4HL03	Leishmania braziliensis	79%	100%
A4I8I3	Leishmania infantum	93%	100%
D0AAN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q4Q8	Leishmania major	91%	100%
Q6NL34	Drosophila melanogaster	27%	78%
V5DMD9	Trypanosoma cruzi	36%	100%