Robl_LC7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Roadblock/LC7 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3D6_LEIMU

TriTrypDb:

LmxM.31.3555

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0005868	cytoplasmic dynein complex	4	8
GO:0005874	microtubule	6	8
GO:0005875	microtubule associated complex	2	8
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0099080	supramolecular complex	2	8
GO:0099081	supramolecular polymer	3	8
GO:0099512	supramolecular fiber	4	8
GO:0099513	polymeric cytoskeletal fiber	5	8
GO:0110165	cellular anatomical entity	1	8
GO:1902494	catalytic complex	2	8

Expansion

Sequence features

E9B3D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3D6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0045505	dynein intermediate chain binding	3	8
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	103	107	PF00082	0.472
CLV_PCSK_SKI1_1	17	21	PF00082	0.339
CLV_PCSK_SKI1_1	82	86	PF00082	0.448
DEG_APCC_DBOX_1	102	110	PF00400	0.441
DOC_CYCLIN_RxL_1	100	108	PF00134	0.443
DOC_MAPK_MEF2A_6	17	24	PF00069	0.366
DOC_PP2B_LxvP_1	61	64	PF13499	0.345
DOC_USP7_MATH_1	71	75	PF00917	0.577
DOC_USP7_UBL2_3	77	81	PF12436	0.535
DOC_WW_Pin1_4	64	69	PF00397	0.439
DOC_WW_Pin1_4	72	77	PF00397	0.503
DOC_WW_Pin1_4	84	89	PF00397	0.474
LIG_14-3-3_CanoR_1	101	106	PF00244	0.390
LIG_14-3-3_CanoR_1	112	119	PF00244	0.372
LIG_14-3-3_CanoR_1	12	16	PF00244	0.426
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BRCT_BRCA1_1	113	117	PF00533	0.451
LIG_FHA_1	14	20	PF00498	0.251
LIG_FHA_2	68	74	PF00498	0.510
LIG_LIR_Gen_1	34	44	PF02991	0.251
LIG_LIR_Gen_1	46	55	PF02991	0.306
LIG_LIR_Nem_3	34	39	PF02991	0.251
LIG_MYND_2	88	92	PF01753	0.378
LIG_SH2_STAP1	47	51	PF00017	0.322
LIG_SH2_STAT5	15	18	PF00017	0.272
LIG_SH3_3	119	125	PF00018	0.454
LIG_SH3_3	62	68	PF00018	0.395
LIG_SUMO_SIM_anti_2	94	101	PF11976	0.469
MOD_CDK_SPK_2	72	77	PF00069	0.443
MOD_CK1_1	67	73	PF00069	0.664
MOD_CK2_1	67	73	PF00069	0.571
MOD_CK2_1	92	98	PF00069	0.477
MOD_GlcNHglycan	1	4	PF01048	0.548
MOD_GSK3_1	39	46	PF00069	0.402
MOD_GSK3_1	67	74	PF00069	0.605
MOD_NEK2_1	39	44	PF00069	0.389
MOD_PKA_2	11	17	PF00069	0.426
MOD_PKA_2	111	117	PF00069	0.370
MOD_PKA_2	32	38	PF00069	0.310
MOD_Plk_1	39	45	PF00069	0.366
MOD_Plk_1	93	99	PF00069	0.461
MOD_ProDKin_1	64	70	PF00069	0.446
MOD_ProDKin_1	72	78	PF00069	0.506
MOD_ProDKin_1	84	90	PF00069	0.473
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.382
TRG_ENDOCYTIC_2	47	50	PF00928	0.322
TRG_ER_diArg_1	100	103	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D8	Leptomonas seymouri	71%	98%
A0A0N0P8V1	Leptomonas seymouri	26%	100%
A0A0S4JND4	Bodo saltans	33%	100%
A0A3Q8IJQ7	Leishmania donovani	26%	100%
A4H9K8	Leishmania braziliensis	28%	91%
A4HKZ6	Leishmania braziliensis	82%	100%
A4HXX4	Leishmania infantum	26%	100%
D0AAN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ARN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
Q4QDU1	Leishmania major	26%	91%
V5B5T5	Trypanosoma cruzi	44%	100%