Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3D7_LEIMU

TriTrypDb:

LmxM.31.3560

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.385
CLV_NRD_NRD_1	143	145	PF00675	0.436
CLV_NRD_NRD_1	146	148	PF00675	0.465
CLV_NRD_NRD_1	149	151	PF00675	0.483
CLV_NRD_NRD_1	298	300	PF00675	0.401
CLV_NRD_NRD_1	5	7	PF00675	0.555
CLV_NRD_NRD_1	567	569	PF00675	0.607
CLV_PCSK_KEX2_1	143	145	PF00082	0.518
CLV_PCSK_KEX2_1	298	300	PF00082	0.401
CLV_PCSK_KEX2_1	5	7	PF00082	0.555
CLV_PCSK_SKI1_1	143	147	PF00082	0.483
CLV_PCSK_SKI1_1	151	155	PF00082	0.445
CLV_PCSK_SKI1_1	243	247	PF00082	0.363
CLV_PCSK_SKI1_1	5	9	PF00082	0.658
CLV_Separin_Metazoa	93	97	PF03568	0.453
DEG_APCC_DBOX_1	242	250	PF00400	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DEG_SPOP_SBC_1	363	367	PF00917	0.529
DOC_CYCLIN_RxL_1	422	432	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.483
DOC_MAPK_gen_1	240	248	PF00069	0.439
DOC_MAPK_MEF2A_6	215	223	PF00069	0.291
DOC_PP2B_LxvP_1	106	109	PF13499	0.468
DOC_PP2B_LxvP_1	124	127	PF13499	0.329
DOC_PP2B_LxvP_1	533	536	PF13499	0.515
DOC_PP4_FxxP_1	233	236	PF00568	0.414
DOC_PP4_FxxP_1	301	304	PF00568	0.367
DOC_USP7_MATH_1	135	139	PF00917	0.479
DOC_USP7_MATH_1	363	367	PF00917	0.563
DOC_USP7_MATH_1	467	471	PF00917	0.748
DOC_USP7_MATH_1	522	526	PF00917	0.476
DOC_USP7_MATH_1	53	57	PF00917	0.674
DOC_USP7_MATH_1	65	69	PF00917	0.583
DOC_USP7_UBL2_3	148	152	PF12436	0.438
DOC_WW_Pin1_4	253	258	PF00397	0.407
DOC_WW_Pin1_4	46	51	PF00397	0.575
DOC_WW_Pin1_4	472	477	PF00397	0.599
DOC_WW_Pin1_4	482	487	PF00397	0.497
DOC_WW_Pin1_4	505	510	PF00397	0.461
DOC_WW_Pin1_4	557	562	PF00397	0.447
DOC_WW_Pin1_4	61	66	PF00397	0.590
LIG_14-3-3_CanoR_1	298	302	PF00244	0.396
LIG_14-3-3_CanoR_1	354	363	PF00244	0.549
LIG_14-3-3_CanoR_1	481	486	PF00244	0.504
LIG_Actin_WH2_2	433	448	PF00022	0.413
LIG_AP2alpha_2	231	233	PF02296	0.417
LIG_BRCT_BRCA1_1	255	259	PF00533	0.382
LIG_BRCT_BRCA1_1	364	368	PF00533	0.510
LIG_FHA_1	195	201	PF00498	0.562
LIG_FHA_1	2	8	PF00498	0.660
LIG_FHA_1	207	213	PF00498	0.439
LIG_FHA_1	424	430	PF00498	0.388
LIG_FHA_2	152	158	PF00498	0.482
LIG_FHA_2	205	211	PF00498	0.436
LIG_FHA_2	373	379	PF00498	0.429
LIG_FHA_2	515	521	PF00498	0.456
LIG_FHA_2	558	564	PF00498	0.467
LIG_FHA_2	74	80	PF00498	0.550
LIG_FHA_2	83	89	PF00498	0.386
LIG_LIR_Apic_2	231	236	PF02991	0.345
LIG_LIR_Apic_2	247	253	PF02991	0.370
LIG_LIR_Apic_2	300	304	PF02991	0.351
LIG_LIR_Gen_1	22	33	PF02991	0.445
LIG_LIR_Gen_1	305	316	PF02991	0.380
LIG_LIR_Nem_3	138	142	PF02991	0.419
LIG_LIR_Nem_3	22	28	PF02991	0.476
LIG_LIR_Nem_3	305	311	PF02991	0.376
LIG_LIR_Nem_3	336	341	PF02991	0.596
LIG_MAD2	6	14	PF02301	0.645
LIG_NRBOX	292	298	PF00104	0.419
LIG_REV1ctd_RIR_1	224	231	PF16727	0.377
LIG_SH2_CRK	250	254	PF00017	0.578
LIG_SH2_CRK	279	283	PF00017	0.370
LIG_SH2_SRC	413	416	PF00017	0.422
LIG_SH2_STAP1	19	23	PF00017	0.376
LIG_SH2_STAT5	2	5	PF00017	0.492
LIG_SH2_STAT5	25	28	PF00017	0.430
LIG_SH2_STAT5	284	287	PF00017	0.325
LIG_SH2_STAT5	33	36	PF00017	0.332
LIG_SH2_STAT5	413	416	PF00017	0.422
LIG_SH3_2	476	481	PF14604	0.604
LIG_SH3_3	10	16	PF00018	0.510
LIG_SH3_3	251	257	PF00018	0.401
LIG_SH3_3	47	53	PF00018	0.551
LIG_SH3_3	473	479	PF00018	0.617
LIG_SH3_3	506	512	PF00018	0.536
LIG_SH3_3	67	73	PF00018	0.702
LIG_SH3_3	94	100	PF00018	0.566
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.430
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.419
LIG_TRAF2_1	120	123	PF00917	0.486
LIG_TRAF2_1	154	157	PF00917	0.503
LIG_UBA3_1	107	113	PF00899	0.426
LIG_UBA3_1	515	521	PF00899	0.491
LIG_WRC_WIRS_1	136	141	PF05994	0.482
LIG_WW_3	14	18	PF00397	0.494
MOD_CDK_SPK_2	46	51	PF00069	0.506
MOD_CDK_SPK_2	505	510	PF00069	0.525
MOD_CK1_1	194	200	PF00069	0.510
MOD_CK1_1	396	402	PF00069	0.576
MOD_CK1_1	418	424	PF00069	0.405
MOD_CK1_1	514	520	PF00069	0.493
MOD_CK1_1	64	70	PF00069	0.626
MOD_CK2_1	151	157	PF00069	0.480
MOD_CK2_1	204	210	PF00069	0.395
MOD_CK2_1	396	402	PF00069	0.576
MOD_CK2_1	482	488	PF00069	0.442
MOD_CK2_1	514	520	PF00069	0.493
MOD_CK2_1	557	563	PF00069	0.458
MOD_CK2_1	73	79	PF00069	0.548
MOD_CK2_1	82	88	PF00069	0.460
MOD_CMANNOS	307	310	PF00535	0.343
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.676
MOD_GlcNHglycan	133	136	PF01048	0.374
MOD_GlcNHglycan	170	174	PF01048	0.603
MOD_GlcNHglycan	304	307	PF01048	0.321
MOD_GlcNHglycan	335	338	PF01048	0.588
MOD_GlcNHglycan	358	361	PF01048	0.636
MOD_GlcNHglycan	398	401	PF01048	0.735
MOD_GlcNHglycan	533	536	PF01048	0.623
MOD_GSK3_1	127	134	PF00069	0.361
MOD_GSK3_1	169	176	PF00069	0.597
MOD_GSK3_1	29	36	PF00069	0.434
MOD_GSK3_1	414	421	PF00069	0.394
MOD_GSK3_1	468	475	PF00069	0.662
MOD_GSK3_1	61	68	PF00069	0.616
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	260	265	PF00069	0.410
MOD_NEK2_1	370	375	PF00069	0.429
MOD_NEK2_1	405	410	PF00069	0.390
MOD_NEK2_1	423	428	PF00069	0.390
MOD_NEK2_1	429	434	PF00069	0.421
MOD_PIKK_1	474	480	PF00454	0.490
MOD_PKA_1	151	157	PF00069	0.510
MOD_PKA_2	219	225	PF00069	0.459
MOD_PKA_2	297	303	PF00069	0.391
MOD_PKA_2	342	348	PF00069	0.613
MOD_Plk_1	418	424	PF00069	0.415
MOD_Plk_1	65	71	PF00069	0.619
MOD_Plk_2-3	204	210	PF00069	0.447
MOD_Plk_2-3	372	378	PF00069	0.437
MOD_Plk_2-3	82	88	PF00069	0.329
MOD_Plk_4	111	117	PF00069	0.302
MOD_Plk_4	135	141	PF00069	0.438
MOD_Plk_4	219	225	PF00069	0.311
MOD_Plk_4	29	35	PF00069	0.378
MOD_Plk_4	372	378	PF00069	0.272
MOD_Plk_4	418	424	PF00069	0.415
MOD_Plk_4	511	517	PF00069	0.509
MOD_Plk_4	82	88	PF00069	0.493
MOD_ProDKin_1	253	259	PF00069	0.400
MOD_ProDKin_1	46	52	PF00069	0.582
MOD_ProDKin_1	472	478	PF00069	0.599
MOD_ProDKin_1	482	488	PF00069	0.489
MOD_ProDKin_1	505	511	PF00069	0.464
MOD_ProDKin_1	557	563	PF00069	0.458
MOD_ProDKin_1	61	67	PF00069	0.589
MOD_SUMO_rev_2	563	570	PF00179	0.519
TRG_DiLeu_BaEn_1	156	161	PF01217	0.410
TRG_DiLeu_BaEn_1	208	213	PF01217	0.411
TRG_DiLeu_BaEn_1	244	249	PF01217	0.432
TRG_DiLeu_BaEn_2	254	260	PF01217	0.377
TRG_DiLeu_BaEn_4	156	162	PF01217	0.410
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.552
TRG_ENDOCYTIC_2	25	28	PF00928	0.430
TRG_ENDOCYTIC_2	279	282	PF00928	0.371
TRG_ENDOCYTIC_2	308	311	PF00928	0.390
TRG_ER_diArg_1	142	144	PF00400	0.502
TRG_ER_diArg_1	297	299	PF00400	0.440
TRG_ER_diArg_1	5	7	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P3	Leptomonas seymouri	38%	100%
A0A3Q8IFU0	Leishmania donovani	89%	100%
A4HKZ7	Leishmania braziliensis	73%	100%
A4I8H7	Leishmania infantum	88%	100%
Q4Q4R5	Leishmania major	87%	100%