TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3D2_LEIMU

TriTrypDb:

LmxM.31.3480

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.734
CLV_C14_Caspase3-7	323	327	PF00656	0.586
CLV_NRD_NRD_1	390	392	PF00675	0.497
CLV_NRD_NRD_1	431	433	PF00675	0.496
CLV_NRD_NRD_1	6	8	PF00675	0.753
CLV_PCSK_KEX2_1	12	14	PF00082	0.666
CLV_PCSK_KEX2_1	389	391	PF00082	0.460
CLV_PCSK_KEX2_1	431	433	PF00082	0.437
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.699
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.460
CLV_PCSK_SKI1_1	13	17	PF00082	0.725
CLV_PCSK_SKI1_1	225	229	PF00082	0.440
CLV_PCSK_SKI1_1	343	347	PF00082	0.493
CLV_PCSK_SKI1_1	362	366	PF00082	0.588
CLV_PCSK_SKI1_1	70	74	PF00082	0.460
DEG_APCC_DBOX_1	12	20	PF00400	0.726
DEG_APCC_DBOX_1	442	450	PF00400	0.479
DOC_CYCLIN_yClb5_NLxxxL_5	469	478	PF00134	0.498
DOC_MAPK_gen_1	94	102	PF00069	0.445
DOC_MAPK_MEF2A_6	243	251	PF00069	0.451
DOC_MAPK_MEF2A_6	270	277	PF00069	0.365
DOC_MAPK_MEF2A_6	94	102	PF00069	0.445
DOC_MAPK_NFAT4_5	270	278	PF00069	0.406
DOC_PP2B_LxvP_1	19	22	PF13499	0.702
DOC_PP2B_LxvP_1	561	564	PF13499	0.456
DOC_PP4_FxxP_1	15	18	PF00568	0.700
DOC_USP7_MATH_1	11	15	PF00917	0.648
DOC_USP7_MATH_1	168	172	PF00917	0.577
DOC_USP7_MATH_1	381	385	PF00917	0.598
DOC_USP7_MATH_1	483	487	PF00917	0.630
DOC_USP7_MATH_1	496	500	PF00917	0.695
DOC_USP7_MATH_1	528	532	PF00917	0.424
DOC_USP7_MATH_1	617	621	PF00917	0.514
DOC_USP7_UBL2_3	361	365	PF12436	0.602
DOC_USP7_UBL2_3	8	12	PF12436	0.761
DOC_WW_Pin1_4	23	28	PF00397	0.712
LIG_14-3-3_CanoR_1	184	194	PF00244	0.385
LIG_14-3-3_CanoR_1	405	414	PF00244	0.473
LIG_14-3-3_CanoR_1	431	435	PF00244	0.461
LIG_14-3-3_CanoR_1	443	447	PF00244	0.395
LIG_14-3-3_CanoR_1	506	512	PF00244	0.678
LIG_14-3-3_CanoR_1	70	75	PF00244	0.466
LIG_14-3-3_CanoR_1	90	98	PF00244	0.608
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BRCT_BRCA1_1	522	526	PF00533	0.467
LIG_BRCT_BRCA1_1	608	612	PF00533	0.430
LIG_CtBP_PxDLS_1	22	26	PF00389	0.470
LIG_eIF4E_1	272	278	PF01652	0.443
LIG_FHA_1	142	148	PF00498	0.588
LIG_FHA_1	236	242	PF00498	0.306
LIG_FHA_1	418	424	PF00498	0.510
LIG_FHA_1	43	49	PF00498	0.485
LIG_FHA_1	487	493	PF00498	0.616
LIG_FHA_1	496	502	PF00498	0.712
LIG_FHA_1	506	512	PF00498	0.517
LIG_FHA_1	551	557	PF00498	0.435
LIG_FHA_1	97	103	PF00498	0.482
LIG_FHA_2	200	206	PF00498	0.450
LIG_FHA_2	230	236	PF00498	0.600
LIG_FHA_2	408	414	PF00498	0.487
LIG_FHA_2	71	77	PF00498	0.402
LIG_LIR_Apic_2	14	18	PF02991	0.696
LIG_LIR_Apic_2	181	186	PF02991	0.540
LIG_LIR_Gen_1	215	223	PF02991	0.369
LIG_LIR_Gen_1	433	442	PF02991	0.362
LIG_LIR_Gen_1	49	58	PF02991	0.565
LIG_LIR_Gen_1	508	517	PF02991	0.718
LIG_LIR_Gen_1	523	534	PF02991	0.324
LIG_LIR_Nem_3	215	220	PF02991	0.363
LIG_LIR_Nem_3	271	275	PF02991	0.446
LIG_LIR_Nem_3	433	437	PF02991	0.385
LIG_LIR_Nem_3	49	53	PF02991	0.564
LIG_LIR_Nem_3	508	512	PF02991	0.729
LIG_LIR_Nem_3	523	529	PF02991	0.337
LIG_LIR_Nem_3	608	613	PF02991	0.514
LIG_NRBOX	276	282	PF00104	0.309
LIG_Pex14_2	213	217	PF04695	0.372
LIG_SH2_CRK	183	187	PF00017	0.517
LIG_SH2_CRK	272	276	PF00017	0.443
LIG_SH2_NCK_1	288	292	PF00017	0.441
LIG_SH2_NCK_1	613	617	PF00017	0.500
LIG_SH2_SRC	288	291	PF00017	0.476
LIG_SH2_STAP1	613	617	PF00017	0.485
LIG_SH2_STAT3	633	636	PF00017	0.434
LIG_SH2_STAT5	151	154	PF00017	0.495
LIG_SH2_STAT5	240	243	PF00017	0.434
LIG_SH2_STAT5	593	596	PF00017	0.429
LIG_SH2_STAT5	613	616	PF00017	0.233
LIG_SH2_STAT5	630	633	PF00017	0.233
LIG_SH3_3	38	44	PF00018	0.477
LIG_SH3_3	461	467	PF00018	0.581
LIG_SH3_3	618	624	PF00018	0.389
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.341
LIG_SUMO_SIM_par_1	274	279	PF11976	0.360
LIG_SUMO_SIM_par_1	68	77	PF11976	0.483
LIG_SUMO_SIM_par_1	98	104	PF11976	0.453
LIG_TRAF2_1	136	139	PF00917	0.664
LIG_TRAF2_1	2	5	PF00917	0.482
LIG_TRAF2_1	333	336	PF00917	0.518
LIG_TRAF2_2	627	632	PF00917	0.346
LIG_TRFH_1	509	513	PF08558	0.509
LIG_UBA3_1	261	270	PF00899	0.400
MOD_CK1_1	218	224	PF00069	0.449
MOD_CK1_1	34	40	PF00069	0.746
MOD_CK1_1	486	492	PF00069	0.522
MOD_CK1_1	89	95	PF00069	0.586
MOD_CK2_1	106	112	PF00069	0.755
MOD_CK2_1	11	17	PF00069	0.636
MOD_CK2_1	229	235	PF00069	0.608
MOD_CK2_1	381	387	PF00069	0.541
MOD_CK2_1	407	413	PF00069	0.464
MOD_CK2_1	43	49	PF00069	0.545
MOD_CK2_1	612	618	PF00069	0.416
MOD_CK2_1	70	76	PF00069	0.442
MOD_GlcNHglycan	1	4	PF01048	0.763
MOD_GlcNHglycan	108	111	PF01048	0.778
MOD_GlcNHglycan	130	134	PF01048	0.700
MOD_GlcNHglycan	170	173	PF01048	0.517
MOD_GlcNHglycan	33	36	PF01048	0.675
MOD_GlcNHglycan	352	355	PF01048	0.560
MOD_GlcNHglycan	384	387	PF01048	0.608
MOD_GlcNHglycan	45	48	PF01048	0.518
MOD_GlcNHglycan	498	501	PF01048	0.726
MOD_GlcNHglycan	514	517	PF01048	0.536
MOD_GlcNHglycan	60	63	PF01048	0.468
MOD_GlcNHglycan	614	617	PF01048	0.367
MOD_GlcNHglycan	91	94	PF01048	0.680
MOD_GSK3_1	247	254	PF00069	0.229
MOD_GSK3_1	397	404	PF00069	0.498
MOD_GSK3_1	417	424	PF00069	0.517
MOD_GSK3_1	479	486	PF00069	0.693
MOD_GSK3_1	92	99	PF00069	0.616
MOD_NEK2_1	247	252	PF00069	0.439
MOD_NEK2_1	276	281	PF00069	0.322
MOD_NEK2_1	406	411	PF00069	0.476
MOD_NEK2_1	437	442	PF00069	0.400
MOD_NEK2_1	550	555	PF00069	0.438
MOD_NEK2_1	556	561	PF00069	0.440
MOD_NEK2_1	58	63	PF00069	0.560
MOD_NEK2_1	612	617	PF00069	0.420
MOD_NEK2_2	199	204	PF00069	0.254
MOD_NEK2_2	507	512	PF00069	0.569
MOD_PIKK_1	421	427	PF00454	0.577
MOD_PIKK_1	437	443	PF00454	0.422
MOD_PIKK_1	556	562	PF00454	0.443
MOD_PKA_1	360	366	PF00069	0.596
MOD_PKA_2	229	235	PF00069	0.563
MOD_PKA_2	430	436	PF00069	0.453
MOD_PKA_2	442	448	PF00069	0.362
MOD_PKA_2	505	511	PF00069	0.572
MOD_PKA_2	89	95	PF00069	0.629
MOD_Plk_1	129	135	PF00069	0.526
MOD_Plk_1	486	492	PF00069	0.412
MOD_Plk_1	556	562	PF00069	0.445
MOD_Plk_1	617	623	PF00069	0.466
MOD_Plk_2-3	229	235	PF00069	0.514
MOD_Plk_4	268	274	PF00069	0.447
MOD_Plk_4	276	282	PF00069	0.313
MOD_Plk_4	442	448	PF00069	0.467
MOD_Plk_4	529	535	PF00069	0.400
MOD_Plk_4	545	551	PF00069	0.309
MOD_ProDKin_1	23	29	PF00069	0.711
MOD_SUMO_rev_2	84	89	PF00179	0.587
TRG_DiLeu_BaEn_1	545	550	PF01217	0.378
TRG_DiLeu_BaEn_3	76	82	PF01217	0.554
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.488
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.472
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.490
TRG_ENDOCYTIC_2	272	275	PF00928	0.444
TRG_ER_diArg_1	390	392	PF00400	0.497
TRG_ER_diArg_1	430	432	PF00400	0.573
TRG_ER_diArg_1	447	450	PF00400	0.285
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK53	Leptomonas seymouri	60%	99%
A0A1X0NRY3	Trypanosomatidae	27%	100%
A0A3Q8IHE5	Leishmania donovani	92%	100%
A0A422P2Z2	Trypanosoma rangeli	27%	100%
A4HKZ1	Leishmania braziliensis	75%	100%
A4I8H2	Leishmania infantum	92%	100%
D0AAP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q4S4	Leishmania major	91%	100%
V5BQY9	Trypanosoma cruzi	26%	100%