Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B3D5_LEIMU

TriTrypDb:

LmxM.31.3550

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3D5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.631
CLV_C14_Caspase3-7	378	382	PF00656	0.794
CLV_C14_Caspase3-7	98	102	PF00656	0.539
CLV_NRD_NRD_1	210	212	PF00675	0.515
CLV_NRD_NRD_1	355	357	PF00675	0.734
CLV_NRD_NRD_1	368	370	PF00675	0.624
CLV_NRD_NRD_1	404	406	PF00675	0.776
CLV_NRD_NRD_1	58	60	PF00675	0.597
CLV_NRD_NRD_1	79	81	PF00675	0.521
CLV_PCSK_FUR_1	402	406	PF00082	0.606
CLV_PCSK_KEX2_1	353	355	PF00082	0.725
CLV_PCSK_KEX2_1	367	369	PF00082	0.606
CLV_PCSK_KEX2_1	402	404	PF00082	0.774
CLV_PCSK_KEX2_1	409	411	PF00082	0.701
CLV_PCSK_KEX2_1	413	415	PF00082	0.638
CLV_PCSK_KEX2_1	58	60	PF00082	0.618
CLV_PCSK_KEX2_1	73	75	PF00082	0.626
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.537
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.767
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.766
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.722
CLV_PCSK_PC7_1	363	369	PF00082	0.640
CLV_PCSK_PC7_1	405	411	PF00082	0.527
CLV_PCSK_SKI1_1	172	176	PF00082	0.686
CLV_PCSK_SKI1_1	414	418	PF00082	0.722
CLV_PCSK_SKI1_1	59	63	PF00082	0.621
DEG_APCC_DBOX_1	273	281	PF00400	0.537
DEG_MDM2_SWIB_1	220	228	PF02201	0.673
DEG_Nend_Nbox_1	1	3	PF02207	0.749
DEG_SCF_TRCP1_1	65	70	PF00400	0.473
DOC_ANK_TNKS_1	355	362	PF00023	0.527
DOC_CYCLIN_RxL_1	56	66	PF00134	0.566
DOC_MAPK_gen_1	271	279	PF00069	0.540
DOC_MAPK_MEF2A_6	165	173	PF00069	0.597
DOC_USP7_MATH_1	123	127	PF00917	0.617
DOC_USP7_MATH_1	155	159	PF00917	0.630
DOC_USP7_MATH_1	187	191	PF00917	0.709
DOC_USP7_MATH_1	192	196	PF00917	0.770
DOC_USP7_MATH_1	201	205	PF00917	0.594
DOC_USP7_MATH_1	233	237	PF00917	0.591
DOC_USP7_MATH_1	348	352	PF00917	0.714
DOC_USP7_MATH_1	69	73	PF00917	0.585
DOC_USP7_UBL2_3	409	413	PF12436	0.738
DOC_WW_Pin1_4	190	195	PF00397	0.738
DOC_WW_Pin1_4	344	349	PF00397	0.638
DOC_WW_Pin1_4	384	389	PF00397	0.747
DOC_WW_Pin1_4	96	101	PF00397	0.604
LIG_14-3-3_CanoR_1	122	132	PF00244	0.689
LIG_14-3-3_CanoR_1	274	280	PF00244	0.732
LIG_14-3-3_CanoR_1	438	443	PF00244	0.671
LIG_14-3-3_CanoR_1	68	75	PF00244	0.667
LIG_Actin_WH2_2	156	174	PF00022	0.680
LIG_FHA_1	155	161	PF00498	0.644
LIG_FHA_1	173	179	PF00498	0.616
LIG_FHA_1	2	8	PF00498	0.558
LIG_FHA_1	220	226	PF00498	0.431
LIG_FHA_2	148	154	PF00498	0.590
LIG_FHA_2	35	41	PF00498	0.470
LIG_FHA_2	88	94	PF00498	0.793
LIG_FHA_2	96	102	PF00498	0.693
LIG_GBD_Chelix_1	206	214	PF00786	0.672
LIG_GBD_Chelix_1	53	61	PF00786	0.702
LIG_LIR_Gen_1	222	232	PF02991	0.614
LIG_LIR_Nem_3	222	227	PF02991	0.623
LIG_PDZ_Class_1	438	443	PF00595	0.668
LIG_Pex14_1	213	217	PF04695	0.665
LIG_Pex14_2	217	221	PF04695	0.690
LIG_SH2_SRC	370	373	PF00017	0.528
LIG_SH2_STAP1	299	303	PF00017	0.613
LIG_SH2_STAT3	298	301	PF00017	0.693
LIG_SH2_STAT5	216	219	PF00017	0.673
LIG_SH2_STAT5	370	373	PF00017	0.537
LIG_SH2_STAT5	75	78	PF00017	0.615
LIG_SH3_3	138	144	PF00018	0.730
LIG_SH3_3	188	194	PF00018	0.637
LIG_SH3_3	270	276	PF00018	0.540
LIG_SH3_3	79	85	PF00018	0.608
LIG_Sin3_3	129	136	PF02671	0.476
LIG_SUMO_SIM_par_1	429	435	PF11976	0.645
LIG_TRAF2_1	18	21	PF00917	0.691
LIG_UBA3_1	45	52	PF00899	0.546
LIG_WW_3	271	275	PF00397	0.537
MOD_CK1_1	190	196	PF00069	0.715
MOD_CK1_1	231	237	PF00069	0.658
MOD_CK1_1	3	9	PF00069	0.714
MOD_CK1_1	344	350	PF00069	0.594
MOD_CK1_1	374	380	PF00069	0.786
MOD_CK1_1	382	388	PF00069	0.608
MOD_CK1_1	87	93	PF00069	0.734
MOD_CK2_1	15	21	PF00069	0.684
MOD_CK2_1	332	338	PF00069	0.626
MOD_CK2_1	34	40	PF00069	0.455
MOD_CK2_1	384	390	PF00069	0.521
MOD_GlcNHglycan	126	129	PF01048	0.508
MOD_GlcNHglycan	156	160	PF01048	0.711
MOD_GlcNHglycan	197	200	PF01048	0.579
MOD_GlcNHglycan	233	236	PF01048	0.581
MOD_GlcNHglycan	334	337	PF01048	0.545
MOD_GlcNHglycan	350	353	PF01048	0.783
MOD_GlcNHglycan	377	380	PF01048	0.633
MOD_GlcNHglycan	418	422	PF01048	0.606
MOD_GlcNHglycan	64	68	PF01048	0.726
MOD_GlcNHglycan	86	89	PF01048	0.802
MOD_GSK3_1	101	108	PF00069	0.641
MOD_GSK3_1	143	150	PF00069	0.725
MOD_GSK3_1	190	197	PF00069	0.602
MOD_GSK3_1	227	234	PF00069	0.680
MOD_GSK3_1	253	260	PF00069	0.711
MOD_GSK3_1	344	351	PF00069	0.567
MOD_GSK3_1	371	378	PF00069	0.796
MOD_GSK3_1	380	387	PF00069	0.635
MOD_GSK3_1	63	70	PF00069	0.657
MOD_GSK3_1	87	94	PF00069	0.771
MOD_N-GLC_2	312	314	PF02516	0.488
MOD_NEK2_1	173	178	PF00069	0.691
MOD_NEK2_1	206	211	PF00069	0.553
MOD_NEK2_1	227	232	PF00069	0.705
MOD_NEK2_1	329	334	PF00069	0.741
MOD_NEK2_1	417	422	PF00069	0.532
MOD_NEK2_1	63	68	PF00069	0.652
MOD_PIKK_1	101	107	PF00454	0.815
MOD_PIKK_1	330	336	PF00454	0.737
MOD_PKA_1	73	79	PF00069	0.715
MOD_PKA_2	228	234	PF00069	0.541
MOD_PKA_2	375	381	PF00069	0.596
MOD_PKA_2	67	73	PF00069	0.682
MOD_Plk_1	155	161	PF00069	0.714
MOD_Plk_1	380	386	PF00069	0.586
MOD_Plk_4	275	281	PF00069	0.709
MOD_Plk_4	3	9	PF00069	0.644
MOD_ProDKin_1	190	196	PF00069	0.739
MOD_ProDKin_1	344	350	PF00069	0.639
MOD_ProDKin_1	384	390	PF00069	0.746
MOD_ProDKin_1	96	102	PF00069	0.605
TRG_ENDOCYTIC_2	216	219	PF00928	0.601
TRG_ER_diArg_1	119	122	PF00400	0.740
TRG_ER_diArg_1	354	356	PF00400	0.730
TRG_ER_diArg_1	367	369	PF00400	0.665
TRG_ER_diArg_1	402	405	PF00400	0.712
TRG_ER_diArg_1	437	440	PF00400	0.730
TRG_ER_diArg_1	57	59	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7T2	Leishmania donovani	80%	100%
A4HKZ5	Leishmania braziliensis	57%	100%
A4I8H5	Leishmania infantum	80%	100%
Q4Q4R7	Leishmania major	80%	100%