PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3E2_LEIMU

TriTrypDb:

LmxM.31.3620

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DOC_CKS1_1	201	206	PF01111	0.450
DOC_PP2B_LxvP_1	180	183	PF13499	0.380
DOC_USP7_UBL2_3	190	194	PF12436	0.432
DOC_WW_Pin1_4	200	205	PF00397	0.531
DOC_WW_Pin1_4	214	219	PF00397	0.346
DOC_WW_Pin1_4	46	51	PF00397	0.643
DOC_WW_Pin1_4	72	77	PF00397	0.712
DOC_WW_Pin1_4	78	83	PF00397	0.630
DOC_WW_Pin1_4	87	92	PF00397	0.671
LIG_14-3-3_CanoR_1	22	29	PF00244	0.609
LIG_BRCT_BRCA1_1	113	117	PF00533	0.545
LIG_BRCT_BRCA1_1	120	124	PF00533	0.392
LIG_FHA_1	227	233	PF00498	0.357
LIG_FHA_1	24	30	PF00498	0.475
LIG_FHA_1	58	64	PF00498	0.570
LIG_FHA_2	201	207	PF00498	0.406
LIG_FHA_2	72	78	PF00498	0.648
LIG_FHA_2	99	105	PF00498	0.498
LIG_GSK3_LRP6_1	46	51	PF00069	0.500
LIG_LIR_Apic_2	200	204	PF02991	0.557
LIG_LIR_Apic_2	233	238	PF02991	0.489
LIG_LIR_Gen_1	222	232	PF02991	0.371
LIG_LIR_Nem_3	195	199	PF02991	0.351
LIG_LIR_Nem_3	222	227	PF02991	0.375
LIG_LIR_Nem_3	229	234	PF02991	0.356
LIG_Pex14_1	160	164	PF04695	0.448
LIG_SH2_PTP2	128	131	PF00017	0.381
LIG_SH2_PTP2	231	234	PF00017	0.430
LIG_SH2_STAP1	140	144	PF00017	0.447
LIG_SH2_STAT5	128	131	PF00017	0.381
LIG_SH2_STAT5	196	199	PF00017	0.357
LIG_SH2_STAT5	202	205	PF00017	0.413
LIG_SH2_STAT5	231	234	PF00017	0.430
LIG_SH2_STAT5	235	238	PF00017	0.504
LIG_SH3_2	47	52	PF14604	0.635
LIG_SH3_3	173	179	PF00018	0.362
LIG_SH3_3	44	50	PF00018	0.608
LIG_SH3_3	91	97	PF00018	0.701
LIG_SUMO_SIM_par_1	178	185	PF11976	0.389
LIG_TRAF2_1	3	6	PF00917	0.556
LIG_WRC_WIRS_1	161	166	PF05994	0.418
MOD_CDC14_SPxK_1	49	52	PF00782	0.623
MOD_CDC14_SPxK_1	75	78	PF00782	0.651
MOD_CDC14_SPxK_1	90	93	PF00782	0.493
MOD_CDK_SPxK_1	46	52	PF00069	0.616
MOD_CDK_SPxK_1	72	78	PF00069	0.651
MOD_CDK_SPxK_1	87	93	PF00069	0.499
MOD_CDK_SPxxK_3	214	221	PF00069	0.433
MOD_CK1_1	166	172	PF00069	0.419
MOD_CK1_1	55	61	PF00069	0.634
MOD_CK1_1	67	73	PF00069	0.710
MOD_CK2_1	139	145	PF00069	0.441
MOD_CK2_1	200	206	PF00069	0.405
MOD_CK2_1	214	220	PF00069	0.353
MOD_CK2_1	98	104	PF00069	0.526
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.623
MOD_GlcNHglycan	113	116	PF01048	0.531
MOD_GlcNHglycan	131	134	PF01048	0.448
MOD_GlcNHglycan	19	22	PF01048	0.418
MOD_GlcNHglycan	258	261	PF01048	0.600
MOD_GlcNHglycan	54	57	PF01048	0.676
MOD_GlcNHglycan	82	85	PF01048	0.720
MOD_GlcNHglycan	87	90	PF01048	0.729
MOD_GSK3_1	131	138	PF00069	0.395
MOD_GSK3_1	64	71	PF00069	0.653
MOD_N-GLC_1	192	197	PF02516	0.517
MOD_NEK2_1	15	20	PF00069	0.545
MOD_NEK2_1	256	261	PF00069	0.603
MOD_NEK2_1	29	34	PF00069	0.622
MOD_PK_1	64	70	PF00069	0.746
MOD_PKA_2	111	117	PF00069	0.581
MOD_PKA_2	166	172	PF00069	0.425
MOD_Plk_1	192	198	PF00069	0.395
MOD_Plk_4	103	109	PF00069	0.465
MOD_Plk_4	192	198	PF00069	0.378
MOD_ProDKin_1	200	206	PF00069	0.535
MOD_ProDKin_1	214	220	PF00069	0.343
MOD_ProDKin_1	46	52	PF00069	0.647
MOD_ProDKin_1	72	78	PF00069	0.714
MOD_ProDKin_1	87	93	PF00069	0.675
MOD_SUMO_rev_2	184	192	PF00179	0.420
TRG_DiLeu_BaEn_1	223	228	PF01217	0.476
TRG_DiLeu_BaEn_1	6	11	PF01217	0.598
TRG_DiLeu_BaEn_4	6	12	PF01217	0.544
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.361
TRG_DiLeu_LyEn_5	6	11	PF01217	0.543
TRG_ENDOCYTIC_2	128	131	PF00928	0.405
TRG_ENDOCYTIC_2	196	199	PF00928	0.348
TRG_ENDOCYTIC_2	231	234	PF00928	0.430
TRG_ER_diArg_1	150	153	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT8	Leptomonas seymouri	57%	95%
A0A3Q8IG98	Leishmania donovani	91%	100%
A0A3R7P3C4	Trypanosoma rangeli	49%	100%
A4HL01	Leishmania braziliensis	76%	100%
A4I8I2	Leishmania infantum	92%	100%
Q4Q4R0	Leishmania major	90%	100%