Zinc-finger of a C2HC-type family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania mexicana

UniProt:

E9B3C9_LEIMU

TriTrypDb:

LmxM.31.3450

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.732
CLV_NRD_NRD_1	218	220	PF00675	0.646
CLV_NRD_NRD_1	473	475	PF00675	0.389
CLV_NRD_NRD_1	497	499	PF00675	0.568
CLV_NRD_NRD_1	515	517	PF00675	0.692
CLV_PCSK_KEX2_1	192	194	PF00082	0.732
CLV_PCSK_KEX2_1	50	52	PF00082	0.553
CLV_PCSK_KEX2_1	515	517	PF00082	0.756
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.547
CLV_PCSK_SKI1_1	140	144	PF00082	0.352
CLV_PCSK_SKI1_1	158	162	PF00082	0.573
CLV_PCSK_SKI1_1	3	7	PF00082	0.499
CLV_PCSK_SKI1_1	328	332	PF00082	0.700
CLV_PCSK_SKI1_1	474	478	PF00082	0.381
CLV_PCSK_SKI1_1	515	519	PF00082	0.648
CLV_PCSK_SKI1_1	63	67	PF00082	0.474
CLV_PCSK_SKI1_1	75	79	PF00082	0.593
DEG_SCF_FBW7_1	339	346	PF00400	0.528
DEG_SPOP_SBC_1	173	177	PF00917	0.587
DEG_SPOP_SBC_1	179	183	PF00917	0.644
DOC_CKS1_1	340	345	PF01111	0.526
DOC_MAPK_gen_1	498	505	PF00069	0.592
DOC_MAPK_HePTP_8	278	290	PF00069	0.506
DOC_MAPK_MEF2A_6	281	290	PF00069	0.684
DOC_MAPK_RevD_3	503	516	PF00069	0.579
DOC_PP1_RVXF_1	305	311	PF00149	0.709
DOC_PP1_RVXF_1	49	56	PF00149	0.432
DOC_USP7_MATH_1	111	115	PF00917	0.414
DOC_USP7_MATH_1	352	356	PF00917	0.730
DOC_USP7_MATH_1	402	406	PF00917	0.570
DOC_USP7_MATH_1	525	529	PF00917	0.625
DOC_USP7_UBL2_3	9	13	PF12436	0.733
DOC_WW_Pin1_4	130	135	PF00397	0.389
DOC_WW_Pin1_4	182	187	PF00397	0.564
DOC_WW_Pin1_4	296	301	PF00397	0.647
DOC_WW_Pin1_4	339	344	PF00397	0.681
DOC_WW_Pin1_4	381	386	PF00397	0.669
DOC_WW_Pin1_4	510	515	PF00397	0.807
DOC_WW_Pin1_4	517	522	PF00397	0.662
DOC_WW_Pin1_4	66	71	PF00397	0.479
LIG_14-3-3_CanoR_1	109	119	PF00244	0.466
LIG_14-3-3_CanoR_1	301	310	PF00244	0.671
LIG_14-3-3_CanoR_1	434	442	PF00244	0.577
LIG_14-3-3_CanoR_1	459	468	PF00244	0.560
LIG_BIR_III_4	392	396	PF00653	0.703
LIG_BRCT_BRCA1_1	227	231	PF00533	0.523
LIG_FHA_1	259	265	PF00498	0.711
LIG_FHA_1	35	41	PF00498	0.396
LIG_FHA_1	500	506	PF00498	0.632
LIG_FHA_1	507	513	PF00498	0.637
LIG_FHA_2	312	318	PF00498	0.685
LIG_FHA_2	367	373	PF00498	0.695
LIG_FHA_2	460	466	PF00498	0.572
LIG_GSK3_LRP6_1	339	344	PF00069	0.527
LIG_Integrin_RGD_1	57	59	PF01839	0.455
LIG_LIR_Gen_1	309	318	PF02991	0.692
LIG_LIR_Nem_3	361	365	PF02991	0.516
LIG_LIR_Nem_3	446	451	PF02991	0.563
LIG_SH2_CRK	119	123	PF00017	0.446
LIG_SH2_CRK	362	366	PF00017	0.517
LIG_SH2_NCK_1	362	366	PF00017	0.517
LIG_SH2_NCK_1	96	100	PF00017	0.560
LIG_SH2_SRC	362	365	PF00017	0.516
LIG_SH2_STAT5	29	32	PF00017	0.337
LIG_SH2_STAT5	471	474	PF00017	0.335
LIG_SH2_STAT5	48	51	PF00017	0.543
LIG_SH3_1	518	524	PF00018	0.629
LIG_SH3_3	167	173	PF00018	0.660
LIG_SH3_3	263	269	PF00018	0.660
LIG_SH3_3	294	300	PF00018	0.649
LIG_SH3_3	323	329	PF00018	0.649
LIG_SH3_3	333	339	PF00018	0.661
LIG_SH3_3	501	507	PF00018	0.780
LIG_SH3_3	518	524	PF00018	0.527
LIG_SH3_3	64	70	PF00018	0.471
LIG_SH3_4	9	16	PF00018	0.634
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.683
LIG_SUMO_SIM_par_1	285	291	PF11976	0.634
LIG_UBA3_1	147	155	PF00899	0.214
MOD_CDK_SPK_2	296	301	PF00069	0.622
MOD_CDK_SPK_2	510	515	PF00069	0.822
MOD_CDK_SPK_2	66	71	PF00069	0.533
MOD_CDK_SPxK_1	510	516	PF00069	0.746
MOD_CK1_1	178	184	PF00069	0.648
MOD_CK1_1	222	228	PF00069	0.818
MOD_CK1_1	366	372	PF00069	0.796
MOD_CK1_1	528	534	PF00069	0.637
MOD_CK2_1	366	372	PF00069	0.519
MOD_CK2_1	66	72	PF00069	0.458
MOD_Cter_Amidation	190	193	PF01082	0.510
MOD_Cter_Amidation	472	475	PF01082	0.389
MOD_GlcNHglycan	177	180	PF01048	0.703
MOD_GlcNHglycan	182	185	PF01048	0.735
MOD_GlcNHglycan	221	224	PF01048	0.547
MOD_GlcNHglycan	323	326	PF01048	0.730
MOD_GlcNHglycan	354	357	PF01048	0.641
MOD_GlcNHglycan	435	438	PF01048	0.611
MOD_GlcNHglycan	527	530	PF01048	0.700
MOD_GSK3_1	174	181	PF00069	0.718
MOD_GSK3_1	215	222	PF00069	0.772
MOD_GSK3_1	241	248	PF00069	0.741
MOD_GSK3_1	254	261	PF00069	0.571
MOD_GSK3_1	292	299	PF00069	0.799
MOD_GSK3_1	339	346	PF00069	0.676
MOD_GSK3_1	383	390	PF00069	0.602
MOD_GSK3_1	506	513	PF00069	0.756
MOD_GSK3_1	9	16	PF00069	0.499
MOD_LATS_1	447	453	PF00433	0.437
MOD_N-GLC_1	127	132	PF02516	0.517
MOD_N-GLC_1	244	249	PF02516	0.715
MOD_N-GLC_1	352	357	PF02516	0.738
MOD_N-GLC_1	443	448	PF02516	0.576
MOD_N-GLC_1	449	454	PF02516	0.558
MOD_NEK2_1	127	132	PF00069	0.517
MOD_NEK2_1	320	325	PF00069	0.661
MOD_NEK2_1	374	379	PF00069	0.548
MOD_PIKK_1	363	369	PF00454	0.689
MOD_PIKK_1	374	380	PF00454	0.490
MOD_PKA_1	219	225	PF00069	0.605
MOD_PKA_2	306	312	PF00069	0.648
MOD_PKA_2	433	439	PF00069	0.583
MOD_PKA_2	458	464	PF00069	0.594
MOD_PKA_2	505	511	PF00069	0.572
MOD_Plk_1	127	133	PF00069	0.466
MOD_Plk_1	402	408	PF00069	0.605
MOD_Plk_1	443	449	PF00069	0.577
MOD_Plk_4	306	312	PF00069	0.781
MOD_ProDKin_1	130	136	PF00069	0.389
MOD_ProDKin_1	182	188	PF00069	0.559
MOD_ProDKin_1	296	302	PF00069	0.646
MOD_ProDKin_1	339	345	PF00069	0.677
MOD_ProDKin_1	381	387	PF00069	0.668
MOD_ProDKin_1	510	516	PF00069	0.810
MOD_ProDKin_1	517	523	PF00069	0.662
MOD_ProDKin_1	66	72	PF00069	0.480
MOD_SUMO_for_1	430	433	PF00179	0.513
MOD_SUMO_rev_2	392	402	PF00179	0.742
MOD_SUMO_rev_2	545	551	PF00179	0.574
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.214
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.540
TRG_ENDOCYTIC_2	119	122	PF00928	0.453
TRG_ENDOCYTIC_2	362	365	PF00928	0.580
TRG_ER_diArg_1	192	195	PF00400	0.682
TRG_ER_diArg_1	514	516	PF00400	0.685
TRG_NES_CRM1_1	282	294	PF08389	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN9	Leptomonas seymouri	40%	82%
A0A3Q8ITN7	Leishmania donovani	82%	100%
A4HKY8	Leishmania braziliensis	58%	100%
A4I8G9	Leishmania infantum	82%	100%
Q4Q4S7	Leishmania major	81%	100%