Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3E1_LEIMU

TriTrypDb:

LmxM.31.3610

Length:

147

Annotations

LeishMANIAdb annotations

This small protein family has no close known relatives. They might not even be membrane proteins.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B3E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	142	146	PF00082	0.640
DEG_APCC_DBOX_1	59	67	PF00400	0.662
DOC_PP1_RVXF_1	22	28	PF00149	0.583
DOC_PP4_FxxP_1	96	99	PF00568	0.422
DOC_PP4_MxPP_1	1	4	PF00568	0.592
DOC_USP7_MATH_1	4	8	PF00917	0.584
LIG_14-3-3_CanoR_1	24	28	PF00244	0.685
LIG_14-3-3_CanoR_1	46	52	PF00244	0.592
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_1	1	5	PF00653	0.591
LIG_BIR_III_3	1	5	PF00653	0.591
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.459
LIG_FHA_1	132	138	PF00498	0.461
LIG_LIR_Apic_2	119	123	PF02991	0.398
LIG_LIR_Apic_2	26	30	PF02991	0.588
LIG_LIR_Gen_1	87	97	PF02991	0.331
LIG_LIR_Nem_3	16	20	PF02991	0.579
LIG_LIR_Nem_3	49	54	PF02991	0.618
LIG_NRBOX	76	82	PF00104	0.415
LIG_Pex14_1	27	31	PF04695	0.600
LIG_Pex14_2	13	17	PF04695	0.679
LIG_SH2_SRC	97	100	PF00017	0.400
LIG_SH2_STAP1	111	115	PF00017	0.385
LIG_SH2_STAT5	143	146	PF00017	0.486
LIG_SH2_STAT5	97	100	PF00017	0.374
LIG_SH3_3	132	138	PF00018	0.399
LIG_SH3_3	96	102	PF00018	0.359
MOD_CMANNOS	117	120	PF00535	0.670
MOD_GlcNHglycan	74	77	PF01048	0.279
MOD_GSK3_1	133	140	PF00069	0.381
MOD_NEK2_1	47	52	PF00069	0.609
MOD_PKA_2	23	29	PF00069	0.682
MOD_Plk_4	23	29	PF00069	0.597
MOD_Plk_4	47	53	PF00069	0.608
TRG_ENDOCYTIC_2	31	34	PF00928	0.594
TRG_ENDOCYTIC_2	54	57	PF00928	0.610
TRG_ENDOCYTIC_2	89	92	PF00928	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP5	Leptomonas seymouri	86%	100%
A0A0S4JRP2	Bodo saltans	68%	100%
A0A1X0NRX4	Trypanosomatidae	66%	100%
A0A3S7X678	Leishmania donovani	98%	100%
A0A422P365	Trypanosoma rangeli	67%	100%
A4HL00	Leishmania braziliensis	94%	100%
A4I8I1	Leishmania infantum	98%	100%
D0AAN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
Q4Q4R1	Leishmania major	98%	100%
V5B5U3	Trypanosoma cruzi	68%	100%