Putative RNA-binding, protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding, protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3D1_LEIMU

TriTrypDb:

LmxM.31.3470

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3D1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	432	436	PF00656	0.649
CLV_C14_Caspase3-7	442	446	PF00656	0.534
CLV_NRD_NRD_1	341	343	PF00675	0.439
CLV_NRD_NRD_1	377	379	PF00675	0.489
CLV_NRD_NRD_1	386	388	PF00675	0.481
CLV_NRD_NRD_1	394	396	PF00675	0.489
CLV_NRD_NRD_1	45	47	PF00675	0.422
CLV_NRD_NRD_1	58	60	PF00675	0.532
CLV_NRD_NRD_1	74	76	PF00675	0.430
CLV_PCSK_FUR_1	377	381	PF00082	0.488
CLV_PCSK_FUR_1	382	386	PF00082	0.490
CLV_PCSK_KEX2_1	341	343	PF00082	0.439
CLV_PCSK_KEX2_1	376	378	PF00082	0.488
CLV_PCSK_KEX2_1	379	381	PF00082	0.486
CLV_PCSK_KEX2_1	384	386	PF00082	0.496
CLV_PCSK_KEX2_1	393	395	PF00082	0.477
CLV_PCSK_KEX2_1	58	60	PF00082	0.547
CLV_PCSK_KEX2_1	74	76	PF00082	0.444
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.488
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.486
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.477
CLV_PCSK_PC7_1	380	386	PF00082	0.546
CLV_PCSK_PC7_1	390	396	PF00082	0.425
CLV_PCSK_SKI1_1	197	201	PF00082	0.528
CLV_PCSK_SKI1_1	342	346	PF00082	0.472
CLV_PCSK_SKI1_1	390	394	PF00082	0.486
CLV_PCSK_SKI1_1	395	399	PF00082	0.480
CLV_PCSK_SKI1_1	47	51	PF00082	0.450
CLV_PCSK_SKI1_1	473	477	PF00082	0.269
CLV_PCSK_SKI1_1	503	507	PF00082	0.198
CLV_PCSK_SKI1_1	82	86	PF00082	0.494
DEG_APCC_DBOX_1	81	89	PF00400	0.462
DEG_COP1_1	449	458	PF00400	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.485
DEG_SCF_FBW7_1	123	129	PF00400	0.510
DOC_CDC14_PxL_1	17	25	PF14671	0.530
DOC_CKS1_1	115	120	PF01111	0.602
DOC_CKS1_1	123	128	PF01111	0.565
DOC_CYCLIN_RxL_1	194	205	PF00134	0.538
DOC_MAPK_gen_1	390	400	PF00069	0.568
DOC_MAPK_gen_1	46	54	PF00069	0.357
DOC_MAPK_MEF2A_6	312	319	PF00069	0.369
DOC_MAPK_MEF2A_6	46	54	PF00069	0.423
DOC_PP1_RVXF_1	195	202	PF00149	0.535
DOC_PP4_FxxP_1	201	204	PF00568	0.543
DOC_USP7_MATH_1	124	128	PF00917	0.627
DOC_USP7_MATH_1	169	173	PF00917	0.640
DOC_USP7_MATH_1	367	371	PF00917	0.472
DOC_USP7_MATH_1	420	424	PF00917	0.682
DOC_USP7_MATH_2	165	171	PF00917	0.515
DOC_WW_Pin1_4	114	119	PF00397	0.593
DOC_WW_Pin1_4	122	127	PF00397	0.606
DOC_WW_Pin1_4	130	135	PF00397	0.675
DOC_WW_Pin1_4	147	152	PF00397	0.588
DOC_WW_Pin1_4	154	159	PF00397	0.642
DOC_WW_Pin1_4	161	166	PF00397	0.539
DOC_WW_Pin1_4	171	176	PF00397	0.643
DOC_WW_Pin1_4	249	254	PF00397	0.407
DOC_WW_Pin1_4	405	410	PF00397	0.539
DOC_WW_Pin1_4	436	441	PF00397	0.594
LIG_14-3-3_CanoR_1	486	490	PF00244	0.469
LIG_14-3-3_CanoR_1	503	508	PF00244	0.469
LIG_14-3-3_CanoR_1	523	528	PF00244	0.448
LIG_14-3-3_CanoR_1	548	553	PF00244	0.530
LIG_14-3-3_CanoR_1	97	105	PF00244	0.581
LIG_BIR_III_2	131	135	PF00653	0.487
LIG_BRCT_BRCA1_1	492	496	PF00533	0.469
LIG_DLG_GKlike_1	523	531	PF00625	0.568
LIG_eIF4E_1	522	528	PF01652	0.469
LIG_FHA_1	105	111	PF00498	0.503
LIG_FHA_1	155	161	PF00498	0.606
LIG_FHA_1	219	225	PF00498	0.436
LIG_FHA_1	269	275	PF00498	0.396
LIG_FHA_1	284	290	PF00498	0.380
LIG_FHA_1	328	334	PF00498	0.483
LIG_FHA_1	495	501	PF00498	0.455
LIG_FHA_1	65	71	PF00498	0.570
LIG_FHA_2	148	154	PF00498	0.637
LIG_FHA_2	162	168	PF00498	0.709
LIG_FHA_2	267	273	PF00498	0.557
LIG_FHA_2	465	471	PF00498	0.469
LIG_FHA_2	479	485	PF00498	0.469
LIG_FHA_2	504	510	PF00498	0.397
LIG_FHA_2	559	565	PF00498	0.606
LIG_GBD_Chelix_1	48	56	PF00786	0.398
LIG_IBAR_NPY_1	240	242	PF08397	0.410
LIG_LIR_Nem_3	520	525	PF02991	0.454
LIG_LIR_Nem_3	7	11	PF02991	0.399
LIG_LIR_Nem_3	89	93	PF02991	0.514
LIG_NRBOX	471	477	PF00104	0.469
LIG_NRBOX	49	55	PF00104	0.354
LIG_PCNA_PIPBox_1	81	90	PF02747	0.531
LIG_PDZ_Class_2	563	568	PF00595	0.489
LIG_PDZ_Wminus1_1	566	568	PF00595	0.466
LIG_PTB_Apo_2	237	244	PF02174	0.399
LIG_PTB_Apo_2	516	523	PF02174	0.516
LIG_PTB_Phospho_1	516	522	PF10480	0.516
LIG_Rb_pABgroove_1	18	26	PF01858	0.484
LIG_REV1ctd_RIR_1	198	203	PF16727	0.470
LIG_SH2_CRK	38	42	PF00017	0.511
LIG_SH2_CRK	479	483	PF00017	0.469
LIG_SH2_CRK	525	529	PF00017	0.377
LIG_SH2_NCK_1	525	529	PF00017	0.442
LIG_SH2_STAP1	24	28	PF00017	0.465
LIG_SH2_STAT5	225	228	PF00017	0.417
LIG_SH2_STAT5	242	245	PF00017	0.427
LIG_SH2_STAT5	262	265	PF00017	0.351
LIG_SH2_STAT5	288	291	PF00017	0.349
LIG_SH2_STAT5	310	313	PF00017	0.469
LIG_SH3_3	120	126	PF00018	0.718
LIG_SH3_3	176	182	PF00018	0.665
LIG_SUMO_SIM_anti_2	534	540	PF11976	0.436
LIG_SUMO_SIM_par_1	291	298	PF11976	0.359
LIG_SUMO_SIM_par_1	49	55	PF11976	0.437
LIG_SUMO_SIM_par_1	537	543	PF11976	0.452
LIG_TRAF2_1	410	413	PF00917	0.647
LIG_TRAF2_1	506	509	PF00917	0.469
MOD_CDK_SPxxK_3	161	168	PF00069	0.559
MOD_CDK_SPxxK_3	171	178	PF00069	0.663
MOD_CDK_SPxxK_3	249	256	PF00069	0.389
MOD_CK1_1	116	122	PF00069	0.682
MOD_CK1_1	174	180	PF00069	0.670
MOD_CK1_1	280	286	PF00069	0.434
MOD_CK1_1	407	413	PF00069	0.604
MOD_CK1_1	423	429	PF00069	0.538
MOD_CK1_1	430	436	PF00069	0.622
MOD_CK1_1	438	444	PF00069	0.649
MOD_CK1_1	526	532	PF00069	0.424
MOD_CK1_1	99	105	PF00069	0.576
MOD_CK2_1	108	114	PF00069	0.580
MOD_CK2_1	147	153	PF00069	0.641
MOD_CK2_1	161	167	PF00069	0.542
MOD_CK2_1	266	272	PF00069	0.423
MOD_CK2_1	407	413	PF00069	0.591
MOD_CK2_1	478	484	PF00069	0.469
MOD_CK2_1	503	509	PF00069	0.472
MOD_CK2_1	558	564	PF00069	0.544
MOD_CK2_1	86	92	PF00069	0.503
MOD_Cter_Amidation	72	75	PF01082	0.420
MOD_GlcNHglycan	126	129	PF01048	0.628
MOD_GlcNHglycan	169	172	PF01048	0.616
MOD_GlcNHglycan	282	285	PF01048	0.477
MOD_GlcNHglycan	359	363	PF01048	0.565
MOD_GlcNHglycan	422	425	PF01048	0.734
MOD_GlcNHglycan	426	429	PF01048	0.787
MOD_GlcNHglycan	445	448	PF01048	0.530
MOD_GlcNHglycan	490	495	PF01048	0.269
MOD_GlcNHglycan	528	531	PF01048	0.357
MOD_GlcNHglycan	62	65	PF01048	0.705
MOD_GSK3_1	104	111	PF00069	0.511
MOD_GSK3_1	122	129	PF00069	0.646
MOD_GSK3_1	145	152	PF00069	0.600
MOD_GSK3_1	163	170	PF00069	0.777
MOD_GSK3_1	189	196	PF00069	0.590
MOD_GSK3_1	367	374	PF00069	0.424
MOD_GSK3_1	403	410	PF00069	0.583
MOD_GSK3_1	419	426	PF00069	0.522
MOD_GSK3_1	427	434	PF00069	0.579
MOD_GSK3_1	435	442	PF00069	0.608
MOD_GSK3_1	490	497	PF00069	0.469
MOD_GSK3_1	60	67	PF00069	0.535
MOD_N-GLC_1	60	65	PF02516	0.511
MOD_NEK2_1	104	109	PF00069	0.459
MOD_NEK2_1	113	118	PF00069	0.480
MOD_NEK2_1	218	223	PF00069	0.455
MOD_NEK2_1	266	271	PF00069	0.465
MOD_NEK2_1	37	42	PF00069	0.443
MOD_NEK2_1	511	516	PF00069	0.491
MOD_NEK2_1	60	65	PF00069	0.555
MOD_PIKK_1	116	122	PF00454	0.596
MOD_PIKK_1	26	32	PF00454	0.542
MOD_PK_1	393	399	PF00069	0.557
MOD_PKA_1	393	399	PF00069	0.557
MOD_PKA_2	167	173	PF00069	0.684
MOD_PKA_2	202	208	PF00069	0.573
MOD_PKA_2	393	399	PF00069	0.557
MOD_PKA_2	485	491	PF00069	0.469
MOD_PKA_2	96	102	PF00069	0.584
MOD_Plk_1	235	241	PF00069	0.427
MOD_Plk_1	388	394	PF00069	0.361
MOD_Plk_1	558	564	PF00069	0.520
MOD_Plk_4	283	289	PF00069	0.392
MOD_Plk_4	517	523	PF00069	0.464
MOD_ProDKin_1	114	120	PF00069	0.594
MOD_ProDKin_1	122	128	PF00069	0.608
MOD_ProDKin_1	130	136	PF00069	0.673
MOD_ProDKin_1	147	153	PF00069	0.589
MOD_ProDKin_1	154	160	PF00069	0.642
MOD_ProDKin_1	161	167	PF00069	0.542
MOD_ProDKin_1	171	177	PF00069	0.642
MOD_ProDKin_1	249	255	PF00069	0.406
MOD_ProDKin_1	405	411	PF00069	0.541
MOD_ProDKin_1	436	442	PF00069	0.594
TRG_DiLeu_BaEn_4	508	514	PF01217	0.516
TRG_ENDOCYTIC_2	225	228	PF00928	0.424
TRG_ENDOCYTIC_2	24	27	PF00928	0.461
TRG_ENDOCYTIC_2	246	249	PF00928	0.470
TRG_ENDOCYTIC_2	34	37	PF00928	0.469
TRG_ENDOCYTIC_2	38	41	PF00928	0.440
TRG_ENDOCYTIC_2	479	482	PF00928	0.469
TRG_ENDOCYTIC_2	525	528	PF00928	0.385
TRG_ER_diArg_1	340	342	PF00400	0.420
TRG_ER_diArg_1	347	350	PF00400	0.538
TRG_ER_diArg_1	377	380	PF00400	0.490
TRG_ER_diArg_1	382	385	PF00400	0.491
TRG_ER_diArg_1	58	60	PF00400	0.547
TRG_ER_diArg_1	74	76	PF00400	0.430
TRG_NLS_Bipartite_1	376	397	PF00514	0.480
TRG_NLS_MonoExtC_3	377	382	PF00514	0.496
TRG_NLS_MonoExtN_4	376	383	PF00514	0.485
TRG_NLS_MonoExtN_4	390	397	PF00514	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT8	Leptomonas seymouri	55%	100%
A0A3Q8IDF9	Leishmania donovani	89%	100%
A4HKZ0	Leishmania braziliensis	77%	99%
A4I8H1	Leishmania infantum	89%	100%
Q4Q4S5	Leishmania major	88%	100%